PhD position in RNA and Genome Biology
How are transcription and genome surveillance coordinated? This question is of fundamental importance for the repair of damaged DNA and the protection of genomes against transposable elements; it has thus implications for cancer and evolution. We want to further understand this phenomenon using the fruit fly (Drosophila melanogaster) as a model and transfer our findings to cultured mammalian cells wherever possible. Specifically, we want to find out how cells translate stalling of the transcription machinery (e.g. on repeat sequences or damaged DNA) into a double-stranded RNA response, leading to RNAi.
We use cutting-edge genome editing tools or RNAi-based knock-downs and combine this with deep sequencing and proteomics. We analyze the resulting data with bioinformatics tools. Please see the webpage for more details on the work of the Förstemann lab.
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