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Keppler Lab - Research

Strategies to Identify Novel Cellular Interactors of HIV

HIV consists of a small genome and thus relies heavily on the host cellular machinery for production of viral progeny. To exploit cellular proteins for replication and to overcome host cellular factors with antiviral activity, HIV has evolved a set of accessory and regulatory proteins that apparently shape an optimized environment for its replication and facilitate evasion from innate immunity, respectively.

We seek to identify new interactors of the HIV-host interplay, which are required for the HIV replication cycle. A particular focus lies on resting CD4 T-cells. By using techniques ranging from classical cell biological and biochemical methods to state-of-the art analysis by e.g. mass spectrometry we try to identify new cellular interaction partners. Identified candidates are analyzed in more detail to understand their function within the context of HIV infection in primary target cells.