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Blum Lab - Genomics

2018   |  2017   |   2016   |   2015   |   2014   |   2013   |   2012   |   2011   |   2010   |   2009   |   2008   | 2007   |   2006  |   2005   |   2004   |   2003   |   2002   |   2001   |   2000 and before


2018

Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals.
Shah N, Maqbool MA, Yahia Y, El Aabidine AZ, Esnault C, Forné I, Decker TM, Martin D, Schüller R, Krebs S, Blum H, Imhof A, Eick D, Andrau JC
Mol Cell. 2018 Jan 4;69(1):48-61. PubMed

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2017

A 29-gene and cytogenetic score for the prediction of resistance to induction treatment in acute myeloid leukemia.
Herold T, Jurinovic V, Batcha AMN, Bamopoulos SA, Rothenberg-Thurley M, Ksienzyk B, Hartmann L, Greif PA, Philippou-Massier J, Krebs S, Blum H, Amler S, Schneider S, Konstandin N, Sauerland MC, Görlich D, Berdel WE, Wörmann BJ, Tischer J, Subklewe M, Bohlander SK, Braess J, Hiddemann W, Metzeler KH, Mansmann U, Spiekermann K
Haematologica. 2017 Dec 14. PubMed

Effect of lactation on conceptus-maternal interactions at the initiation of implantation in cattle: I. Effects on the conceptus transcriptome and amino acid composition of the uterine luminal fluid.
Forde N, Simintiras CA, Sturmey RG, Graf A , Wolf E, Blum H , Lonergan P
Biol Reprod. 2017 Oct 27. PubMed

EDetection of two non-synonymous SNPs in SLC45A2 on BTA20 as candidate causal mutations for oculocutaneous albinism in Braunvieh cattle.
Rothammer S, Kunz E, Seichter D, Krebs S, Wassertheurer M, Fries R, Brem G, Medugorac I
Genet Sel Evol. 2017 Oct 5;49(1):73PubMed

EBF1 binds to EBNA2 and promotes the assembly of EBNA2 chromatin complexes in B cells.
Glaser LV, Rieger S, Thumann S, Beer S, Kuklik-Roos C, Martin DE, Maier KC, Harth-Hertle ML, Grüning B, Backofen R, Krebs S, Blum H, Zimmer R, Erhard F, Kempkes B
PLoS Pathog. 2017 Oct 2;13(10):e1006664PubMed

Effect of metabolic status on conceptus-maternal interactions on day 19 in dairy cattle: II. Effects on the endometrial transcriptome.
Bauersachs S, Simintiras CA, Sturmey RG, Krebs S, Bick J, Blum H, Wolf E, Lonergan P, Forde N
Biol Reprod. 2017 Sep 1;97(3):413-425PubMed

Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 (I27N) mutant mice.
Kumar S, Rathkolb B, Sabrautzki S, Krebs S, Kemter E, Becker L, Beckers J, Bekeredjian R, Brommage R, Calzada-Wack J, Garrett L, Hölter SM, Horsch M, Klingenspor M, Klopstock T, Moreth K, Neff F, Rozman J, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Wolf E, Aigner B
J Biomed Sci. 2017 Aug 17;24(1):57. PubMed

The Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes.
Blutke A, Renner S, Flenkenthaler F, Backman M, Haesner S, Kemter E, Ländström E, Braun-Reichhart C, Albl B, Streckel E, Rathkolb B, Prehn C, Palladini A, Grzybek M, Krebs S, Bauersachs S, Bähr A, Brühschwein A, Deeg CA, De Monte E, Dmochewitz M, Eberle C, Emrich D, Fux R, Groth F, Gumbert S, Heitmann A, Hinrichs A, Keßler B, Kurome M, Leipig-Rudolph M, Matiasek K, Öztürk H, Otzdorff C, Reichenbach M, Reichenbach HD, Rieger A, Rieseberg B, Rosati M, Saucedo MN, Schleicher A, Schneider MR, Simmet K, Steinmetz J, Übel N, Zehetmaier P, Jung A, Adamski J, Coskun Ü, Hrabě de Angelis M, Simmet C, Ritzmann M, Meyer-Lindenberg A, Blum H, Arnold GJ, Fröhlich T, Wanke R, Wolf E
Mol Metab. 2017 Jun 13;6(8):931-940. PubMed

Splicing stimulates siRNA formation at Drosophila DNA double-strand breaks.
Merk K, Breinig M, Böttcher R, Krebs S, Blum H, Boutros M, Förstemann K
PLoS Genet. 2017 Jun 19;13(6):e1006861. PubMed

Investigation of intra-herd spread of Mycobacterium caprae in cattle by generation and use of a whole-genome sequence.
Broeckl S, Krebs S, Varadharajan A, Straubinger RK, Blum H, Buettner M
Vet Res Commun. 2017 Jun;41(2):113-128PubMed

Lost in plasmids: next generation sequencing and the complex genome of the tick-borne pathogen Borrelia burgdorferi.
Margos G, Hepner S, Mang C, Marosevic D, Reynolds SE, Krebs S, Sing A, Derdakova M, Reiter MA, Fingerle V
BMC Genomics. 2017 May 30;18(1):422PubMed

Transcriptome analysis of dominant-negative Brd4 mutants identifies Brd4-specific target genes of small molecule inhibitor JQ1.
Decker TM, Kluge M, Krebs S, Shah N, Blum H, Friedel CC, Eick D
Sci Rep. 2017 May 10;7(1):1684PubMed

Acute myeloid leukemia in the elderly is characterized by a distinct genetic and epigenetic landscape.
Silva P, Neumann M, Schroeder MP, Vosberg S, Schlee C, Isaakidis K, Ortiz-Tanchez J, Fransecky LR, Hartung T, Türkmen S, Graf A, Krebs S, Blum H, Müller-Tidow C, Thiede C, Ehninger G, Serve H, Hecht J, Berdel WE, Greif PA, Röllig C, Baldus CD. 
Leukemia. 2017 Apr 25. [Epub ahead of print]. PubMed

Whole-genome analysis of introgressive hybridization and characterization of the bovine legacy of Mongolian yaks.
Medugorac I, Graf A, Grohs C, Rothammer S, Zagdsuren Y, Gladyr E, Zinovieva N, Barbieri J, Seichter D, Russ I, Eggen A, Hellenthal G, Brem G, Blum H, Krebs S, Capitan A
Nat Genet. 2017 Mar;49(3):470-475PubMed

TT-seq captures enhancer landscapes immediately after T-cell stimulation.
Michel M, Demel C, Zacher B, Schwalb B, Krebs S, Blum H, Gagneur J, Cramer P
Mol Syst Biol. 2017 Mar 7;13(3):920PubMed

In-depth mutational analyses of colorectal neuroendocrine carcinomas with adenoma or adenocarcinoma components.
Woischke C, Schaaf CW, Yang HM, Vieth M, Veits L, Geddert H, Märkl B, Stömmer P, Schaeffer DF, Frölich M, Blum H, Vosberg S, Greif PA, Jung A, Kirchner T, Horst D
Mod Pathol. 2017 Jan;30(1):95-103. PubMed

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells.
Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T
Nat Immunol. 2017 Jan;18(1):74-85. PubMed

Acute myeloid leukemia with del(9q) is characterized by frequent mutations of NPM1, DNMT3A, WT1 and low expression of TLE4.
Herold T, Metzeler KH, Vosberg S, Hartmann L, Jurinovic V, Opatz S, Konstandin NP, Schneider S, Zellmeier E, Ksienzyk B, Graf A, Krebs S, Blum H, Cristina Sauerland M, Büchner T, Berdel WE, Wörmann BJ, Mansmann U, Hiddemann W, Bohlander SK, Spiekermann K, Greif PA
Genes Chromosomes Cancer. 2017 Jan;56(1):75-86. PubMed

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2016

ADNP is a therapeutically inducible repressor of WNT signaling in colorectal cancer.
Blaj C, Bringmann A, Schmidt EM, Urbischek M, Lamprecht S, Fröhlich T, Arnold GJ, Krebs S, Blum H, Hermeking H, Jung A, Kirchner T, Horst D.
Clin Cancer Res. 2016 Nov 30.[Epub ahead of print]. PubMed

The 1.78-kb insertion in the 3'-untranslated region of RXFP2 does not segregate with horn status in sheep breeds with variable horn status.
Lühken G, Krebs S, Rothammer S, Küpper J, Mioč B, Russ I, Medugorac I
Genet Sel Evol. 2016 Oct 19;48(1):78.
PubMed

Recurrent evolution of host and vector association in bacteria of the Borrelia burgdorferi sensu lato species complex.
Becker NS, Margos G, Blum H, Krebs S, Graf A, Lane RS, Castillo-Ramírez S, Sing A, Fingerle V
BMC Genomics. 2016 Sep 15;17(1):734. PubMed

Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure.
Mossner M, Jann JC, Wittig J, Nolte F, Fey S, Nowak V, Obländer J, Pressler J, Palme I, Xanthopoulos C, Boch T, Metzgeroth G, Röhl H, Witt SH, Dukal H, Klein C, Schmitt S, Gelß P, Platzbecker U, Balaian E, Fabarius A, Blum H, Schulze TJ, Meggendorfer M, Haferlach C, Trumpp A, Hofmann WK, Medyouf H, Nowak D
Blood. 2016 Sep 1;128(9):1246-59PubMed

ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation.
Hartmann L, Dutta S, Opatz S, Vosberg S, Reiter K, Leubolt G, Metzeler KH, Herold T, Bamopoulos SA, Bräundl K, Zellmeier E, Ksienzyk B, Konstandin NP, Schneider S, Hopfner KP, Graf A, Krebs S, Blum H, Middeke JM, Stölzel F, Thiede C, Wolf S, Bohlander SK, Preiss C, Chen-Wichmann L, Wichmann C, Sauerland MC, Büchner T, Berdel WE, Wörmann BJ, Braess J, Hiddemann W, Spiekermann K, Greif PA
Nat Commun. 2016 Jun 2;7:11733. PubMed

Close Correlation of Copy Number Aberrations Detected by Next-Generation Sequencing with Results from Routine Cytogenetics in Acute Myeloid Leukemia.
Vosberg S, Herold T, Hartmann L, Neumann M, Opatz S, Metzeler KH, Schneider S, Graf A, Krebs S, Blum H, Baldus CD, Hiddemann W, Spiekermann K, Bohlander SK, Mansmann U, Greif PA.
Genes Chromosomes Cancer. 2016 Mar 25. [Epub ahead of print]. PubMed

Mitochondrial genomes of the freshwater sponges Spongilla lacustris and Ephydatia cf. muelleri.
Francis WR, Eitel M, Vargas S, Krebs S, Blum H, Wörheide G
Mitochondrial DNA (2016) Part B: 1-2. PubMed

Trans-Atlantic exchanges have shaped the population structure of the Lyme disease agent Borrelia burgdorferi sensu stricto.
Castillo-Ramírez S, Fingerle V, Jungnick S, Straubinger RK, Krebs S, Blum H, Meinel DM, Hofmann H, Guertler P, Sing A, Margos G
Sci Rep. 2016 Mar 9;6:22794PubMed

Complete mitochondrial genome of Muricea crassa and Muricea purpurea (Anthozoa: Octocorallia) from the eastern tropical Pacific.
Poliseno A, Breedy O, Eitel M, Woerheide G, Guzman HM, Krebs S, Blum H, Vargas SR
bioRxiv. 
Mar. 24, 2016. PubMed

TRAPLINE: a standardized and automated pipeline for RNA sequencing data analysis, evaluation and annotation.
Wolfien M, Rimmbach C, Schmitz U, Jung JJ, Krebs S, Steinhoff G, David R, Wolkenhauer O
BMC Bioinformatics. 2016 Jan 6;17(1):21PubMed

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2015

The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models.
Dutta S, Krause A, Vosberg S, Herold T, Ksienzyk B, Quintanilla-Martinez L, Tizazu B, Chopra M, Graf A, Krebs S, Blum H, Greif PA, Vetter A, Metzeler K, Rothenberg-Thurley M, Schneider MR, Dahlhoff M, Spiekermann K, Zimber-Strobl U, Wolf E, Bohlander SK
Leukemia. 2015 Dec 21. doi: 10.1038/leu.2015.349. [Epub ahead of print]. PubMed

Melanocyte antigen triggers autoimmunity in human psoriasis.
Arakawa A, Siewert K, Stöhr J, Besgen P, Kim SM, Rühl G, Nickel J, Vollmer S, Thomas P, Krebs S, Pinkert S, Spannagl M, Held K, Kammerbauer C, Besch R, Dornmair K, Prinz JC
J Exp Med. 2015 Dec 14;212(13):2203-12. PubMed

Expression of microRNAs and isomiRs in the porcine endometrium: implications for gene regulation at the maternal-conceptus interface.
Krawczynski K, Bauersachs S, Reliszko ZP, Graf A, Kaczmarek MM
BMC Genomics. 2015 Nov 6;16:906. PubMed

The Region of Difference Four is a Robust Genetic Marker for Subtyping Mycobacterium caprae Isolates and is Linked to Spatial Distribution of Three Subtypes.
Rettinger A, Broeckl S, Fink M, Prodinger WM, Blum H, Krebs S, Domogalla J, Just F, Gellert S, Straubinger RK, Büttner M.
Transbound Emerg Dis. 2015 Oct 31. [Epub ahead of print] PubMed

Young woman with mild bone marrow dysplasia, GATA2 and ASXL1 mutation treated with allogeneic hematopoietic stem cell transplantation.
Lübking A, Vosberg S, Konstandin NP, Dufour A, Graf A, Krebs S, Blum H, Weber A, Lenhoff S, Ehinger M, Spiekermann K, Greif PA, Cammenga J
Leuk Res Rep. 2015 Oct 17;4(2):72-5. PubMed

Tumor Necrosis Factor Alpha and Insulin-Like Growth Factor 1 Induced Modifications of the Gene Expression Kinetics of Differentiating Skeletal Muscle Cells.
Meyer SU, Krebs S, Thirion C, Blum H, Krause S, Pfaffl MW
PLoS One. 2015 Oct 8;10(10):e0139520. PubMed

Comparing effects of perfusion and hydrostatic pressure on gene profiles of human chondrocyte.
Zhu G, Mayer-Wagner S, Schröder C, Woiczinski M, Blum H, Lavagi I, Krebs S, Redeker JI, Hölzer A, Jansson V, Betz O, Müller PE
J Biotechnol. 2015 Sep 20;210:59-65PubMed

Lack of Rybp in Mouse Embryonic Stem Cells Impairs Cardiac Differentiation.
Ujhelly O, Szabo V, Kovacs G, Vajda F, Mallok S, Prorok J, Acsai K, Hegedus Z, Krebs S, Dinnyes A, Pirity MK
Stem Cells Dev. 2015 Sep 15;24(18):2193-205PubMed

Integrative Analysis of MicroRNA and mRNA Data Reveals an Orchestrated Function of MicroRNAs in Skeletal Myocyte Differentiation in Response to TNF-α or IGF1.
Meyer SU, Sass S, Mueller NS, Krebs S, Bauersachs S, Kaiser S, Blum H, Thirion C, Krause S, Theis FJ, Pfaffl MW
PLoS One. 2015 Aug 13;10(8). 
PubMed

GATA2 deficiency in children and adults with severe pulmonary alveolar proteinosis and hematologic disorders.
Griese M, Zarbock R, Costabel U, Hildebrandt J, Theegarten D, Albert M, Thiel A, Schams A, Lange J, Krenke K, Wesselak T, Schön C, Kappler M, Blum H, Krebs S, Jung A, Kröner C, Klein C, Campo I, Luisetti M, Bonella F
BMC Pulm Med. 2015 Aug 12;15:87. PubMed

Parapoxvirus (PPV) of red deer reveals subclinical infection and confirms a unique species.
Friederichs S, Krebs S, Blum H, Lang H, Büttner M
J Gen Virol. 2015 Jun;96(Pt 6):1446-62PubMed

Remodeling of the Nuclear Envelope and Lamina during Bovine Preimplantation Development and Its Functional Implications.
Popken J, Graf A, Krebs S, Blum H, Schmid VJ, Strauss A, Guengoer T, Zakhartchenko V, Wolf E, Cremer T
PLoS One. 2015 May 1;10(5):e0124619PubMed

Gatzmann F, Metzler D, Krebs S, Blum H, Sing A, Takano A, Kawabata H, Fingerle V, Margos G, Becker NS
NGS population genetics analyses reveal divergent evolution of a Lyme Borreliosis agent in Europe and Asia.
Ticks Tick Borne Dis. 2015 Apr;6(3):344-51. PubMed

Effects of the glucagon-like peptide-1 receptor agonist liraglutide in juvenile transgenic pigs modeling a pre-diabetic condition.
Streckel E, Braun-Reichhart C, Herbach N, Dahlhoff M, Kessler B, Blutke A, Bähr A, Übel N, Eddicks M, Ritzmann M, Krebs S, Göke B, Blum H, Wanke R, Wolf E, Renner S
J Transl Med. 2015 Feb 25;13:73PubMed

Zoonotic transmission of toxigenic Corynebacterium ulcerans strain, Germany, 2012.
Meinel DM, Konrad R, Berger A, König C, Schmidt-Wieland T, Hogardt M, Bischoff H, Ackermann N, Hörmansdorfer S, Krebs S, Blum H, Margos G, Sing A
Emerg Infect Dis. 2015 Feb;21(2):356-8. PubMed

Mutational spectrum of adult T-ALL.
Neumann M, Vosberg S, Schlee C, Heesch S, Schwartz S, Gökbuget N, Hoelzer D, Graf A, Krebs S, Bartram I, Blum H, Brüggemann M, Hecht J, Bohlander SK, Greif PA, Baldus CD
Emerg Oncotarget. 2015 Feb 20;6(5):2754-66. PubMed

Ancient Transposable Elements Transformed the Uterine Regulatory Landscape and Transcriptome during the Evolution of Mammalian Pregnancy.
Lynch VJ, Nnamani MC, Kapusta A, Brayer K, Plaza SL, Mazur EC, Emera D, Sheikh SZ, Grützner F, Bauersachs S, Graf A, Young SL, Lieb JD, DeMayo FJ, Feschotte C, Wagner GP. 
Cell Rep. 2015 Jan 27. pii: S2211-1247(14)01105-X. PubMed

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2014

82 structural remodelling of the nuclear envelope in bovine pre-implantation embryos.
Popken J, Graf A, Krebs S, Blum H, Guengoer T, Zakhartchenko V, Wolf E, Cremer T.
Reprod Fertil Dev. 2014 Dec;27(1):134. PubMed

Next generation sequencing analysis of nine Corynebacterium ulcerans isolates reveals zoonotic transmission and a novel putative diphtheria toxin-encoding pathogenicity island.
Meinel DM, Margos G, Konrad R, Krebs S, Blum H, Sing A.
Genome Med. 2014 Nov 28;6(11):113. PubMed

Reprogramming of fibroblast nuclei in cloned bovine embryos involves major structural remodeling with both striking similarities and differences to nuclear phenotypes of in vitro fertilized embryos.
Popken J, Brero A, Koehler D, Schmid VJ, Strauss A, Wuensch A, Guengoer T, Graf A, Krebs S, Blum H, Zakhartchenko V, Wolf E, Cremer T.
Nucleus. 2014 Nov 2;5(6):555-89. PubMed

Oxyphil cell metaplasia in the parathyroids is characterized by somatic mtDNA mutations in ND genes and COX- activity-impairing genes.
Müller-Höcker J, Schäfer S, Krebs S, Blum H, Zsurka G, Kunz WS, Prokisch H, Seibel P, Jung A.
Am J Pathol. 2014 Nov;184(11):2922-35. PubMed

Genome activation in bovine embryos: Review of the literature and new insights from RNA sequencing experiments.
Graf A
, Krebs S, Heininen-Brown M, Zakhartchenko V, Blum H, Wolf E.
Anim Reprod Sci. 2014 Sep;149(1-2):46-58. PubMed

Isolated trisomy 13 defines a genetically homogenous AML subgroup with
high frequency of mutations in spliceosome genes and poor prognosis.
Herold T, Metzeler KH, Vosberg S, Hartmann L, Röllig C, Stölzel F, Schneider
S, Hubmann M, Zellmeier E, Ksienzyk B, Jurinovic V, Pasalic Z, Kakadia PM, Dufour
A, Graf A, Krebs S, Blum H, Sauerland MC, Büchner T, Berdel WE, Woermann BJ,
Bornhäuser M, Ehninger G, Mansmann U, Hiddemann W, Bohlander SK, Spiekermann K, Greif PA.
Blood. 2014 Aug 21;124(8):1304-11. PubMed

Evidence for a role of E-cadherin in suppressing liver carcinogenesis in mice and men.
Schneider MR, Hiltwein F, Grill J, Blum H, Krebs S, Klanner A, Bauersachs S,
Bruns C, Longerich T, Horst D, Brandl L, de Toni E, Herbst A, Kolligs FT.
Carcinogenesis. 2014 Aug;35(8):1855-62. PubMed

Mutational spectrum of adult T-ALL.
Neumann M, Vosberg S, Schlee C, Heesch S, Schwartz S, Gökbuget N, Hoelzer D, Graf A, Krebs S, Bartram I, Blum H, Brüggemann M, Hecht J, Bohlander SK, Greif PA, Baldus CD.
Oncotarget. 2014 Jul 15. PubMed

Uniformity of nucleosome preservation pattern in Mammalian sperm and its connection to repetitive DNA elements.
Samans B, Yang Y, Krebs S, Sarode GV, Blum H, Reichenbach M, Wolf E, Steger K, Dansranjavin T, Schagdarsurengin U.
Dev Cell. 2014 Jul 14;30(1):23-35. PubMed

FAT1 expression and mutations in adult acute lymphoblastic leukemia.
Neumann M, Seehawer M, Schlee C, Vosberg S, Heesch S, von der Heide EK, Graf A, Krebs S, Blum H, Gökbuget N, Schwartz S, Hoelzer D, Greif PA, Baldus CD.
Blood Cancer J. 2014 Jun 27;4:e224. PubMed

Side population cells of pancreatic cancer show characteristics of cancer stem cells responsible for resistance and metastasis.
Niess H, Camaj P, Renner A, Ischenko I, Zhao Y, Krebs S, Mysliwietz J, Jäckel
C, Nelson PJ, Blum H, Jauch KW, Ellwart JW, Bruns CJ. 
Target Oncol. 2014 Jun 22. PubMed

Programming and Isolation of Highly Pure Physiologically and Pharmacologically Functional Sinus-Nodal Bodies from Pluripotent Stem Cells.
Jung J, Husse B, Rimmbach C, Krebs S, Stieber J, Steinhoff G, Dendorfer A, Franz WM.
Stem Cell Reports. 2014 Apr 17;2(5):592-605. PubMed

Complete Genome Sequence of a Wild-Type Measles Virus Isolated during the Spring
2013 Epidemic in Germany.
Sparrer KM, Krebs S, Jäger G, Santibanez S, Mankertz A, Blum H, Conzelmann KK.
Genome Announc. 2014 Apr 17;2(2). PubMed

Hütz K, Mejías-Luque R, Farsakova K, Ogris M, Krebs S, Anton M, Vieth M, Schüller U, Schneider MR, Blum H, Wagner E, Jung A, Gerhard M.
The stem cell factor SOX2 regulates the tumorigenic potential in human gastric cancer cells.
Carcinogenesis. 2014 Apr;35(4):942-50.
PubMed

Fine mapping of genome activation in bovine embryos by RNA sequencing.
Graf A
, Krebs S, Zakhartchenko V, Schwalb B, Blum H, Wolf E.
Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4139-44. PubMed

Hypoxia-independent Gene Expression Mediated by Sox9 Promotes Aggressive Pancreatic Tumor Biology.
Camaj P, Jackel C, Krebs S, Detoni EN, Blum H, Jauch KW, Nelson PJ, Bruns CJ.
Mol Cancer Res. 2014 Mar;12(3):421-32.PubMed

Comparative and retrospective molecular analysis of Parapoxvirus (PPV) isolates.
Friederichs S, Krebs S, Blum H, Wolf E, Lang H, von Buttlar H, Büttner M.
Virus Res. 2014 Mar 6;181:11-21PubMed

Comprehensive analysis of β-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/β-catenin signaling.
Herbst A, Jurinovic V, Krebs S, Thieme SE, Blum H, Göke B, Kolligs FT.
BMC Genomics. 2014 Jan 28;15(1):74. PubMed

Generation and Characterization of a Porcine Model of Duchenne Muscular Dystrophy.
Blutke A, Klymiuk N, Graf A, Krause S, Burkhardt K, Wuensch A, Krebs S, Kessler B, Zakhartchenko V, Kurome M, Kemter E, Nagashima H, Schoser B, Herbach N, Blum H, Wanke R, Thirion C, Lochmüller H, Walter MC, Wolf E
Journal of Comparative Pathology. 2014 Jan; 150(1):80. PubMed

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2013

Transcriptome changes in the porcine endometrium during the preattachment phase.
Samborski A
, Graf A, Krebs S, Kessler B, Reichenbach M, Reichenbach HD, Ulbrich SE, Bauersachs S.
Biol Reprod. 2013 Dec 12;89(6):134. PubMed

Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle.
Klymiuk N, Blutke A, Graf A, Krause S, Burkhardt K, Wuensch A, Krebs S, Kessler B, Zakhartchenko V, Kurome M, Kemter E, Nagashima H, Schoser B, Herbach N, Blum H, Wanke R, Aartsma-Rus A, Thirion C, Lochmüller H, Walter MC, Wolf E
Hum. Mol. Genet. 2013 Nov 1;22(21):4368-82. PubMed

Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia.
Opatz S, Polzer H, Herold T, Konstandin NP, Ksienzyk B, Zellmeier E, Vosberg S, Graf A, Krebs S, Blum H, Hopfner KP, Kakadia PM, Schneider S, Dufour A, Braess J, Sauerland MC, Berdel WE, Büchner T, Woermann BJ, Hiddemann W, Spiekermann K, Bohlander SK, Greif PA. 
Blood. 2013 Sep;122(10):1761-9. PubMed

iTRAQ proteome analysis reflects a progressed differentiation state of epiblast derived versus inner cell mass derived murine embryonic stem cells.
Fröhlich T, Kösters M, Graf A, Wolf E, Kobolak J, Brochard V, Dinnyés A, Jouneau A, Arnold GJ.
J Proteomics. 2013 Sep 2;90:38-51. PubMed

Whole exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations.
Neumann M, Heesch S, Schlee C, Schwartz S, Gökbuget N, Hoelzer D, Konstandin NP, Ksienzyk B, Vosberg S, Graf AKrebs SBlum H, Raff T, Brüggemann M, Hofmann WK, Hecht J, Bohlander SK, Greif PA, Baldus CD.
Blood. 2013 Jun 6;121(23):4749-52. PubMed

Novel Insights into the Bovine Polled Phentoype and Horn Ontogenesis in Bovidae.
Allais-Bonnet A, Grohs C, Medugorac I, Krebs S, Djari A, Graf A, Fritz S, Seichter D, Baur A, Russ I, Bouet S, Rothammer S, Wahlberg P, Esquerré D, Hoze C, Boussaha M, Weiss B, Thépot D, Fouilloux M, Rossignol M, Marle-Köster E, Hreiðarsdóttir GE, Barbey S, Dozias D, Cobo E, Reversé P, Catros O, Marchand J, Soulas P, Roy P, Marquant-Leguienne B, Bourhis DL, Clément L, Salas-Cortes L, Venot E, Pannetier M, Phocas F, Klopp C, Rocha D, Fouchet M, Journaux L, Bernard-Capel C, Ponsart C, Eggen A, Blum H, Gallard Y, Boichard D, Pailhoux E, Capitan A
PLoS One. 2013 May 22;8(5):e63512. PubMed

Permanent Neonatal Diabetes in INSC94Y Transgenic Pigs.
Renner S, Braun-Reichhart C, Blutke A, Herbach N, Emrich D, Streckel E, Wünsch
A, Kessler B, Kurome M, Bähr A, Klymiuk N, Krebs S, Puk O, Nagashima H, Graw J,
Blum H, Wanke R, Wolf E.
Diabetes. 2013 May;62(5):1505-11. PubMed

Region of difference four (RD4) in Alpine Mycobacterium caprae isolates indicates three variants.
Domogalla J, Prodinger WM, Blum H, Krebs S, Gellert S, Müller M, Neuendorf E, Sedlmaier F, Büttner M.
J Clin Microbiol. 2013 May;51(5):1381-8. PubMed

Roquin Paralogs 1 and 2 Redundantly Repress the Icos and Ox40 Costimulator mRNAs and Control Follicular Helper T Cell Differentiation.
Vogel KU, Edelmann SL, Jeltsch KM, Bertossi A, Heger K, Heinz GA, Zöller J, Warth SC, Hoefig KP, Lohs C, Neff F, Kremmer E, Schick J, Repsilber D, Geerlof A, Blum H, Wurst W, Heikenwälder M, Schmidt-Supprian M, Heissmeyer V.
Immunity. 2013 Apr 18;38(4):655-68. PubMed

Deep Sequencing of the Porcine Endometrial Transcriptome on Day 14 of Pregnancy.
Samborski A
, Graf A, Krebs S, Kessler B, Bauersachs S.
Biol Reprod. 2013 Apr 4;88(4):84. PubMed

Immune aspects of embryo-maternal cross-talk in the bovine uterus.
Bauersachs S,
Wolf E.
J Reprod Immunol. 2013 Mar;97(1):20-6. PubMed

Differentially regulated microRNAs during human sebaceous lipogenesis.
Schneider MR, Samborski ABauersachs S, Zouboulis CC.
J Dermatol Sci. 2013 Feb 9. pii: S0923-1811(13)00038-8. PubMed

A Comprehensive Gene Expression Analysis of Resistance Formation upon Metronomic Cyclophosphamide Therapy.
Kubisch R, Meissner L, Krebs S, Blum H, Günther M, Roidl A, Wagner E.
Transl Oncol. 2013 Feb;6(1):1-9. PubMed

LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation.
Solovei I, Wang AS, Thanisch K, Schmidt CS, Krebs S, Zwerger M, Cohen TV, Devys D, Foisner R, Peichl L, Herrmann H, Blum H, Engelkamp D, Stewart CL, Leonhardt H, Joffe B.
Cell. 2013 Jan 31;152(3):584-98. PubMed

Transcriptional profiling to address molecular determinants of endometrial receptivity - Lessons from studies in livestock species.
Ulbrich SE, Groebner AE, Bauersachs S.
Methods. 2013 Jan;59(1):108-15. PubMed

Detection and comparison of microRNA expression in the serum of Doberman Pinschers with dilated cardiomyopathy and healthy controls.
Steudemann C, Bauersachs S, Weber K, Wess G.
BMC Vet Res. 2013 Jan 17;9(1):12. PubMed

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2012

Truncation of MIMT1 gene in the PEG3 domain leads to major changes in placental gene expression and stillbirth in cattle.
Flisikowski K, Venhoranta H, Bauersachs S, Hänninen R, Fürst RW, Saalfrank A,
Ulbrich SE, Taponen J, Lohi H, Wolf E, Kind A, Andersson M, Schnieke A.
Biol Reprod. 2012 Dec 21;87(6):140.
PubMed

Exploration of global gene expression changes during the estrous cycle in equine endometrium.
Gebhardt S
, Merkl M, Herbach N, Wanke R, Handler J, Bauersachs S.
Biol Reprod. 2012 Dec 13;87(6):136. PubMed

Ultrashort and progressive 4sU-tagging reveals key characteristics of RNA processing at nucleotide resolution.
Windhager L, Bonfert T, Burger K, Ruzsics Z, Krebs S, Kaufmann S, Malterer G,
L'Hernault A, Schilhabel M, Schreiber S, Rosenstiel P, Zimmer R, Eick D, Friedel
CC, Dölken L.
Genome Res. 2012 Oct;22(10):2031-42. PubMed

Uterine NK Cells Are Critical in Shaping DC Immunogenic Functions Compatible with Pregnancy Progression.
Tirado-González I, Barrientos G, Freitag N, Otto T, Thijssen VL, Moschansky P, von Kwiatkowski P, Klapp BF, Winterhager E, Bauersachs S, Blois SM.
PLoS One. 2012;7(10). PubMed

Transcriptome analyses of bovine, porcine and equine endometrium during the pre-implantation phase.
Bauersachs S
, Wolf E.
Anim Reprod Sci. 2012 Sep;134(1-2):84-94. PubMed

Changing metabolic signatures of amino acids and lipids during the prediabetic period in a pig model with impaired incretin function and reduced β-cell mass.
Renner S, Römisch-Margl W, Prehn C, Krebs S, Adamski J, Göke B, Blum H, Suhre
K, Roscher AA, Wolf E.
Diabetes. 2012 Aug;61(8):2166-75. PubMed

GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia.
Greif PA, Dufour A, Konstandin NP, Ksienzyk B, Zellmeier E, Tizazu B, Sturm J, Benthaus T, Herold T, Yaghmaie M, Dörge P, Hopfner KP, Hauser A, Graf A, Krebs S, Blum H, Kakadia PM, Schneider S, Hoster E, Schneider F, Stanulla M, Braess J, Sauerland MC, Berdel WE, Büchner T, Woermann BJ, Hiddemann W, Spiekermann K, Bohlander SK.
Blood. 2012 Jul 12;120(2):395-403. PubMed

Bovine polledness - an autosomal dominant trait with allelic heterogeneity.
Medugorac I, Seichter D, Graf A, Russ I, Blum H, Göpel KH, Rothammer S,
Förster M, Krebs S.
PLoS One. 2012;7(6):e39477. PubMed

Hosting the preimplantation embryo: potentials and limitations of different approaches for analysing embryo-endometrium interactions in cattle.
Ulbrich SE, Wolf E, Bauersachs S.
Reprod Fertil Dev. 2012;25(1):62-70. PubMed

Comparison of the effects of early pregnancy with human interferon, alpha 2 (IFNA2), on gene expression in bovine endometrium.
Bauersachs S
, Ulbrich SE, Reichenbach HD, Reichenbach M, Büttner M, Meyer HH,
Spencer TE, Minten M, Sax G, Winter G, Wolf E.
Biol Reprod. 2012 Feb 29;86(2):46. PubMed

Gene expression profiling of bovine peripartal placentomes: detection of molecular pathways potentially involved in release of foetal membranes.
Streyl D, Kenngott R, Herbach N, Wanke R, Blum H, Sinowatz F, Wolf E, Zerbe H, Bauersachs S. Reproduction. 143(1):85-105. PubMed

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2011

Somatic mutations in acute promyelocytic leukemia (APL) identified by exome sequencing.
Greif PA, Yaghmaie M, Konstandin NP, Ksienzyk B, Alimoghaddam K, Ghavamzadeh A, Hauser A, Graf A, Krebs S, Blum H and Bohlander SK. (2011).
Leukemia 25, 1519-1522.
PubMed

Reduced Amino Acids in the Bovine Uterine Lumen of Cloned versus In Vitro Fertilized Pregnancies Prior to Implantation.
Groebner AE, Zakhartchenko V, Bauersachs S, Rubio-Aliaga I, Daniel H, Büttner M, Reichenbach HD, Meyer HH, Wolf E, Ulbrich SE. (2011)
Cell Reprogram. 13(5):403-10. PubMed

Exploration of relationships between production and fertility traits in dairy cattle via association studies of SNPs within candidate genes derived by expression profiling.
Pimentel EC, Bauersachs S, Tietze M, Simianer H, Tetens J, Thaller G, Reinhardt F, Wolf E, König S.(2011)
Anim Genet. 42(3):251-262. PubMed

Bovine endometrial metallopeptidases MMP14 and MMP2 and the metallopeptidase inhibitor TIMP2 participate in maternal preparation of pregnancy.
Ulbrich SE, Meyer SU, Zitta K, Hiendleder S, Sinowatz F, Bauersachs S, Büttner M, Fröhlich T, Arnold G, Reichenbach HD, Wolf E, Meyer HH.(2011)
Mol Cell Endocrinol. 332(1-2):48-57. PubMed

Comparison of the Effects of Early Pregnancy with Human Interferon, Alpha 2 (IFNA2), on Gene Expression in Bovine Endometrium.
Bauersachs S
, Ulbrich SE, Reichenbach HD, Reichenbach M, Büttner M, Meyer HH, Spencer TE, Minten M, Sax G, Winter G, Wolf E. (2011 Oct)
Biol Reprod. 2011 Oct 27. PubMed

Comparative kinetics of Escherichia coli- and Staphylococcus aureus-specific activation of key immune pathways in mammary epithelial cells demonstrates that S. aureus elicits a delayed response dominated by interleukin-6 (IL-6) but not by IL-1A or tumor necrosis factor alpha.
Gunther, J., Esch, K., Poschadel, N., Petzl, W., Zerbe, H., Mitterhuemer, S., Blum, H. and Seyfert, H. M. (2011).
Infect Immun 79, 695-707. PubMed

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2010

Actions and interactions of progesterone and estrogen on transcriptome profiles of the bovine endometrium.
Shimizu, T., Krebs, S., Bauersachs, S., Blum, H., Wolf, E. and Miyamoto, A. (2010).
Physiol Genomics 42A, 290-300. PubMed

Microarray Analysis of Equine Endometrium at Days 8 and 12 of Pregnancy.
Merkl M
, Ulbrich SE, Otzdorff C, Herbach N, Wanke R, Wolf E, Handler J, Bauersachs S.(2010)
Biol Reprod. 83(5):874-86PubMed

Differential endometrial gene expression in pregnant and nonpregnant sows.
Ostrup, E., Bauersachs, S., Blum, H., Wolf, E. and Hyttel, P. (2010).
Biol Reprod 83, 277-285. PubMed

Escherichia coli infection induces distinct local and systemic transcriptome responses in the mammary gland.
Mitterhuemer, S.
, Petzl, W., Krebs, S., Mehne, D., Klanner, A., Wolf, E., Zerbe, H. and Blum, H. (2010).
BMC Genomics 11, 138. PubMed

Creating new knowledge for ruminant reproduction from rapidly expanding and evolving scientific databases.
Bauersachs S
, Blum H, Krebs S, Fröhlich T, Arnold GJ, Wolf E.
Soc Reprod Fertil Suppl. 2010;67:29-40. PubMed

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2009

EFEMP1 expression promotes in vivo tumor growth in human pancreatic adenocarcinoma.
Seeliger, H., Camaj, P., Ischenko, I., Kleespies, A., De Toni, E. N., Thieme, S. E., Blum, H., Assmann, G., Jauch, K. W. and Bruns, C. J. (2009).
Mol Cancer Res 7, 189-198. PubMed

EFEMP1 binds the EGF receptor and activates MAPK and Akt pathways in pancreatic carcinoma cells.
Camaj, P., Seeliger, H., Ischenko, I., Krebs, S., Blum, H., De Toni, E. N., Faktorova, D., Jauch, K. W. and Bruns, C. J. (2009).
Biol Chem 390, 1293-1302. PubMed

A simple and loss-free method to remove TRIzol contaminations from minute RNA samples.
Krebs, S., Fischaleck, M. and Blum, H.
(2009).
Anal Biochem 387, 136-138. PubMed

The endometrium responds differently to cloned versus fertilized embryos.
Bauersachs, S.
, Ulbrich, S. E., Zakhartchenko, V., Minten, M., Reichenbach, M., Reichenbach, H. D., Blum, H., Spencer, T. E. and Wolf, E. (2009).
Proc Natl Acad Sci U S A 106, 5681-5686. PubMed

Evidence for Estrogen-Dependent Uterine Serpin (SERPINA14) Expression During Estrus in the Bovine Endometrial Glandular Epithelium and Lumen.
Ulbrich SE, Frohlich T, Schulke K, Englberger E, Waldschmitt N, Arnold GJ, Reichenbach HD, Reichenbach M, Wolf E, Meyer HHD, and Bauersachs S. (2009)
Biol Reprod 81: 795-805. PubMed

Dickkopf-4 is frequently down-regulated and inhibits growth of colorectal cancer cells.
Baehs, S., Herbst, A., Thieme, S. E., Perschl, C., Behrens, A., Scheel, S., Jung, A., Brabletz, T., Goke, B., Blum, H. and Kolligs, F. T. (2009).
Cancer Lett 276, 152-159. PubMed

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2008

Dynamic changes in messenger RNA profiles of bovine endometrium during the oestrous cycle.
Mitko, K.
, Ulbrich, S. E., Wenigerkind, H., Sinowatz, F., Blum, H., Wolf, E. and Bauersachs, S. (2008).
Reproduction 135, 225-240. PubMed

OPG is regulated by beta-catenin and mediates resistance to TRAIL-induced apoptosis in colon cancer.
De Toni, E. N., Thieme, S. E., Herbst, A., Behrens, A., Stieber, P., Jung, A., Blum, H., Goke, B. and Kolligs, F. T. (2008).
Clin Cancer Res 14, 4713-4718.
PubMed

Transcriptome studies of bovine endometrium reveal molecular profiles characteristic for specific stages of estrous cycle and early pregnancy.
Bauersachs, S., Mitko, K.
, Ulbrich, S. E., Blum, H. and Wolf, E. (2008).
Exp Clin Endocrinol Diabetes 116, 371-384. PubMed

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2007

Technical note: Bovine oviduct and endometrium array version 1: a tailored tool for studying bovine endometrium biology and pathophysiology.
Bauersachs, S., Mitko, K.,
Blum, H. and Wolf, E. (2007).
J Dairy Sci 90, 4420-4423. PubMed

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2006

Monozygotic twin model reveals novel embryo-induced transcriptome changes of bovine endometrium in the preattachment period.
Klein, C.,
Bauersachs, S., Ulbrich, S. E., Einspanier, R., Meyer, H. H., Schmidt, S. E., Reichenbach, H. D., Vermehren, M., Sinowatz, F., Blum, H. and Wolf, E. (2006).
Biol Reprod 74, 253-264. PubMed

Embryo-induced transcriptome changes in bovine endometrium reveal species-specific and common molecular markers of uterine receptivity.
Bauersachs, S.
, Ulbrich, S. E., Gross, K., Schmidt, S. E., Meyer, H. H., Wenigerkind, H., Vermehren, M., Sinowatz, F., Blum, H. and Wolf, E. (2006).
Reproduction 132, 319-331. PubMed

Ulbrich SE, Rehfeld S, Bauersachs S, Wolf E, Rottmayer R, Hiendleder S, Vermehren M, Sinowatz F, Meyer HH, Einspanier R.(2006)
Region-specific expression of nitric oxide synthases in the bovine oviduct during the oestrous cycle and in vitro.
J Endocrinol 188: 205-213. PubMed

Purification of His-tagged hybrid phage antibody.
Donzeau, M., Bauersachs, S., Blum, H., Reichelt, P., Rohnisch, T. and Nagel, W. (2006).
Anal Biochem 352, 154-156. PubMed

Methods for transcriptome and proteome research: applications for studying the biology of reproduction in cattle.
Wolf E
, Hiendleder S, Bauersachs S, Frohlich T, Sinowatz F, Blum H, Arnold GJ.
Berl Munch Tierarztl Wochenschr 2006; 119: 7-16. PubMed

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2005

Functional genomics: tools for improving farm animal health and welfare. Hiendleder S, Bauersachs S, Boulesteix A, Blum H, Arnold GJ, Frohlich T, Wolf E.(2005)
Rev Sci Tech 24: 355-377. PubMed

Gene expression profiling of bovine endometrium during the oestrous cycle: detection of molecular pathways involved in functional changes.
Bauersachs S
, Ulbrich SE, Gross K, Schmidt SE, Meyer HH, Einspanier R, Wenigerkind H, Vermehren M, Blum H, Sinowatz F and Wolf E (2005).
J Mol Endocrinol 34, 889-908.PubMed

Transcriptome analysis of a human colorectal cancer cell line shows molecular targets of insulin-like growth factor-binding protein-4 overexpression.
Diehl D, Lahm H, Wolf E, Bauersachs S. (2005)
Int J Cancer 113: 588-599. PubMed

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2004

Monitoring gene expression changes in bovine oviduct epithelial cells during the oestrous cycle. Bauersachs S., Rehfeld S., Ulbrich S. E., Mallok S., Prelle K., Wenigerkind H., Einspanier R., Blum H. and Wolf E. (2004).
J Mol Endocrinol 32, 449-466. PubMed

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2003

Embryo-maternal communication in bovine - strategies for deciphering a complex cross-talk.
Wolf E
, Arnold GJ, Bauersachs S, Beier HM, Blum H, Einspanier R, Frohlich T, Herrler A, Hiendleder S, Kolle S, Prelle K, Reichenbach HD, Stojkovic M, Wenigerkind H, Sinowatz F. (2003)
Reprod Domest Anim 38: 276-289. PubMed

Regulation of ipsilateral and contralateral bovine oviduct epithelial cell function in the postovulation period: a transcriptomics approach. 
Bauersachs S., Blum H., Mallok S., Wenigerkind H., Rief S., Prelle K. and Wolf E. (2003).
Biol Reprod 68, 1170-1177. PubMed

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2001

Sequences and replication of genomes of the archaeal rudiviruses SIRV1 and SIRV2: relationships to the archaeal lipothrixvirus SIFV and some eukaryal viruses.
Peng X, Blum H, She Q, Mallok S, Brügger K, Garrett RA, Zillig W, Prangishvili D
Virology. 2001 Dec 20;291(2):226-34. PubMed

Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A.(2001)
Genome Res 11: 422-435. PubMed

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