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Stingele Lab - Cellular Biochemistry

stingele_mainResearch Topics

  • Nucleic acid quality control
  • Repair of DNA-protein crosslinks
  • Resolution of RNA damage

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Prof. Julian Stingele

phone: +49 (0)89 - 2180 71101
stingele@genzentrum.lmu.de

Nucleic acid quality control is essential for cellular homeostastis and to counteract cancer development and ageing. We are trying to understand how cells detect and resolve damage to DNA and RNA. We investigate these processes by combining various approaches including cell biology, genetic engineering, proteomics, and in vitro reconstitution. Read more...

Selected Publications

RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks.
Zhao S, Cordes J, Caban KM, Götz MJ, Mackens-Kiani T, Veltri AJ, Sinha NK, Weickert P, Kaya S, Hewitt G, Nedialkova DD, Fröhlich T, Beckmann R, Buskirk AR, Green R, Stingele J.
Mol Cell. 2023 Nov 2:S1097-2765(23)00849-3. doi: 10.1016/j.molcel.2023.10.012. PubMed

A non-proteolytic release mechanism for HMCES-DNA-protein crosslinks.
Donsbach M, Dürauer S, Grünert F, Nguyen KT, Nigam R, Yaneva D, Weickert P, Bezalel-Buch R, Semlow DR, Stingele J.
EMBO J. 2023 Jul 31:e113360. doi: 10.15252/embj.2022113360. Online ahead of print. PubMed

The FANCJ helicase unfolds DNA-protein crosslinks to promote their repair.
Yaneva D, Sparks JL, Donsbach M, Zhao S, Weickert P, Bezalel-Buch R, Stingele J*, Walter JC*.
Mol Cell. 2023 Jan 5;83(1):43-56.e10. doi: 10.1016/j.molcel.2022.12.005. PubMed

DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease.
Reinking HK, Kang HS, Götz MJ, Li HY, Kieser A, Zhao S, Acampora AC, Weickert P, Fessler E, Jae LT, Sattler M, Stingele J.
Mol Cell. 2020 Oct 1;80(1):102-113.e6. doi: 10.1016/j.molcel.2020.08.003. Epub 2020 Aug 26. PubMed

 

More publications

News

November 2023: ERC Consolidator Grant

Our lab receives 2 million Euro in EU funding

November 2023 - New Paper

Translation-coupled resolution of RNA-protein crosslinks

October 2023: New PhD student

Welcome Carla!!

July 2023 - New Paper

A non-proteolytic release mechanism for HMCES-DNA-protein crosslinks.