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PhD Position in Functional Genomics

The Jae lab at the Gene Center of the Ludwig-Maximilians University Munich (LMU) is looking for a highly motivated and skilled

PhD student in the area of functional genomics in the human system

We make use of a combination of genome-wide ultra-deep mutagenesis in haploid human cells and CRISPR/Cas technology to link phenotypes to genotypes and explore genetic interactions relevant for human disease (Science, 2013) and exposure to pathogens (Science, 2014; Nature, 2016). Mapping genetic interactions through unbiased knock-out genetics is not only a remarkably useful tool in the mechanistic dissection of complex cellular phenomena, but can also aid the annotation of orphan genes and potentially reveal new strategies to therapeutically combat disease (Science, 2015). Recently, we have developed a novel approach that allows the direct genetic dissection of any cellular phenotype that can be quantified at the single cell level by flow cytometry (Nature, 2017). The successful PhD candidate will employ state-of-the-art techniques from large-scale genome-wide screens to genome engineering and mechanistic dissection of the role of candidate genes. Possible projects revolve around signal transduction, cellular stress response, and the role of mitochondria in neurodegeneration/aging.

The Jae lab is a small, independent group embedded in the stimulating, interdisciplinary environment of the life sciences campus Großhadern of the Ludwig-Maximilians University Munich (LMU). Our lab is located in the brand-new research center for Molecular Biosystems (BioSysM) with access to excellent instrumentation and facilities in-house and on campus. Downtown Munich can be reached by public transport within 20 minutes, the German Alps in just over 1 hour.

Your profile

We are seeking highly motivated candidates who share our dedication to science and enthusiasm for interdisciplinary research with an excellent Master’s degree (or equivalent) in biomedicine, human biology, biology, biochemistry, or similar. You are expected to be able to perform experiments independently, analyze data of high complexity, and work well in a team. Excellent communication skills and a solid background in molecular and cellular biology techniques, as well as genetics are required. Expertise in bioinformatics and a sense of humor are a plus.

Application

The application should include a CV, a letter of motivation, relevant certificates, and contact information for 2 references. The salary will be in accordance with the German model for the public sector (TV-L). Please send your application to Lucas Jae jae@genzentrum.lmu.de

Since we work with continuous selection and appointment, we encourage you to send your application as soon as possible.

The University of Munich is an equal opportunity employer. Handicapped candidates with equal qualifications will be given preference.

For more information about our lab at the LMU and our research please visit our website.