PhD Position in Physical Biochemistry

The Stigler lab at the Gene Center of the Ludwig-Maximilians University Munich (LMU) is looking for a motivated PhD student from biochemistry, biophysics or related fields who is interested in studying the folding and assembly of alpha-helical repeat proteins using single molecule optical tweezers.

Close to 30% of all proteins in humans contain repetitive arrays of short peptide building blocks, which often manifest in curved shapes of protein tertiary structures. The repetitive nature of this architecture has made these structures very attractive for protein design and nanomedicine. However, the way how these structures fold and assemble at the molecular level is poorly understood. In this project, we develop and use methods based on optical tweezers to study the structure and mechanics of these proteins.

You should have a keen interest in getting to the bottom of things, and bring experience with molecular cloning and the purification of recombinant proteins. Prior knowledge of single molecule techniques, quantitative data analysis and programming skills are a plus.

Please send your application (including a CV, a short letter of motivation, relevant certificates, and contact information for two references) by September 30, 2023 to stigler@genzentrum.lmu.de. The University of Munich is an equal opportunity employer. Handicapped candidates with equal qualifications will be given preference.

For more information about the Stigler lab at the LMU and their research please visit the Stigler website.

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