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Structural Biology

What does a human collided disome look like?

27.10.2022

In collaboration with the Inada lab, the Beckmann lab shows that mammalian disomes form a distinct structural interface, in which uS10 K63-linked polyubiquitination is critical for ribosome dissociation.

 

 

Model representation of three small ribosomal subunit precursors highlighting conformational and compositional changes during maturation. Activation and release of the endonuclease NOB1 (red) is shown in small boxes. Image: Beckmann lab, LMU

 

Original Publication:

A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.
Narita, M., Denk, T., Matsuo, Y., Sugiyama T, Kikuguchi C, Ito S, Sato N, Suzuki T, Hashimoto S, Machová I, Tesina P, Beckmann R, Inada T.
Nat Commun. 2022 Oct 27;13(1):6411. doi: 10.1038/s41467-022-34097-9.