Halic Lab - Genome Expression and Maintenance
- Genome Expression
- Genome Maintenance
- Initiation of Heterochromatin Formation
Regulation of genome expression is essential for many cellular processes including cell proliferation, differentiation, development and viability. It has become clear over the past decade that small RNA silencing pathways are involved in the cellular control of gene expression and in protection of the genome against mobile repetitive DNA sequences, retroelements and transposons. Read more...
Tailing and degradation of Argonaute-bound small RNAs protect the genome from uncontrolled RNAi.
Pisacane P, Halic M.
Nat Commun. 2017 May 25;8:15332. doi: 10.1038/ncomms15332. PubMed
Accumulation of RNA on chromatin disrupts heterochromatic silencing.
Brönner C, Salvi L, Zocco M, Ugolini I, Halic M.
Genome Res. 2017 Apr 12. doi: 10.1101/gr.216986.116. PubMed
The Chp1 chromodomain binds the H3K9me tail and the nucleosome core to assemble heterochromatin.
Zocco M, Marasovic M, Pisacane P, Bilokapic S, Halic M.
Cell Discov. 2016 Apr 19;2:16004. doi: 10.1038/celldisc.2016.4. eCollection 2016. PubMed