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Herzog Lab - Biological Mass Spectrometry

herzog_mainResearch Topics

  • Chemical crosslinking and mass spectrometry
  • Kinetochore architecture and its role in cell cycle regulation
  • Centromere associated protein complexes


Dr. Franz Herzog

phone: +49 (0)89 - 2180 76937

The major task of cell division is the accurate dissemination of the genetic information to daughter cells. Macromolecular protein assemblies provide a structural framework and serve as site for feedback control mechanisms ensuring the correct order of events. We combine mass spectrometry, chemical crosslinking, biochemistry and cell biology to investigate the architecture and mechanism of protein complexes built on centromeric chromatin. Read more...

Selected Publications

compleXView: a server for the interpretation of protein abundance and connectivity information to identify protein complexes.
Solis-Mezarino V, Herzog F.
Nucleic Acids Res. 2017 May 12. doi: 10.1093/nar/gkx411. PubMed

Insights from biochemical reconstitution into the architecture of human kinetochores.
Weir JR, Faesen AC, Klare K, Petrovic A, Basilico F, Fischböck J, Pentakota S, Keller J, Pesenti ME, Pan D, Vogt D, Wohlgemuth S, Herzog F, Musacchio A.
Nature. 2016 Sep 8;537(7619):249-253. doi: 10.1038/nature19333. Epub 2016 Aug 31. PubMed

xVis: a web server for the schematic visualization and interpretation of crosslink-derived spatial restraints.
Grimm M, Zimniak T, Kahraman A, Herzog F.
Nucleic Acids Res. 2015 Jul 1;43(W1):W362-9. doi: 10.1093/nar/gkv463. Epub 2015 May 8. PubMed

Structural probing of a protein phosphatase 2A network by chemical cross-linking and mass spectrometry.
Herzog F, Kahraman A, Boehringer D, Mak R, Bracher A, Walzthoeni T, Leitner A, Beck M, Hartl FU, Ban N, Malmström L, Aebersold R.
Science. 2012 Sep 14;337(6100):1348-52. doi: 10.1126/science.1221483. PubMed

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