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Uhlenhaut Lab - Molecular Endocrinology

uhlenhaut_mainResearch Topics

  • Genomics
  • Nuclear Hormone Receptors
  • Metabolic Homeostasis
  • Transcription

Nuclear hormone receptors comprise a large family of ligand-gated transcription factors that act as important regulators of numerous physiological processes such as reproduction, metabolism, homeostasis, inflammation and development. Read more...

Selected Publications

DNA residence time is a regulatory factor of transcription repression.
Clauß K, Popp AP, Schulze L, Hettich J, Reisser M, Escoter Torres L, Uhlenhaut NH, Gebhardt JCM.
Nucleic Acids Res. 2017 Nov 2;45(19):11121-11130. doi: 10.1093/nar/gkx728. PubMed

The E2A splice variant E47 regulates the differentiation of projection neurons via p57(KIP2) during cortical development.
Pfurr S, Chu YH, Bohrer C, Greulich F, Beattie R, Mammadzada K, Hils M, Arnold SJ, Taylor V, Schachtrup K, Uhlenhaut NH, Schachtrup C.
Development. 2017 Nov 1;144(21):3917-3931. doi: 10.1242/dev.145698. Epub 2017 Sep 22. PubMed

Rapid Genome-wide Recruitment of RNA Polymerase II Drives Transcription, Splicing, and Translation Events during T Cell Responses.
Davari K, Lichti J, Gallus C, Greulich F, Uhlenhaut NH, Heinig M, Friedel CC, Glasmacher E.
Cell Rep. 2017 Apr 18;19(3):643-654. doi: 10.1016/j.celrep.2017.03.069. PubMed

MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity.
Moretti I, Ciciliot S, Dyar KA, Abraham R, Murgia M, Agatea L, Akimoto T, Bicciato S, Forcato M, Pierre P, Uhlenhaut NH, Rigby PW, Carvajal JJ, Blaauw B, Calabria E, Schiaffino S.
Nat Commun. 2016 Aug 3;7:12397. doi: 10.1038/ncomms12397. PubMed

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