Structural Biology: Ribosomes
Eukaryotic ribosome biogenesis: large subunit synthesis
29.02.2024
Ribosome production is essential for cell growth. Approximately 200 assembly factors drive this complicated pathway that starts in the nucleolus and ends in the cytoplasm. A large number of structural snapshots of thepre-60S pathway have revealed the principles behind large subunit synthesis (part II). Part I, which unravels the mechanisms of small ribosome synthesis, was published in May 2023. Both works are the result of a great collaboration between the working groups of Ed Hurt and Roland Beckmann over a period of more than 10 years.
Please use this link to watch the movie about the synthesis of the large subunit: https://ars.els-cdn.com/content/image/1-s2.0-S0092867424001120-mmc1.mp4
Until April 19, 2024, you can access SnapShot I for free here: https://authors.elsevier.com/a/1igrbL7PXqPnW
Watch here the video about the formation of ribosomes in the eukaryotic cell: https://ars.els-cdn.com/content/image/1-s2.0-S0092867423004646-mmc1.mp4
Original Publications:
SnapShot: Eukaryotic ribosome biogenesis II
Ed Hurt, Janet Iwasa, Roland Beckmann
Cell, 2024 February 29;187(5):1314-1314.e1 https://doi.org/10.1016/j.cell.2024.01.043
SnapShot: Eukaryotic ribosome biogenesis I.
Hurt E, Cheng J, Baβler J, Iwasa J, Beckmann R.
Cell. 2023 May 11;186(10):2282-2282.e1. https://doi.org/10.1016/j.cell.2023.04.030