Julian Stingele is one of the 2023 ERC Consolidator awardees.
Cellular biomolecules are constantly subjected to complex crosslinking damage, which is caused by reactive metabolites and various exogenous sources. In his new ERC project DECONSTRUCT (Deconstruction of complex crosslinking damage), Julian Stingele, Professor of Cellular Biochemistry, will investigate how crosslinking damage to RNA and proteins affects cellular homeostasis. To this end, he will employ novel experimental model systems combined with genetic and proteomic approaches to elucidate the molecular mechanisms by which crosslinking damage can be detected and resolved. Julian Stingele received an ERC Starting Grant already in 2018 to investigate DNA-protein crosslinks.