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Stingele Lab - Cellular Biochemistry

stingele_mainResearch Topics

  • Maintenance of Genome Stability
  • Endogenous Sources of DNA Damage
  • Repair of DNA-Protein Crosslinks

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Prof. Julian Stingele

phone: +49 (0)89 - 2180 71080

Maintenance of genome stability is essential to counteract cancer development and ageing. We are trying to understand how cells detect, signal and repair DNA damage. Moreover, we are interested in identifying the endogenous processes causing DNA damage in human cells. We investigate these processes by combining various approaches including genetic engineering, cell biology and biochemistry. Read more...

Selected Publications

A ubiquitin switch controls autocatalytic inactivation of the DNA-protein crosslink repair protease SPRTN.
Zhao S, Kieser A, Li HY, Reinking HK, Weickert P, Euteneuer S, Yaneva D, Acampora AC, Götz MJ, Feederle R, Stingele J.
Nucleic Acids Res. 2021 Jan 25;49(2):902-915. doi: 10.1093/nar/gkaa1224. PubMed

DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease.
Reinking HK, Kang HS, Götz MJ, Li HY, Kieser A, Zhao S, Acampora AC, Weickert P, Fessler E, Jae LT, Sattler M, Stingele J.
Mol Cell. 2020 Oct 1;80(1):102-113.e6. doi: 10.1016/j.molcel.2020.08.003. Epub 2020 Aug 26. PubMed

Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN.
Stingele J, Bellelli R, Alte F, Hewitt G, Sarek G, Maslen SL, Tsutakawa SE, Borg A, Kjær S, Tainer JA, Skehel JM, Groll M, Boulton SJ.
Mol Cell. 2016 Nov 17;64(4):688-703. doi: 10.1016/j.molcel.2016.09.031. Epub 2016 Oct 27. PubMed

A DNA-dependent protease involved in DNA-protein crosslink repair.
Stingele J, Schwarz MS, Bloemeke N, Wolf PG, Jentsch S.
Cell. 2014 Jul 17;158(2):327-38. doi: 10.1016/j.cell.2014.04.053. Epub 2014 Jul 3. PubMed

More publications


April 2021: New PhD student

Max continues his outstanding Master thesis work!

December 2020 - New Paper

A ubiquitin switch controls activty of the DNA-protein crosslink repair protease SPRTN.

December 2020: EMBO Young Investigator Programme

Julian was selected as EMBO Young Investigator! 

November 2020: Stefan Jentsch Fellowship

Max was awarded a Stefan Jentsch Fellowship by the German Society for Research on DNA repair for his Master thesis project!