Stingele Lab - Cellular Biochemistry
- Maintenance of Genome Stability
- Endogenous Sources of DNA Damage
- Repair of DNA-Protein Crosslinks
phone: +49 (0)89 - 2180 71080
Maintenance of genome stability is essential to counteract cancer development and ageing. We are trying to understand how cells detect, signal and repair DNA damage. Moreover, we are interested in identifying the endogenous processes causing DNA damage in human cells. We investigate these processes by combining various approaches including genetic engineering, cell biology and biochemistry. Read more...
A ubiquitin switch controls autocatalytic inactivation of the DNA-protein crosslink repair protease SPRTN.
Zhao S, Kieser A, Li HY, Reinking HK, Weickert P, Euteneuer S, Yaneva D, Acampora AC, Götz MJ, Feederle R, Stingele J.
Nucleic Acids Res. 2020 Dec 22:gkaa1224. doi: 10.1093/nar/gkaa1224. PubMed
DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease.
Reinking HK, Kang HS, Götz MJ, Li HY, Kieser A, Zhao S, Acampora AC, Weickert P, Fessler E, Jae LT, Sattler M, Stingele J.
Mol Cell. 2020 Aug 19:S1097-2765(20)30546-3. doi: 10.1016/j.molcel.2020.08.003. PubMed
Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN.
Stingele J, Bellelli R, Alte F, Hewitt G, Sarek G, Maslen SL, Tsutakawa SE, Borg A, Kjær S, Tainer JA, Skehel JM, Groll M, Boulton SJ.
Mol Cell. 2016 Nov 17;64(4):688-703. doi: 10.1016/j.molcel.2016.09.031. Epub 2016 Oct 27. PubMed
A DNA-dependent protease involved in DNA-protein crosslink repair.
Stingele J, Schwarz MS, Bloemeke N, Wolf PG, Jentsch S.
Cell. 2014 Jul 17;158(2):327-38. doi: 10.1016/j.cell.2014.04.053. Epub 2014 Jul 3. PubMed