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Stingele Lab - Cellular Biochemistry

stingele_mainResearch Topics

  • Nucleic acid quality control
  • Repair of DNA-protein crosslinks
  • Resolution of RNA damage

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Prof. Julian Stingele

phone: +49 (0)89 - 2180 71101

Nucleic acid quality control is essential for cellular homeostastis and to counteract cancer development and ageing. We are trying to understand how cells detect and resolve damage to DNA and RNA. We investigate these processes by combining various approaches including cell biology, genetic engineering, proteomics, and in vitro reconstitution. Read more...

Selected Publications

Transcription-coupled repair of DNA-protein cross-links depends on CSA and CSB.
Carnie CJ, Acampora AC, Bader AS, Erdenebat C, Zhao S, Bitensky E, van den Heuvel D, Parnas A, Gupta V, D'Alessandro G, Sczaniecka-Clift M, Weickert P, Aygenli F, Götz MJ, Cordes J, Esain-Garcia I, Melidis L, Wondergem AP, Lam S, Robles MS, Balasubramanian S, Adar S, Luijsterburg MS, Jackson SP, Stingele J.
Nat Cell Biol. 2024 May;26(5):797-810. doi: 10.1038/s41556-024-01391-1. Epub 2024 Apr 10. PubMed

RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks.
Zhao S, Cordes J, Caban KM, Götz MJ, Mackens-Kiani T, Veltri AJ, Sinha NK, Weickert P, Kaya S, Hewitt G, Nedialkova DD, Fröhlich T, Beckmann R, Buskirk AR, Green R, Stingele J.
Mol Cell. 2023 Nov 2:S1097-2765(23)00849-3. doi: 10.1016/j.molcel.2023.10.012. PubMed

The FANCJ helicase unfolds DNA-protein crosslinks to promote their repair.
Yaneva D, Sparks JL, Donsbach M, Zhao S, Weickert P, Bezalel-Buch R, Stingele J*, Walter JC*.
Mol Cell. 2023 Jan 5;83(1):43-56.e10. doi: 10.1016/j.molcel.2022.12.005. PubMed

DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease.
Reinking HK, Kang HS, Götz MJ, Li HY, Kieser A, Zhao S, Acampora AC, Weickert P, Fessler E, Jae LT, Sattler M, Stingele J.
Mol Cell. 2020 Oct 1;80(1):102-113.e6. doi: 10.1016/j.molcel.2020.08.003. Epub 2020 Aug 26. PubMed


More publications


May 2024 - New Paper

TOPORS promotes repair of DNA-protein crosslinks.

May 2024 - New Paper

A new transcription-coupled DNA repair pathway.

November 2023: ERC Consolidator Grant

Our lab receives 2 million Euro in EU funding

November 2023 - New Paper

Translation-coupled resolution of RNA-protein crosslinks