Hornung Lab - Innate Immunity
Research Topics
- Nucleic Acid Sensors
- Inflammasomes
- Genome Engineering
Prof. Veit Hornung
phone: +49 (0)89 - 2180 71109
hornung@genzentrum.lmu.de
Assistant: Emma Weber
phone: +49 (0)89 - 2180 71110
hornung.office@genzentrum.lmu.de
Follow us on Twitter: @hornung_lab
We are trying to understand what mechanisms are employed by the innate immune system to distinguish self from non-self or harmless from dangerous, respectively. Central to this complex task is a repertoire of pattern recognition receptors (PRRs) that have evolved to detect the presence of microorganisms. The ligands or targets of these PRRs are commonly referred to as microbe-associated molecular patterns (MAMPs). Read more...
Selected Publications
Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activation.
Bérouti M, Lammens K, Heiss M, Hansbauer L, Bauernfried S, Stöckl J, Pinci F, Piseddu I, Greulich W, Wang M, Jung C, Fröhlich T, Carell T, Hopfner KP, Hornung V.
Immunity. 2024;57:1482-1496.e1488. doi: 10.1016/j.immuni.2024.04.010.
Link
Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation.
Stafford CA, Gassauer AM, de Oliveira Mann CC, Tanzer MC, Fessler E, Wefers B, Nagl D, Kuut G, Sulek K, Vasilopoulou C, Schwojer SJ, Wiest A, Pfautsch MK, Wurst W, Yabal M, Fröhlich T, Mann M, Gisch N, Jae LT, Hornung V.
Nature. 2022;609:590-596. doi: 10.1038/s41586-022-05125-x.
Link
Human NLRP1 is a sensor for double-stranded RNA.
Bauernfried S, Scherr MJ, Pichlmair A, Duderstadt KE, Hornung V.
Science. 2021;371. doi: 10.1126/science.abd0811.
Link
TLR8 Is a Sensor of RNase T2 Degradation Products.
Greulich W, Wagner M, Gaidt MM, Stafford C, Cheng Y, Linder A, Carell T, Hornung V.
Cell. 2019;179:1264-1275.e1213. doi: 10.1016/j.cell.2019.11.001.
Link
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.
Gaidt MM, Ebert TS, Chauhan D, Ramshorn K, Pinci F, Zuber S, O'Duill F, Schmid-Burgk JL, Hoss F, Buhmann R, Wittmann G, Latz E, Subklewe M, Hornung V.
Cell. 2017;171:1110-1124.e1118. doi: 10.1016/j.cell.2017.09.039.
Link
More publications
News
Highly Cited Researcher 2024
Veit Hornung has once again been identified as a Highly Cited Researcher by Clarivate Analytics. He is one of 18 LMU researchers to receive this distinction, which recognizes the top 1% of cited researchers worldwide. More info here.
New Publication
Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activation.
Congratulations to Marleen Bérouti on this great work! Check out the full story here!