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Hornung Lab - Innate Immunity

Research Topics

  • Inflammasome
  • Nucleic Acid Sensors
  • Genome Engineering

Prof. Veit Hornung

phone: +49 (0)89 - 2180 71109

Assistant: Annika Büscher

phone: +49 (0)89 - 2180 71110

Follow us on Twitter: @hornung_lab

We are trying to understand what mechanisms are employed by the innate immune system to distinguish self from non-self or harmless from dangerous, respectively. Central to this complex task is a repertoire of pattern recognition receptors (PRRs) that have evolved to detect the presence of microorganisms. The ligands or targets of these PRRs are commonly referred to as microbe-associated molecular patterns (MAMPs). Read more...

Selected Publications

Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation.
Stafford CA, Gassauer AM, de Oliveira Mann CC, Tanzer MC, Fessler E, Wefers B, Nagl D, Kuut G, Sulek K, Vasilopoulou C, Schwojer SJ, Wiest A, Pfautsch MK, Wurst W, Yabal M, Fröhlich T, Mann M, Gisch N, Jae LT, Hornung V.
Nature. 2022 Aug 24. doi: 10.1038/s41586-022-05125-x. Online ahead of print. pdf

Human NLRP1 is a sensor for double-stranded RNA.
Bauernfried S, Scherr MJ, Pichlmair A, Duderstadt KE, Hornung V.
Science. 2020 Nov 26:eabd0811. doi: 10.1126/science.abd0811. Epub 2020 Nov 26. Full text

TLR8 Is a Sensor of RNase T2 Degradation Products.
Greulich W, Wagner M, Gaidt MM, Stafford C, Cheng Y, Linder A, Carell T, Hornung V.
Cell. 2019 Nov 27;179(6):1264-1275.e13. doi: 10.1016/j.cell.2019.11.001. Full text

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.
Gaidt MM, Ebert TS, Chauhan D, Ramshorn K, Pinci F, Zuber S, O'Duill F, Schmid-Burgk JL, Hoss F, Buhmann R, Wittmann G, Latz E, Subklewe M, Hornung V.
Cell. 2017 Nov 16;171(5):1110-1124.e18. doi: 10.1016/j.cell.2017.09.039. Epub 2017 Oct 12. Full text

More publications


EMBO conference

Registration Open!

Organizer Prof. Dr. Veit Hornung invites to the EMBO conference "The Inflammasomes - 2024" held at BMC in Martinsried 24 – 27 September 2024

>>>Apply now<<<

New Publication

Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activatio.

Congratulations to Marleen Bérouti on this great work! Check out the full story here!



Congratulations to Dr. Inga Szymanska on obtaining her doctorate!