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Hornung Lab - Innate Immunity

Research Topics

  • Inflammasome
  • Nucleic Acid Sensors
  • Genome Engineering

Prof. Veit Hornung

phone: +49 (0)89 - 2180 71109
hornung@genzentrum.lmu.de

Assistant: Xiaoshan Hu

phone: +49 (0)89 - 2180 71110
hornung.office@genzentrum.lmu.de

Follow us on Twitter: @hornung_lab

We are trying to understand what mechanisms are employed by the innate immune system to distinguish self from non-self or harmless from dangerous, respectively. Central to this complex task is a repertoire of pattern recognition receptors (PRRs) that have evolved to detect the presence of microorganisms. The ligands or targets of these PRRs are commonly referred to as microbe-associated molecular patterns (MAMPs). Read more...

Selected Publications

Human NLRP1 is a sensor for double-stranded RNA.
Bauernfried S, Scherr MJ, Pichlmair A, Duderstadt KE, Hornung V.
Science. 2020 Nov 26:eabd0811. doi: 10.1126/science.abd0811. [Epub ahead of print]. PDF Full text

TLR8 Is a Sensor of RNase T2 Degradation Products.
Greulich W, Wagner M, Gaidt MM, Stafford C, Cheng Y, Linder A, Carell T, Hornung V.
Cell. 2019 Nov 27;179(6):1264-1275.e13. doi: 10.1016/j.cell.2019.11.001. Full text

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.
Gaidt MM, Ebert TS, Chauhan D, Ramshorn K, Pinci F, Zuber S, O'Duill F, Schmid-Burgk JL, Hoss F, Buhmann R, Wittmann G, Latz E, Subklewe M, Hornung V.
Cell. 2017 Nov 16;171(5):1110-1124.e18. doi: 10.1016/j.cell.2017.09.039. Epub 2017 Oct 12. Full text

Human Monocytes Engage an Alternative Inflammasome Pathway.
Gaidt MM, Ebert TS, Chauhan D, Schmidt T, Schmid-Burgk JL, Rapino F, Robertson AA, Cooper MA, Graf T, Hornung V.
Immunity. 2016 Apr 19;44(4):833-46. doi: 10.1016/j.immuni.2016.01.012. Epub 2016 Mar 29. Full text

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.
Ablasser A, Schmid-Burgk JL, Hemmerling I, Horvath GL, Schmidt T, Latz E, Hornung V.
Nature. 2013 Nov 28;503(7477):530-4. doi: 10.1038/nature12640. Epub 2013 Sep 29. Full text

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.
Ablasser A, Goldeck M, Cavlar T, Deimling T, Witte G, Röhl I, Hopfner KP, Ludwig J, Hornung V.
Nature. 2013 Jun 20;498(7454):380-4. doi: 10.1038/nature12306. Epub 2013 May 30. Full text

More publications

News

News

Congratulations to Wilhelm Greulich on achieving his doctorate degree!

New Publication

Congratulations to Stefan Bauernfried on his successful publication!
Read more