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Adler Lab - Biology of Cytomegaloviruses

adler_main49817Research Topics

  • Virus Entry and Cell Tropism
  • Modulation of Antiviral Immune Responses
  • CMV Vectors for Immune Therapy



 

PD Dr. Barbara Adler

phone: +49 (0)89 - 2180 76863
adler@genzentrum.lmu.de

Infections with human cytomegalovirus (HCMV) are a major cause of mortality in immunocompromised humans and of childhood disabilities. We are interested in the role of cytomegalovirus envelope glycoprotein complexes in cell entry and in shaping the antiviral immune response with the aim to design vaccines protecting from HCMV infection and CMV vectors for immune therapy of infectious diseases and tumors. Read more...

Selected Publications

Eletreby M, Thiessen L, Prager A, Brizic I, Materljan J, Kubic L, Jäger K, Jurinović K, Jerak J, Krey K, Adler B. Dissecting the cytomegalovirus CC chemokine: Chemokine activity and gHgLchemokine-dependent cell tropism are independent players in CMV infection.
PLoS Pathog.
2023 Dec 8;19(12):e1011793. doi: 10.1371/journal.ppat.1011793. PubMed

Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells.
Rožmanić C, Lisnić B, Pribanić Matešić M, Mihalić A, Hiršl L, Park E, Lesac Brizić A, Indenbirken D, Viduka I, Šantić M, Adler B, Yokoyama WM, Krmpotić A, Juranić Lisnić V, Jonjić S, Brizić I.
Nat Commun. 2023 Oct 12;14(1):6412. doi: 10.1038/s41467-023-42182-w. PubMed

Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry.
Wu Y, Prager A, Boos S, Resch M, Brizic I, Mach M, Wildner S, Scrivano L, Adler B.
PLoS Pathog. 2017 Apr 12;13(4):e1006281. doi: 10.1371/journal.ppat.1006281. PubMed

Structural Basis of Vesicle Formation at the Inner Nuclear Membrane.
Hagen C, Dent KC, Zeev-Ben-Mordehai T, Grange M, Bosse JB, Whittle C, Klupp BG, Siebert CA, Vasishtan D, Bäuerlein FJ, Cheleski J, Werner S, Guttmann P, Rehbein S, Henzler K, Demmerle J, Adler B, Koszinowski U, Schermelleh L, Schneider G, Enquist LW, Plitzko JM, Mettenleiter TC, Grünewald K.
Cell. 2015 Dec 17;163(7):1692-701. doi: 10.1016/j.cell.2015.11.029. PubMed

 

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