Reichart Lab - Emmy Noether Research Group - Translational Cardiovascular Medicine
Research Topics
- Single-cell genomics in cardiovascular diseases
- Gene editing in cardiovascular diseases
The heart tissue is composed of multiple different cell types such as cardiomyocytes, fibroblasts or macrophages. This cellular diversity is necessary for normal heart contractility, relaxation and excitability. Single cell techniques extract cell type-specific information by measuring the transcriptome of each cell type, which helps to unravel the genetic readouts from healthy and diseased hearts. Next-generation CRISPR-based tools allow – even in post-mitotic cells such as cardiomyocytes – precise and efficient genome editing enabling therapeutic approaches in genetic cardiovascular diseases. Read more...
Selected Publications
Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice
Reichart D*, Newby GA*, Wakimoto H*, Lun M, Gorham JM, Curran JJ, Raguram A, DeLaughter DM, Conner DA, Marsiglia JDC, Kohli S, Chmatal L, Page DC, Zabaleta N, Vandenberghe L, Liu DR, Seidman JG, Seidman C.
Nat Med. 2023 Feb;29(2):412-421. doi: 10.1038/s41591-022-02190-7. PubMed
Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies
Reichart D*, Lindberg EL*, Maatz H*, Miranda AMA, Viveiros A, Shvetsov N, Gärtner A, Nadelmann ER, Lee M, Kanemaru K, Ruiz-Orera J, Strohmenger V, DeLaughter DM, Patone G, Zhang H, Woehler A, Lippert C, Kim Y, Adami E, Gorham JM, Barnett SN, Brown K, Buchan RJ, Chowdhury RA, Constantinou C, Cranley J, Felkin LE, Fox H, Ghauri A, Gummert J, Kanda M, Li R, Mach L, McDonough B, Samari S, Shahriaran F, Yapp C, Stanasiuk C, Theotokis PI, Theis FJ, van den Bogaerdt A, Wakimoto H, Ware JS, Worth CL, Barton PJR, Lee YA, Teichmann SA, Milting H#, Noseda M#, Oudit GY#, Heinig M#, Seidman JG#, Hubner N#, Seidman CE#.
Science. 2022 Aug 5;377(6606):eabo1984. doi: 10.1126/science.abo1984. PubMed
Cells of the adult human heart
Litviňuková M*, Talavera-López C*, Maatz H*, Reichart D*, Worth CL, Lindberg EL, Kanda M, Polanski K, Heinig M, Lee M, Nadelmann ER, Roberts K, Tuck L, Fasouli ES, DeLaughter DM, McDonough B, Wakimoto H, Gorham JM, Samari S, Mahbubani KT, Saeb-Parsy K, Patone G, Boyle JJ, Zhang H, Zhang H, Viveiros A, Oudit GY, Bayraktar OA, Seidman JG, Seidman CE, Noseda M, Hubner N, Teichmann SA.
Nature. 2020 Dec;588(7838):466-472. doi: 10.1038/s41586-020-2797-4. PubMed