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Hopfner Lab - Structural Molecular Biology

hopfner_mainResearch Topics

  • Cryo-EM and crystallography
  • Structural Genome Biology
  • Innate Immune RNA and DNA Sensing
  • Therapeutic Protein Engineering

We are interested in how cells shape and protect their genomic information. Using cryo-EM, X-ray crystallography and functional approaches, we study the architectures and mechanisms of macromolecular complexes in genome biology with a focus on chromatin remodelers, DNA double-strand break repair enzymes and innate immune nucleic acid sensors. Moreover, we also focus on innovative antibody engineering with the aim of exploiting immune checkpoints to improve cancer immunotherapy. Read more...

Selected Publications

Structural basis for ATP dependent chromatin remodelling by the INO80 complex.
Eustermann S, Schall K, Kostrewa D, Lakomek K, Strauss M, Moldt M, Hopfner KP.
Nature. 2018 April 11; doi:10.1038/s41586-018-0029-y. PubMed

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.
Andreeva L, Hiller B, Kostrewa D, Lässig C, de Oliveira Mann CC, Jan Drexler D, Maiser A, Gaidt M, Leonhardt H, Hornung V, Hopfner KP.
Nature. 2017 Sep 21;549(7672):394-398. doi: 10.1038/nature23890. Epub 2017 Sep 13. PubMed

Structural mechanism of cytosolic DNA sensing by cGAS.
Civril F, Deimling T, de Oliveira Mann CC, Ablasser A, Moldt M, Witte G, Hornung V, Hopfner KP.
Nature. 2013 Jun 20;498(7454):332-7. PubMed

The Mre11:Rad50 structure shows an ATP-dependent molecular clamp in DNA double-strand break repair.
Lammens K, Bemeleit DJ, Möckel C, Clausing E, Schele A, Hartung S, Schiller CB, Lucas M, Angermüller C, Söding J, Strässer K, Hopfner KP.
Cell. 2011 Apr 1;145(1):54-66. PubMed

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05.10.2018 - New Publications

Our latest research on BCL10-MALT1 filaments, bacterial DNA ds break sensor SbcCD and Swi/Snf2 remodeler Mot1. Read more...

11.04.2018 - New Publication

Structural basis for ATP-dependent chromatin remodelling by the INO80 complex.

01.02.2018 - New Publication

Single-molecule nucleosome remodeling by INO80 and effects of histone tails.