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Hopfner Lab - Structural Molecular Biology

Hopfner_main49571Research Topics

  • Cryo-EM and crystallography
  • Structural Genome Biology
  • Innate Immune RNA and DNA Sensing
  • Therapeutic Protein Engineering

We are interested in how cells shape and protect their genomic information. Using cryo-EM, X-ray crystallography and functional approaches, we study the architectures and mechanisms of macromolecular complexes in genome biology with a focus on chromatin remodelers, DNA double-strand break repair enzymes and innate immune nucleic acid sensors. Moreover, we also focus on innovative antibody engineering with the aim of exploiting immune checkpoints to improve cancer immunotherapy. Read more...

Selected Publications

Structural basis for sequestration and autoinhibition of cGAS by chromatin.
Michalski S, de Oliveira Mann CC, Stafford CA, Witte G, Bartho J, Lammens K, Hornung V, Hopfner KP.
Nature. 2020 Nov;587(7835):678-682. doi: 10.1038/s41586-020-2748-0. PubMed

Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex.
Käshammer L, Saathoff JH, Lammens K, Gut F, Bartho J, Alt A, Kessler B, Hopfner KP.
Mol Cell. 2019 Nov 7;76(3):382-394.e6. doi: 10.1016/j.molcel.2019.07.035. PubMed

Structural basis for ATP dependent chromatin remodelling by the INO80 complex.
Eustermann S, Schall K, Kostrewa D, Lakomek K, Strauss M, Moldt M, Hopfner KP.
Nature. 2018 April 11; doi:10.1038/s41586-018-0029-y. PubMed

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.
Andreeva L, Hiller B, Kostrewa D, Lässig C, de Oliveira Mann CC, Jan Drexler D, Maiser A, Gaidt M, Leonhardt H, Hornung V, Hopfner KP.
Nature. 2017 Sep 21;549(7672):394-398. doi: 10.1038/nature23890. Epub 2017 Sep 13. PubMed


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23.09.2021 - New Publication

Molecular basis of human ATM kinase inhibition

30.07.2021 - OPSYON

New webpage of the Hopfner and Subklewe spin-off is online now

10.09.2020 - New Publication

cGAS meets the nucleosome