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Keppler Lab - HIV-host Interactions and Chemo-Sensitization

Research Topics

  • Intrinsic Immunity
  • HIV Pathogenesis ex vivo
  • HIV-1 Animal Models
  • Novel Cellular Interactors of HIV

Prof. Oliver Keppler

phone: +49 (0)89 - 2180 72901

Assistant: Brigitte Held

phone: +49 (0)89 - 2180 72901

HIV/AIDS has become one of the most devastating pandemics in recorded history. AIDS is the fourth-biggest global killer and the leading cause of death in Africa. HIV/AIDS persists as a major cause of morbidity in Western societies, since currently available pharmacotherapies can only partly control, but not cure this immunodestructive viral infection. Furthermore, these drugs frequently cause severe side effects and HIV drug resistance development is rapidly emerging. Globally, the lack of effective treatment regimens causes immense human suffering and high cost for society. My laboratory seeks to better understand the pathological interplay of HIV with the host’s immune system and its target cells with the goal of providing new approaches for prophylaxis and therapy. Read more...

Selected Publications

Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML. Oellerich T+, Schneider C+, Thomas D, Knecht KM, Buzovetsky O, Kaderali L, Schliemann C, Bohnenberger H, Angenendt L, Hartmann W, Wardelmann E, Rothenburger T, Mohr S, Scheich S, Comoglio F, Wilke A, Ströbel P, Serve H, Michaelis M, Ferreirós N, Geisslinger G, Xiong Y, Keppler OT*, Cinatl J Jr*.
Nat Commun. 2019 Aug 2;10(1):3475. doi: 10.1038/s41467-019-11413-4. PubMed

SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.
Schneider C+, Oellerich T+, Baldauf HM+, Schwarz SM+, Thomas D, Flick R, Bohnenberger H, Kaderali L, Stegmann L, Cremer A, Martin M, Lohmeyer J, Michaelis M, Hornung V, Schliemann C, Berdel WE, Hartmann W, Wardelmann E, Comoglio F, Hansmann ML, Yakunin AF, Geisslinger G, Ströbel P, Ferreirós N, Serve H, Keppler OT*, Cinatl J Jr.*
Nat Med. 2017 Feb;23(2):250-255. doi: 10.1038/nm.4255. PubMed

The deoxynucleoside triphosphate triphosphohydrolase SAMHD1 restricts HIV-1 infection in resting CD4+ T cells.
Baldauf HM+, Pan X+, Erikson E, Schmidt S, Daddacha W, Burggraf M, Schenkova K, Ambiel I, Wabnitz G, Gramberg T, Panitz S, Flory E, Landau NR, Sertel S, Rutsch F, Lasitschka F, Kim B, König R, Fackler OT*, Keppler OT*.
Nat Med. 2012 Nov;18(11):1682-7. doi: 10.1038/nm.2964. PubMed

HIV-1 antagonism of CD317 is species-specific and involves Vpu-mediated proteasomal degradation of the restriction factor.
Goffinet C, Allespach I, Homann S, Tervo HM, Habermann A, Rupp D, Oberbremer L, Kern C, Tibroni N, Welsch S, Krijnse-Locker J, Banting G, Kräusslich HG, Fackler OT*, Keppler OT*.
Cell Host Microbe. 2009 Mar 19;5(3):285-97. doi: 10.1016/j.chom.2009.01.009. PubMed

More publications