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Keppler Lab - HIV-host Interactions and Chemo-Sensitization

Research Topics

  • HIV reservoir
  • SARS-CoV-2
  • SAMDHD1-dependent chemoresistance


Prof. Oliver Keppler

phone: +49 (0)89 - 2180 72901

Assistant: Brigitte Held

phone: +49 (0)89 - 2180 72901

The Keppler laboratory investigates fundamental principles of virus-host interactions, in particular for the pandemic pathogens HIV and SARS-CoV-2, as well as specific mechanisms of resistance to chemotherapy in different malignancies. Using state-of-the-art technology and primary model systems, we seek to unravel the immunodestruction induced by HIV and the ability of the virus to infect and establish latency in resting CD4 T cells.  Read more...

Selected Publications

Potent high-avidity neutralizing antibodies and T cell responses after COVID-19 vaccination in individuals with B cell lymphoma and multiple myeloma.
Keppler-Hafkemeyer A*, Greil C, Wratil PR, Shoumariyeh K, Stern M, Hafkemeyer A, Ashok D, Hollaus A, Lupoli G, Priller A, Bischof ML, Ihorst G, Engelhardt M, Marks R, Finke J, Bertrand H, Dächert C, Muenchhoff M, Badell I, Emmerich F, Halder H, Spaeth PM, Knolle PA, Protzer U, von Bergwelt-Baildon M, Duyster J, Hartmann TN, Moosmann A, Keppler OT*.
Nat Cancer 2023 Jan;4(1):81-95. PubMed

Three exposures to the spike protein of SARS-CoV-2 by either infection or vaccination elicit superior neutralizing immunity to all variants of concern.
Wratil PR, Stern M, Priller A, Willmann A, Almanzar G, Vogel E, Feuerherd M, Cheng CC, Yazici S, Christa C, Jeske S, Lupoli G, Vogt T, Albanese M, Mejías-Pérez E, Bauernfried S, Graf N, Mijocevic H, Vu M, Tinnefeld K, Wettengel J, Hoffmann D, Muenchhoff M, Daechert C, Mairhofer H, Krebs S, Fingerle V, Graf A, Steininger P, Blum H, Hornung V, Liebl B, Überla K, Prelog M, Knolle P, Keppler OT*, Protzer U*.
Nat Med. 2022 Jan 28. doi: 10.1038/s41591-022-01715-4. PubMed

Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4+ T cells allows complex functional analyses.
Albanese M, Ruhle A, Mittermaier J, Mejías-Pérez E, Gapp M, Linder A, Schmacke NA, Hofmann K, Hennrich AA, Levy DN, Humpe A, Conzelmann KK, Hornung V, Fackler OT, Keppler OT.
Nat Methods. 2022 Jan;19(1):81-89. doi: 10.1038/s41592-021-01328-8. Epub 2021 Dec 23. PubMed

Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML. Oellerich T+, Schneider C+, Thomas D, Knecht KM, Buzovetsky O, Kaderali L, Schliemann C, Bohnenberger H, Angenendt L, Hartmann W, Wardelmann E, Rothenburger T, Mohr S, Scheich S, Comoglio F, Wilke A, Ströbel P, Serve H, Michaelis M, Ferreirós N, Geisslinger G, Xiong Y, Keppler OT*, Cinatl J Jr*.
Nat Commun. 2019 Aug 2;10(1):3475. doi: 10.1038/s41467-019-11413-4. PubMed

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