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Stigler Lab - Biophysics of Structural Dynamics in Chromosomes

stigler_mainResearch Topics

  • Mechanics of Intrachromosomal Crosslinks
  • Establishment of Hierarchically Structured Chromosomes

Prof. Johannes Stigler

phone: +49 (0)89 - 2180 76951

Chromosomes provide the fundamental scaffold for the maintenance, regulation and propagation of genetic information. Recent experimental findings have shown that eukaryotic chromosomes are highly structured and that the three-dimensional folding of chromosomes is directly linked to gene regulation. Our lab uses biophysical single molecule techniques to determine the processes that lead to the three-dimensional folding of chromosomes. Read more...

Selected Publications

Single-Molecule Imaging Reveals a Collapsed Conformational State for DNA-Bound Cohesin.
Stigler J, Çamdere GÖ, Koshland DE, Greene EC.
Cell Rep. 2016 May 3;15(5):988-998. doi: 10.1016/j.celrep.2016.04.003. Epub 2016 Apr 21. PubMed

Sequence-resolved free energy profiles of stress-bearing vimentin intermediate filaments.
Ramm B, Stigler J, Hinczewski M, Thirumalai D, Herrmann H, Woehlke G, Rief M.
Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11359-64. doi: 10.1073/pnas.1403122111. Epub 2014 Jul 21. PubMed

The complex folding network of single calmodulin molecules.
Stigler J, Ziegler F, Gieseke A, Gebhardt JC, Rief M.
Science. 2011 Oct 28;334(6055):512-6. doi: 10.1126/science.1207598. PubMed

More publications


New publication

Our single molecule work on ATP-dependent cohesin-Scc2/4 compaction and DNA tethering got published (in collaboration with the labs of David Rueda and Luis Aragon).

New member in our lab

Dieter joined us as a PhD student in February 2019.

New member in our lab

Loredana joined our lab as a PhD student in November 2018.

Open Position

We are seeking a motivated postdoc to join our lab. Please send your applications to Johannes Stigler.