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Stigler Lab - Biophysics of Structural Dynamics in Chromosomes

stigler_mainResearch Topics

  • Mechanics of Intrachromosomal Crosslinks
  • Establishment of Hierarchically Structured Chromosomes





Prof. Johannes Stigler

phone: +49 (0)89 - 2180 76962
stigler@genzentrum.lmu.de

Chromosomes provide the fundamental scaffold for the maintenance, regulation and propagation of genetic information. Recent experimental findings have shown that eukaryotic chromosomes are highly structured and that the three-dimensional folding of chromosomes is directly linked to gene regulation. Our lab uses biophysical single molecule techniques to determine the processes that lead to the three-dimensional folding of chromosomes. Read more...

Selected Publications

Single-Molecule Imaging Reveals a Collapsed Conformational State for DNA-Bound Cohesin.
Stigler J, Çamdere GÖ, Koshland DE, Greene EC.
Cell Rep. 2016 May 3;15(5):988-998. doi: 10.1016/j.celrep.2016.04.003. Epub 2016 Apr 21. PubMed

Sequence-resolved free energy profiles of stress-bearing vimentin intermediate filaments.
Ramm B, Stigler J, Hinczewski M, Thirumalai D, Herrmann H, Woehlke G, Rief M.
Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11359-64. doi: 10.1073/pnas.1403122111. Epub 2014 Jul 21. PubMed

The complex folding network of single calmodulin molecules.
Stigler J, Ziegler F, Gieseke A, Gebhardt JC, Rief M.
Science. 2011 Oct 28;334(6055):512-6. doi: 10.1126/science.1207598. PubMed

More publications

News

New member in our lab

Dieter joined us as a PhD student in February 2019.

New member in our lab

Loredana joined our lab as a PhD student in November 2018.

New member in our lab

Sigrun joined us as a lab technician in November 2018.

Open Position

We are seeking a motivated postdoc to join our lab. Please send your applications to Johannes Stigler.