Beckmann Lab - Structural Biology of the Ribosome
Research Topics
- Cryo-Electron Microscopy
- Quality Control and mRNA Surveillance
- Protein Targeting and Translocation
- Ribosome Biogenesis
Prof. Roland Beckmann
phone: +49 (0)89 - 2180 76900
beckmann@genzentrum.lmu.de
Assistant: Gudrun Römer
phone: +49 (0)89 - 2180 76901
roemer@genzentrum.lmu.de
The ribosome serves, apart from its function in translation, as platform for various regulatory processes which are at the center of our research. Here, we focus on understanding molecular mechanisms of gene expression regulation, mRNA surveillance and ribosome quality control, co-translational targeting and translocation of proteins to and across a target membrane and assembly of the 40S and 60S ribosomal subunits using cryo-EM. Read more...
Selected Publications
The Ccr4-Not complex monitors the translating ribosome for codon optimality.
Buschauer R, Matsuo Y, Sugiyama T, Chen YH, Alhusaini N, Sweet T, Ikeuchi K, Cheng J, Matsuki Y, Nobuta R, Gilmozzi A, Berninghausen O, Tesina P, Becker T, Coller J, Inada T, Beckmann R.
Science. 2020 Apr 17;368(6488). pii: eaay6912. doi: 10.1126/science.aay6912. PubMed
Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis.
Su T, Izawa T, Thoms M, Yamashita Y, Cheng J, Berninghausen O, Hartl FU, Inada T, Neupert W, Beckmann R.
Nature. 2019 Jun;570(7762):538-542. doi: 10.1038/s41586-019-1307-z. PubMed
Visualizing late states of human 40S ribosomal subunit maturation.
Ameismeier M, Cheng J, Berninghausen O, Beckmann R.
Nature. 2018 Jun;558(7709):249-253. doi: 10.1038/s41586-018-0193-0. PubMed
Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum.
Braunger K, Pfeffer S, Shrimal S, Gilmore R, Berninghausen O, Mandon EC, Becker T, Förster F, Beckmann R.
Science. 2018 Mar 8. pii: eaar7899. doi: 10.1126/science.aar7899. PubMed