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Beckmann Lab - Cryo-EM and Single Particle Analysis

Research Topics

    • Cryo-Electron Microscopy
    • Quality Control and mRNA Surveillance
    • Protein Targeting and Translocation
    • Ribosome Biogenesis

The ribosome serves, apart from its function in translation, as platform for various regulatory processes which are at the center of our research. Here, we focus on understanding molecular mechanisms of gene expression regulation, mRNA surveillance and ribosome quality control, co-translational targeting and translocation of proteins to and across a target membrane and assembly of the 40S and 60S ribosomal subunits using cryo-EM. Read more...

Selected Publications

Visualizing late states of human 40S ribosomal subunit maturation.
Ameismeier M, Cheng J, Berninghausen O, Beckmann R.
Nature. 2018 Jun 6. doi: 10.1038/s41586-018-0193-0. PubMed

Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum.
Braunger K, Pfeffer S, Shrimal S, Gilmore R, Berninghausen O, Mandon EC, Becker T, Förster F, Beckmann R.
Science. 2018 Mar 8. pii: eaar7899. doi: 10.1126/science.aar7899. PubMed

Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes.
Kater L, Thoms M, Barrio-Garcia C, Cheng J, Ismail S, Ahmed YL, Bange G, Kressler D, Berninghausen O, Sinning I, Hurt E, Beckmann R.
Cell. 2017 Dec 14;171(7):1599-1610.e14. doi: 10.1016/j.cell.2017.11.039. PubMed

The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex.
Schmidt C, Kowalinski E, Shanmuganathan V, Defenouillère Q, Braunger K, Heuer A, Pech M, Namane A, Berninghausen O, Fromont-Racine M, Jacquier A, Conti E, Becker T, Beckmann R.
Science. 2016 Dec 16;354(6318):1431-1433. PubMed

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06.06.2018 - New Paper

Visualizing late states of human 40S ribosomal subunit maturation.

13.04.2018 - New Paper

Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum.