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Beckmann Lab - Structural Biology of the Ribosome

Research Topics

    • Cryo-Electron Microscopy
    • Quality Control and mRNA Surveillance
    • Protein Targeting and Translocation
    • Ribosome Biogenesis

The ribosome serves, apart from its function in translation, as platform for various regulatory processes which are at the center of our research. Here, we focus on understanding molecular mechanisms of gene expression regulation, mRNA surveillance and ribosome quality control, co-translational targeting and translocation of proteins to and across a target membrane and assembly of the 40S and 60S ribosomal subunits using cryo-EM. Read more...

Selected Publications

The Ccr4-Not complex monitors the translating ribosome for codon optimality.
Buschauer R, Matsuo Y, Sugiyama T, Chen YH, Alhusaini N, Sweet T, Ikeuchi K, Cheng J, Matsuki Y, Nobuta R, Gilmozzi A, Berninghausen O, Tesina P, Becker T, Coller J, Inada T, Beckmann R.
Science. 2020 Apr 17;368(6488). pii: eaay6912. doi: 10.1126/science.aay6912. PubMed

Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis.
Su T, Izawa T, Thoms M, Yamashita Y, Cheng J, Berninghausen O, Hartl FU, Inada T, Neupert W, Beckmann R.
Nature. 2019 Jun;570(7762):538-542. doi: 10.1038/s41586-019-1307-z. PubMed

Visualizing late states of human 40S ribosomal subunit maturation.
Ameismeier M, Cheng J, Berninghausen O, Beckmann R.
Nature. 2018 Jun;558(7709):249-253. doi: 10.1038/s41586-018-0193-0. PubMed

Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum.
Braunger K, Pfeffer S, Shrimal S, Gilmore R, Berninghausen O, Mandon EC, Becker T, Förster F, Beckmann R.
Science. 2018 Mar 8. pii: eaar7899. doi: 10.1126/science.aar7899. PubMed

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20.05.2020 - New Paper

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.

17.04.2020 - New Paper

The Ccr4-Not complex monitors the translating ribosome for codon optimality.

27.01.2020 - New Paper

Structure of the Bcs1 AAA-ATPase suggests an airlock-like translocation mechanism for folded proteins