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Mechanisms of Translation-coupled Quality Control.
Inada T, Beckmann R.
J Mol Biol. 2024 March 15;436(6):168496. doi: 10.1016/j.jmb.2024.168496. PubMed

SnapShot: Eukaryotic ribosome biogenesis II.
Hurt E, Iwasa J, Beckmann R.
Cell. 2024 February 29;187(5):1314-1314.e1. doi: 10.1016/j.cell.2024.01.043. PubMed

UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.
DaRosa PA, Penchev I, Gumbin SC, Scavone F, Wąchalska M, Paulo JA, Ordureau A, Peter JJ, Kulathu Y, Harper JW, Becker T, Beckmann R, Kopito RR.
Nature. 2024 February 21;627(8003):445-452. doi: 10.1038/s41586-024-07073-0. PubMed

B. subtilis MutS2 splits stalled ribosomes into subunits without mRNA cleavage.
Park EN, Mackens-Kiani T, Berhane R, Esser H, Erdenebat C, Burroughs AM, Berninghausen O, Aravind L, Beckmann R, Green R, Buskirk AR.
EMBO J. 2024 February 15;43(4):484-506. doi: 10.1038/s44318-023-00010-3. PubMed


SnapShot: Eukaryotic ribosome biogenesis I.
Hurt E, Cheng J, Baβler J, Iwasa J, Beckmann R.
Cell. 2023 May 11;186(10):2282-2282.e1. doi: 10.1016/j.cell.2023.04.030. PubMed

Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2.
Ikeuchi K, Ivic N, Buschauer R, Cheng J, Fröhlich T, Matsuo Y, Berninghausen O, Inada T, Becker T, Beckmann R.
Nat Commun. 2023 May 12;14(1):2730. doi: 10.1038/s41467-023-38161-w. PubMed

Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.
Lau B, Huang Z, Kellner N, Niu S, Berninghausen O, Beckmann R, Hurt E, Cheng J.
EMBO Rep. 2023 May 2:e56910. doi: 10.15252/embr.202356910. Online ahead of print. PubMed

The dynamic architecture of Map1- and NatB-ribosome complexes coordinates the sequential modifications of nascent polypeptide chains.
Knorr AG, Mackens-Kiani T, Musial J, Berninghausen O, Becker T, Beatrix B, Beckmann R.
PLoS Biol. 2023 Apr 20;21(4):e3001995. doi: 10.1371/journal.pbio.3001995. eCollection 2023 Apr. PubMed

Concurrent remodelling of nucleolar 60S subunit precursors by the Rea1 ATPase and Spb4 RNA helicase.
Mitterer V, Thoms M, Buschauer R, Berninghausen O, Hurt E, Beckmann R.
Elife. 2023 Mar 17;12:e84877. doi: 10.7554/eLife.84877. PubMed

Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control.
Tesina P, Ebine S, Buschauer R, Thoms M, Matsuo Y, Inada T, Beckmann R.
Mol Cell. 2023 Feb 16;83(4):607-621.e4. doi: 10.1016/j.molcel.2023.01.020. PubMed

Structural basis for clearing of ribosome collisions by the RQT complex.
Best K, Ikeuchi K, Kater L, Best D, Musial J, Matsuo Y, Berninghausen O, Becker T, Inada T, Beckmann R.
Nat Commun. 2023 Feb 17;14(1):921. doi: 10.1038/s41467-023-36230-8. PubMed

Two modes of Cue2-mediated mRNA cleavage with distinct substrate recognition initiate no-go decay.
Tomomatsu S, Watanabe A, Tesina P, Hashimoto S, Ikeuchi K, Li S, Matsuo Y, Beckmann R, Inada T.
Nucleic Acids Res. 2023 Jan 11;51(1):253-270. doi: 10.1093/nar/gkac1172. PubMed


Cms1 coordinates stepwise local 90S pre-ribosome assembly with timely snR83 release.
Lau B, Beine-Golovchuk O, Kornprobst M, Cheng J, Kressler D, Jády B, Kiss T, Beckmann R, Hurt E.
Cell Rep. 2022 Nov 22;41(8):111684. doi: 10.1016/j.celrep.2022.111684. PubMed

IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network.
Schmacke NA, O'Duill F, Gaidt MM, Szymanska I, Kamper JM, Schmid-Burgk JL, Mädler SC, Mackens-Kiani T, Kozaki T, Chauhan D, Nagl D, Stafford CA, Harz H, Fröhlich AL, Pinci F, Ginhoux F, Beckmann R, Mann M, Leonhardt H, Hornung V.
Immunity. 2022 Dec 13;55(12):2271-2284.e7. doi: 10.1016/j.immuni.2022.10.021. PubMed

The nucleoplasmic phase of pre-40S formation prior to nuclear export.
Cheng J, Lau B, Thoms M, Ameismeier M, Berninghausen O, Hurt E, Beckmann R.
Nucleic Acids Res. 2022 Nov 11;50(20):11924-11937. doi: 10.1093/nar/gkac961. PubMed

A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.
Narita M, Denk T, Matsuo Y, Sugiyama T, Kikuguchi C, Ito S, Sato N, Suzuki T, Hashimoto S, Machová I, Tesina P, Beckmann R, Inada T.
Nat Commun. 2022 Oct 27;13(1):6411. doi: 10.1038/s41467-022-34097-9. PubMed

In vitro structural maturation of an early stage pre-40S particle coupled with U3 snoRNA release and central pseudoknot formation.
Cheng J, La Venuta G, Lau B, Berninghausen O, Beckmann R, Hurt E.
Nucleic Acids Res. 2022 Oct 20:gkac910. doi: 10.1093/nar/gkac910. PubMed

A dynamic rRNA ribomethylome drives stemness in acute myeloid leukemia.
Zhou F, Aroua N, Liu Y, Rohde C, Cheng J, Wirth AK, Fijalkowska D, Göllner S, Lotze M, Yun H, Yu X, Pabst C, Sauer T, Oellerich T, Serve H, Rollig C, Bornhauser M, Thiede C, Baldus C, Frye M, Raffel S, Krijgsveld J, Jeremias I, Beckmann R, Trumpp A, Muller-Tidow C.
Cancer Discov. 2022 Oct 19:CD-22-0210. doi: 10.1158/2159-8290.CD-22-0210. PubMed

Author Correction: Modulating co-translational protein folding by rational design and ribosome engineering.
Ahn M, Włodarski T, Mitropoulou A, Chan SHS, Sidhu H, Plessa E, Becker TA, Budisa N, Waudby CA, Beckmann R, Cassaignau AME, Cabrita LD, Christodoulou J.
Nat Commun. 2022 Sep 16;13(1):5441. doi: 10.1038/s41467-022-33270-4. PubMed

Sensing of individual stalled 80S ribosomes by Fap1 for nonfunctional rRNA turnover.
Li S, Ikeuchi K, Kato M, Buschauer R, Sugiyama T, Adachi S, Kusano H, Natsume T, Berninghausen O, Matsuo Y, Becker T, Beckmann R, Inada T.
Mol Cell. 2022 Sep 15;82(18):3424-3437.e8. doi: 10.1016/j.molcel.2022.08.018. PubMed

Ice thickness monitoring for cryo-EM grids by interferometry imaging.
Hohle MM, Lammens K, Gut F, Wang B, Kahler S, Kugler K, Till M, Beckmann R, Hopfner KP, Jung C.
Sci Rep. 2022 Sep 12;12(1):15330. doi: 10.1038/s41598-022-16978-7. PubMed

Modulating co-translational protein folding by rational design and ribosome engineering.
Ahn M, Włodarski T, Mitropoulou A, Chan SHS, Sidhu H, Plessa E, Becker TA, Budisa N, Waudby CA, Beckmann R, Cassaignau AME, Cabrita LD, Christodoulou J.
Nat Commun. 2022 Jul 22;13(1):4243. doi: 10.1038/s41467-022-31906-z. PubMed

Emergence of the primordial pre-60S from the 90S pre-ribosome.
Ismail S, Flemming D, Thoms M, Gomes-Filho JV, Randau L, Beckmann R, Hurt E.
Cell Rep. 2022 Apr 5;39(1):110640. doi: 10.1016/j.celrep.2022.110640. PubMed

Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria.
Saito K, Kratzat H, Campbell A, Buschauer R, Burroughs AM, Berninghausen O, Aravind L, Green R, Beckmann R, Buskirk AR.
Nature. 2022 Mar;603(7901):503-508. doi: 10.1038/s41586-022-04416-7. Epub 2022 Mar 9. PubMed

Inhibition of SRP-dependent protein secretion by the bacterial alarmone (p)ppGpp.
Czech L, Mais CN, Kratzat H, Sarmah P, Giammarinaro P, Freibert SA, Esser HF, Musial J, Berninghausen O, Steinchen W, Beckmann R, Koch HG, Bange G.
Nat Commun. 2022 Feb 25;13(1):1069. doi: 10.1038/s41467-022-28675-0. PubMed



Structural basis of l-tryptophan-dependent inhibition of release factor 2 by the TnaC arrest peptide.
Su T, Kudva R, Becker T, Buschauer R, Komar T, Berninghausen O, von Heijne G, Cheng J, Beckmann R.
Nucleic Acids Res. 2021 Aug 17:gkab665. doi: 10.1093/nar/gkab665. Epub ahead of print. PMID: 34403461. PubMed

A distinct assembly pathway of the human 39S late pre-mitoribosome.
Cheng J, Berninghausen O, Beckmann R.
Nat Commun. 2021 Jul 27;12(1):4544. doi: 10.1038/s41467-021-24818-x. PMID: 34315873; PMCID: PMC8316566. PubMed

The SARS-unique domain (SUD) of SARS-CoV and SARS-CoV-2 interacts with human Paip1 to enhance viral RNA translation.
Lei J, Ma-Lauer Y, Han Y, Thoms M, Buschauer R, Jores J, Thiel V, Beckmann R, Deng W, Leonhardt H, Hilgenfeld R, von Brunn A.
EMBO J. 2021 Apr 20:e102277. doi: 10.15252/embj.2019102277. Epub ahead of print. PMID: 33876849. PubMed

Structure of Gcn1 bound to stalled and colliding 80S ribosomes.
Pochopien AA, Beckert B, Kasvandik S, Berninghausen O, Beckmann R, Tenson T, Wilson DN.
Proc Natl Acad Sci U S A.
2021 Apr 6;118(14):e2022756118. doi: 10.1073/pnas.2022756118. PMID: 33790014. PubMed

SAP domain forms a flexible part of DNA aperture in Ku70/80.
Hnízda A, Tesina P, Nguyen TB, Kukačka Z, Kater L, Chaplin AK, Beckmann R, Ascher DB, Novák P, Blundell TL.
FEBS J. 2021 Jan 29. doi: 10.1111/febs.15732. Epub ahead of print. PMID: 33511782. PubMed



Structure of the Maturing 90S Pre-ribosome in Association with the RNA Exosome.
Lau B, Cheng J, Flemming D, La Venuta G, Berninghausen O, Beckmann R, Hurt E.
Mol Cell. 2020 Dec 8:S1097-2765(20)30787-5. doi: 10.1016/j.molcel.2020.11.009. PubMed

Architecture of the active post-translational Sec translocon.
Weng TH, Steinchen W, Beatrix B, Berninghausen O, Becker T, Bange G, Cheng J, Beckmann R.
EMBO J. 2020 Dec 11:e105643. doi: 10.15252/embj.2020105643. PubMed

A structural inventory of native ribosomal ABCE1-43S pre-initiation complexes.
Kratzat H, Mackens-Kiani T, Ameismeier M, Potocnjak M, Cheng J, Dacheux E, Namane A, Berninghausen O, Herzog F, Fromont-Racine M, Becker T, Beckmann R.
EMBO J. 2020 Dec 8:e105179. doi: 10.15252/embj.2020105179.  PubMed

Structural basis for the final steps of human 40S ribosome maturation.
Ameismeier M, Zemp I, van den Heuvel J, Thoms M, Berninghausen O, Kutay U, Beckmann R.
Nature. 2020 Nov 18. doi: 10.1038/s41586-020-2929-x.  PubMed

90S pre-ribosome transformation into the primordial 40S subunit.
Cheng J, Lau B, La Venuta G, Ameismeier M, Berninghausen O, Hurt E, Beckmann R.
Science. 2020 Sep 18;369(6510):1470-1476. doi: 10.1126/science.abb4119 PubMed

An ATP-dependent partner switch links flagellar C-ring assembly with gene expression.
Blagotinsek V, Schwan M, Steinchen W, Mrusek D, Hook JC, Rossmann F, Freibert SA, Kratzat H, Murat G, Kressler D, Beckmann R, Beeby M, Thormann KM, Bange G.
Proc Natl Acad Sci U S A. 2020;202006470. doi:10.1073/pnas.2006470117 PubMed

EDF1 coordinates cellular responses to ribosome collisions.
Sinha NK, Ordureau A, Best K, Saba JA, Zinshteyn B, Sundaramoorthy E, Fulzele A, Garshott DM, Denk T, Thoms M, Paulo JA, Harper W, Bennett EJ, Beckmann R, Green R.
Elife. 2020 Aug 3;9:e58828. doi: 10.7554/eLife.58828. PubMed

Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes.
Wells JN, Buschauer R, Mackens-Kiani T, Best K, Kratzat H, Berninghausen O, Becker T, Gilbert W, Cheng J, Beckmann R.
PLoS Biol. 2020;18(7):e3000780. doi:10.1371/journal.pbio.3000780. PubMed

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Thoms M, Buschauer R, Ameismeier M, Koepke L, Denk T, Hirschenberger M, Kratzat H, Hayn M, Mackens-Kiani T, Cheng J, Straub JH, Stürzel CM, Fröhlich T, Berninghausen O, Becker T, Kirchhoff F, Sparrer K, Beckmann R.
Science. 2020 Jul 17:eabc8665. doi: 10.1126/science.abc8665. PubMed

Construction of the Central Protuberance and L1 Stalk during 60S Subunit Biogenesis.
Kater L, Mitterer V, Thoms M, Cheng J, Berninghausen O, Beckmann R, Hurt E.
Mol Cell. 2020;S1097-2765(20)30434-2. doi:10.1016/j.molcel.2020.06.032. PubMed

Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel.
Osterman IA, Wieland M, Maviza TP, Lashkevich KA, Lukianov DA, Komarova ES, Zakalyukina YV, Buschauer R, Shiriaev DI, Leyn SA, Zlamal JE, Biryukov MV, Skvortsov DA, Tashlitsky VN, Polshakov VI, Cheng J, Polikanov YS, Bogdanov AA, Osterman AL, Dmitriev SE, Beckmann R, Dontsova OA, Wilson DN, Sergiev PV.
Nat Chem Biol. 2020 Jun 29.doi: 10.1038/s41589-020-0578-x. PubMed

The Ccr4-Not complex monitors the translating ribosome for codon optimality.
Buschauer R, Matsuo Y, Sugiyama T, Chen YH, Alhusaini N, Sweet T, Ikeuchi K, Cheng J, Matsuki Y, Nobuta R, Gilmozzi A, Berninghausen O, Tesina P, Becker T, Coller J, Inada T, Beckmann R.
Science. 2020 Apr 17;368(6488). pii: eaay6912. doi: 10.1126/science.aay6912. PubMed

RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1.
Matsuo Y, Tesina P, Nakajima S, Mizuno M, Endo A, Buschauer R, Cheng J, Shounai O, Ikeuchi K, Saeki Y, Becker T, Beckmann R, Inada T.
Nat Struct Mol Biol. 2020 Mar 23. doi: 10.1038/s41594-020-0393-9. PubMed

Molecular analysis of the ribosome recycling factor ABCE1 bound to the 30S post-splitting complex.
Nürenberg-Goloub E, Kratzat H, Heinemann H, Heuer A, Kötter P, Berninghausen O, Becker T, Tampé R, Beckmann R.
EMBO J. 2020 Feb 17:e103788. doi: 10.15252/embj.2019103788. PubMed

Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts.
Tesina P, Lessen LN, Buschauer R, Cheng J, Wu CC, Berninghausen O, Buskirk AR, Becker T, Beckmann R, Green R.
EMBO J. 2020 Feb 3;39(3):e103365. doi: 10.15252/embj.2019103365. Epub 2019 Dec 20. PubMed

Structure of the Bcs1 AAA-ATPase suggests an airlock-like translocation mechanism for folded proteins.
Kater L, Wagener N, Berninghausen O, Becker T, Neupert W, Beckmann R.
Nat Struct Mol Biol. 2020 Jan 27. doi: 10.1038/s41594-019-0364-1. PubMed



Partially inserted nascent chain unzips the lateral gate of the Sec translocon.
Kater L, Frieg B, Berninghausen O, Gohlke H, Beckmann R, Kedrov A.
EMBO Rep. 2019 Aug 5:e48191. doi: 10.15252/embr.201948191.  PubMed

Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.
Cheng J, Baßler J, Fischer P, Lau B, Kellner N, Kunze R, Griesel S, Kallas M, Berninghausen O, Strauss D, Beckmann R, Hurt E.
Mol Cell. 2019 Jul 15. pii: S1097-2765(19)30489-7. doi: 10.1016/j.molcel.2019.06.032. PubMed

Structural and mutational analysis of the ribosome-arresting human XBP1u.
Shanmuganathan V, Schiller N, Magoulopoulou A, Cheng J, Braunger K, Cymer F, Berninghausen O, Beatrix B, Kohno K, Heijne GV, Beckmann R.
Elife. 2019 Jun 27;8. pii: e46267. doi: 10.7554/eLife.46267. PubMed

Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis.
Su T, Izawa T, Thoms M, Yamashita Y, Cheng J, Berninghausen O, Hartl FU, Inada T, Neupert W, Beckmann R.
Nature. 2019 Jun 12. doi: 10.1038/s41586-019-1307-z. PubMed

Structure of the 80S ribosome-Xrn1 nuclease complex.
Tesina P, Heckel E, Cheng J, Fromont-Racine M, Buschauer R, Kater L, Beatrix B, Berninghausen O, Jacquier A, Becker T, Beckmann R.
Nat Struct Mol Biol. 2019 Apr;26(4):275-280. doi: 10.1038/s41594-019-0202-5. Epub 2019 Mar 25. PubMed

Collided ribosomes form a unique structural interface to induce Hel2-driven quality control pathways.
Ikeuchi K, Tesina P, Matsuo Y, Sugiyama T, Cheng J, Saeki Y, Tanaka K, Becker T, Beckmann R, Inada T.
EMBO J. 2019 Jan 4. pii: e100276. doi: 10.15252/embj.2018100276. PubMed

Reconstitution of the human SRP system and quantitative and systematic analysis of its ribosome interactions.
Wild K, Juaire KD, Soni K, Shanmuganathan V, Hendricks A, Segnitz B, Beckmann R, Sinning I.
Nucleic Acids Res. 2019 Jan 15. doi: 10.1093/nar/gky1324. PubMed

Ribosome-NatA architecture reveals that rRNA expansion segments coordinate N-terminal acetylation.
Knorr AG, Schmidt C, Tesina P, Berninghausen O, Becker T, Beatrix B, Beckmann R.
Nat Struct Mol Biol. 2019 Jan;26(1):35-39. doi: 10.1038/s41594-018-0165-y. PubMed



BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages.
Chauhan D, Bartok E, Gaidt MM, Bock FJ, Herrmann J, Seeger JM, Broz P, Beckmann R, Kashkar H, Tait SWG, Müller R, Hornung V.
Cell Rep. 2018 Nov 27;25(9):2354-2368.e5. doi: 10.1016/j.celrep.2018.10.087. PubMed

Folding pathway of an Ig domain is conserved on and off the ribosome.
Tian P, Steward A, Kudva R, Su T, Shilling PJ, Nickson AA, Hollins JJ, Beckmann R, von Heijne G, Clarke J, Best RB.
Proc Natl Acad Sci U S A. 2018 Nov 9. pii: 201810523. doi: 10.1073/pnas.1810523115. PubMed

Suppressor mutations in Rpf2-Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation.
Thoms M, Mitterer V, Kater L, Falquet L, Beckmann R, Kressler D, Hurt E.
Nat Commun. 2018 Oct 5;9(1):4094. doi: 10.1038/s41467-018-06660-w. PubMed

Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1.
Beckert B, Turk M, Czech A, Berninghausen O, Beckmann R, Ignatova Z, Plitzko JM, Wilson DN.
Nat Microbiol. 2018 Sep 3. doi: 10.1038/s41564-018-0237-0.  PubMed

Spectrum and functional validation of PSMB5 mutations in multiple myeloma.
Barrio S, Stühmer T, Da-Viá M, Barrio-Garcia C, Lehners N, Besse A, Cuenca I, Garitano-Trojaola A, Fink S, Leich E, Chatterjee M, Driessen C, Martinez-Lopez J, Rosenwald A, Beckmann R, Bargou RC, Braggio E, Stewart AK, Raab MS, Einsele H, Kortüm KM.
Leukemia. 2018 Jul 19. doi: 10.1038/s41375-018-0216-8.  PubMed

ALKBH5-induced demethylation of mono- and dimethylated adenosine.
Ensfelder TT, Kurz MQ, Iwan K, Geiger S, Matheisl S, Müller M, Beckmann R, Carell T.
Chem Commun (Camb). 2018 Aug 11;54(62):8591-8593. doi: 10.1039/c8cc03980a. PubMed

Visualizing late states of human 40S ribosomal subunit maturation.
Ameismeier M, Cheng J, Berninghausen O, Beckmann R.
. 2018 Jun 6. doi: 10.1038/s41586-018-0193-0. PubMed

Reconstitution of Isotopically Labeled Ribosomal Protein L29 in the 50S Large Ribosomal Subunit for Solution-State and Solid-State NMR.
Barbet-Massin E, van der Sluis E, Musial J, Beckmann R, Reif B.
Methods Mol Biol. 2018;1764:87-100. doi: 10.1007/978-1-4939-7759-8_6. PubMed

Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum.
Braunger K, Pfeffer S, Shrimal S, Gilmore R, Berninghausen O, Mandon EC, Becker T, Förster F, Beckmann R.
Science. 2018 Mar 8. pii: eaar7899. doi: 10.1126/science.aar7899. PubMed



Interdependent action of KH domain proteins Krr1 and Dim2 drive the 40S platform assembly.
Sturm M, Cheng J, Baßler J, Beckmann R, Hurt E.
Nat Commun. 2017 Dec 20;8(1):2213. doi: 10.1038/s41467-017-02199-4. PubMed

Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes.
Kater L, Thoms M, Barrio-Garcia C, Cheng J, Ismail S, Ahmed YL, Bange G, Kressler D, Berninghausen O, Sinning I, Hurt E, Beckmann R.
Cell. 2017 Dec 14;171(7):1599-1610.e14. doi: 10.1016/j.cell.2017.11.039. PubMed

Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae.
Heuer A, Thomson E, Schmidt C, Berninghausen O, Becker T, Hurt E, Beckmann R.
Elife. 2017 Nov 20;6. pii: e30189. doi: 10.7554/eLife.30189. PubMed

Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P.
Huter P, Arenz S, Bock LV, Graf M, Frister JO, Heuer A, Peil L, Starosta AL, Wohlgemuth I, Peske F, Nováček J, Berninghausen O, Grubmüller H, Tenson T, Beckmann R, Rodnina MV, Vaiana AC, Wilson DN.
Mol Cell. 2017 Nov 2;68(3):515-527.e6. doi: 10.1016/j.molcel.2017.10.014. PubMed

Preribosomes escaping from the nucleus are caught during translation by cytoplasmic quality control.
Sarkar A, Thoms M, Barrio-Garcia C, Thomson E, Flemming D, Beckmann R, Hurt E
Nat Struct Mol Biol. 2017 Dec;24(12):1107-1115. doi: 10.1038/nsmb.3495 PubMed

3.2-Å-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.
Cheng J, Kellner N, Berninghausen O, Hurt E, Beckmann R.
Nat Struct Mol Biol. 2017 Nov;24(11):954-964. doi: 10.1038/nsmb.3476 PubMed

Ubiquitination of stalled ribosome triggers ribosome-associated quality control.
Matsuo Y, Ikeuchi K, Saeki Y, Iwasaki S, Schmidt C, Udagawa T, Sato F, Tsuchiya H, Becker T, Tanaka K, Ingolia NT, Beckmann R, Inada T
Nat Commun. 2017 Jul 31;8(1):159. doi: 10.1038/s41467-017-00188-1 PubMed

An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome.
Florin T, Maracci C, Graf M, Karki P, Klepacki D, Berninghausen O, Beckmann R, Vázquez-Laslop N, Wilson DN, Rodnina MV, Mankin AS.
Nat Struct Mol Biol. 2017 Sep;24(9):752-757. doi: 10.1038/nsmb.3439 PubMed

The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling.
Su T, Cheng J, Sohmen D, Hedman R, Berninghausen O, von Heijne G, Wilson DN, Beckmann R.
Elife. 2017 May 30;6. pii: e25642. doi: 10.7554/eLife.25642. PubMed

Structure of the Bacillus subtilis hibernating 100S ribosome reveals the basis for 70S dimerization.
Beckert B, Abdelshahid M, Schäfer H, Steinchen W, Arenz S, Berninghausen O, Beckmann R, Bange G, Turgay K, Wilson DN.
. 2017 May 3. pii: e201696189. doi: 10.15252/embj.201696189. PubMed

Sucrose sensing through nascent peptide-meditated ribosome stalling at the stop codon of Arabidopsis bZIP11 uORF2.
Yamashita Y, Takamatsu S, Glasbrenner M, Becker T, Naito S, Beckmann R.
. 2017 May;591(9):1266-1277. doi: 10.1002/1873-3468.12634. Epub 2017 Apr 10. PubMed

Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation.
Heuer A, Gerovac M, Schmidt C, Trowitzsch S, Preis A, Kötter P, Berninghausen O, Becker T, Beckmann R, Tampé R.
Nat Struct Mol Biol
. 2017 May;24(5):453-460. doi: 10.1038/nsmb.3396. Epub 2017 Apr 3. PubMed

Cotranslational folding of spectrin domains via partially structured states.
Nilsson OB, Nickson AA, Hollins JJ, Wickles S, Steward A, Beckmann R, von Heijne G, Clarke J.
Nat Struct Mol Biol. 2017 Mar;24(3):221-225. doi: 10.1038/nsmb.3355. Epub 2017 Jan 23. PubMed



The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex.
Schmidt C, Kowalinski E, Shanmuganathan V, Defenouillère Q, Braunger K, Heuer A, Pech M, Namane A, Berninghausen O, Fromont-Racine M, Jacquier A, Conti E, Becker T, Beckmann R.
Science. 2016 Dec 16;354(6318):1431-1433. PubMed

Structural Dynamics of the YidC:Ribosome Complex during Membrane Protein Biogenesis.
Kedrov A, Wickles S, Crevenna AH, van der Sluis EO, Buschauer R, Berninghausen O, Lamb DC, Beckmann R.
Cell Rep. 2016 Dec 13;17(11):2943-2954. doi: 10.1016/j.celrep.2016.11.059. PubMed

Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons.
Huter P, Müller C, Beckert B, Arenz S, Berninghausen O, Beckmann R, Wilson DN.
. 2017 Jan 26;541(7638):546-549. doi: 10.1038/nature20821. Epub 2016 Dec 1. PubMed

Structure of the ribosome post-recycling complex probed by chemical cross-linking and mass spectrometry.
Kiosze-Becker K, Ori A, Gerovac M, Heuer A, Närenberg-Goloub E, Rashid UJ, Becker T, Beckmann R, Beck M, Tampé R.
Nat Commun
. 2016 Nov 8;7:13248. doi: 10.1038/ncomms13248. PubMed

Ribosome-stalk biogenesis is coupled with recruitment of nuclear-export factor to the nascent 60S subunit.
Sarkar A, Pech M, Thoms M, Beckmann R, Hurt E.
Nat Struct Mol Biol
. 2016 Dec;23(12):1074-1082. doi: 10.1038/nsmb.3312. Epub 2016 Oct 24. PubMed

Architecture of the 90S Pre-ribosome: A Structural View on the Birth of the Eukaryotic Ribosome.
Kornprobst M, Turk M, Kellner N, Cheng J, Flemming D, Koš-Braun I, Koš M, Thoms M, Berninghausen O, Beckmann R, Hurt E.
. 2016 Jul 14;166(2):380-93. doi: 10.1016/j.cell.2016.06.014. PubMed

Dynamic Behavior of Trigger Factor on the Ribosome.
Deeng J, Chan KY, van der Sluis EO, Berninghausen O, Han W, Gumbart J, Schulten K, Beatrix B, Beckmann R.
J Mol Biol. 2016 Sep 11;428(18):3588-602. doi: 10.1016/j.jmb.2016.06.007. PubMed

A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest.
Arenz S, Bock LV, Graf M, Innis CA, Beckmann R, Grubmüller H, Vaiana AC, Wilson DN.
Nat Commun
. 2016 Jul 6;7:12026. doi: 10.1038/ncomms12026. PubMed

The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis.
Arenz S, Abdelshahid M, Sohmen D, Payoe R, Starosta AL, Berninghausen O, Hauryliuk V, Beckmann R, Wilson DN.
Nucleic Acids Res
. 2016 Jul 27;44(13):6471-81. doi: 10.1093/nar/gkw470. Epub 2016 May 25. PubMed

Correction: ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.
Lässig C, Matheisl S, Sparrer KM, de Oliveira Mann CC, Moldt M, Patel JR, Goldeck M, Hartmann G, García-Sastre A, Hornung V, Conzelmann KK, Beckmann R, Hopfner KP.
. 2016 Mar 2;5. pii: e14954. doi: 10.7554/eLife.14954. No abstract available. PubMed

Small protein domains fold inside the ribosome exit tunnel.
Marino J, von Heijne G, Beckmann R.
FEBS Lett. 2016 Mar;590(5):655-60. doi: 10.1002/1873-3468.12098. Epub 2016 Feb 25. PubMed

Translation regulation via nascent polypeptide-mediated ribosome stalling.
Wilson DN, Arenz S, Beckmann R.
Curr Opin Struct Biol. 2016 Apr;37:123-33. doi: 10.1016/ Epub 2016 Feb 7. Review. PubMed

Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome.
Schmidt C, Becker T, Heuer A, Braunger K, Shanmuganathan V, Pech M, Berninghausen O, Wilson DN, Beckmann R.
Nucleic Acids Res. 2016 Feb 29;44(4):1944-51. doi: 10.1093/nar/gkv1517. Epub 2015 Dec 28. PubMed



Architecture of the Rix1-Rea1 checkpoint machinery during pre-60S-ribosome remodeling.
Barrio-Garcia C, Thoms M, Flemming D, Kater L, Berninghausen O, Baßler J, Beckmann R, Hurt E.
Nat Struct Mol Biol
. 2016 Jan;23(1):37-44. doi: 10.1038/nsmb.3132. Epub 2015 Nov 30. PubMed

ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.
Lässig C, Matheisl S, Sparrer KM, de Oliveira Mann CC, Moldt M, Patel JR, Goldeck M, Hartmann G, Garcí­a-Sastre A, Hornung V, Conzelmann KK, Beckmann R, Hopfner KP.
. 2015 Nov 26;4. pii: e10859. doi: 10.7554/eLife.10859. Erratum in: Elife. 2016;5. pii: e14954. doi: 10.7554/eLife.14954. PubMed 

Structure of the native Sec61 protein-conducting channel.
Pfeffer S, Burbaum L, Unverdorben P, Pech M, Chen Y, Zimmermann R, Beckmann R, Förster F.
Nat Commun
. 2015 Sep 28;6:8403. doi: 10.1038/ncomms9403. PubMed

Structure of a human translation termination complex.
Matheisl S, Berninghausen O, Becker T, Beckmann R.
Nucleic Acids Res
. 2015 Oct 15;43(18):8615-26. doi: 10.1093/nar/gkv909. Epub 2015 Sep 17. PubMed

Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions.
Beckert B, Kedrov A, Sohmen D, Kempf G, Wild K, Sinning I, Stahlberg H, Wilson DN, Beckmann R.
Nat Struct Mol Biol
. 2015 Oct;22(10):767-73. doi: 10.1038/nsmb.3086. Epub 2015 Sep 7. PubMed

Cotranslational Protein Folding inside the Ribosome Exit Tunnel.
Nilsson OB, Hedman R, Marino J, Wickles S, Bischoff L, Johansson M, Müller-Lucks A, Trovato F, Puglisi JD, O'Brien EP, Beckmann R, von Heijne G.
Cell Rep
. 2015 Sep 8;12(10):1533-40. doi: 10.1016/j.celrep.2015.07.065. Epub 2015 Aug 28. PubMed

A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation.
Baßler J, Paternoga H, Holdermann I, Thoms M, Granneman S, Barrio-Garcia C, Nyarko A, Lee W, Stier G, Clark SA, Schraivogel D, Kallas M, Beckmann R, Tollervey D, Barbar E, Sinning I, Hurt E.
J Cell Biol
. 2015 Jul 6;210(1):169-70. doi: 10.1083/jcb.20140811106112015c. No abstract available. PubMed

Role of the Cytosolic Loop C2 and the C Terminus of YidC in Ribosome Binding and Insertion Activity.
Geng Y, Kedrov A, Caumanns JJ, Crevenna AH, Lamb DC, Beckmann R, Driessen AJ.
J Biol Chem
. 2015 Jul 10;290(28):17250-61. doi: 10.1074/jbc.M115.650309. Epub 2015 May 28. PubMed

Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stalling.
Sohmen D, Chiba S, Shimokawa-Chiba N, Innis CA, Berninghausen O, Beckmann R, Ito K, Wilson DN.
Nat Commun
. 2015 Apr 23;6:6941. doi: 10.1038/ncomms7941. PubMed

Structural biology. Mitoribosome oddities.
Beckmann R, Herrmann JM.
. 2015 Apr 17;348(6232):288-9. doi: 10.1126/science.aab1054. Epub 2015 Apr 16. No abstract available. PubMed

Cryo-EM structure of the tetracycline resistance protein TetM in complex with a translating ribosome at 3.9-Å… resolution.
Arenz S, Nguyen F, Beckmann R, Wilson DN.
Proc Natl Acad Sci U S A
. 2015 Apr 28;112(17):5401-6. doi: 10.1073. Epub 2015 Apr 13. PubMed

Parallel Structural Evolution of Mitochondrial Ribosomes and OXPHOS Complexes.
van der Sluis EO, Bauerschmitt H, Becker T, Mielke T, Frauenfeld J, Berninghausen O, Neupert W, Herrmann JM, Beckmann R.
Genome Biol Evol
. 2015 Apr 9;7(5):1235-51. doi: 10.1093/gbe/evv061. PubMed



A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation.
Baßler J, Paternoga H, Holdermann I, Thoms M, Granneman S, Barrio-Garcia C, Nyarko A, Lee W, Stier G, Clark SA, Schraivogel D, Kallas M, Beckmann R, Tollervey D, Barbar E, Sinning I, Hurt E.
J Cell Biol
. 2014 Nov 24;207(4):481-98. doi: 10.1083/jcb.201408111. Epub 2014 Nov 17. Erratum in: J Cell Biol. 2015 Jul 6;210(1):169-70. Lee, Woonghee [added]. PubMed

Molecular basis for the ribosome functioning as an L-tryptophan sensor.
Bischoff L, Berninghausen O, Beckmann R.
Cell Rep
. 2014 Oct 23;9(2):469-75. doi: 10.1016/j.celrep.2014.09.011. Epub 2014 Oct 9. PubMed

Drug sensing by the ribosome induces translational arrest via active site perturbation.
Arenz S, Meydan S, Starosta AL, Berninghausen O, Beckmann R, Vázquez-Laslop N, Wilson DN.
Mol Cell
. 2014 Nov 6;56(3):446-52. doi: 10.1016/j.molcel.2014.09.014. Epub 2014 Oct 8. PubMed

A structural model of the active ribosome-bound membrane protein insertase YidC.
Wickles S, Singharoy A, Andreani J, Seemayer S, Bischoff L, Berninghausen O, Soeding J, Schulten K, van der Sluis EO, Beckmann R.
. 2014 Jul 10;3:e03035. doi: 10.7554/eLife.03035. PubMed

Cryoelectron microscopic structures of eukaryotic translation termination complexes containing eRF1-eRF3 or eRF1-ABCE1.
Preis A, Heuer A, Barrio-Garcia C, Hauser A, Eyler DE, Berninghausen O, Green R, Becker T, Beckmann R.
Cell Rep. 2014 Jul 10;8(1):59-65. doi: 10.1016/j.celrep.2014.04.058. Epub 2014 Jul 4. PubMed

Visualization of a polytopic membrane protein during SecY-mediated membrane insertion.
Bischoff L, Wickles S, Berninghausen O, van der Sluis EO, Beckmann R.
Nat Commun
. 2014 Jun 10;5:4103. doi: 10.1038/ncomms5103. PubMed

Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide. Arenz S, Ramu H, Gupta P, Berninghausen O, Beckmann R, Vázquez-Laslop N, Mankin AS, Wilson DN.
Nat Commun. 2014 Mar 24;5:3501. doi: 10.1038/ncomms4501. PubMed

60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle.
Leidig C, Thoms M, Holdermann I, Bradatsch B, Berninghausen O, Bange G, Sinning I, Hurt E, Beckmann R.
Nat Commun. 2014 Mar 24;5:3491. doi: 10.1038/ncomms4491. PubMed

A new system for naming ribosomal proteins.
Ban N, Beckmann R, Cate JH, Dinman JD, Dragon F, Ellis SR, Lafontaine DL, Lindahl L, Liljas A, Lipton JM, McAlear MA, Moore PB, Noller HF, Ortega J, Panse VG, Ramakrishnan V, Spahn CM, Steitz TA, Tchorzewski M, Tollervey D, Warren AJ, Williamson JR, et al.
Curr Opin Struct Biol
. 2014 Feb;24:165-9. doi: 10.1016/ Epub 2014 Feb 10. Review. PubMed 

Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion.
Gogala M, Becker T, Beatrix B, Armache JP, Barrio-Garcia C, Berninghausen O, Beckmann R.
Nature. 2014 Feb 6;506(7486):107-10. doi: 10.1038/nature12950. PubMed

Structure of the mammalian oligosaccharyl-transferase complex in the native ER protein translocon.
Pfeffer S, Dudek J, Gogala M, Schorr S, Linxweiler J, Lang S, Becker T, Beckmann R, Zimmermann R, Förster F.
Nat Commun. 2014;5:3072. doi: 10.1038/ncomms4072. PubMed



The C-terminal regions of YidC from Rhodopirellula baltica and Oceanicaulis alexandrii bind to ribosomes and partially substitute for SRP receptor function in Escherichia coli.
Seitl I, Wickles S, Beckmann R, Kuhn A, Kiefer D. Mol Microbiol. 2014 Jan;91(2):408-21. doi: 10.1111/mmi.12465. Epub 2013 Dec 12. PubMed

Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex.
Tosi A, Haas C, Herzog F, Gilmozzi A, Berninghausen O, Ungewickell C, Gerhold CB, Lakomek K, Aebersold R, Beckmann R, Hopfner KP.
. 2013 Sep 12;154(6):1207-19. doi: 10.1016/j.cell.2013.08.016. PubMed

Structures of the human and Drosophila 80S ribosome.
Anger AM, Armache JP, Berninghausen O, Habeck M, Subklewe M, Wilson DN, Beckmann R.
. 2013 May 2;497(7447):80-5. doi: 10.1038/nature12104. PubMed

Automatic post-picking using MAPPOS improves particle image detection from cryo-EM micrographs.
Norousi R, Wickles S, Leidig C, Becker T, Schmid VJ, Beckmann R, Tresch A.
J Struct Biol
. 2013 May;182(2):59-66. doi: 10.1016/j.jsb.2013.02.008. Epub 2013 Feb 21. PubMed



Promiscuous behaviour of archaeal ribosomal proteins: implications for eukaryotic ribosome evolution.
Armache JP, Anger AM, Márquez V, Franckenberg S, Fröhlich T, Villa E, Berninghausen O, Thomm M, Arnold GJ, Beckmann R, Wilson DN.
Nucleic Acids Res
. 2013 Jan;41(2):1284-93. doi: 10.1093/nar/gks1259. Epub 2012 Dec 6. PubMed

Structural characterization of a eukaryotic chaperone--the ribosome-associated complex.
Leidig C, Bange G, Kopp J, Amlacher S, Aravind A, Wickles S, Witte G, Hurt E, Beckmann R, Sinning I.
Nat Struct Mol Biol. 2013 Jan;20(1):23-8. doi: 10.1038/nsmb.2447. Epub 2012 Dec 2. PubMed

Structure of the pre-60S ribosomal subunit with nuclear export factor Arx1 bound at the exit tunnel.
Bradatsch B, Leidig C, Granneman S, Gnädig M, Tollervey D, Böttcher B, Beckmann R, Hurt E.
Nat Struct Mol Biol
. 2012 Dec;19(12):1234-41. doi: 10.1038/nsmb.2438. Epub 2012 Nov 11. PubMed

Structural view on recycling of archaeal and eukaryotic ribosomes after canonical termination and ribosome rescue.
Franckenberg S, Becker T, Beckmann R.
Curr Opin Struct Biol
. 2012 Dec;22(6):786-96. doi: 10.1016/ Epub 2012 Sep 29. Review. PubMed

Structural basis for TetM-mediated tetracycline resistance.
Dönhöfer A, Franckenberg S, Wickles S, Berninghausen O, Beckmann R, Wilson DN.
Proc Natl Acad Sci U S A
. 2012 Oct 16;109(42):16900-5. doi: 10.1073 Epub 2012 Oct 1. PubMed

Mechanisms of SecM-mediated stalling in the ribosome.
Gumbart J, Schreiner E, Wilson DN, Beckmann R, Schulten K.
Biophys J
. 2012 Jul 18;103(2):331-41. doi: 10.1016/j.bpj.2012.06.005. Epub 2012 Jul 17. PubMed

Solution structure of the natively assembled yeast ribosomal stalk determined by small-angle X-ray scattering.
Grela P, Gajda MJ, Armache JP, Beckmann R, Krokowski D, Svergun DI, Grankowski N, Tchórzewski M.
Biochem J. 2012 Jun 1;444(2):205-9. doi: 10.1042/BJ20120115. PubMed

Structural basis of highly conserved ribosome recycling in eukaryotes and archaea.
Becker T, Franckenberg S, Wickles S, Shoemaker CJ, Anger AM, Armache JP, Sieber H, Ungewickell C, Berninghausen O, Daberkow I, Karcher A, Thomm M, Hopfner KP, Green R, Beckmann R.
Nature. 2012 Feb 22;482(7386):501-6. doi: 10.1038/nature10829. PubMed



The DARC site: a database of aligned ribosomal complexes.
Jarasch A, Dziuk P, Becker T, Armache JP, Hauser A, Wilson DN, Beckmann R.
Nucleic Acids Res
. 2012 Jan;40(Database issue):D495-500. doi: 10.1093/nar/gkr824. Epub 2011 Oct 18. PubMed

Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex with its substrate TBP.
Wollmann P, Cui S, Viswanathan R, Berninghausen O, Wells MN, Moldt M, Witte G, Butryn A, Wendler P, Beckmann R, Auble DT, Hopfner KP.
. 2011 Jul 6;475(7356):403-7. doi: 10.1038/nature10215. PubMed

Structure of the no-go mRNA decay complex Dom34-Hbs1 bound to a stalled 80S ribosome.
Becker T, Armache JP, Jarasch A, Anger AM, Villa E, Sieber H, Motaal BA, Mielke T, Berninghausen O, Beckmann R.
Nat Struct Mol Biol
. 2011 Jun;18(6):715-20. doi: 10.1038/nsmb.2057. Epub 2011 May 29. PubMed

Signal sequence-independent SRP-SR complex formation at the membrane suggests an alternative targeting pathway within the SRP cycle.
Braig D, Mircheva M, Sachelaru I, van der Sluis EO, Sturm L, Beckmann R, Koch HG.
Mol Biol Cell
. 2011 Jul 1;22(13):2309-23. doi: 10.1091/mbc.E11-02-0152. Epub 2011 May 5. PubMed

Cryo-EM structure of the ribosome-SecYE complex in the membrane environment. Frauenfeld J, Gumbart J, Sluis EO, Funes S, Gartmann M, Beatrix B, Mielke T, Berninghausen O, Becker T, Schulten K, Beckmann R.
Nat Struct Mol Biol. 2011 May;18(5):614-21. doi: 10.1038/nsmb.2026. Epub 2011 Apr 17. PubMed

The ribosomal tunnel as a functional environment for nascent polypeptide folding and translational stalling.
Wilson DN, Beckmann R.
Curr Opin Struct Biol
. 2011 Apr;21(2):274-82. doi: 10.1016/ Review. PubMed

SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase center.
Bhushan S, Hoffmann T, Seidelt B, Frauenfeld J, Mielke T, Berninghausen O, Wilson DN, Beckmann R.
PLoS Biol
. 2011 Jan 18;9(1):e1000581. doi: 10.1371/journal.pbio.1000581. PubMed



Proteomic characterization of archaeal ribosomes reveals the presence of novel archaeal-specific ribosomal proteins.
Márquez V, Fröhlich T, Armache JP, Sohmen D, Dönhöfer A, Mikolajka A, Berninghausen O, Thomm M, Beckmann R, Arnold GJ, Wilson DN.
J Mol Biol
. 2011 Feb 4;405(5):1215-32. doi: 10.1016/j.jmb.2010.11.055. Epub 2010 Dec 4. PubMed

Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.
Armache JP, Jarasch A, Anger AM, Villa E, Becker T, Bhushan S, Jossinet F, Habeck M, Dindar G, Franckenberg S, Marquez V, Mielke T, Thomm M, Berninghausen O, Beatrix B, Söding J, Westhof E, Wilson DN, Beckmann R.
Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19748-53. doi: 10.1073 Epub 2010 Oct 27. PubMed

Localization of eukaryote-specific ribosomal proteins in a 5.5-Ã… cryo-EM map of the 80S eukaryotic ribosome. Armache JP, Jarasch A, Anger AM, Villa E, Becker T, Bhushan S, Jossinet F, Habeck M, Dindar G, Franckenberg S, Marquez V, Mielke T, Thomm M, Berninghausen O, Beatrix B, Söding J, Westhof E, Wilson DN, Beckmann R.
Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19754-9. doi: 10.1073 Epub 2010 Oct 25. PubMed

Structural basis for translational stalling by human cytomegalovirus and fungal arginine attenuator peptide.
Bhushan S, Meyer H, Starosta AL, Becker T, Mielke T, Berninghausen O, Sattler M, Wilson DN, Beckmann R.
Mol Cell
. 2010 Oct 8;40(1):138-46. doi: 10.1016/j.molcel.2010.09.009. PubMed

Dual binding mode of the nascent polypeptide-associated complex reveals a novel universal adapter site on the ribosome.
Pech M, Spreter T, Beckmann R, Beatrix B.
J Biol Chem
. 2010 Jun 18;285(25):19679-87. doi: 10.1074/jbc.M109.092536. Epub 2010 Apr 21. PubMed

Mechanism of eIF6-mediated inhibition of ribosomal subunit joining.
Gartmann M, Blau M, Armache JP, Mielke T, Topf M, Beckmann R.
J Biol Chem. 2010 May 14;285(20):14848-51. doi: 10.1074/jbc.C109.096057. Epub 2010 Mar 31. PubMed

alpha-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnel.
Bhushan S, Gartmann M, Halic M, Armache JP, Jarasch A, Mielke T, Berninghausen O, Wilson DN, Beckmann R.
Nat Struct Mol Biol. 2010 Mar;17(3):313-7. doi: 10.1038/nsmb.1756. Epub 2010 Feb 7. PubMed

Coupled chaperone action in folding and assembly of hexadecameric Rubisco.
Liu C, Young AL, Starling-Windhof A, Bracher A, Saschenbrecker S, Rao BV, Rao KV, Berninghausen O, Mielke T, Hartl FU, Beckmann R, Hayer-Hartl M.
Nature. 2010 Jan 14;463(7278):197-202. doi: 10.1038/nature08651. PubMed



Structural insight into nascent polypeptide chain-mediated translational stalling.
Seidelt B, Innis CA, Wilson DN, Gartmann M, Armache JP, Villa E, Trabuco LG, Becker T, Mielke T, Schulten K, Steitz TA, Beckmann R.
. 2009 Dec 4;326(5958):1412-5. doi: 10.1126/science.1177662. Epub 2009 Oct 29. PubMed

Structure of monomeric yeast and mammalian Sec61 complexes interacting with the translating ribosome.
Becker T, Bhushan S, Jarasch A, Armache JP, Funes S, Jossinet F, Gumbart J, Mielke T, Berninghausen O, Schulten K, Westhof E, Gilmore R, Mandon EC, Beckmann R.
. 2009 Dec 4;326(5958):1369-73. doi: 10.1126/science.1178535. Epub 2009 Oct 29. PubMed



Structure of an archaeal RNA polymerase.
Kusser AG, Bertero MG, Naji S, Becker T, Thomm M, Beckmann R, Cramer P.
J Mol Biol. 2008 Feb 15;376(2):303-7. doi: 10.1016/j.jmb.2007.08.066. Epub 2007 Sep 5. PubMed



Functional architecture of RNA polymerase I.
Kuhn CD, Geiger SR, Baumli S, Gartmann M, Gerber J, Jennebach S, Mielke T, Tschochner H, Beckmann R, Cramer P.
Cell. 2007 Dec 28;131(7):1260-72. PubMed



Following the signal sequence from ribosomal tunnel exit to signal recognition particle.
Halic M, Blau M, Becker T, Mielke T, Pool MR, Wild K, Sinning I, Beckmann R.
. 2006 Nov 23;444(7118):507-11. Epub 2006 Oct 29. PubMed

Structure of eEF3 and the mechanism of transfer RNA release from the E-site.
Andersen CB, Becker T, Blau M, Anand M, Halic M, Balar B, Mielke T, Boesen T, Pedersen JS, Spahn CM, Kinzy TG, Andersen GR, Beckmann R.
. 2006 Oct 12;443(7112):663-8. Epub 2006 Aug 23. PubMed

Signal recognition particle receptor exposes the ribosomal translocon binding site.
Halic M, Gartmann M, Schlenker O, Mielke T, Pool MR, Sinning I, Beckmann R.
. 2006 May 5;312(5774):745-7. PubMed



ERj1p uses a universal ribosomal adaptor site to coordinate the 80S ribosome at the membrane.
Blau M, Mullapudi S, Becker T, Dudek J, Zimmermann R, Penczek PA, Beckmann R.
Nat Struct Mol Biol
. 2005 Nov;12(11):1015-6. PubMed

Localization and dynamic behavior of ribosomal protein L30e.
Halic M, Becker T, Frank J, Spahn CM, Beckmann R.
Nat Struct Mol Biol
. 2005 May;12(5):467-8. Epub 2005 May 1. PubMed

The signal recognition particle and its interactions during protein targeting.
Halic M, Beckmann R.
Curr Opin Struct Biol. 2005 Feb;15(1):116-25. Review. PubMed



SRP meets the ribosome.
Wild K, Halic M, Sinning I, Beckmann R.
Nat Struct Mol Biol. 2004 Nov;11(11):1049-53. Review. PubMed

Rearrangement of the 16S precursor subunits is essential for the formation of the active 20S proteasome.
Mullapudi S, Pullan L, Bishop OT, Khalil H, Stoops JK, Beckmann R, Kloetzel PM, Krüger E, Penczek PA.
Biophys J
. 2004 Dec;87(6):4098-105. Epub 2004 Sep 10. PubMed

Structure of the signal recognition particle interacting with the elongation-arrested ribosome.
Halic M, Becker T, Pool MR, Spahn CM, Grassucci RA, Frank J, Beckmann R.
. 2004 Feb 26;427(6977):808-14. PubMed

Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation.
Spahn CM, Gomez-Lorenzo MG, Grassucci RA, Jörgensen R, Andersen GR, Beckmann R, Penczek PA, Ballesta JP, Frank J.
. 2004 Mar 10;23(5):1008-19. Epub 2004 Feb 19. PubMed



Structure of the filamentous phage pIV multimer by cryo-electron microscopy.
Opalka N, Beckmann R, Boisset N, Simon MN, Russel M, Darst SA.
J Mol Biol. 2003 Jan 17;325(3):461-70. PubMed




The active 80S ribosome-Sec61 complex, in: The Ribosome, Symposia on Quantitative Biology.
Beckmann R, Spahn CMT, Frank J, Blobel G.
Cold Spring Harbor Lab Press. 2002 Vol LXVI, 543-554. PubMed

Structure of the 80S Ribosome from Saccharomyces cerevisiae-tRNA-Ribosome and Subunit-Subunit Interactions.
Spahn CM, Beckmann R, Eswar N, Penczek PA, Sali A, Blobel G, Frank J.
Cell. 2001 Nov 2;107(3):373-86. PubMed

Architecture of the Protein-Conducting Channel Associated with the Translating 80S Ribosome.
Beckmann R, Spahn CM, Eswar N, Helmers J, Penczek PA, Sali A, Frank J, Blobel G.
Cell. 2001 Nov 2;107(3):361-72. PubMed


2000 and before

Crystal Structures of Ribosome Anti-Association Factor IF6.
Groft CM, Beckmann R, Sali A, Burley SK.
Nat Struct Biol. 2000 Dec;7(12):1156-64. PubMed

Alignment of Conduits for the Nascent Polypeptide Chain in the Ribosome-Sec61 Complex.
Beckmann R, Bubeck D, Grassucci R, Penczek P, Verschoor A, Blobel G, Frank J.
Science. 1997 Dec 19;278(5346):2123-6. PubMed

Large-conductance cation channels in the envelope of nuclei from rat cerebral cortex.
Draguhn A, Börner G, Beckmann R, Buchner K, Heinemann U, Hucho F.
J Membr Biol. 1997 Jul 15;158(2):159-66. PubMed

Bradykinin Induces Rise of Free Calcium in Nuclei of Neuroblastoma X Glioma Hybrid Ng 108-15 Cells.
Beckmann R, Lindschau C, Haller H, Buchner K.
J Neurosci Res. 1995 Apr 1;40(5):571-8. PubMed

Differential Nuclear Localization of Protein Kinase C Isoforms in Neuroblastoma X Glioma Hybrid Cells.
Beckmann R, Lindschau C, Haller H, Hucho F, Buchner K.
Eur J Biochem. 1994; 222, 335-343. PubMed

Nuclear Substrates of Protein Kinase C.
Beckmann R, Buchner K, Jungblut PR, Eckerskorn C, Weise C, Hilbert R and Hucho F.
Eur J Biochem. 1992; 210, 45-51. PubMed

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