Canzar Lab - Algorithmic Computational Biology
- Computational Genomics & Transcriptomics
- Algorithm Engineering
- Protein-Protein Interaction Networks
- Combinatorial Optimization
Next-generation sequencing instruments produce a huge number of short DNA 'reads', each of which carries little information by itself. These reads therefore have to be pieced together by well-engineered algorithms to reconstruct biologically meaningful measurements. The lab's goal is the development of accurate mathematical models, efficient algorithms, and usable software to solve these complex, high-dimensional puzzles. Read more...
The dynamic landscape of fission yeast meiosis alternative-splice isoforms.
Kuang Z, Boeke JD , Canzar S .
Genome Res. 2017 Jan;27(1):145-156. doi: 10.1101/gr.208041.116. Epub 2016 Nov 17. PubMed
BASIC: BCR assembly from single cells.
Canzar S, Neu KE, Tang Q, Wilson PC, Khan AA .
Bioinformatics. 2017 Feb 1;33(3):425-427. doi: 10.1093/bioinformatics/btw631. PubMed
ModuleAlign: module-based global alignment of protein-protein interaction networks.
Hashemifar S, Ma J, Naveed H, Canzar S , Xu J .
Bioinformatics. 2016 Sep 1;32(17):i658-i664. doi: 10.1093/bioinformatics/btw447. PubMed
CIDANE: comprehensive isoform discovery and abundance estimation.
Canzar S , Andreotti S, Weese D, Reinert K, Klau GW.
Genome Biol. 2016 Jan 30;17:16. doi: 10.1186/s13059-015-0865-0. PubMed
28.03.2019 - New paper
A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis
16.01.2019 - CIDANE protocol
Guided Reconstruction of Full-Length Isoforms from Short Reads by CIDANE.
27.12.2018 - RECOMB paper
Dynamic pseudo-time warping of complex single-cell trajectories
04.12.2018 - New paper
Genome wide association analysis in a mouse advanced intercross line
01.10.2018 - New lab member
Francisca Rojas Ringeling, MD, PhD, joins our lab as Postdoc. Welcome on board!
18.07.2018 - BGF grant
For Francisca Rojas Ringeling, MD, PhD. Congratulations!
21.06.2018 - New paper
Exploring the functional impact of alternative splicing on human protein isoforms using available annotation sources.
At 22st International Conference on Research in Computational Molecular Biology, Paris.
18.04.2018 - RECOMB paper
Chromatyping: Reconstructing Nucleosome Profiles from NOMe Sequencing Data
16.04.2018 - New lab member
Pablo Monteagudo joins our lab as PhD student. Welcome on board!
02.01.2018 - New lab member
Israa Al-Qassem joins our lab as PhD student. Welcome on board!
02.01.2018 - New lab member
Hoan Do joins our lab as PhD student. Welcome on board!
11.12.2017 - New preprint
Genome wide association study of behavioral, physiological and gene expression traits in a multigenerational mouse intercross.
01.12.2017 - Guest
Francisca Rojas Ringeling, MD, PhD (Johns Hopkins) visits the lab Dec '17 - Oct '18. Welcome!