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Canzar Lab - Algorithmic Computational Biology

Research Topics

  • Computational Genomics & Transcriptomics
  • Algorithm Engineering
  • Protein-Protein Interaction Networks
  • Combinatorial Optimization

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Dr. Stefan Canzar

phone: +49 (0)89 - 2180 71050
stefan.canzar@lmu.de

Next-generation sequencing instruments produce a huge number of short DNA 'reads', each of which carries little information by itself. These reads therefore have to be pieced together by well-engineered algorithms to reconstruct biologically meaningful measurements. The lab's goal is the development of accurate mathematical models, efficient algorithms, and usable software to solve these complex, high-dimensional puzzles. Read more...

Selected Publications

A generalization of t-SNE and UMAP to single-cell multimodal omics.
Van Do H, Canzar S.
Genome Biology. 2021;22(1):130. doi: 10.1186/s13059-021-02356-5.

Linear-time cluster ensembles of large-scale single-cell RNA-seq and multimodal data.
Van Do H, Rojas Ringeling F, Canzar S.
Genome Research. 2021;31(4):677-688 doi: 10.1101/gr.267906.120

McSplicer: a probabilistic model for estimating splice site usage from RNA-seq data.
Alqassem I, Sonthalia Y, Klitzke-Feser E, Shim H, Canzar S.
Bioinformatics. 2021. doi: 10.1093/bioinformatics/btab050.

Sphetcher: Spherical thresholding improves sketching of single-cell transcriptomic heterogeneity.
Van Do H, Elbassioni K, Canzar S.
iScience. 2020;23(6):101126. doi: 10.1016/j.isci.2020.101126

More publications

News

20.07.2021 - New preprint
Anti Tai Mapping for Unordered Labeled Trees

01.07.2021 - DFG funding
We are part of LETSIMMUN, a collaborative research center funded by the DFG

27.06.2021 - New preprint
Fast metric multidimensional scaling using a neural network

03.05.2021 - New paper
j-SNE and j-UMAP generalize t-SNE and UMAP to single-cell multimodal omics

19.02.2021 - New paper
Specter for (fast) multi-modal clustering of single cells accepted at Genome Research.

30.01.2021 - New paper
McSplicer infers a probabilistic model of alternative splicing

21.02.2020 - New paper

Single-cell sampling by Van Hoan Do accepted for presentation at RECOMB-seq and for publication at iScience

18.12.2019 - DAAD Project funding

Application of Generic Optimizer in Medical Imaging Classification Problems