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Muenchhoff Lab - Host-Virus Interactions of Pandemic Pathogens

muenchhoff_main0596Research Topics

  • Immunopathogenesis of viral infections
  • Adaptive viral evolution
  • Molecular characterization of pandemic pathogens
  • HIV persistence

We are interested in host-virus interactions of the two pandemic pathogens HIV-1 and SARS-CoV-2. We aim to decipher immunological signatures of differential disease phenotypes in cohorts of SARS-CoV-2- and HIV-1-infected individuals. Building on our platform for genomic surveillance of SARS-CoV-2 we are investigating its evolution in adaptation to the human host. Our group is developing state-of-the-art methods to study HIV persistence. Read more...

Selected Publications

Accumulation of mutations in antibody and CD8 T cell epitopes in a B cell depleted lymphoma patient with chronic SARS-CoV-2 infection.
Khatamzas E*, Antwerpen MH*, Rehn A, Graf A, Hellmuth JC, Hollaus A, Mohr AW, Gaitzsch E, Weiglein T, Georgi E, Scherer C, Stecher SS, Gruetzner S, Blum H, Krebs S, Reischer A, Leutbecher A, Subklewe M, Dick A, Zange S, Girl P, Müller K, Weigert O, Hopfner KP, Stemmler HJ, von Bergwelt-Baildon M, Keppler OT, Wölfel R, Muenchhoff M*, Moosmann A*. *equal contribution
Nat Commun, 2022 Sep 23;13(1):5586. doi: 10.1038/s41467-022-32772-5. PubMed

Genomic epidemiology reveals multiple introductions of SARS-CoV-2 followed by community and nosocomial spread, Germany, February to May 2020.
Muenchhoff M, Graf A, Krebs S, Quartucci C, Hasmann S, Hellmuth JC, Scherer C, Osterman A, Boehm S, Mandel C, Becker-Pennrich AS, Zoller M, Stubbe HC, Munker S, Munker D, Milger K, Gapp M, Schneider S, Ruhle A, Jocham L, Nicolai L, Pekayvaz K, Weinberger T, Mairhofer H, Khatamzas E, Hofmann K, Spaeth PM, Bender S, Kääb S, Zwissler B, Mayerle J, Behr J, von Bergwelt-Baildon M, Reincke M, Grabein B, Hinske CL, Blum H, Keppler OT.
Euro Surveill, 2021 Oct;26(43):2002066. doi: 10.2807/1560-7917.ES.2021.26.43.2002066. PubMed

Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection.
Muenchhoff M, Adland E, Karimanzira O, Crowther C, Pace M, Csala A, Leitman E, Moonsamy A, McGregor C, Hurst J, Groll A, Mori M, Sinmyee S, Thobakgale C, Tudor-Williams G, Prendergast AJ, Kloverpris H, Roider J, Leslie A, Shingadia D, Brits T, Daniels S, Frater J, Willberg CB, Walker BD, Ndung'u T, Jooste P, Moore PL, Morris L, Goulder P.
Sci Transl Med, 2016 Sep 28;8(358):358ra125. doi: 10.1126/scitranslmed.aag1048. PubMed

Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence.
Payne R*, Muenchhoff M*, Mann J, Roberts HE, Matthews P, Adland E, Hempenstall A, Huang KH, Brockman M, Brumme Z, Sinclair M, Miura T, Frater J, Essex M, Shapiro R, Walker BD, Ndung'u T, McLean AR, Carlson JM, Goulder PJ. *equal contribution
Proc Natl Acad Sci, 2014 Dec 16;111(50):E5393-400. doi: 10.1073/pnas.1413339111. PubMed

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