Wolf Lab - Engineering Innovative Medical Models
Research Topics
- Diabetes and Metabolic Research
- Rare Monogenic Diseases
- Xenotransplantation
- Biology of Reproduction
Prof. Eckhard Wolf
phone: +49 (0)89 - 2180 76800
ewolf@lmu.de
Assistant: Heike Zierahn
phone: +49 (0)89 - 2180 76800
Heike.Zierahn@lmu.de
The translation of new discoveries in basic medical research into clinical applications is a long, costly, and often inefficient process. To accelerate progress in translational medicine, we develop genetically tailored pigs as models for metabolic research (diabetes mellitus, obesity, atherosclerosis) and for rare monogenic diseases. Another key focus is the creation of genetically multi-modified pigs as sources of cells, tissues, and organs for xenotransplantation. Our porcine disease models help overcome the limitations of current model systems in predicting the efficacy and safety of new therapies in humans. Genetically modified pigs for organ donation offer a realistic solution to the current shortage of human organs available for transplantation. Read more...
Selected Publications
Pregnancy establishment in cattle without embryonic interferon tau.
Ali A, Zakhartchenko V, Güngör T, Nüske S, Stöckl JB, Hecken S, Hauser A, Krebs S, Reese S, Suchowski M, Friedl R, Schwanitz S, Scholz AM, Blutke A, Protschka M, Büttner M, Fröhlich T, Reichenbach HD, Wolf E.
Nat Commun 2026; 17:10609. PubMed
Advances in Organ and Tissue Xenotransplantation.
Ali A, Kemter E, Wolf E.
Annu Rev Anim Biosci 2024; 12:369-390. PubMed
Systemic deletion of DMD exon 51 rescues clinically severe Duchenne muscular dystrophy in a pig model lacking DMD exon 52.
Stirm M, Shashikadze B, Blutke A, Kemter E, Lange A, Stöckl JB, Jaudas F, Laane L, Kurome M, Keßler B, Zakhartchenko V, Bähr A, Klymiuk N, Nagashima H, Walter MC, Wurst W, Kupatt C, Fröhlich T, Wolf E.
Proc Natl Acad Sci U S A 2023;120:e2301250120. PubMed
Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs.
Kemter E, Müller A, Neukam M, Ivanova A, Klymiuk N, Renner S, Yang K, Broichhagen J, Kurome M, Zakhartchenko V, Kessler B, Knoch KP, Bickle M, Ludwig B, Johnsson K, Lickert H, Kurth T, Wolf E*, Solimena M.*
Proc Natl Acad Sci U S A 2021; 118:e2107665118 PubMed
Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy.
Moretti A, Fonteyne L, Giesert F, Hoppmann P, Meier AB, Bozoglu T, Baehr A, Schneider CM, Sinnecker D, Klett K, Frohlich T, Rahman FA, Haufe T, Sun S, Jurisch V, Kessler B, Hinkel R, Dirschinger R, Martens E, Jilek C, Graf A, Krebs S, Santamaria G, Kurome M, Zakhartchenko V, Campbell B, Voelse K, Wolf A, Ziegler T, Reichert S, Lee S, Flenkenthaler F, Dorn T, Jeremias I, Blum H, Dendorfer A, Schnieke A, Krause S, Walter MC, Klymiuk N, Laugwitz KL, Wolf E*, Wurst W*, Kupatt C*.
Nat Med. 2020; 26:207-214. PubMed