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Wolf Lab - Growth, Metabolism and Reproduction in Mammals

wolfResearch Topics

  • ERBB System
  • Monogenic Kidney Diseases
  • Reproductive Biology
  • Translational Animal Models

Prof. Eckhard Wolf

phone: +49 (0)89 - 2180 76800

Assistant: Sylvia Hornig

phone: +49 (0)89 - 2180 76800

Forward and reverse genetics approaches in mouse models are used to characterize the functions of components of the EGF-receptor system and to understand the molecular basis of kidney diseases. In addition, we are interested in early development of livestock embryos and use genetic engineering for tailoring pigs as models of human diseases (diabetes, rare monogenic diseases) and as donors of cells, tissues and organs for xenotransplantation. Read more...

Selected Publications

Directed self-assembly of a xenogeneic vascularized endocrine pancreas for type 1 diabetes.
Citro A, Neroni A, Pignatelli C, Campo F, Policardi M, Monieri M, Pellegrini S, Dugnani E, Manenti F, Maffia MC, Valla L, Kemter E, Marzinotto I, Olgasi C, Cucci A, Follenzi A, Lampasona V, Wolf E, Piemonti L.
Nat Commun 2023; 14:878 PubMed

Transgenic pigs expressing near infrared fluorescent protein-A novel tool for noninvasive imaging of islet xenotransplants.
Kemter E, Citro A, Wolf-Van Buerck L, Qiu Y, Böttcher A, Policardi M, Pellegrini S, Valla L, Alunni-Fabbroni M, Kobolák J, Kessler B, Kurome M, Zakhartchenko V, Dinnyes A, Cyran CC, Lickert H, Piemonti L, Seissler J, Wolf E.
Xenotransplantation 2022; 29:e12719 PubMed

Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs.
Kemter E, Müller A, Neukam M, Ivanova A, Klymiuk N, Renner S, Yang K, Broichhagen J, Kurome M, Zakhartchenko V, Kessler B, Knoch KP, Bickle M, Ludwig B, Johnsson K, Lickert H, Kurth T, Wolf E*, Solimena M.*
Proc Natl Acad Sci U S A 2021; 118:e2107665118 PubMed

Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy.
Moretti A, Fonteyne L, Giesert F, Hoppmann P, Meier AB, Bozoglu T, Baehr A, Schneider CM, Sinnecker D, Klett K, Frohlich T, Rahman FA, Haufe T, Sun S, Jurisch V, Kessler B, Hinkel R, Dirschinger R, Martens E, Jilek C, Graf A, Krebs S, Santamaria G, Kurome M, Zakhartchenko V, Campbell B, Voelse K, Wolf A, Ziegler T, Reichert S, Lee S, Flenkenthaler F, Dorn T, Jeremias I, Blum H, Dendorfer A, Schnieke A, Krause S, Walter MC, Klymiuk N, Laugwitz KL, Wolf E*, Wurst W*, Kupatt C*.
Nat Med. 2020; 26:207-214. PubMed

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