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Wolf Lab - Growth, Metabolism and Reproduction in Mammals

wolfResearch Topics

  • ERBB System
  • Monogenic Kidney Diseases
  • Reproductive Biology
  • Translational Animal Models

Prof. Eckhard Wolf

phone: +49 (0)89 - 2180 76800

Assistant: Sylvia Hornig

phone: +49 (0)89 - 2180 76800

Forward and reverse genetics approaches in mouse models are used to characterize the functions of components of the EGF-receptor system and to understand the molecular basis of kidney diseases. In addition, we are interested in early development of livestock embryos and use genetic engineering for tailoring pigs as models of human diseases (diabetes, rare monogenic diseases) and as donors of cells, tissues and organs for xenotransplantation. Read more...

Selected Publications

Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy.
Moretti A, Fonteyne L, Giesert F, Hoppmann P, Meier AB, Bozoglu T, Baehr A, Schneider CM, Sinnecker D, Klett K, Frohlich T, Rahman FA, Haufe T, Sun S, Jurisch V, Kessler B, Hinkel R, Dirschinger R, Martens E, Jilek C, Graf A, Krebs S, Santamaria G, Kurome M, Zakhartchenko V, Campbell B, Voelse K, Wolf A, Ziegler T, Reichert S, Lee S, Flenkenthaler F, Dorn T, Jeremias I, Blum H, Dendorfer A, Schnieke A, Krause S, Walter MC, Klymiuk N, Laugwitz KL, Wolf E*, Wurst W*, Kupatt C*.
Nat Med. 2020; 26:207-214. PubMed

Cellular and Molecular Probing of Intact Human Organs.
Zhao S, Todorov MI, Cai R, Maskari RA, Steinke H, Kemter E, Mai H, Rong Z, Warmer M, Stanic K, Schoppe O, Paetzold JC, Gesierich B, Wong MN, Huber TB, Duering M, Bruns OT, Menze B, Lipfert J, Puelles VG, Wolf E, Bechmann I, Erturk A.
Cell 2020; 180:796-812. PubMed

Multi-omics insights into functional alterations of the liver in insulin-deficient diabetes mellitus.
Backman M, Flenkenthaler F, Blutke A, Dahlhoff M, Landstrom E, Renner S, Philippou-Massier J, Krebs S, Rathkolb B, Prehn C, Grzybek M, Coskun U, Rothe M, Adamski J, de Angelis MH, Wanke R, Frohlich T, Arnold GJ, Blum H, Wolf E.
Molecular metabolism 2019; 26:30-44. PubMed

Consistent success in life-supporting porcine cardiac xenotransplantation.
Längin M, Mayr T, Reichart B, Michel S, Buchholz S, Guethoff S, Dashkevich A, Baehr A, Egerer S, Bauer A, Mihalj M, Panelli A, Issl L, Ying J, Fresch AK, Buttgereit I, Mokelke M, Radan J, Werner F, Lutzmann I, Steen S, Sjoberg T, Paskevicius A, Qiuming L, Sfriso R, Rieben R, Dahlhoff M, Kessler B, Kemter E, Kurome M, Zakhartchenko V, Klett K, Hinkel R, Kupatt C, Falkenau A, Reu S, Ellgass R, Herzog R, Binder U, Wich G, Skerra A, Ayares D, Kind A, Schonmann U, Kaup FJ, Hagl C, Wolf E, Klymiuk N, Brenner P, Abicht JM.
Nature 2018; 564:430-433. PubMed

OCT4/POU5F1 is required for NANOG expression in bovine blastocysts
Simmet K, Zakhartchenko V, Philippou-Massier J, Blum H, Klymiuk N, Wolf E.
Proc Natl Acad Sci U S A. 2018; 115:2770-2775. PubMed

INS-eGFP transgenic pigs: a novel reporter system for studying maturation, growth and vascularisation of neonatal islet-like cell clusters.
Kemter E, Cohrs CM, Schäfer M, Schuster M, Steinmeyer K, Wolf-van Buerck L, Wolf A, Wuensch A, Kurome M, Kessler B, Zakhartchenko V, Loehn M, Ivashchenko Y, Seissler J, Schulte AM, Speier S, Wolf E.
Diabetologia. 2017 Jun;60(6):1152-1156. doi: 10.1007/s00125-017-4250-2. Epub 2017 Mar 18. PubMed

Direct introduction of gene constructs into the pronucleus-like structure of cloned embryos: a new strategy for the generation of genetically modified pigs.
Kurome M, Leuchs S, Kessler B, Kemter E, Jemiller EM, Foerster B, Klymiuk N, Zakhartchenko V, Wolf E.
Transgenic Res. 2017 Apr;26(2):309-318. doi: 10.1007/s11248-016-0004-z. Epub 2016 Dec 10. PubMed

Incretin actions and consequences of incretin-based therapies: lessons from complementary animal models.
Renner S, Blutke A, Streckel E, Wanke R, Wolf E.
J Pathol. 2016 Jan;238(2):345-58. doi: 10.1002 Epub 2015 Nov 30. Review. PubMed

Fine mapping of genome activation in bovine embryos by RNA sequencing.
Graf A, Krebs S, Zakhartchenko V, Schwalb B, Blum H, Wolf E.
Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4139-44. doi: 10.1073/pnas.1321569111. PubMed

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