Klein Lab - Molecular Medicine
Research Topics
- Neutrophil Granulocytes
- Primary Immunodeficiency Disorders
- Gene Therapy
- Mucosal Immunology
Prof. Christoph Klein
phone: +49 (0)89 - 4400 57701
christoph.klein@med.uni-muenchen.de
Assistant: Gerlinde Graf
phone: +49 (0)89 - 4400 57701
gerlinde.graf@med.uni-muenchen.de
Our mission is to understand the basic principles of the blood and immune system by studying human patients with rare inherited disorders. Starting with the analysis of the patients’ phenotype, we unravel the genetic etiology of rare diseases using a variety of in vitro and in vivo model systems. We aim to develop novel therapeutic strategies with a particular focus on cell and gene therapy. Read more...
Selected Publications
Generation of complex bone marrow organoids from human induced pluripotent stem cells.
Frenz-Wiessner S, Fairley SD, Buser M, Goek I, Salewskij K, Jonsson G, Illig D, Zu Putlitz B, Petersheim D, Li Y, Chen PH, Kalauz M, Conca R, Sterr M, Geuder J, Mizoguchi Y, Megens RTA, Linder MI, Kotlarz D, Rudelius M, Penninger JM, Marr C, Klein C.
Nat Methods. 2024 May;21(5):868-881. doi: 10.1038/s41592-024-02172-2. Epub 2024 Feb 19. PubMed
Human MD2 deficiency-an inborn error of immunity with pleiotropic features.
Li Y, Yu Z, Schenk M, Lagovsky I, Illig D, Walz C, Rohlfs M, Conca R, Muise AM, Snapper SB, Uhlig HH, Garty BZ, Klein C, Kotlarz D.
J Allergy Clin Immunol. 2023 Mar;151(3):791-796.e7. doi: 10.1016/j.jaci.2022.09.033. PubMed
Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes.
Linder MI, Mizoguchi Y, Hesse S, Csaba G, Tatematsu M, Łyszkiewicz M, Ziȩtara N, Jeske T, Hastreiter M, Rohlfs M, Liu Y, Grabowski P, Ahomaa K, Maier-Begandt D, Schwestka M, Pazhakh V, Isiaku AI, Briones Miranda B, Blombery P, Saito MK, Rusha E, Alizadeh Z, Pourpak Z, Kobayashi M, Rezaei N, Unal E, Hauck F, Drukker M, Walzog B, Rappsilber J, Zimmer R, Lieschke GJ, Klein C.
Blood. 2023 Feb 9;141(6):645-658. doi: 10.1182/blood.2022016783. PubMed
HAX1-dependent control of mitochondrial proteostasis governs neutrophil granulocyte differentiation. Fan Y, Murgia M, Linder MI, Mizoguchi Y, Wang C, Łyszkiewicz M, Ziȩtara N, Liu Y, Frenz S, Sciuccati G, Partida-Gaytan A, Alizadeh Z, Rezaei N, Rehling P, Dennerlein S, Mann M, Klein C.
J Clin Invest. 2022 May 2;132(9):e153153. doi: 10.1172/JCI153153. PubMed