Arulanandam (JP) Lab - Structural Biology of Cell Division
Research Topics
- Integrative Structural Cell Biology
- Mechanisms of Chromosome Segregation
- RNA Modifications and Spindle Assembly
Prof. Jeyaprakash Arulanandam (JP)
His ERC-funded lab has started at the Gene Center on 1st March 2023. Please note his job operning.
phone: +49 (0)89 - 2180 76962
jparul@genzentrum.lmu.de
We are interested in understanding the mechanism of chromosome segregation during cell division. Particularly, we aim to obtain high-resolution mechanistic insights into how centromere assembly and function and RNA-modification activities ensure error-free chromosome segregation. Towards this goal, we employ an integrative structure-function approach combining cryoEM, Crystallography and CrossLinking/MS with proteomics and cell biology.
Selected Publications
Mechanistic Basis for Sgo1-Mediated Centromere Localisation and Function of the CPC.
Abad, M. A*., Gupta, T*., Hadders, M, A., Meppelink, A., Wopken, J. P., Blackburn, E., Zou, J., Gireesh, A., Buzuk, L., Kelly, D, A., McHugh, T., Rappsilber, J., Lens, S. M. A and Jeyaprakash, A. A.
J. Cell Biol (2022) 221(8):e202108156 Doi:10.1083/jcb.202108156 (*equal contibution) PubMed
Structural Basis for Centromere Maintenance by Drosophila CENP-A Chaperone Cal1.
Medina-Pritchard, B., Lazou, V., Zou, J., Byron O., Abad, M. A., Rappsilber, J., Heun, P and Jeyaprakash, A. A.
EMBO J (2020) Doi:10.15252/embj.2019103234. PubMed
Direct Nucleosome Binding of Borealin Secures Chromosome Association and Function of the CPC.
Abad, M. A., Ruppert, J. G., Buzuk, L., Wear, M. A., Zou, J., Webb, K. M., Kelly, D. A., Voigt, P., Rappsilber, J., Earnshaw, W. C and Jeyaprakash, A. A.
J Cell Biol (2019) 218(12):3912-3925. PubMed
Structural Basis for Microtubule Recognition by the Human Kinetochore Ska Complex.
Abad, M. A., Medina, B., Santamaria, A., Zou, J., Plasberg-Hill, C., Madhumalar, A., Jayachandran, U., Redli, P. M., Rappsilber, J., Nigg, E. A. and Jeyaprakash. A. A.
Nat Commun (2014) Jan13; 5:2964. Doi:10.1038/ncomms3964 PubMed