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Subklewe Lab - Translational Cancer Immunology

Research Topics

  • Novel Target Antigens
  • Antibodies + CAR-T Cells
  • Vaccination + Checkpoint Blockade
  • Immune Monitoring + Biomarkers




Prof. Marion Subklewe

phone: +49 (0)89 - 4400 73133
subklewe@genzentrum.lmu.de

The Laboratory for Translational Cancer Immunology develops immunotherapies for malignant neoplasia, with a special focus on acute leukemia and B-cell lymphoma. We seek to understand mechanisms of action and resistance of cellular- and antibody-based immunotherapy. The goal is to identify predictive biomarkers for selecting the suitable immunotherapy for each individual patient. Read more...

Selected Publications

Bifunctional PD-1 x αCD3 x αCD33 fusion protein reverses adaptive immune escape in acute myeloid leukemia.
Herrmann M, Krupka C, Deiser K, Brauchle B, Marcinek A, Ogrinc Wagner A, Rataj F, Mocikat R, Metzeler KH, Spiekermann K, Kobold S, Fenn NC, Hopfner KP, Subklewe M.
Blood. 2018 Oct 1. doi: 10.1182/blood-2018-05-849802. PubMed

Coexpression profile of leukemic stem cell markers for combinatorial targeted therapy in AML.
Haubner S, Perna F, Köhnke T, Schmidt C, Berman S, Augsberger C, Schnorfeil FM, Krupka C, Lichtenegger FS, Liu X, Kerbs P, Schneider S, Metzeler KH, Spiekermann K, Hiddemann W, Greif PA, Herold T, Sadelain M, Subklewe M.
Leukemia. 2018 Jun 26. doi: 10.1038/s41375-018-0180-3. PubMed

Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells.
Lichtenegger FS, Rothe M, Schnorfeil FM, Deiser K, Krupka C, Augsberger C, Schlüter M, Neitz J, Subklewe M.
Front Immunol. 2018 Feb 27;9:385. doi: 10.3389/fimmu.2018.00385. PubMed

Blockade of the PD-1/PD-L1 axis augments lysis of AML cells by the CD33/CD3 BiTE antibody construct AMG 330: reversing a T-cell-induced immune escape mechanism.
Krupka C, Kufer P, Kischel R, Zugmaier G, Lichtenegger FS, Köhnke T, Vick B, Jeremias I, Metzeler KH, Altmann T, Schneider S, Fiegl M, Spiekermann K, Bauerle PA, Hiddemann W, Riethmüller G, Subklewe M.
Leukemia. 2016 Feb;30(2):484-91. doi: 10.1038/leu.2015.214. PubMed

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