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Jae Lab - Functional Genomics

Research Topic

  • Functional Genomics
  • Mitochondria
  • Stress Response

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Prof. Dr. Lucas Jae

phone: +49 (0)89 - 2180 71004
jae@genzentrum.lmu.de

We combine CRISPR genome engineering with ultradeep mutagenesis and synthetic biology to study the genetic basis of cellular processes that underlie human disease. Our focus lies in the area of mitochondria, proteostasis, and stress response. Read more...

Selected Publications

DELE1 tracks perturbed protein import and processing in human mitochondria.
Fessler E†, Krumwiede L, Jae LT†.
Nature Commun. 2022 Apr 6; 13:1853 | https://doi.org/10.1038/s41467-022-29479-y Link

A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.
Fessler E, Eckl EM, Schmitt S, Mancilla IA, Meyer-Bender MF, Hanf M, Philippou-Massier J, Krebs S, Zischka H, Jae LT†.
Nature. 2020 Mar 19; 579(7799) doi: 10.1038/s41586-020-2076-4. Link

Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling.
Brockmann M, Blomen VA, Nieuwenhuis J, Stickel E, Raaben M, Bleijerveld OB, Altelaar AFM, Jae LT†, Brummelkamp TR†.
Nature. 2017 Jun 8;546(7657):307-311. doi: 10.1038/nature22376. Epub 2017 May 31. PubMed

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators.
Mezzadra R*, Sun C*, Jae LT*, Gomez-Eerland R, de Vries E, Wu W, Logtenberg MEW, Slagter M, Rozeman EA, Hofland I, Broeks A, Horlings HM, Wessels LFA, Blank CU, Xiao Y, Heck AJR, Borst J, Brummelkamp TR†, Schumacher TNM†.
Nature. 2017 Sep 7;549(7670):106-110. doi: 10.1038/nature23669. Epub 2017 Aug 16. PubMed

Gene essentiality and synthetic lethality in haploid human cells.
Blomen VA*, Májek P*, Jae LT*, Bigenzahn JW, Nieuwenhuis J, Staring J, Sacco R, van Diemen FR, Olk N, Stukalov A, Marceau C, Janssen H, Carette JE, Bennett KL, Colinge J†, Superti-Furga G†, Brummelkamp TR†.
Science. 2015 Nov 27;350(6264):1092-6. doi: 10.1126/science.aac7557. Epub 2015 Oct 15. PubMed

More publications

News

10/2023 - New Paper

The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A. Nice collaboration with the Ladurner and Mattiroli labs. Read the full story here

10/2023 - Vallee Scholar Award

Deeply honored that we have been selected for a Vallee Scholar Award of the Vallee Foundation based in Cambridge, Massachusetts. Great team effort by the lab that laid the groundwork for the planned research agenda.

10/2023 - Engelhorn Fellowship Gonca

Gonca is being awarded a postdoctoral fellowship of The Peter & Traudl Engelhorn Foundation. Fantastic support for fundamental research that will supercharge her investigation of the integrated stress response! 

07/2023 - Welcome Gonca

Gonca Cetin from Turkey joins the lab for her postdoctral work. Welcome Gonca!