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Jae Lab - Functional Genomics

Research Topic

  • Functional Genomics
  • Mitochondria
  • Stress Response

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Prof. Dr. Lucas Jae

phone: +49 (0)89 - 2180 71004

We combine CRISPR genome engineering with ultradeep mutagenesis and synthetic biology to study the genetic basis of cellular processes that underlie human disease. Our focus lies in the area of mitochondria, proteostasis, and stress response. Read more...

Selected Publications

DELE1 tracks perturbed protein import and processing in human mitochondria.
Fessler E†, Krumwiede L, Jae LT†.
Nature Commun. 2022 Apr 6; 13:1853 | Link

A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.
Fessler E, Eckl EM, Schmitt S, Mancilla IA, Meyer-Bender MF, Hanf M, Philippou-Massier J, Krebs S, Zischka H, Jae LT†.
Nature. 2020 Mar 19; 579(7799) doi: 10.1038/s41586-020-2076-4. Link

Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling.
Brockmann M, Blomen VA, Nieuwenhuis J, Stickel E, Raaben M, Bleijerveld OB, Altelaar AFM, Jae LT†, Brummelkamp TR†.
Nature. 2017 Jun 8;546(7657):307-311. doi: 10.1038/nature22376. Epub 2017 May 31. PubMed

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators.
Mezzadra R*, Sun C*, Jae LT*, Gomez-Eerland R, de Vries E, Wu W, Logtenberg MEW, Slagter M, Rozeman EA, Hofland I, Broeks A, Horlings HM, Wessels LFA, Blank CU, Xiao Y, Heck AJR, Borst J, Brummelkamp TR†, Schumacher TNM†.
Nature. 2017 Sep 7;549(7670):106-110. doi: 10.1038/nature23669. Epub 2017 Aug 16. PubMed

Gene essentiality and synthetic lethality in haploid human cells.
Blomen VA*, Májek P*, Jae LT*, Bigenzahn JW, Nieuwenhuis J, Staring J, Sacco R, van Diemen FR, Olk N, Stukalov A, Marceau C, Janssen H, Carette JE, Bennett KL, Colinge J†, Superti-Furga G†, Brummelkamp TR†.
Science. 2015 Nov 27;350(6264):1092-6. doi: 10.1126/science.aac7557. Epub 2015 Oct 15. PubMed

More publications


24.08.2022 - New Paper

A haploid genetic screen by Evelyn identifies the kinase NAGK as the missing link in bacterial cell wall detection by NOD2. Great collaboration with the Hornung lab! Read the full story at Nature.

15.07.2022 - New Paper

Check out the role of the OMA1-DELE1-HRI pathway discovered by Evelyn in the cellular response against protein misfolding in CHCHD10 mitochondrial myopathy. Great collaboration with the Narendra lab at the NIH. Full story available here.

Welcome Michael & Madleen

New undergraduate students Madleen and Michael join the lab. Michael is studying cellular proteostasis mechanisms and Madleen investigates cellular responses to metabolic rewiring. As an inaugural experiment, we already collectively tested the metabolic impact of consuming Madleen's famed cherry pie. Preliminary result: Omnomnom. Great to have you two around!

15.07.2022 - BIF Hanna

Hanna is being awarded a prestigious PhD fellowship by Boehringer Ingelheim. She will investigate cellular proteostasis in the wake of mitochondrial dysfunction. Amazing news!