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Jae Lab - Functional Genomics

Research Topic

  • Functional Genomics
  • Mitochondria
  • Stress Response

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Prof. Dr. Lucas Jae

phone: +49 (0)89 - 2180 71004

We combine CRISPR genome engineering with ultradeep mutagenesis and synthetic biology to study the genetic basis of cellular processes that underlie human disease. Our focus lies in the area of mitochondria, proteostasis, and stress response. Read more...

Selected Publications

DELE1 tracks perturbed protein import and processing in human mitochondria.
Fessler E†, Krumwiede L, Jae LT†.
Nature Commun. 2022 Apr 6; 13:1853 | Link

A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.
Fessler E, Eckl EM, Schmitt S, Mancilla IA, Meyer-Bender MF, Hanf M, Philippou-Massier J, Krebs S, Zischka H, Jae LT†.
Nature. 2020 Mar 19; 579(7799) doi: 10.1038/s41586-020-2076-4. Link

Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling.
Brockmann M, Blomen VA, Nieuwenhuis J, Stickel E, Raaben M, Bleijerveld OB, Altelaar AFM, Jae LT†, Brummelkamp TR†.
Nature. 2017 Jun 8;546(7657):307-311. doi: 10.1038/nature22376. Epub 2017 May 31. PubMed

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators.
Mezzadra R*, Sun C*, Jae LT*, Gomez-Eerland R, de Vries E, Wu W, Logtenberg MEW, Slagter M, Rozeman EA, Hofland I, Broeks A, Horlings HM, Wessels LFA, Blank CU, Xiao Y, Heck AJR, Borst J, Brummelkamp TR†, Schumacher TNM†.
Nature. 2017 Sep 7;549(7670):106-110. doi: 10.1038/nature23669. Epub 2017 Aug 16. PubMed

Gene essentiality and synthetic lethality in haploid human cells.
Blomen VA*, Májek P*, Jae LT*, Bigenzahn JW, Nieuwenhuis J, Staring J, Sacco R, van Diemen FR, Olk N, Stukalov A, Marceau C, Janssen H, Carette JE, Bennett KL, Colinge J†, Superti-Furga G†, Brummelkamp TR†.
Science. 2015 Nov 27;350(6264):1092-6. doi: 10.1126/science.aac7557. Epub 2015 Oct 15. PubMed

More publications


20.06.2022 - Krupp Award

We are being awarded the 2022 Krupp Award of the Alfried Krupp von Bohlen and Halbach Foundation. Fantastic news and welcome support in our quest to unlock mitochondria with functional genomics. Interested? Come join the ride here.

06.04.2022 - New Paper

Mitochondrial stress integration by DELE1 through the ancient conserved processes of protein import and processing in the organelle with implications for human neurodegenerative settings. Fantastic work by Evelyn and Luisa. Check out the full stroy here!

01.10.2021 - Life Sciences Bridge Award

Our lab is awarded the 2021 Life Sciences Bridge Award of the Aventis Foundation. Their generous support will fuel our hunt for mitochondrial stress mechanisms.

02.08.2021 - Welcome back Lena

We are excited to welcome back our own Swabian allstar, Lena Langer, for her MSc thesis. Wodsch aut, die isch a Käpsele!