Jae Lab - Functional Genomics
Research Topic
- Functional Genomics
- Mitochondria
- Stress Response
JaeLab@Bluesky
Prof. Dr. Lucas Jae
phone: +49 (0)89 - 2180 71004
jae@genzentrum.lmu.de
We combine CRISPR genome engineering with ultradeep mutagenesis and synthetic biology to study the genetic basis of cellular processes that underlie human disease. Our focus lies in the area of mitochondria, proteostasis, and stress response. Read more...
Selected Publications
DELE1 tracks perturbed protein import and processing in human mitochondria.
Fessler E†, Krumwiede L, Jae LT†.
Nature Commun. 2022 Apr 6; 13:1853 | https://doi.org/10.1038/s41467-022-29479-y Link
A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.
Fessler E, Eckl EM, Schmitt S, Mancilla IA, Meyer-Bender MF, Hanf M, Philippou-Massier J, Krebs S, Zischka H, Jae LT†.
Nature. 2020 Mar 19; 579(7799) doi: 10.1038/s41586-020-2076-4. Link
Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling.
Brockmann M, Blomen VA, Nieuwenhuis J, Stickel E, Raaben M, Bleijerveld OB, Altelaar AFM, Jae LT†, Brummelkamp TR†.
Nature. 2017 Jun 8;546(7657):307-311. doi: 10.1038/nature22376. Epub 2017 May 31. PubMed
Identification of CMTM6 and CMTM4 as PD-L1 protein regulators.
Mezzadra R*, Sun C*, Jae LT*, Gomez-Eerland R, de Vries E, Wu W, Logtenberg MEW, Slagter M, Rozeman EA, Hofland I, Broeks A, Horlings HM, Wessels LFA, Blank CU, Xiao Y, Heck AJR, Borst J, Brummelkamp TR†, Schumacher TNM†.
Nature. 2017 Sep 7;549(7670):106-110. doi: 10.1038/nature23669. Epub 2017 Aug 16. PubMed
Gene essentiality and synthetic lethality in haploid human cells.
Blomen VA*, Májek P*, Jae LT*, Bigenzahn JW, Nieuwenhuis J, Staring J, Sacco R, van Diemen FR, Olk N, Stukalov A, Marceau C, Janssen H, Carette JE, Bennett KL, Colinge J†, Superti-Furga G†, Brummelkamp TR†.
Science. 2015 Nov 27;350(6264):1092-6. doi: 10.1126/science.aac7557. Epub 2015 Oct 15. PubMed
More publications
News
12/2025 - ERC Consolidator Grant mitoSCALES
Our ERC Consolidator Grant application mitoSCALES (scales of mitochondrial stress response) was successful. mitoSCALES will dissect human mitochondrial stress processes from the atomic to the intercellular scale. Read the press release here.
11/2025 - New Paper
Targeting prohibitins activates the ISR through DELE1-HRI by impairing protein import into the mitochondrial matrix. Nice collaboration with joan Gil's lab. Read the full story here.
10/2025 - Welcome Ben
Benjamin Strickland, trained in hormone receptor biology, joins the lab for his postdoctral work. Welcome!
09/2025 - New Paper
The mitochondrial disulphide relay substrate FAM136A safeguards IMS proteostasis and cellular fitness. Fantastic collaboration with the Riemer lab. Read the full story here.