Jae Lab - Publications
2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013
2025
Hoffmann L, Eckl EM, Berouti M, Pries M, Koller A, Guhl C, Hellmich UA, Hornung V, Xiang W, Jae LT, Kielkowski P.
AMPylation regulates PLD3 processing.
bioRxiv. 2025.01. 09.632087. Link
2024
Fieler H and Jae LT.
Gestresste Mitochondrien: zwischen Zellschutz und Zelltod.
BIOspektrum. 2024;30:502–504. doi: 10.1007/s12268-024-2254-2. German. Link
2023
Mandemaker IK, Fessler E, Corujo D, Kotthoff C, Wegerer A, Rouillon C, Buschbeck M, Jae LT, Mattiroli F, Ladurner AG.
The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A.
Cell Rep. 2023 Oct 18;42(10):113300. doi: 10.1016/j.celrep.2023.113300. Link
Stok C, Tsaridou S, van den Tempel N, Everts M, Elles W, Bakker FJ, Kok Y, Alves IT, Jae LT, Raas MWD, Huis In 't Veld PJ, de Boer HR, Bhattacharya A, Karanika E, Warner H, Chen M, van de Kooij B, Dessapt J, Ter Morsche L, Perepelkina P, Fradet-Turcotte A, Guryev V, Tromer EC, Chan KL, Fehrmann RSN, van Vugt MATM.
FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics.
Cell Rep. 2023 Jun 21;42(7):112668. doi: 10.1016/j.celrep.2023.112668. Link
Sekine Y, Houston R, Eckl EM, Fessler E, Narendra DP, Jae LT, Sekine S.
A mitochondrial iron-responsive pathway regulated by DELE1.
Mol Cell. 2023 Jun 15. doi: 10.1016/j.molcel.2023.05.031. Link
2022
Stafford CA, Gassauer AM, de Oliveira Mann CC, Tanzer MC, Fessler E, Wefers B, Nagl D, Kuut G, Sulek K, Vasilopoulou C, Schwojer SJ, Wiest A, Pfautsch MK, Wurst W, Yabal M, Fröhlich T, Mann M, Gisch N, Jae LT, Hornung V.
Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation.
Nature. 2022 Aug 24. doi: 10.1038/s41586-022-05125-x Link
Shammas MK, Huang X, Wu BP, Fessler E, Song I, Randolph NP, Li Y, Bleck CK, Springer DA, Fratter C, Barbosa IA, Powers AF, Quirós PM, Lopez-Otin C, Jae LT, Poulton J, Narendra DP.
OMA1 mediates local and global stress responses against protein misfolding in CHCHD10 mitochondrial myopathy.
J Clin Invest. 2022 June 14;e157504. doi: 10.1172/JCI157504 Link
Fessler E†, Krumwiede L, Jae LT†.
DELE1 tracks perturbed protein import and processing in human mitochondria.
Nature Commun. 2022 Apr 6. doi: 10.1038/s41467-022-29479-y Link
2021
Eckl EM, Ziegemann O, Krumwiede L, Fessler E, Jae LT†.
Sensing, signaling and surviving mitochondrial stress.
Cell. Mol. Life Sci. 2021. doi: 10.1007/s00018-021-03887-7 Review. Link
2020
Fessler E, Eckl EM, Schmitt S, Mancilla IA, Meyer-Bender MF, Hanf M, Philippou-Massier J, Krebs S, Zischka H, Jae LT†.
A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.
Nature. 2020 Mar 19; 579(7799) doi: 10.1038/s41586-020-2076-4. Link
Highlighted in:
Tremblay BP & Haynes CM. Nature. 2020 Mar 19;579(7799) doi: 10.1038/d41586-020-00552-0. Link
Reinking HK, Kang HS, Götz MJ, Li HY, Kieser A, Zhao S, Acampora AC, Weickert P, Fessler E, Jae LT, Sattler M, Stingele J.
DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease.
Mol Cell. 2020 Aug 19:S1097-2765(20)30546-3. doi: 10.1016/j.molcel.2020.08.003. PubMed
Loregger A*, Raaben M*, Nieuwenhuis J*, Tan JME, Jae LT, van den Hengel LG, Hendrix S, van den Berg M, Scheij S, Song JY, Huijbers IJ, Kroese LJ, Ottenhoff R, van Weeghel M, van de Sluis B, Brummelkamp TR†, Zelcer N†.
Haploid genetic screens identify SPRING/C12orf49 as a determinant of SREBP signaling and cholesterol metabolism.
Nature Commun. 2020 Feb 28; 11(1128). doi: 10.1038/s41467-020-14811-1. Link
2019
Heijink AM*, Talens F*, Jae LT, van Gijn SE, Fehrmann RSN, Brummelkamp TR, van Vugt MATM†.
BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity.
Nature Commun. 2019 Nov 21; 563(7732):559-563. doi: 10.1038/s41586-018-0702-1. Pubmed
2018
Jangra RK*, Herbert AS*, Li R*, Jae LT*, Kleinfelter LM, Slough MM, Barker SL, Guardado-Calvo P, Rromán-Sosa G, Dieterle ME, Kuehne AI, Muena NA, Wirchnianski AS, Nyakatura EK, Fels JM, Ng M, Mittler E, Pan J, Bharrhan S, Wec AZ, Lai JR, Sidhu SS, Tischler ND, Rey FA, Moffat J, Brummelkamp TR†, Wang Z†, Dye JM†, Chandran K†.
Protocadherin-1 is essential for cell entry by New World hantaviruses.
Nature. 2018 Nov 21; 563(7732):559-563. doi: 10.1038/s41586-018-0702-1. Pubmed
Fessler E and Jae LT†.
Haploid Screening for the Identification of Host Factors in Virus Infection.
Methods Mol Biol. 2018 Aug 28;1836:121-137. doi: 10.1007/978-1-4939-8678-1_6. Pubmed
2017
Maroofian R*, Riemersma M*, Jae LT, Zhianabed N, Willemsen MH, Wissink-Lindhout WM, Willemsen MA, de Brouwer APM, Mehrjardi MYV, Ashrafi MR, Kusters B, Kleefstra T, Jamshidi Y, Nasseri M, Pfundt R, Brummelkamp TR, Abbaszadegan MR, Lefeber DJ, van Bokhoven H.
B3GALNT2 mutations associated with non-syndromic autosomal recessive intellectual disability reveal a lack of genotype-phenotype associations in the muscular dystrophy-dystroglycanopathies.
Genome Med. 2017 Dec 22;9(1):118. doi: 10.1186/s13073-017-0505-2. Pubmed
Raaben M, Jae LT, Herbert AS, Kuehne AI, Stubbs SH, Chou Y, Blomen VA, Dye JM, Whelan SP†, Brummelkamp TR†.
NRP2 and CD63 are host factors for Lujo virus cell entry.
Cell Host & Microbe. 2017 Nov 8;22(5):688–696. doi: 10.1016/j.chom.2017.10.002. Pubmed
Mezzadra R*, Sun C*, Jae LT*, Gomez-Eerland R, de Vries E, Wu W, Logtenberg MEW, Slagter M, Rozeman EA, Hofland I, Broeks A, Horlings HM, Wessels LFA, Blank CU, Xiao Y, Heck AJR, Borst J, Brummelkamp TR†, Schumacher TNM†.
Identification of CMTM6 and CMTM4 as PD-L1 protein regulators.
Nature. 2017 Sep 7;549(7670):106-110. doi: 10.1038/nature23669. Epub 2017 Aug 16. PubMed
Brockmann M*, Blomen VA*, Nieuwenhuis J, Stickel E, Raaben M, Bleijerveld OB, Altelaar AFM, Jae LT†, Brummelkamp TR†.
Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling.
Nature. 2017 Jun 8;546(7657):307-311. doi: 10.1038/nature22376. Epub 2017 May 31. PubMed
2016
Pillay S*, Meyer NL*, Puschnik AS, Davulcu O, Diep J, Ishikawa Y, Jae LT, Wosen JE, Nagamine CM, Chapman MS, and Carette JE.
An essential receptor for adeno-associated virus infection.
Nature. 2016 Feb 4;530(7588):108-12. doi: doi.org/10.1038/nature16465. Pubmed
Baggen J*, Thibaut HJ*, Staring J, Jae LT, Liu Y, Guo H, Slager JJ, de Bruin JW, van Vliet AL, Blomen VA, Overduin P, Sheng J, de Haan CA, de Vries E, Meijer A, Rossmann MG, Brummelkamp TR, van Kuppeveld FJ.
Enterovirus D68 receptor requirements unveiled by haploid genetics.
Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1399-404. doi: 10.1073. Epub 2016 Jan 19. PubMed
2015
Riemersma M, Froese DS, van Tol W, Engelke UF, Kopec J, van Scherpenzeel M, Ashikov A, Krojer T, von Delft F, Tessari M, Buczkowska A, Swiezewska E, Jae LT, Brummelkamp TR, Manya H, Endo T, van Bokhoven H, Yue WW, Lefeber DJ.
Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.
Chem Biol. 2015 Dec 17;22(12):1643-52. doi: 10.1016/j.chembiol.2015.10.014. Epub 2015 Dec 10. PubMed
Blomen VA*, Mà¡jek P*, Jae LT*, Bigenzahn JW, Nieuwenhuis J, Staring J, Sacco R, van Diemen FR, Olk N, Stukalov A, Marceau C, Janssen H, Carette JE, Bennett KL, Colinge J†, Superti-Furga G†, Brummelkamp TR†.
Gene essentiality and synthetic lethality in haploid human cells.
Science. 2015 Nov 27;350(6264):1092-6. doi: 10.1126/science.aac7557. Epub 2015 Oct 15. PubMed
Riblett AM*, Blomen VA*, Jae LT*, Altamura LA, Doms RW, Brummelkamp TR, Wojcechowskyj JA.
A Haploid Genetic Screen Identifies Heparan Sulfate Proteoglycans Supporting Rift Valley Fever Virus Infection.
J Virol. 2015 Nov 18;90(3):1414-23. doi: 10.1128/JVI.02055-15. PubMed
Kleinfelter LM*, Jangra RK*, Jae LT*, Herbert AS, Mittler E, Stiles KM, Wirchnianski AS, Kielian M, Brummelkamp TR, Dye JM, Chandran K.
Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion.
MBio. 2015 Jun 30;6(4):e00801. doi: 10.1128/mBio.00801-15. PubMed
Jae LT, Brummelkamp TR.
Emerging intracellular receptors for hemorrhagic fever viruses.
Trends Microbiol. 2015 Jul;23(7):392-400. doi: 10.1016/j.tim.2015.04.006. Epub 2015 May 21. Review. PubMed
2014
Jae LT, Raaben M, Herbert AS, Kuehne AI, Wirchnianski AS, Soh TK, Stubbs SH, Janssen H, Damme M, Saftig P, Whelan SP†, Dye JM†, Brummelkamp TR†.
Lassa virus entry requires a trigger-induced receptor switch.
Science. 2014 Jun 27;344(6191):1506-10. doi: 10.1126/science.1252480. PubMed
2013
Jae LT, Raaben M, Riemersma M, van Beusekom E, Blomen VA, Velds A, Kerkhoven RM, Carette JE, Topaloglu H, Meinecke P, Wessels MW, Lefeber DJ, Whelan SP†, van Bokhoven H†, Brummelkamp TR†.
Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry.
Science. 2013 Apr 26;340(6131):479-83. doi: 10.1126/science.1233675. Epub 2013 Mar 21. PubMed
* equal contribution
† corresponding authors