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Klughammer Lab - Systems Immunology

klughammer_mainResearch Topics

  • Systems immunology
  • Computational (epi-) genomics and transcriptomics
  • Spatio-molecular tissue organization
Multi-cellular life is enabled by intricate molecular systems for information storage, propagation, and interpretation that make millions of individual cells work together as a unit. Tremendous advances in high-throughput molecular profiling techniques now allow us to comprehensively study this molecular information at high resolution. Using these high-dimensional representations of cellular systems we want to understand how and why cells do what they do in health and disease, with a special focus on the immune system which is involved in virtually all aspects of multicellular life. Read more...

Selected Publications

Comparative analysis of genome-scale, base-resolution DNA methylation profiles across 580 animal species
Klughammer K*#, Romanovskaia D*, Nemc A, Posautz A, Seid C, Schuster LC, Keinath MC, Sebastian J, Ramos L, Kosack L, Evankow A, Prinz D, Kirchberger S, Ergüner B, Datlinger P, Fortelny N, Schmidl C, Farlik M, Skjærven K, Bergthaler A, Liedvogel M, Thaller D, Burger PA, Hermann M, Distel M, Distel DL, Kübber-Heiss A, Bock C#
Nat Commun. 2023 Jan;14, 232. doi: 10.1038/s41467-022-34828-y

High-definition spatial transcriptomics for in situ tissue profiling.
Vickovic S, Eraslan G*, Salmén F*, Klughammer J*, Stenbeck L*, Schapiro D, Äijö T, Bonneau R, Bergenstråhle L, Navarro JF, Gould J, Griffin GK, Borg Å, Ronaghi M, Frisén J, Lundeberg J, Regev A, Ståhl PL.
Nat Methods. 2019 Oct;16(10):987-990. doi: 10.1038/s41592-019-0548-y. PubMed

The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space.
Klughammer J*, Kiesel B*, Roetzer T, Fortelny N, Nemc A, Nenning KH, Furtner J, Sheffield NC, Datlinger P, Peter N, Nowosielski M, Augustin M, Mischkulnig M, Ströbel T, Alpar D, Ergüner B, Senekowitsch M, Moser P, Freyschlag CF, Kerschbaumer J, Thomé C, Grams AE, Stockhammer G, Kitzwoegerer M, Oberndorfer S, Marhold F, Weis S, Trenkler J, Buchroithner J, Pichler J, Haybaeck J, Krassnig S, Mahdy Ali K, von Campe G, Payer F, Sherif C, Preiser J, Hauser T, Winkler PA, Kleindienst W, Würtz F, Brandner-Kokalj T, Stultschnig M, Schweiger S, Dieckmann K, Preusser M, Langs G, Baumann B, Knosp E, Widhalm G, Marosi C, Hainfellner JA, Woehrer A, Bock C.
Nat Med. 2018 Oct;24(10):1611-1624. doi: 10.1038/s41591-018-0156-x. PubMed

Single-cell transcriptomes reveal characteristic features of human pancreatic islet cell types.
Li J*, Klughammer J*, Farlik M*, Penz T*, Spittler A, Barbieux C, Berishvili E, Bock C, Kubicek S.
EMBO Rep. 2016 Feb;17(2):178-87. doi: 10.15252/embr.201540946. PubMed