Maximilian Muenchhoff - Publications
2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014
2023
Antiviral drugs block replication of highly immune-evasive Omicron subvariants ex vivo, but fail to reduce tissue inflammation.
Dichtl S, Diem G, Jäger M, Zaderer V, Lupoli G, Dächert C, Muenchhoff M, Graf A, Blum H, Keppler OT, Lass-Flörl C, Weiss G, Wilflingseder D, Posch W.
Antiviral Res. 2023 Mar 23;213:105581. doi: 10.1016/j.antiviral.2023.105581. PubMed
Slow progression of pediatric HIV associates with early CD8+ T cell PD-1 expression and a stem-like phenotype.
Vieira V, Lim N, Singh A, Leitman E, Dsouza R, Adland E, Muenchhoff M, Roider J, Marin Lopez M, Carabelli J, Giandhari J, Groll A, Jooste P, Prado JG, Thobakgale C, Dong K, Kiepiela P, Prendergast AJ, Tudor-Williams G, Frater J, Walker BD, Ndung'u T, Ramsuran V, Leslie A, Kløverpris HN, Goulder P.
JCI Insight. 2023 Feb 8;8(3):e156049. doi: 10.1172/jci.insight.156049. PMID: 36602861 Free PMC article. PubMed
Potent high-avidity neutralizing antibodies and T cell responses after COVID-19 vaccination in individuals with B cell lymphoma and multiple myeloma.
Keppler-Hafkemeyer A, Greil C, Wratil PR, Shoumariyeh K, Stern M, Hafkemeyer A, Ashok D, Hollaus A, Lupoli G, Priller A, Bischof ML, Ihorst G, Engelhardt M, Marks R, Finke J, Bertrand H, Dächert C, Muenchhoff M, Badell I, Emmerich F, Halder H, Spaeth PM, Knolle PA, Protzer U, von Bergwelt-Baildon M, Duyster J, Hartmann TN, Moosmann A, Keppler OT.
Nat Cancer. 2023 Jan;4(1):81-95. doi: 10.1038/s43018-022-00502-x. Epub 2022 Dec 21. PMID: 36543907 Free PMC article. PubMed
Thyroidal Angiotensin-Converting Enzyme 2 Protein Expression and Thyroid Function Tests in Patients with COVID-19: Results from a Retrospective Case Series and a Prospective Cohort Study.
Koehler VF, Knösel T, Hasmann SE, Scherer C, Hellmuth JC, Muenchhoff M, Munker SM, Hoster E, Ladurner R, Spitzweg C.
Thyroid. 2023 Feb;33(2):177-185. doi: 10.1089/thy.2022.0229. PMID: 36453232 PubMed
Distinct and dynamic activation profiles of circulating dendritic cells and monocytes in mild COVID-19 and after yellow fever vaccination.
Winheim E, Eser T, Deák F, Ahmed MIM, Baranov O, Rinke L, Eisenächer K, Santos-Peral A, Karimzadeh H, Pritsch M, Scherer C, Muenchhoff M, Hellmuth JC, von Bergwelt-Baildon M, Olbrich L, Hoelscher M, Wieser A, Kroidl I, Rothenfusser S, Geldmacher C, Krug AB.
Eur J Immunol. 2023 Mar;53(3):e2250090. doi: 10.1002/eji.202250090. Epub 2022 Dec 9. PMID: 36404054 PubMed
Variable detection of Omicron-BA.1 and -BA.2 by SARS-CoV-2 rapid antigen tests.
Osterman A, Badell I, Dächert C, Schneider N, Kaufmann AY, Öztan GN, Huber M, Späth PM, Stern M, Autenrieth H, Muenchhoff M, Graf A, Krebs S, Blum H, Czibere L, Durner J, Kaderali L, Baldauf HM, Keppler OT.
Med Microbiol Immunol. 2023 Feb;212(1):13-23. doi: 10.1007/s00430-022-00752-7. Epub 2022 Nov 12. PMID: 36370197 Free PMC article. PubMed
Proteomics reveals antiviral host response and NETosis during acute COVID-19 in high-risk patients.
Bauer A, Pachl E, Hellmuth JC, Kneidinger N, Heydarian M, Frankenberger M, Stubbe HC, Ryffel B, Petrera A, Hauck SM, Behr J, Kaiser R, Scherer C, Deng L, Teupser D, Ahmidi N, Muenchhoff M, Schubert B, Hilgendorff A.
Biochim Biophys Acta Mol Basis Dis. 2023 Feb;1869(2):166592. doi: 10.1016/j.bbadis.2022.166592. PubMed
2022
Accumulation of mutations in antibody and CD8 T cell epitopes in a B cell depleted lymphoma patient with chronic SARS-CoV-2 infection.
Khatamzas E, Antwerpen MH, Rehn A, Graf A, Hellmuth JC, Hollaus A, Mohr AW, Gaitzsch E, Weiglein T, Georgi E, Scherer C, Stecher SS, Gruetzner S, Blum H, Krebs S, Reischer A, Leutbecher A, Subklewe M, Dick A, Zange S, Girl P, Müller K, Weigert O, Hopfner KP, Stemmler HJ, von Bergwelt-Baildon M, Keppler OT, Wölfel R, Muenchhoff M, Moosmann A.
Nat Commun. 2022 Sep 23;13(1):5586. doi: 10.1038/s41467-022-32772-5. PMID: 36151076 PubMed
Secondary zoonotic dog-to-human transmission of SARS-CoV-2 suggested by timeline but refuted by viral genome sequencing.
Hoppe JM, Füeßl LU, Hartmann K, Hofmann-Lehmann R, Graf A, Krebs S, Blum H, Badell I, Keppler OT, Muenchhoff M.
Infection. 2023 Feb;51(1):253-259. doi: 10.1007/s15010-022-01902-y. Epub 2022 Aug 20. PMID: 35986880 PubMed
Ketone Bodies Improve Human CD8+ Cytotoxic T-Cell Immune Response During COVID-19 Infection.
Hirschberger S, Gellert L, Effinger D, Muenchhoff M, Herrmann M, Briegel JM, Zwißler B, Kreth S.
Front Med (Lausanne). 2022 Jun 16;9:923502. doi: 10.3389/fmed.2022.923502. eCollection 2022. PubMed
Should routine risk reduction procedures for the prevention and control of pandemics become a standard in all oncological outpatient clinics? The prospective COVID-19 cohort study: protect-CoV.
Fey T, Erickson N, Stahler A, Muenchhoff M, Keppler OT, Ruehlmann K, Krauss-Pfeiffer G, Steinberg H, Graf A, Krebs S, Blum H, Khatamzas E, Seynstahl S, Casuscelli J, Markwardt D, Forstpointner R, Schinköthe T, von Bergwelt-Baildon M, Heinemann V.
Med Oncol. 2022 Apr 10;39(6):104. doi: 10.1007/s12032-022-01700-4. PMID: 35397689 PubMed
Effects of SARS-CoV-2 on prenatal lung growth assessed by fetal MRI.
Stoecklein S, Koliogiannis V, Prester T, Kolben T, Jegen M, Hübener C, Hasbargen U, Flemmer A, Dietrich O, Schinner R, Dinkel J, Fink N, Muenchhoff M, Hintz S, Delius M, Mahner S, Ricke J, Hilgendorff A.
Lancet Respir Med. 2022 Apr;10(4):e36-e37. doi: 10.1016/S2213-2600(22)00060-1. Epub 2022 Mar 16. PMID: 35305309 PubMed
Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection.
Pekayvaz K, Leunig A, Kaiser R, Joppich M, Brambs S, Janjic A, Popp O, Nixdorf D, Fumagalli V, Schmidt N, Polewka V, Anjum A, Knottenberg V, Eivers L, Wange LE, Gold C, Kirchner M, Muenchhoff M, Hellmuth JC, Scherer C, Rubio-Acero R, Eser T, Deák F, Puchinger K, Kuhl N, Linder A, Saar K, Tomas L, Schulz C, Wieser A, Enard W, Kroidl I, Geldmacher C, von Bergwelt-Baildon M, Keppler OT, Munschauer M, Iannacone M, Zimmer R, Mertins P, Hubner N, Hoelscher M, Massberg S, Stark K, Nicolai L.
Nat Commun. 2022 Feb 23;13(1):1018. doi: 10.1038/s41467-022-28508-0. PMID: 35197461 PubMEd
Impaired detection of omicron by SARS-CoV-2 rapid antigen tests.
Osterman A, Badell I, Basara E, Stern M, Kriesel F, Eletreby M, Öztan GN, Huber M, Autenrieth H, Knabe R, Späth PM, Muenchhoff M, Graf A, Krebs S, Blum H, Durner J, Czibere L, Dächert C, Kaderali L, Baldauf HM, Keppler OT.
Med Microbiol Immunol. 2022 Jun;211(2-3):105-117. doi: 10.1007/s00430-022-00730-z. Epub 2022 Feb 20. PMID: 35187580 PubMed
Three exposures to the spike protein of SARS-CoV-2 by either infection or vaccination elicit superior neutralizing immunity to all variants of concern.
Wratil PR, Stern M, Priller A, Willmann A, Almanzar G, Vogel E, Feuerherd M, Cheng CC, Yazici S, Christa C, Jeske S, Lupoli G, Vogt T, Albanese M, Mejías-Pérez E, Bauernfried S, Graf N, Mijocevic H, Vu M, Tinnefeld K, Wettengel J, Hoffmann D, Muenchhoff M, Daechert C, Mairhofer H, Krebs S, Fingerle V, Graf A, Steininger P, Blum H, Hornung V, Liebl B, Überla K, Prelog M, Knolle P, Keppler OT, Protzer U.
Nat Med. 2022 Mar;28(3):496-503. doi: 10.1038/s41591-022-01715-4. Epub 2022 Jan 28. PMID: 35090165 PubMed
Rapid and sensitive identification of omicron by variant-specific PCR and nanopore sequencing: paradigm for diagnostics of emerging SARS-CoV-2 variants.
Dächert C, Muenchhoff M, Graf A, Autenrieth H, Bender S, Mairhofer H, Wratil PR, Thieme S, Krebs S, Grzimek-Koschewa N, Blum H, Keppler OT.
Med Microbiol Immunol. 2022 Feb;211(1):71-77. doi: 10.1007/s00430-022-00728-7. Epub 2022 Jan 21. PMID: 35061086 PubMed
2021
Case Report: Unilateral Sixth Cranial Nerve Palsy Associated With COVID-19 in a 2-year-old Child.
Knoflach K, Holzapfel E, Roser T, Rudolph L, Paolini M, Muenchhoff M, Osterman A, Griese M, Kappler M, von Both U.
Front Pediatr. 2021 Dec 17;9:756014. doi: 10.3389/fped.2021.756014. eCollection 2021. PMID: 34976891 PubMed
Detection of SARS-CoV-2-RNA in post-mortem samples of human eyes.
Penkava J, Muenchhoff M, Badell I, Osterman A, Delbridge C, Niederbuchner F, Soliman S, Rudelius M, Graf A, Krebs S, Blum H, Ulbig M, Baumann C, Zapp D, Maier M, Keppler OT, Lohmann CP, Ledderose S. Graefes
Arch Clin Exp Ophthalmol. 2022 May;260(5):1789-1797. doi: 10.1007/s00417-021-05529-x. Epub 2021 Dec 28. PMID: 34962592 PubMed
Evidence for increased SARS-CoV-2 susceptibility and COVID-19 severity related to pre-existing immunity to seasonal coronaviruses.
Wratil PR, Schmacke NA, Karakoc B, Dulovic A, Junker D, Becker M, Rothbauer U, Osterman A, Spaeth PM, Ruhle A, Gapp M, Schneider S, Muenchhoff M, Hellmuth JC, Scherer C, Mayerle J, Reincke M, Behr J, Kääb S, Zwissler B, von Bergwelt-Baildon M, Eberle J, Kaderali L, Schneiderhan-Marra N, Hornung V, Keppler OT.
Cell Rep. 2021 Dec 28;37(13):110169. doi: 10.1016/j.celrep.2021.110169. Epub 2021 Dec 7. PMID: 34932974 PubMed
Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patients.
Rausch L, Lutz K, Schifferer M, Winheim E, Gruber R, Oesterhaus EF, Rinke L, Hellmuth JC, Scherer C, Muenchhoff M, Mandel C, Bergwelt-Baildon M, Simons M, Straub T, Krug AB, Kranich J, Brocker T.
J Extracell Vesicles. 2021 Dec;10(14):e12173. doi: 10.1002/jev2.12173. PMID: 34854246 PubMed
An HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell-mediated immune control in adults.
Vieira VA, Adland E, Malone DFG, Martin MP, Groll A, Ansari MA, Garcia-Guerrero MC, Puertas MC, Muenchhoff M, Guash CF, Brander C, Martinez-Picado J, Bamford A, Tudor-Williams G, Ndung'u T, Walker BD, Ramsuran V, Frater J, Jooste P, Peppa D, Carrington M, Goulder PJR.
PLoS Pathog. 2021 Nov 18;17(11):e1010090. doi: 10.1371/journal.ppat.1010090. eCollection 2021 Nov. PMID: 34793581 PubMed
Two Distinct Mechanisms Leading to Loss of Virological Control in the Rare Group of Antiretroviral Therapy-Naive, Transiently Aviremic Children Living with HIV.
Vieira VA, Adland E, Grayson NE, Csala A, Richards F, Dacon C, Athavale R, Tsai MH, D'Souza R, Muenchhoff M, Bonsall D, Jooste P, Goulder PJR.
J Virol. 2022 Jan 26;96(2):e0153521. doi: 10.1128/JVI.01535-21. Epub 2021 Nov 10. PMID: 34757843 PubMed
Genomic epidemiology reveals multiple introductions of SARS-CoV-2 followed by community and nosocomial spread, Germany, February to May 2020.
Muenchhoff M, Graf A, Krebs S, Quartucci C, Hasmann S, Hellmuth JC, Scherer C, Osterman A, Boehm S, Mandel C, Becker-Pennrich AS, Zoller M, Stubbe HC, Munker S, Munker D, Milger K, Gapp M, Schneider S, Ruhle A, Jocham L, Nicolai L, Pekayvaz K, Weinberger T, Mairhofer H, Khatamzas E, Hofmann K, Spaeth PM, Bender S, Kääb S, Zwissler B, Mayerle J, Behr J, von Bergwelt-Baildon M, Reincke M, Grabein B, Hinske CL, Blum H, Keppler OT.
Euro Surveill. 2021 Oct;26(43):2002066. doi: 10.2807/1560-7917.ES.2021.26.43.2002066. PMID: 34713795 PubMed
Impaired function and delayed regeneration of dendritic cells in COVID-19.
Winheim E, Rinke L, Lutz K, Reischer A, Leutbecher A, Wolfram L, Rausch L, Kranich J, Wratil PR, Huber JE, Baumjohann D, Rothenfusser S, Schubert B, Hilgendorff A, Hellmuth JC, Scherer C, Muenchhoff M, von Bergwelt-Baildon M, Stark K, Straub T, Brocker T, Keppler OT, Subklewe M, Krug AB.
PLoS Pathog. 2021 Oct 6;17(10):e1009742. doi: 10.1371/journal.ppat.1009742. eCollection 2021 Oct. PMID: 34614036 Free PMC article. Clinical Trial. PubMed
Robust HIV-specific CD4+ and CD8+ T-cell responses distinguish elite control in adolescents living with HIV from viremic nonprogressors.
Vieira VA, Millar J, Adland E, Muenchhoff M, Roider J, Guash CF, Peluso D, Thomé B, Garcia-Guerrero MC, Puertas MC, Bamford A, Brander C, Carrington M, Martinez-Picado J, Frater J, Tudor-Williams G, Goulder P.
AIDS. 2022 Jan 1;36(1):95-105. doi: 10.1097/QAD.0000000000003078. PMID: 34581306 PubMed
Comparison of four commercial, automated antigen tests to detect SARS-CoV-2 variants of concern.
Osterman A, Iglhaut M, Lehner A, Späth P, Stern M, Autenrieth H, Muenchhoff M, Graf A, Krebs S, Blum H, Baiker A, Grzimek-Koschewa N, Protzer U, Kaderali L, Baldauf HM, Keppler OT.
Med Microbiol Immunol. 2021 Dec;210(5-6):263-275. doi: 10.1007/s00430-021-00719-0. Epub 2021 Aug 20. PMID: 34415422 PubMed
Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19.
Kaiser R, Leunig A, Pekayvaz K, Popp O, Joppich M, Polewka V, Escaig R, Anjum A, Hoffknecht ML, Gold C, Brambs S, Engel A, Stockhausen S, Knottenberg V, Titova A, Haji M, Scherer C, Muenchhoff M, Hellmuth JC, Saar K, Schubert B, Hilgendorff A, Schulz C, Kääb S, Zimmer R, Hübner N, Massberg S, Mertins P, Nicolai L, Stark K.
JCI Insight. 2021 Sep 22;6(18):e150862. doi: 10.1172/jci.insight.150862. PMID: 34403366 Free PMC article. PubMed
Spatially resolved qualified sewage spot sampling to track SARS-CoV-2 dynamics in Munich - One year of experience.
Rubio-Acero R, Beyerl J, Muenchhoff M, Roth MS, Castelletti N, Paunovic I, Radon K, Springer B, Nagel C, Boehm B, Böhmer MM, Graf A, Blum H, Krebs S, Keppler OT, Osterman A, Khan ZN, Hoelscher M, Wieser A; KoCo19-Study Group.
Sci Total Environ. 2021 Nov 25;797:149031. doi: 10.1016/j.scitotenv.2021.149031. Epub 2021 Jul 21. PMID: 34346361 PubMed
Anti-platelet factor 4 antibodies causing VITT do not cross-react with SARS-CoV-2 spike protein.
Greinacher A, Selleng K, Mayerle J, Palankar R, Wesche J, Reiche S, Aebischer A, Warkentin TE, Muenchhoff M, Hellmuth JC, Keppler OT, Duerschmied D, Lother A, Rieg S, Gawaz MP, Mueller KAL, Scheer CS, Napp M, Hahnenkamp K, Lucchese G, Vogelgesang A, Flöel A, Lovreglio P, Stufano A, Marschalek R, Thiele T; Immune-Response in COVID-19 Vaccination Study Group.
Blood. 2021 Oct 7;138(14):1269-1277. doi: 10.1182/blood.2021012938. PMID: 34280256 PubMed
COVID-19 in Patients Receiving CD20-depleting Immunochemotherapy for B-cell Lymphoma.
Gaitzsch E, Passerini V, Khatamzas E, Strobl CD, Muenchhoff M, Scherer C, Osterman A, Heide M, Reischer A, Subklewe M, Leutbecher A, Tast B, Ruhle A, Weiglein T, Stecher SS, Stemmler HJ, Dreyling M, Girl P, Georgi E, Wölfel R, Mateyka L, D'Ippolito E, Schober K, Busch DH, Kager J, Spinner CD, Treiber M, Rasch S, Lahmer T, Iakoubov R, Schneider J, Protzer U, Winter C, Ruland J, Quante M, Keppler OT, von Bergwelt-Baildon M, Hellmuth J, Weigert O.
Hemasphere. 2021 Jun 28;5(7):e603. doi: 10.1097/HS9.0000000000000603. eCollection 2021 Jul. PMID: 34235400 PubMed
Early Initiation of Antiretroviral Therapy Following In Utero HIV Infection Is Associated With Low Viral Reservoirs but Other Factors Determine Viral Rebound.
Millar JR, Bengu N, Vieira VA, Adland E, Roider J, Muenchhoff M, Fillis R, Sprenger K, Ntlantsana V, Fatti I, Archary M, Groll A, Ismail N, García-Guerrero MC, Matthews PC, Ndung'u T, Puertas MC, Martinez-Picado J, Goulder P.
J Infect Dis. 2021 Dec 1;224(11):1925-1934. doi: 10.1093/infdis/jiab223. PMID: 33963757 PubMed
Coincidental SARS-CoV-2 infection and mRNA vaccination: a case report addressing the most important clinical questions.
Eren OE, Tonon M, Schöberl F, Gießen-Jung C, Moosmann A, Hollaus A, Muenchhoff M, Dimitriadis K.
Infection. 2021 Aug;49(4):785-788. doi: 10.1007/s15010-021-01613-w. Epub 2021 May 7. PMID: 33963523 PubMed
Dynamics of SARS-CoV-2 shedding in the respiratory tract depends on the severity of disease in COVID-19 patients.
Munker D, Osterman A, Stubbe H, Muenchhoff M, Veit T, Weinberger T, Barnikel M, Mumm JN, Milger K, Khatamzas E, Klauss S, Scherer C, Hellmuth JC, Giessen-Jung C, Zoller M, Herold T, Stecher S, de Toni EN, Schulz C, Kneidinger N, Keppler OT, Behr J, Mayerle J, Munker S.
Eur Respir J. 2021 Jul 20;58(1):2002724. doi: 10.1183/13993003.02724-2020. Print 2021 Jul. PMID: 33602859 PubMed
Left and right ventricular dysfunction in patients with COVID-19-associated myocardial injury.
Bieber S, Kraechan A, Hellmuth JC, Muenchhoff M, Scherer C, Schroeder I, Irlbeck M, Kaeaeb S, Massberg S, Hausleiter J, Grabmaier U, Orban M, Weckbach LT.
Infection. 2021 Jun;49(3):491-500. doi: 10.1007/s15010-020-01572-8. Epub 2021 Jan 30. PMID: 33515390 PubMed
Liver function test abnormalities at hospital admission are associated with severe course of SARS-CoV-2 infection: a prospective cohort study.
Weber S, Hellmuth JC, Scherer C, Muenchhoff M, Mayerle J, Gerbes AL.
Gut. 2021 Oct;70(10):1925-1932. doi: 10.1136/gutjnl-2020-323800. Epub 2021 Jan 29. PMID: 33514597 PubMed
Myocardial Inflammation and Dysfunction in COVID-19-Associated Myocardial Injury.
Weckbach LT, Curta A, Bieber S, Kraechan A, Brado J, Hellmuth JC, Muenchhoff M, Scherer C, Schroeder I, Irlbeck M, Maurus S, Ricke J, Klingel K, Kääb S, Orban M, Massberg S, Hausleiter J, Grabmaier U.
Circ Cardiovasc Imaging. 2021 Jan;14(1):e012220. doi: 10.1161/CIRCIMAGING.120.011713. Epub 2021 Jan 19. PMID: 33463366 PubMed
Evaluation of two rapid antigen tests to detect SARS-CoV-2 in a hospital setting.
Osterman A, Baldauf HM, Eletreby M, Wettengel JM, Afridi SQ, Fuchs T, Holzmann E, Maier A, Döring J, Grzimek-Koschewa N, Muenchhoff M, Protzer U, Kaderali L, Keppler OT.
Med Microbiol Immunol. 2021 Feb;210(1):65-72. doi: 10.1007/s00430-020-00698-8. Epub 2021 Jan 16. PMID: 33452927 PubMed
Prospective Longitudinal Serosurvey of Healthcare Workers in the First Wave of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pandemic in a Quaternary Care Hospital in Munich, Germany.
Weinberger T, Steffen J, Osterman A, Mueller TT, Muenchhoff M, Wratil PR, Graf A, Krebs S, Quartucci C, Spaeth PM, Grabein B, Adorjan K, Blum H, Keppler OT, Klein M.
Clin Infect Dis. 2021 Nov 2;73(9):e3055-e3065. doi: 10.1093/cid/ciaa1935. PMID: 33388756 PubMed
Vascular neutrophilic inflammation and immunothrombosis distinguish severe COVID-19 from influenza pneumonia.
Nicolai L, Leunig A, Brambs S, Kaiser R, Joppich M, Hoffknecht ML, Gold C, Engel A, Polewka V, Muenchhoff M, Hellmuth JC, Ruhle A, Ledderose S, Weinberger T, Schulz H, Scherer C, Rudelius M, Zoller M, Keppler OT, Zwißler B, von Bergwelt-Baildon M, Kääb S, Zimmer R, Bülow RD, von Stillfried S, Boor P, Massberg S, Pekayvaz K, Stark K.
J Thromb Haemost. 2021 Feb;19(2):574-581. doi: 10.1111/jth.15179. Epub 2020 Dec 20. PMID: 33217134 PubMed
Liver transplantation in a patient after COVID-19 - Rapid loss of antibodies and prolonged viral RNA shedding.
Niess H, Börner N, Muenchhoff M, Khatamzas E, Stangl M, Graf A, Girl P, Georgi E, Koliogiannis D, Denk G, Irlbeck M, Werner J, Guba M.
Am J Transplant. 2021 Apr;21(4):1629-1632. doi: 10.1111/ajt.16349. Epub 2020 Nov 2. PMID: 33047475 PubMed
2020
Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy.
Singh A, Kazer SW, Roider J, Krista KC, Millar J, Asowata OE, Ngoepe A, Ramsuran D, Fardoos R, Ardain A, Muenchhoff M, Kuhn W, Karim F, Ndung'u T, Shalek AK, Goulder P, Leslie A, Kløverpris HN.
Cell Rep. 2020 Sep 15;32(11):108153. doi: 10.1016/j.celrep.2020.108153. PMID: 32937142 PubMed
Immunothrombotic Dysregulation in COVID-19 Pneumonia Is Associated With Respiratory Failure and Coagulopathy.
Nicolai L, Leunig A, Brambs S, Kaiser R, Weinberger T, Weigand M, Muenchhoff M, Hellmuth JC, Ledderose S, Schulz H, Scherer C, Rudelius M, Zoller M, Höchter D, Keppler O, Teupser D, Zwißler B, von Bergwelt-Baildon M, Kääb S, Massberg S, Pekayvaz K, Stark K.
Circulation. 2020 Sep 22;142(12):1176-1189. doi: 10.1161/CIRCULATIONAHA.120.048488. Epub 2020 Jul 28. PMID: 32755393 PubMed
Multicentre comparison of quantitative PCR-based assays to detect SARS-CoV-2, Germany, March 2020.
Muenchhoff M, Mairhofer H, Nitschko H, Grzimek-Koschewa N, Hoffmann D, Berger A, Rabenau H, Widera M, Ackermann N, Konrad R, Zange S, Graf A, Krebs S, Blum H, Sing A, Liebl B, Wölfel R, Ciesek S, Drosten C, Protzer U, Boehm S, Keppler OT.
Euro Surveill. 2020 Jun;25(24):2001057. doi: 10.2807/1560-7917.ES.2020.25.24.2001057. PMID: 32583765 PubMed
HIGH-FREQUENCY failure of combination antiretroviral therapy in paediatric HIV infection is associated with unmet maternal needs causing maternal NON-ADHERENCE.
Millar JR, Bengu N, Fillis R, Sprenger K, Ntlantsana V, Vieira VA, Khambati N, Archary M, Muenchhoff M, Groll A, Grayson N, Adamson J, Govender K, Dong K, Kiepiela P, Walker BD, Bonsall D, Connor T, Bull MJ, Nxele N, Roider J, Ismail N, Adland E, Puertas MC, Martinez-Picado J, Matthews PC, Ndung'u T, Goulder P; Ucwaningo Lwabantwana Consortium.
EClinicalMedicine. 2020 May 8;22:100344. doi: 10.1016/j.eclinm.2020.100344. eCollection 2020 May. PMID: 32510047 PubMed
Clinical and Epidemiological Features of a Family Cluster of Symptomatic and Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
Wolf GK, Glueck T, Huebner J, Muenchhoff M, Hoffmann D, French LE, Keppler OT, Protzer U.
J Pediatric Infect Dis Soc. 2020 Jul 13;9(3):362-365. doi: 10.1093/jpids/piaa060. PMID: 32441753 PubMed
Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection.
Adland E, Millar J, Bengu N, Muenchhoff M, Fillis R, Sprenger K, Ntlantsana V, Roider J, Vieira V, Govender K, Adamson J, Nxele N, Ochsenbauer C, Kappes J, Mori L, van Lobenstein J, Graza Y, Chinniah K, Kapongo C, Bhoola R, Krishna M, Matthews PC, Poderos RP, Lluch MC, Puertas MC, Prado JG, McKerrow N, Archary M, Ndung'u T, Groll A, Jooste P, Martinez-Picado J, Altfeld M, Goulder P.
Nat Commun. 2020 Apr 14;11(1):1767. doi: 10.1038/s41467-020-15632-y. PMID: 32286302 PubMed
Distinct Immunoglobulin Fc Glycosylation Patterns Are Associated with Disease Nonprogression and Broadly Neutralizing Antibody Responses in Children with HIV Infection.
Muenchhoff M, Chung A W, Roider J, Dugast A S, Richardson S, Kloverpris H, Leslie A, Ndung'u T, Moore P, Alter G, Goulder P J R.
mSphere 5 (2020). https://doi.org/10.1128/mSphere.00880-20
2019
Plasma IL-5 but Not CXCL13 Correlates With Neutralization Breadth in HIV-Infected Children.
Roider J, Porterfield JZ, Ogongo P, Muenchhoff M, Adland E, Groll A, Morris L, Moore PL, Ndung'u T, Kløverpris H, Goulder PJR, Leslie A.
Front Immunol. 2019 Jul 2;10:1497. doi: 10.3389/fimmu.2019.01497. eCollection 2019. PMID: 31333650 PubMed
Increased Regulatory T-Cell Activity and Enhanced T-Cell Homeostatic Signaling in Slow Progressing HIV-infected Children.
Roider J, Ngoepe A, Muenchhoff M, Adland E, Groll A, Ndung'u T, Kløverpris H, Goulder P, Leslie A.
Front Immunol. 2019 Feb 12;10:213. doi: 10.3389/fimmu.2019.00213. eCollection 2019. PMID: 30809229 PubMed
Differential Pathogen-Specific Immune Reconstitution in Antiretroviral Therapy-Treated Human Immunodeficiency Virus-Infected Children.
Muenchhoff M, Adland E, Roider J, Kløverpris H, Leslie A, Boehm S, Keppler OT, Ndung'u T, Goulder PJR.
J Infect Dis. 2019 Apr 16;219(9):1407-1417. doi: 10.1093/infdis/jiy668. PMID: 30624717 Free PMC article. PubMed
Strong sex bias in elite control of paediatric HIV infection.
Vieira VA, Zuidewind P, Muenchhoff M, Roider J, Millar J, Clapson M, Van Zyl A, Shingadia D, Adland E, Athavale R, Grayson N, Ansari MA, Brander C, Guash CF, Naver L, Puthanakit T, Songtaweesin WN, Ananworanich J, Peluso D, Thomé B, Pinto J, Jooste P, Tudor-Williams G, Cotton MF, Goulder P.
AIDS. 2019 Jan 27;33(1):67-75. doi: 10.1097/QAD.0000000000002043. PMID: 30325765 PubMed
2018
High-Frequency, Functional HIV-Specific T-Follicular Helper and Regulatory Cells Are Present Within Germinal Centers in Children but Not Adults.
Roider J, Maehara T, Ngoepe A, Ramsuran D, Muenchhoff M, Adland E, Aicher T, Kazer SW, Jooste P, Karim F, Kuhn W, Shalek AK, Ndung'u T, Morris L, Moore PL, Pillai S, Kløverpris H, Goulder P, Leslie A.
Front Immunol. 2018 Sep 12;9:1975. doi: 10.3389/fimmu.2018.01975. eCollection 2018. PMID: 30258437 Free PMC article. Clinical Trial. PubMed
HIV-1 Subtype C-Infected Children with Exceptional Neutralization Breadth Exhibit Polyclonal Responses Targeting Known Epitopes.
Ditse Z, Muenchhoff M, Adland E, Jooste P, Goulder P, Moore PL, Morris L.
J Virol. 2018 Aug 16;92(17):e00878-18. doi: 10.1128/JVI.00878-18. Print 2018 Sep 1. PMID: 29950423 Free PMC article. PubMed
[The HIV reservoir in resting CD4 T-cells: Barrier on the road to an HIV cure].
Muenchhoff M, Keppler OT. MMW Fortschr Med. 2018 Jun;160(Suppl 2):32-35. doi: 10.1007/s15006-018-0653-3. PMID: 29943331 Review. German. No abstract available. PubMed
Recovery of effective HIV-specific CD4+ T-cell activity following antiretroviral therapy in paediatric infection requires sustained suppression of viraemia.
Adland E, Mori L, Laker L, Csala A, Muenchhoff M, Swordy A, Mori M, Matthews P, Tudor-Williams G, Jooste P, Goulder P.
AIDS. 2018 Jul 17;32(11):1413-1422. doi: 10.1097/QAD.0000000000001844. PubMed
2017
Malnutrition in HIV-Infected Children Is an Indicator of Severe Disease with an Impaired Response to Antiretroviral Therapy.
Muenchhoff M, Healy M, Singh R, Roider J, Groll A, Kindra C, Sibaya T, Moonsamy A, McGregor C, Phan MQ, Palma A, Kloverpris H, Leslie A, Bobat R, LaRussa P, Ndung'u T, Goulder P, Sobieszczyk ME, Archary M.
AIDS Res Hum Retroviruses. 2018 Jan;34(1):46-55. doi: 10.1089/AID.2016.0261. Epub 2017 Sep 6. PMID: 28670966 PubMed
2016
Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression.
Kløverpris HN, Kazer SW, Mjösberg J, Mabuka JM, Wellmann A, Ndhlovu Z, Yadon MC, Nhamoyebonde S, Muenchhoff M, Simoni Y, Andersson F, Kuhn W, Garrett N, Burgers WA, Kamya P, Pretorius K, Dong K, Moodley A, Newell EW, Kasprowicz V, Abdool Karim SS, Goulder P, Shalek AK, Walker BD, Ndung'u T, Leslie A.
Immunity. 2016 Feb 16;44(2):391-405. doi: 10.1016/j.immuni.2016.01.006. Epub 2016 Feb 2. PMID: 26850658 Free PMC article. PubMed
Immune activation and paediatric HIV-1 disease outcome.
Roider JM, Muenchhoff M, Goulder PJ.
Curr Opin HIV AIDS. 2016 Mar;11(2):146-55. doi: 10.1097/COH.0000000000000231. PMID: 26679413 PubMed
Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection.
Muenchhoff M, Adland E, Karimanzira O, Crowther C, Pace M, Csala A, Leitman E, Moonsamy A, McGregor C, Hurst J, Groll A, Mori M, Sinmyee S, Thobakgale C, Tudor-Williams G, Prendergast A J, Kloverpris H, Roider J, Leslie A, Shingadia D, Brits T, Daniels S, Frater J, Willberg C B, Walker B D, Ndung'u T, Jooste P, Moore P L, Morris L, Goulder P.
Sci Transl Med. 2016 Sep 28;8(358):358ra125. doi: 10.1126/scitranslmed.aag1048. PubMed
2015
Sex Differences in Antiretroviral Therapy Initiation in Pediatric HIV Infection.
Mori M, Adland E, Paioni P, Swordy A, Mori L, Laker L, Muenchhoff M, Matthews PC, Tudor-Williams G, Lavandier N, van Zyl A, Hurst J, Walker BD, Ndung'u T, Prendergast A, Goulder P, Jooste P.
PLoS One. 2015 Jul 7;10(7):e0131591. doi: 10.1371/journal.pone.0131591. eCollection 2015. PMID: 26151555 PubMed
Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection.
Adland E, Paioni P, Thobakgale C, Laker L, Mori L, Muenchhoff M, Csala A, Clapson M, Flynn J, Novelli V, Hurst J, Naidoo V, Shapiro R, Huang KH, Frater J, Prendergast A, Prado JG, Ndung'u T, Walker BD, Carrington M, Jooste P, Goulder PJ.
PLoS Pathog. 2015 Jun 15;11(6):e1004954. doi: 10.1371/journal.ppat.1004954. eCollection 2015 Jun. PMID: 26076345 PubMed
Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence.
Payne R, Muenchhoff M, Mann J, Roberts HE, Matthews P, Adland E, Hempenstall A, Huang KH, Brockman M, Brumme Z, Sinclair M, Miura T, Frater J, Essex M, Shapiro R, Walker BD, Ndung'u T, McLean AR, Carlson JM, Goulder PJ.
Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5393-400. doi: 10.1073/pnas.1413339111. Epub 2014 Dec 1. PMID: 25453107 PubMed
Impact of HLA selection pressure on HIV fitness at a population level in Mexico and Barbados.
Juarez-Molina CI, Payne R, Soto-Nava M, Avila-Rios S, Valenzuela-Ponce H, Adland E, Leitman E, Brener J, Muenchhoff M, Branch S, Landis C, Reyes-Teran G, Goulder P.
J Virol. 2014 Sep;88(18):10392-8. doi: 10.1128/JVI.01162-14. PubMed
Immunity to HIV in Early Life.
Muenchhoff M, Prendergast AJ, Goulder PJ.
Front Immunol. 2014 Aug 12;5:391. doi: 10.3389/fimmu.2014.00391. eCollection 2014. PMID: 25161656 Free PMC article. PubMed
Evaluation of the NucliSens EasyQ v2.0 assay in comparison with the Roche Amplicor v1.5 and the Roche CAP/CTM HIV-1 Test v2.0 in quantification of C-clade HIV-1 in plasma.
Muenchhoff M, Madurai S, Hempenstall AJ, Adland E, Carlqvist A, Moonsamy A, Jaggernath M, Mlotshwa B, Siboto E, Ndung'u T, Goulder PJ.
PLoS One. 2014 Aug 26;9(8):e103983. doi: 10.1371/journal.pone.0103983. eCollection 2014. PMID: 25157919 PubMed
Sex differences in pediatric infectious diseases.
Muenchhoff M, Prendergast A J, Goulder P J. Immunity to HIV in Early Life. Frontiers in Immunology 5:391 (2014). https://doi.org/10.3389/fimmu.2014.00391
Muenchhoff M, Goulder P J.
Journal of Infectious Diseases 209 Suppl 3:S120-6 (2014). https://doi.org/10.1093/infdis/jiu232