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Hopfner Lab - Publications

2018   |   2017   |   2016   |   2015   |   2014   |   2013   |   2012   |   2011   |   2010   |   2009   |   2008   |   2007   |   2006   |   2005   |   2004   |   2003   |   2002   |   2001   |   2000 and before


2018

Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants.
Lässig C, Lammens K, Gorenflos López JL, Michalski S, Fettscher O, Hopfner KP.
eLife 2018;7:e38958. PubMed

Human TGF-β1 deficiency causes severe inflammatory bowel disease and encephalopathy.
Kotlarz D, Marquardt B, Barøy T, Lee WS, Konnikova L, Hollizeck S, Magg T, Lehle AS, Walz C, Borggraefe I, Hauck F, Bufler P, Conca R, Wall SM, Schumacher EM, Misceo D, Frengen E, Bentsen BS, Uhlig HH, Hopfner KP, Muise AM, Snapper SB, Strømme P, Klein C.
Nat Genet. 2018 Mar;50(3):344-348. doi: 10.1038/s41588-018-0063-6. Epub 2018 Feb 26. PubMed

Structural basis for ATP dependent chromatin remodelling by the INO80 complex.
Eustermann S, Schall K, Kostrewa D, Lakomek K, Strauss M, Moldt M, Hopfner KP.
Nature. 2018 April 11; doi:10.1038/s41586-018-0029-y. PubMed

Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity.
Chiang JJ, Sparrer KMJ, van Gent M, Lässig C, Huang T, Osterrieder N, Hopfner KP, Gack MU.
Nat Immunol. 2018 Jan;19(1):53-62. doi: 10.1038/s41590-017-0005-y. Epub 2017 Nov 27. PubMed

Single Molecule Nucleosome Remodeling by INO80 and Effects of Histone Tails.
Schwarz M, Schall K, Kallis E, Eustermann S, Guariento M, Moldt M, Hopfner KP, Michaelis J.
FEBS Lett. 2018 Jan 13. doi: 10.1002/1873-3468.12973. [Epub ahead of print] PubMed

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2017

Mechanistic insight into the assembly of the HerA-NurA helicase-nuclease DNA end resection complex.
Ahdash Z, Lau AM, Byrne RT, Lammens K, Stüetzer A, Urlaub H, Booth PJ, Reading E, Hopfner KP, Politis A.
Nucleic Acids Res. 2017 Nov 16;45(20):12025-12038. doi: 10.1093/nar/gkx890. PubMed

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.
Andreeva L, Hiller B, Kostrewa D, Lässig C, de Oliveira Mann CC, Jan Drexler D, Maiser A, Gaidt M, Leonhardt H, Hornung V, Hopfner KP.
Nature. 2017 Sep 21;549(7672):394-398. doi: 10.1038/nature23890. Epub 2017 Sep 13. PubMed

Discrimination of cytosolic self and non-self RNA by RIG-I-like receptors.
Lässig C, Hopfner KP.
J Biol Chem. 2017 Jun 2;292(22):9000-9009. doi: 10.1074/jbc.R117.788398. Epub 2017 Apr 14. PubMed

SIRPα-antibody fusion proteins stimulate phagocytosis and promote elimination of acute myeloid leukemia cells.
Ponce LP, Fenn NC, Moritz N, Krupka C, Kozik JH, Lauber K, Subklewe M, Hopfner KP.
Oncotarget. 2017 Jan 4. doi: 10.18632/oncotarget.14500. PubMed

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2016

RPA Mediates Recruitment of MRX to Forks and Double-Strand Breaks to Hold Sister Chromatids Together.
Seeber A, Hegnauer AM, Hustedt N, Deshpande I, Poli J, Eglinger J, Pasero P, Gut H, Shinohara M, Hopfner KP, Shimada K, Gasser SM.
Mol Cell. 2016 Dec 1;64(5):951-966. doi: 10.1016/j.molcel.2016.10.032. PubMed

CD19-specific triplebody SPM-1 engages NK and γδ T cells for rapid and efficient lysis of malignant B-lymphoid cells.
Schiller CB, Braciak TA, Fenn NC, Seidel UJ, Roskopf CC, Wildenhain S, Honegger A, Schubert IA, Schele A, Lämmermann K, Fey GH, Jacob U, Lang P, Hopfner KP, Oduncu FS.
Oncotarget. 2016 Nov 4. doi: 10.18632/oncotarget.13110. PubMed

Impact of Heterogeneity and Lattice Bond Strength on DNA Triangle Crystal Growth.
Stahl E, Praetorius F, de Oliveira Mann CC, Hopfner KP, Dietz H.
ACS Nano. 2016 Sep 7. PubMed

Structural and biochemical characterization of the cell fate determining nucleotidyltransferase fold protein MAB21L1.
de Oliveira Mann CC, Kiefersauer R, Witte G, Hopfner KP.
Sci Rep. 2016 Jun 8;6:27498. doi: 10.1038/srep27498. PubMed

ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation.
Hartmann L, Dutta S, Opatz S, Vosberg S, Reiter K, Leubolt G, Metzeler KH, Herold T, Bamopoulos SA, Bräundl K, Zellmeier E, Ksienzyk B, Konstandin NP, Schneider S, Hopfner KP, Graf A, Krebs S, Blum H, Middeke JM, Stölzel F, Thiede C, Wolf S, Bohlander SK, Preiss C, Chen-Wichmann L, Wichmann C, Sauerland MC, Büchner T, Berdel WE, Wörmann BJ, Braess J, Hiddemann W, Spiekermann K, Greif PA.
Nat Commun. 2016 Jun 2;7:11733. doi: 10.1038/ncomms11733. PubMed

Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50.
Seifert FU, Lammens K, Stoehr G, Kessler B, Hopfner KP.
EMBO J. 2016 Apr 1;35(7):759-72. doi: 10.15252/embj.201592934. Epub 2016 Feb 19. PubMed

RIG-I-Like Receptors: One STrEP Forward.
Lässig C, Hopfner KP.
Trends Microbiol. 2016 Jul;24(7):517-9. doi: 10.1016/j.tim.2016.05.001. Epub 2016 May 25. PubMed

Architectures and mechanisms of ABC proteins.
Hopfner KP.
Biopolymers. 2016 Mar 31. doi: 10.1002/bip.22843. PubMed

Editorial overview: Macromolecular machines and assemblies.
Barford D, Hopfner KP.
Curr Opin Struct Biol. 2016 Mar 16. pii: S0959-440X(16)30011-2. doi: 10.1016/j.sbi.2016.03.002 PubMed

Dual-targeting triplebody 33-3-19 mediates selective lysis of biphenotypic CD19+ CD33+ leukemia cells.
Roskopf CC, Braciak TA, Fenn NC, Kobold S, Fey GH, Hopfner KP, Oduncu FS.
Oncotarget. 2016 Mar 10. doi: 10.18632/oncotarget.802 PubMed

Chip-based platform for dynamic analysis of NK cell cytolysis mediated by a triplebody.
Chatzopoulou EI, Roskopf CC, Sekhavati F, Braciak TA, Fenn NC, Hopfner KP, Oduncu FS, Fey GH, Rädler JO.
Analyst. 2016 Mar 21;141(7):2284-95. doi: 10.1039/c5an02585k. PubMed

Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress.
Poli J, Gerhold CB, Tosi A, Hustedt N, Seeber A, Sack R, Herzog F, Pasero P, Shimada K, Hopfner KP, Gasser SM.
Genes Dev. 2016 Feb 1;30(3):337-54. PubMed

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2015

ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.
Lässig C, Matheisl S, Sparrer KM, de Oliveira Mann CC, Moldt M, Patel JR, Goldeck M, Hartmann G, García-Sastre A, Hornung V, Conzelmann KK, Beckmann R, Hopfner KP.
Elife. 2015 Nov 26;4. pii: e10859. PubMed

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA.
Herzner AM, Hagmann CA, Goldeck M, Wolter S, Kübler K, Wittmann S, Gramberg T, Andreeva L, Hopfner KP, Mertens C, Zillinger T, Jin T, Xiao TS, Bartok E, Coch C, Ackermann D, Hornung V, Ludwig J, Barchet W, Hartmann G, Schlee M.
Nat Immunol. 2015 Oct;16(10):1025-33. doi: 10.1038/ni.3267. Epub 2015 Sep 7 PubMed

Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1.
Butryn A, Schuller JM, Stoehr G, Runge-Wollmann P, Förster F, Auble DT, Hopfner KP.
Elife. 2015 Aug 10;4. doi: 10.7554/eLife.07432 PubMed

Structure of the catalytic domain of Mre11 from Chaetomium thermophilum.
Seifert FU, Lammens K, Hopfner KP.
Acta Crystallogr F Struct Biol Commun. 2015 Jun 1;71(Pt 6):752-7. doi: 10.1107/S2053230X15007566. Epub 2015 May 22. PubMed

Structural analysis of the di-adenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3'-dATP.
Müller M, Deimling T, Hopfner KP, Witte G.
Biochem J. 2015 May 27. PubMed

Serendipitous crystallization and structure determination of cyanase (CynS) from Serratia proteamaculans.
Butryn A, Stoehr G, Linke-Winnebeck C, Hopfner KP.
Acta Crystallogr F Struct Biol Commun. 2015 Apr;71(Pt 4):471-6. doi: 10.1107/S2053230X15004902. PubMed

Structural basis for dodecameric assembly states and conformational plasticity of the full-length AAA+ ATPases Rvb1 · Rvb2.
Lakomek K, Stoehr G, Tosi A, Schmailzl M, Hopfner KP.
Structure. 2015 Mar 3;23(3):483-95. doi: 10.1016/j.str.2014.12.015. Epub 2015 Feb 5. PubMed

Activity-based probes for detection of active MALT1 paracaspase in immune cells and lymphomas.
Eitelhuber AC, Vosyka O, Nagel D, Bognar M, Lenze D, Lammens K, Schlauderer F, Hlahla D, Hopfner KP, Lenz G, Hummel M, Verhelst SH, Krappmann D.
Chem Biol. 2015 Jan 22;22(1):129-38. doi: 10.1016/j.chembiol.2014.10.021. Epub 2014 Dec 31. PubMed

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2014

Molecular architecture of the HerA-NurA DNA double-strand break resection complex. Byrne RT, Schuller JM, Unverdorben P, Förster F, Hopfner KP.
FEBS Lett. 2014 Dec 20;588(24):4637-44. doi: 10.1016/j.febslet.2014.10.035. Epub 2014 Nov 11. PubMed

c-di-AMP recognition by Styphylococcus aureus PstA
Müller M., Hopfner KP and Witte G.
FEBS Lett. 2014 Nov 27 pii: S0014-5793(14)00827-8. doi: 10.1016/j.febslet.2014.11.022. [Epub ahead of print] PubMed

Structure of the Rad50 DNA double-strand break repair protein in complex with DNA.
Rojowska A, Lammens K, Seifert FU, Direnberger C, Feldmann H, Hopfner KP.
EMBO J. 2014 Oct 27. PubMed

ATP puts the brake on DNA double-strand break repair: A new study shows that ATP switches the Mre11-Rad50-Nbs1 repair factor between signaling and processing of DNA ends.
Hopfner KP.
Bioessays. 2014 Sep 11. doi: 10.1002/bies.201400102 PubMed

RIG-I Holds the CARDs in a Game of Self versus Nonself.
Hopfner KP.
Mol Cell. 2014 Aug 21;55(4):505-7. doi: 10.1016/j.molcel.2014.08.009. PubMed

T cell-recruiting triplebody 19-3-19 mediates serial lysis of malignant B-lymphoid cells by a single T cell.
Roskopf CC, Schiller CB, Braciak TA, Kobold S, Schubert IA, Fey GH, Hopfner KP, Oduncu FS.
Oncotarget. 2014 Aug 30;5(15):6466-83. PubMed

OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids.
Hornung V, Hartmann R, Ablasser A, Hopfner KP.
Nat Rev Immunol. 2014 Aug;14(8):521-8. doi: 10.1038/nri3719. Epub 2014 Jul 18. PubMed

Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia.
Gockel I, Becker J, Wouters MM, Niebisch S, Gockel HR, Hess T, Ramonet D, Zimmermann J, Vigo AG, Trynka G, de León AR, de la Serna JP, Urcelay E, Kumar V, Franke L, Westra HJ, Drescher D, Kneist W, Marquardt JU, Galle PR, Mattheisen M, Annese V, Latiano A, Fumagalli U, Laghi L, Cuomo R, Sarnelli G, Müller M, Eckardt AJ, Tack J, Hoffmann P, Herms S, Mangold E, Heilmann S, Kiesslich R, von Rahden BH, Allescher HD, Schulz HG, Wijmenga C, Heneka MT, Lang H, Hopfner KP, Nöthen MM, Boeckxstaens GE, de Bakker PI, Knapp M, Schumacher J.
Nat Genet. 2014 Aug;46(8):901-4. doi: 10.1038/ng.3029. Epub 2014 Jul 6. PubMed

Structural Studies of DNA End Detection and Resection in Homologous Recombination.
Schiller CB, Seifert FU, Linke-Winnebeck C, Hopfner KP.
Cold Spring Harb Perspect Biol. 2014 Jul 31. pii: a017962. doi: 10.1101/cshperspect.a017962. PubMed

Crystallization of Mouse RIG-I ATPase Domain: In Situ Proteolysis.
Civril F, Hopfner KP.
Methods Mol Biol. 2014;1169:27-35. doi: 10.1007/978-1-4939-0882-0_3. PubMed

Single-molecule choreography between telomere proteins and G quadruplexes.
Hopfner KP.
Structure. 2014 Jun 10;22(6):801-2. doi: 10.1016/j.str.2014.05.011. PubMed

Crystal and solution structure of the human RIG-I SF2 domain
Deimling T, Cui S, Lammens K, Hopfner KP, Witte G.
Acta Cryst. (2014). F70, 1027-1031 PubMed

Editorial overview: Theory and simulation: Macromolecular machines.
Hopfner KP, Smith TJ.
Curr Opin Struct Biol. 2014 May 12. pii: S0959-440X(14)00045-1. doi: 10.1016/j.sbi.2014.04.005. [Epub ahead of print] PubMed

Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production.
Roth S, Rottach A, Lotz-Havla AS, Laux V, Muschaweckh A, Gersting SW, Muntau AC, Hopfner KP, Jin L, Vanness K, Petrini JH, Drexler I, Leonhardt H, Ruland J.
Nat Immunol. 2014 Apr 28. PubMed

In Vivo Ligands of MDA5 and RIG-I in Measles Virus-Infected Cells.
Runge S, Sparrer KM, Lässig C, Hembach K, Baum A, García-Sastre A, Söding J, Conzelmann KK, Hopfner KP.
PLoS Pathog. 2014 Apr 17;10(4):e1004081. PubMed

Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myeloid leukemia.
Janke H, Pastore F, Schumacher D, Herold T, Hopfner KP, Schneider S, Berdel WE, Büchner T, Woermann BJ, Subklewe M, Bohlander SK, Hiddemann W, Spiekermann K, Polzer H.
PLoS One. 2014 Mar 7;9(3):e89560. PubMed

Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses.
Liang Q, Seo GJ, Choi YJ, Kwak MJ, Ge J, Rodgers MA, Shi M, Leslie BJ, Hopfner KP, Ha T, Oh BH, Jung JU.
Cell Host Microbe. 2014 Feb 12;15(2):228-38. doi: 10.1016/j.chom.2014.01.009. PubMed

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2013

NK cells from an AML patient have recovered in remission and reached comparable cytolytic activity to that of a healthy monozygotic twin mediated by the single-chain triplebody SPM-2.
Braciak TA, Wildenhain S, Roskopf CC, Schubert IA, Fey GH, Jacob U, Hopfner KP, Oduncu FS.
J Transl Med. 2013 Nov 16;11(1):289. [Epub ahead of print] PubMed

Structure and Subunit Topology of the INO80 Chromatin Remodeler and Its Nucleosome Complex
Tosi A, Haas C, Herzog F, Gilmozzi A, Berninghausen O, Ungewickell C, Gerhold CB, Lakomek K, Aebersold R, Beckmann R, Hopfner KP.
Cell, Volume 154, Issue 6, 1207-1219, 12 September 2013 PubMed

Structural Analysis of Phenothiazine Derivatives as Allosteric Inhibitors of the MALT1 Paracaspase.
Schlauderer F, Lammens K, Nagel D, Vincendeau M, Eitelhuber AC, Verhelst SH, Kling D, Chrusciel A, Ruland J, Krappmann D, Hopfner KP.
Angew Chem Int Ed Engl. 2013 Aug 14. doi: 10.1002/anie.201304290. PubMed

Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia.
Opatz S, Polzer H, Herold T, Konstandin NP, Ksienzyk B, Zellmeier E, Vosberg S, Graf A, Krebs S, Blum H, Hopfner KP, Kakadia PM, Schneider S, Dufour A, Braess J, Sauerland MC, Berdel WE, Büchner T, Woermann BJ, Hiddemann W, Spiekermann K, Bohlander SK, Greif PA.
Blood. 2013 Sep 5;122(10):1761-9. doi: 10.1182/blood-2013-01-476473. Epub 2013 Jul 22. PubMed

RG7116, a Therapeutic Antibody That Binds the Inactive HER3 Receptor and Is Optimized for Immune Effector Activation.
Mirschberger C, Schiller CB, Schräml M, Dimoudis N, Friess T, Gerdes CA, Reiff U, Lifke V, Hoelzlwimmer G, Kolm I, Hopfner KP, Niederfellner G, Bossenmaier B.
Cancer Res. 2013 Aug 15;73(16):5183-94. doi: 10.1158/0008-5472.CAN-13-0099. Epub 2013 Jun 18. PubMed

Structural mechanism of cytosolic DNA sensing by cGAS.
Civril F, Deimling T, de Oliveira Mann CC, Ablasser A, Moldt M, Witte G, Hornung V, Hopfner KP.
Nature. 2013 May 30. doi: 10.1038/nature12305 PubMed

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.
Ablasser A, Goldeck M, Cavlar T, Deimling T, Witte G, Röhl I, Hopfner KP, Ludwig J, Hornung V.
Nature. 2013 May 30. doi: 10.1038/nature12306 PubMed

Crystal Structure of Human TWEAK in Complex with the Fab Fragment of a Neutralizing Antibody Reveals Insights into Receptor Binding.
Lammens A, Baehner M, Kohnert U, Niewoehner J, von Proff L, Schraeml M, Lammens K, Hopfner KP.
PLoS One. 8;8(5):e62697. doi: 10.1371/journal.pone.0062697 (2013) PubMed

Species-specific detection of the antiviral small-molecule compound CMA by STING.
Cavlar T, Deimling T, Ablasser A, Hopfner KP, Hornung V.
EMBO J. 2013 Apr 19. doi: 10.1038/emboj.2013.86. PubMed

Crystal Structure of an Anti-Ang2 CrossFab Demonstrates Complete Structural and Functional Integrity of the Variable Domain.
Fenn S, Schiller CB, Griese JJ, Duerr H, Imhof-Jung S, Gassner C, Moelleken J, Regula JT, Schaefer W, Thomas M, Klein C, Hopfner KP, Kettenberger H.
PLoS One. 2013 Apr 17;8(4):e61953. doi: 10.1371/journal.pone.0061953. PubMed

Response to: Monoclonal antibodies targeting CD20.
Klein C, Lammens A, Schäfer W, Georges G, Schwaiger M, Mössner E, Hopfner KP, Umaña P, Niederfellner G.
MAbs. 2013 Mar 14;5(3). PubMed

Paramyxovirus V Proteins Disrupt the Fold of the RNA Sensor MDA5 to Inhibit Antiviral Signaling
Motz C, Schuhmann KM, Kirchhofer A, Moldt M, Witte G, Conzelmann KK, Hopfner KP.
Science. January 17 2013 Science DOI: 10.1126/science.1230949 (Science Express) PubMed

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2012

Epitope interactions of monoclonal antibodies targeting CD20 and their relationship to functional properties.
Klein C, Lammens A, Schäfer W, Georges G, Schwaiger M, Mössner E, Hopfner KP, Umana P, Niederfellner G.
MAbs. 2012 Dec 4;5(1). [Epub ahead of print] PubMed

Rustless translation.
Hopfner KP.
Biol Chem. 2012 Oct 1;393(10):1079-88. doi: 10.1515/hsz-2012-0196. PubMed

RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids.
Abdullah Z, Schlee M, Roth S, Mraheil MA, Barchet W, Böttcher J, Hain T, Geiger S, Hayakawa Y, Fritz JH, Civril F, Hopfner KP, Kurts C, Ruland J, Hartmann G, Chakraborty T, Knolle PA.
EMBO J. 2012 Oct 12. doi: 10.1038/emboj.2012.274. PubMed

Structure of Actin-related protein 8 and its contribution to nucleosome binding.
Gerhold CB, Winkler DD, Lakomek K, Seifert FU, Fenn S, Kessler B, Witte G, Luger K, Hopfner KP.
Nucleic Acids Res. 2012 Sep 12. [Epub ahead of print] PubMed

Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.
Schiller CB, Lammens K, Guerini I, Coordes B, Feldmann H, Schlauderer F, Möckel C, Schele A, Strässer K, Jackson SP, Hopfner KP.
Nat Struct Mol Biol. 2012 Jun 17;19(7):693-700. doi: 10.1038/nsmb.2323. PubMed

Correlating calcium binding, Förster resonance energy transfer, and conformational change in the biosensor TN-XXL.
Geiger A, Russo L, Gensch T, Thestrup T, Becker S, Hopfner KP, Griesinger C, Witte G, Griesbeck O.
Biophys J. 2012 May 16;102(10):2401-10. Epub 2012 May 15. PubMed

GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia.
Greif PA, Dufour A, Konstandin NP, Ksienzyk B, Zellmeier E, Tizazu B, Sturm J, Benthaus T, Herold T, Yaghmaie M, Dörge P, Hopfner KP, Hauser A, Graf A, Krebs S, Blum H, Kakadia PM, Schneider S, Hoster E, Schneider F, Stanulla M, Braess J, Sauerland MC, Berdel WE, Büchner T, Woermann BJ, Hiddemann W, Spiekermann K, Bohlander SK.
Blood. 2012 Jul 12;120(2):395-403. Epub 2012 May 30. PubMed

Swi2/Snf2 remodelers: hybrid views on hybrid molecular machines.
Hopfner KP
, Gerhold CB, Lakomek K, Wollmann P.
Curr Opin Struct Biol. 2012 Apr;22(2):225-33. Epub 2012 Mar 23. PubMed

Structural basis of highly conserved ribosome recycling in eukaryotes and archaea.
Becker T, Franckenberg S, Wickles S, Shoemaker CJ, Anger AM, Armache JP, Sieber H, Ungewickell C, Berninghausen O, Daberkow I, Karcher A, Thomm M, Hopfner KP, Green R, Beckmann R.
Nature. 2012 Feb 22;482(7386):501-6. doi: 10.1038/nature10829. PubMed

Syk Kinase-Coupled C-type Lectin Receptors Engage Protein Kinase C-δ to Elicit Card9 Adaptor-Mediated Innate Immunity.
Strasser D, Neumann K, Bergmann H, Marakalala MJ, Guler R, Rojowska A, Hopfner KP, Brombacher F, Urlaub H, Baier G, Brown GD, Leitges M, Ruland J.
Immunity. 2012 Jan 18. [Epub ahead of print] PubMed

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2011

Nuclear actin-related proteins take shape.
Fenn S, Gerhold CB, Hopfner KP.
Bioarchitecture. 2011 Jul;1(4):192-195. Epub 2011 Jul 1. PubMed

The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling.
Civril F, Bennett M, Moldt M, Deimling T, Witte G, Schiesser S, Carell T, Hopfner KP.
EMBO reports (2011) 12, 1127 - 1134;doi:10.1038/embor.2011.190 PubMed

Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth.
Blattner C, Jennebach S, Herzog F, Mayer A, Cheung ACM, Witte G, Lorenzen K, Hopfner KP, Heck AJR, Aebersold R and Cramer P.
Genes Dev. 2011 Sep 22. [Epub ahead of print] PubMed

ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex.
Möckel C, Lammens K, Schele A, Hopfner KP.
Nucl. Acids Res. (2011) September 21, 2011 doi:10.1093/nar/gkr749 PubMed

Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex with its substrate TBP.
Wollmann P, Cui S, Viswanathan R, Berninghausen O, Wells MN, Moldt M, Witte G, Butryn A, Wendler P, Beckmann R, Auble DT, Hopfner KP.
Nature. 2011 Jul 6;475(7356):403-7. doi: 10.1038/nature10215.
News and Views article in NSMB "A bottle opener for TBP." by Sabbi Lall (Nat Struct Mol Biol. 2011 Aug 3;18(8):865. doi: 10.1038/nsmb0811-865.) PubMed

Bispecific digoxigenin-binding antibodies for targeted payload delivery.
Metz S, Haas AK, Daub K, Croasdale R, Stracke J, Lau W, Georges G, Josel HP, Dziadek S, Hopfner KP, Lammens A, Scheuer W, Hoffmann E, Mundigl O, Brinkmann U.
Proc Natl Acad Sci USA. 2011 May 17;108(20):8194-9. Epub 2011 May 2. PubMed

Structural biochemistry of nuclear actin-related proteins 4 and 8 reveals their interaction with actin.
Fenn S, Breitsprecher D, Gerhold CB, Witte G, Faix J, Hopfner KP.
EMBO J. 2011 Apr 15.
Commentary in EMBO J 2011 Jun 1;30(11):2097-8. PubMed

Sensing of viral nucleic acids by RIG-I: From translocation to translation.
Schmidt A, Rothenfusser S, Hopfner KP.
Eur J Cell Biol. 2011 Apr 13. [Epub ahead of print] PubMed

The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair.
Lammens K, Bemeleit DJ, Möckel C, Clausing E, Schele A, Hartung S, Schiller C.B., Lucas M, Angermüller C, Söding J, Sträßer K, Hopfner KP.
Cell. 2011 Apr 1; Vol 145, Issue 1, p.54-66 [Epub ahead of print] PubMed

Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies.
Niederfellner G, Lammens A, Mundigl O, Georges GJ, Schaefer W, Schwaiger M, Franke A, Wiechmann K, Jenewein S, Slootstra JW, Timmerman P, Brännström A, Lindstrom F, Mössner E, Umana P, Hopfner KP, Klein C.
Blood. 2011 Mar 28. [Epub ahead of print] PubMed

Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease.
Cario H, Smith DE, Blom H, Blau N, Bode H, Holzmann K, Pannicke U, Hopfner KP, Rump EM, Ayric Z, Kohne E, Debatin KM, Smulders Y, Schwarz K.
Am J Hum Genet. 2011 Feb 11;88(2):226-31. PubMed

Processive RNA decay by the exosome: Merits of a quantitative Bayesian sampling approach.
Niederberger T, Hartung S, Hopfner KP, Tresch A.
RNA Biol. 2011 Jan 1;8(1). [Epub ahead of print] PubMed

Structure and DNA-binding activity of the Pyrococcus furiosus SMC protein hinge domain.
Griese JJ, Hopfner KP.
Proteins. 2011 Feb;79(2):558-68. PubMed

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2010

Reversible and Controllable Nanolocomotion of an RNA-Processing Machinery.
Lee G, Hartung S, Hopfner KP, Ha T.
Nano Lett. 2010 Nov 17. [Epub ahead of print] PubMed

Mechanism of replication blocking and bypass of Y-family polymerase eta by bulky acetylaminofluorene DNA adducts.
Schorr S, Schneider S, Lammens K, Hopfner KP, Carell T.
Proc Natl Acad Sci USA. 2010 Nov 12. [Epub ahead of print] PubMed

Structural Basis for Adenylate Kinase Activity in ABC ATPases.
Lammens A, Hopfner KP.
J Mol Biol. 2010 Jun 19. [Epub ahead of print] PubMed

Quantitative analysis of processive RNA degradation by the archaeal RNA exosome.
Hartung S, Niederberger T, Hartung M, Tresch A, Hopfner KP.
Nucleic Acids Res. 2010 Apr 14. [Epub ahead of print] PubMed

Structure and DNA binding activity of the mouse condensin hinge domain highlight common and diverse features of SMC proteins.
Griese JJ, Witte G, Hopfner KP.
Nucleic Acids Res. 2010 Feb 5. PubMed

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2009

Modulation of protein properties in living cells using nanobodies.
Kirchhofer A, Helma J, Schmidthals K, Frauer C, Cui S, Karcher A, Pellis M, Muyldermans S, Casas-Delucchi CS, Cardoso MC, Leonhardt H, Hopfner KP, Rothbauer U.
Nat Struct Mol Biol. 2010 Jan;17(1):133-8. Epub 2009 Dec 13.
Research Highlight in Nature Methods (Nat. Methods, February 2010 Vol. 7, No.2, p102) PubMed

DNA double-strand breaks come into focus.
Hopfner, KP
.
Cell. 2009 Oct 2;139(1):25-7 PubMed

5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I.
Schmidt A, Schwerd T, Hamm W, Hellmuth JC, Cui S, Wenzel M, Hoffmann FS, Michallet MC, Besch R, Hopfner KP, Endres S, Rothenfusser S.
Proc Natl Acad Sci USA. 2009 Jul 21;106(29):12067-72. Epub 2009 Jul 2. PubMed

Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II .
Schwarz K, Iolascon A, Verissimo F, Trede NS, Horsley W, Chen W, Paw BH, Hopfner KP, Holzmann K, Russo R, Esposito MR, Spano D, De Falco L, Heinrich K, Joggerst B, Rojewski MT, Perrotta S, Denecke J, Pannicke U, Delaunay J, Pepperkok R, Heimpel H.
Nat Genet. 2009 Aug;41(8):936-40. Epub 2009 Jun 28 PubMed

The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA.
Pippig DA, Hellmuth JC, Cui S, Kirchhofer A, Lammens K, Lammens A, Schmidt A, Rothenfusser S, Hopfner KP.
Nucleic Acids Research. 2009; doi: 10.1093/nar/gkp059 PubMed

Lessons from structural and biochemical studies on the archaeal exosome.
Hartung S, Hopfner KP.
Biochem Soc Trans. 2009 Feb;37(Pt 1):83-7 PubMed

Cytosolic Viral Sensor RIG-I Is a 5'-Triphosphate-Dependent Translocase on Double-Stranded RNA.
Myong S, Cui S, Cornish PV, Kirchhofer A, Gack MU, Jung JU, Hopfner KP, Ha T.
Science. 2009 Jan 1. [Epub ahead of print] PubMed

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2008

Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction.
Gack MU, Kirchhofer A, Shin YC, Inn KS, Liang C, Cui S, Myong S, Ha T, Hopfner KP, Jung JU.
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16743-8. Epub 2008 Oct 23 PubMed

Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates.
Witte G, Hartung S, Büttner K, Hopfner KP.
Mol Cell. 2008 Apr 25;30(2):167-178 Editor's choice in Science Signaling (Sci. Signal., 29 April 2008 Vol. 1, Issue 17, p. ec151) Perspective in Science Signaling by Ute Römling (Sci. Signal., 19 August 2008 Vol. 1, Issue 33, p. pe39) Chosen as ESRF Scientific Highlight 2008 (ESRF Highlights 2008, p56) PubMed

Conformational changes of a Swi2/Snf2 ATPase during its mechano-chemical cycle.
Lewis R, Dürr H, Hopfner KP, Michaelis J.
Nucleic Acids Res., 2008 Apr;36(6):1881-90. Epub 2008 Feb 11. PubMed

The C-Terminal Regulatory Domain Is the RNA 5'-Triphosphate Sensor of RIG-I.
Cui S, Eisenächer K, Kirchhofer A, Brzózka K, Lammens A, Lammens K, Fujita T, Conzelmann KK, Krug A, Hopfner KP.
Mol Cell. 2008 Feb 1;29(2):169-179 PubMed

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2007

X-ray structure of the complete ABC enzyme ABCE1 from Pyrococcus abyssi.
Karcher A, Schele A, Hopfner KP.
J Biol Chem. 2007 Dec 26; [Epub ahead of print] PubMed

The chemistry of transcription through damaged DNA and of translesion synthesis at atomic resolution.
Carell T, Cramer P, Hopfner KP.
Nucleic Acids Symp Ser (Oxf). 2007;(51):103. PubMed

Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta.
Alt A, Lammens K, Chiocchini C, Lammens A, Pieck JC, Kuch D, Hopfner KP, Carell T.
Science. 2007 Nov 9;318(5852):967-70. PubMed

Structural basis for DNA duplex separation by a superfamily-2 helicase.
Büttner K, Nehring S, Hopfner KP.
Nat Struct Mol Biol. 2007 Jul;14(7):647-52. Epub 2007 Jun 10. PubMed

The exosome, plugged.
Hartung S, Hopfner KP.
EMBO Rep. 2007 May; 8(5):456-7. PubMed

Mechanisms of nucleic acid translocases: lessons from structural biology and single-molecule biophysics.
Hopfner KP
, Michaelis J.
Curr Opin Struct Biol. 2007 Feb;17(1):87-95. PubMed

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2006

Establishment of sister chromatid cohesion and the S. cerevisiae replication fork.
Lengronne A, McIntyre J, Katou Y, Kanoh Y, Hopfner KP, Shirahige K, Uhlmann F.
Mol. Cell. 2006;23:1-13. PubMed

The exosome: a macromolecular cage for controlled RNA degradation.
Büttner K, Wenig K, Hopfner KP.
Mol. Microbiology. 2006;61:1372-1379. PubMed

Das Exosom.
Büttner K, Hopfner KP.
Bioforum. 2006; 29:19-21. PubMed

Snf2 family ATPases and DExx box helicases: differences and unifying concepts from high-resolution crystal structures.
Durr H, Flaus A, Owen-Hughes TA, Hopfner KP.
Nucleic Acids Research. 2006;409:375-88. PubMed

Structure-function analysis of SWI2/SNF2 enzymes.
Durr H, Hopfner KP.
Methods Enzymol. 2006;409:375-88. PubMed

Chromosome biology: the crux of the ring.
Uhlmann F, Hopfner KP.
Curr Biol. 2006 Feb 7;16(3):R102-5. PubMed

Point mutations found in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML.
Reindl C, Bagrintseva K, Vempati S, Schnittger S, Ellwart JW, Wenig K, Hopfner KP, Hiddemann W, Spiekermann K.
Blood. 2006 Jan 12; [Epub ahead of print] PubMed

Structure and Function of Rad50/SMC Protein Complexes in Chromosome Biology.
Hopfner KP
.
In Genome Integrity: Facets and Perspectives, Editor D. Lankenau, Springer, Heidelberg. PubMed

The Mre11/Rad50/Nbs1 Complex.
Hopfner KP
.
In DNA Damage Recognition, Editor W Siede, P Doetsch, YW Kow, Taylor & Francis, New York. PubMed

Structural Basis for Transcription Coupled Repair: the N Terminus of Mfd Resembles UvrB with Degenerate ATPase Motifs.
Assenmacher N, Wenig K, Lammens A, Hopfner KP.
J Mol Biol. 2006 Jan 27;355(4):675-83. Epub 2005 Nov 8. PubMed

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2005

Structural Framework for the Mechanism of Archaeal Exosomes in RNA Processing.
Büttner K, Wenig K, Hopfner KP.
Mol Cell. 2005 Nov 11;20(3):461-71. PubMed

Biochemical Characterization and Crystal Structure of a Dim1 Family Associated Protein: Dim2.
Simeoni F, Arvai A, Bello P, Gondeau C, Hopfner KP, Neyroz P, Heitz F, Tainer J, Divita G.
Biochemistry. 2005 Sep 13;44(36):11997-12008. PubMed

X-Ray Structures of the Sulfolobus solfataricus SWI2/SNF2 ATPase Core and Its Complex with DNA.
Dürr H, Körner C, Müller M, Hickmann V, Hopfner KP.
Cell. 2005 May 6;121(3):363-73. PubMed

X-Ray Structure of RLI, an Essential Twin Cassette ABC ATPase Involved in Ribosome Biogenesis and HIV Capsid Assembly.
Karcher A, Buettner K, Märtens B, Jansen RP, Hopfner KP.
Structure (Camb). 2005 Apr;13(4):649-659. PubMed

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2004

Structural Biochemistry of ATP-Driven Dimerization and DNA-Stimulated Activation of SMC ATPases.
Lammens A, Schele A, Hopfner KP.
Curr Biol. 2004 Oct 5;14(19):1778-82. PubMed

MRE11/RAD50/NBS1: complex activities.
Assenmacher N, Hopfner KP.
Chromosoma. 2004 Oct;113(4):157-66. Epub 2004 Aug 10. PubMed

Differential arrangements of conserved building blocks among homologs of the Rad50/Mre11 DNA repair protein complex.
de Jager M, Trujillo KM, Sung P, Hopfner KP, Carney JP, Tainer JA, Connelly JC, Leach DR, Kanaar R, Wyman C.
J Mol Biol. 2004 Jun 11;339(4):937-49. PubMed

MlaA, a hexameric ATPase linked to the Mre11 complex in archaeal genomes.
Manzan A, Pfeiffer G, Hefferin ML, Cara EL, Carney JP, Hopfner KP.
EMBO Reports. 2004 Jan;5(1):54-9. PubMed

Functional and biochemical dissection of the structure-specific nuclease ARTEMIS.
Pannicke U, Ma Y, Hopfner KP, Niewolik D, Lieber MR, Schwarz K.
EMBO J.2004 May 5;23(9):1987-97. Epub 2004 Apr 8. PubMed

Structural and functional analysis of Mre11-3.
Arthur LM, Gustausson K, Hopfner KP, Carson CT, Stracker TH, Karcher A, Felton D, Weitzman MD, Tainer J, Carney JP.
Nucleic Acids Res. 2004 Mar 26;32(6):1886-93. Print 2004. PubMed

The Rad50 signature motif: essential to ATP binding and biological function.
Moncalian G, Lengsfeld B, Bhaskara V, Hopfner KP, Karcher A, Alden E, Tainer JA, Paull TT.
J Mol Biol. 2004 Jan 23;335(4):937-51. PubMed

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2003

Chromosme cohesion: closing time.
Hopfner KP
.
Current Biology. 2003 Nov 11;13(22):R866-8. Review. PubMed

Rad50/SMC proteins and ABC transporters: unifying concepts from high-resolution structures.
Hopfner KP
, Tainer JA.
Curr Op Struct Biol. 2003 Apr;13(2):249-55. Review. PubMed

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2002

Physiological fIXa activation involves a cooperative conformational rearrangement of the 99-loop.
Sichler K, Kopetzki E, Huber R, Bode W, Hopfner KP, Brandstetter H.
J Biol Chem. 2003 Feb 7;278(6):4121-6. Epub 2002 Nov 19. PubMed

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair.
Hopfner KP
, Craig L, Moncalian G, Zinkel, RA, Usui T, Owen BA, Karcher A, Henderson B, Bodmer JL, McMurray CT, Carney JP, Petrini JH , Tainer JA.
Nature. 2002 Aug 1;418(6897):562-6. PubMed

DNA double-strand break repair from head to tail.
Hopfner KP
, Putnam , Tainer JA.
Curr. Op. Struct. Biol. 2002 Feb;12(1):115-22. Review. PubMed

Crystal structure of uninhibited factor VIIa link its cofactor and substrate assisted activation to specific interactions.
Sichler K, Banner DW, D'Arcy A, Hopfner KP, Huber R, Bode W, Kresse GB, Kopetzki E, Brandstetter H.
J. Mol. Biol. 2002 Sep 20;322(3):591-603. PubMed

The influence of residue 190 in the S1 site of trypsin-like serine proteases on substrate selectivity is universally conserved.
Sichler K, Hopfner KP, Kopetzki E, Huber R, Bode W, Brandstetter H.
FEBS Lett. 2002 Oct 23;530(1-3):220-4. PubMed

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2001

Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50 ATPase.
Hopfner KP
, Karcher A, Craig L, Woo TT, Carney JP, Tainer JA.
Cell. 2001 May 18;105(4):473-85. PubMed

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2000 and before

Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily.
Hopfner KP
, Karcher A, Shin DS, Craig L, Arthur LM, Carney JP, Tainer JA.
Cell. 2000 Jun 23;101(7):789-800.. PubMed

Envisioning the fourth dimension of the genetic code: the structural biology of macromolecular recognition and conformational switching in DNA repair.
Hopfner KP
, Parikh SS, Tainer JA.
Cold Spring Harbor Symp. 2000;65:113-26. Review. PubMed

DNA mismatch repair: the hands of a genome guardian.
Hopfner KP
, Tainer JA.
Structure. 2000 Dec 15;8(12):R237-41. Review. PubMed

Mre11 and Rad50 from Pyrococcus furiosus: cloning and biochemical characterization reveal an evolutionarily conserved multiprotein machine.
Hopfner KP
, Karcher A, Shin D, Fairley C, Tainer JA, Carney JP.
J. Bacteriol. 2000 Nov;182(21):6036-41. PubMed

Three-dimensional structures of coagulation factors: pieces of a complex puzzle.
Bode W, Brandstetter H, Hopfner KP, Stubbs M.
In New Frontiers In Vascular Biology. Thrombosis and Hemostasis. 75-92. Eibun Press Ltd.

Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding.
Hopfner KP
, Lang A, Karcher A, Sichler K, Kopetzki E, Brandstetter H, Huber R, Bode W, Engh RA.
Structure. 1999 Aug 15;7(8):989-96. PubMed

Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius.
Hopfner KP
, Eichinger A, Engh RA, Laue F, Ankenbauer W, Huber R, Angerer B.
Proc. Natl. Acad. Sci. USA  1999 Mar 30;96(7):3600-5. PubMed

The ternary microplasmin-staphylokinase-microplasmin complex is a proteinase-cofactor-substrate complex in action.
Parry MA, Fernandez-Catalan C, Bergner A, Huber R, Hopfner KP, Schlott B, Guhrs KH, Bode W.
Nat. Struct. Biol. 1998 Oct;5(10):917-23. PubMed

New enzyme lineages by subdomain shuffling.
Hopfner KP
, Kopetzki E, Kresse GB, Bode W, Huber R, Engh RA.
Proc. Natl. Acad. Sci. USA. 1998 Aug 18;95(17):9813-8. PubMed

Converting blood coagulation factor IXa into factor Xa: dramatic increase in amidolytic activity identifies important active site determinants.
Hopfner KP
, Brandstetter H, Karcher A, Kopetzki E, Huber R, Engh RA, Bode W.
EMBO J. 1997 Nov 17;16(22):6626-35. PubMed

Dramatic enhancement of the catalytic activity of coagulation factor IXa by alcohols.
Sturzebecher J, Kopetzki E, Bode W, Hopfner KP.
FEBS Lett. 1997 Jul 28;412(2):295-300. PubMed

Theory of allosteric effects in serine proteases.
Di Cera E, Hopfner KP, Dang QD (1996).
Biophys J. 1996 Jan;70(1):174-81. PubMed

Binding of fibrinogen A alpha 1-50-beta-galactosidase fusion protein to thrombin stabilizes the slow form.
Lord ST, Rooney MM, Hopfner KP, Di Cera E.
J. Biol. Chem. 1995 Oct 20;270(42):24790-3. PubMed

Chemical compensation in macromolecular bridge-binding to thrombin.
Hopfner KP
, Ayala Y, Szewczuk Z, Konishi Y, Di Cera E.
Biochemistry. 1993 Mar 30;32(12):2947-53. PubMed

Energetics of thrombin-fibrinogen interaction.
Hopfner KP
, Di Cera E.
Biochemistry. 1992 Nov 24;31(46):11567-71. PubMed

Symmetry conditions for binding processes.
Di Cera E, Hopfner KP, Wyman J.
Proc. Natl. Acad. Sci. USA. 1992 Apr 1;89(7):2727-31. PubMed

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