Structural Biology
How DNA glycosylases repair base lesions within nucleosomes
31.10.2024
The mechanism of repairing base lesions within nucleosomes remains to be elucidated. A collaboration between Hopfner and Zhou lab determined the cryo-EM structure of human 8-oxoguanine-DNA glycosylase 1 (hOGG1) bound to 8-oxoguanine lesion in a nucleosome core particle, thereby providing insights into how DNA glycosylases fulfill their repair functions within nucleosomes.
Original publication:
Structural basis for human OGG1 processing 8-oxodGuo within nucleosome core particles.
Ren M, Gut F, Fan Y, Ma J, Shan X, Yikilmazsoy A, Likhodeeva M, Hopfner KP, Zhou C.
Nat Commun. 2024 Oct 31;15(1):9407. doi: 10.1038/s41467-024-53811-3.