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Förstemann Lab - Biology of non-coding RNAs

foerstemann_mainResearch Topics

  • Biogenesis of siRNAs and miRNAs
  • Non-coding Transcription at Sites of DNA Damage
  • Genome Surveillance and Transposon Control
  • Genome Engineering

Genomes are dynamic – epigenetic marks and DNA sequences change as cells differentiate and age. Transcription factors influence chromatin state; replication, transposable elements and DNA damage challenge the genome’s sequence information. We are working with fruit flies (Drosophila melanogaster) to elucidate how non-coding transcription helps to coordinate information retrieval (= transcription) with repair and maintenance activities. Read more...

Selected Publications

Splicing stimulates siRNA Formation at Drosophila DNA Double-Strand Breaks.
Merk K, Breinig M, Böttcher R, Krebs S, Blum H, Boutros M and Förstemann K.
PLoS Genetics. 2017, in press

Homology directed repair is unaffected by the absence of siRNAs in Drosophila melanogaster.
Schmidts I, Böttcher R, Mirkovic-Hösle M, Förstemann K.
Nucleic Acids Res. 2016 Sep 30;44(17):8261-71. doi: 10.1093/nar/gkw570. Epub 2016 Jun 27. PubMed

A small RNA response at DNA ends in Drosophila.
Michalik KM, Böttcher R, Förstemann K.
Nucleic Acids Res. 2012 Oct;40(19):9596-603. doi: 10.1093/nar/gks711. Epub 2012 Jul 30. PubMed

Endo-siRNAs depend on a new isoform of loquacious and target artificially introduced, high-copy sequences.
Hartig JV, Esslinger S, Böttcher R, Saito K, Förstemann K.
EMBO J. 2009 Oct 7;28(19):2932-44. doi: 10.1038/emboj.2009.220. Epub 2009 Jul 30. PubMed

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