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Hopfner Lab - Structural Molecular Biology

hopfner_mainResearch Topics

  • Cryo-EM and crystallography
  • Structural Genome Biology
  • Innate Immune RNA and DNA Sensing
  • Therapeutic Protein Engineering

We are interested in how cells shape and protect their genomic information. Using cryo-EM, X-ray crystallography and functional approaches, we study the architectures and mechanisms of macromolecular complexes in genome biology with a focus on chromatin remodelers, DNA double-strand break repair enzymes and innate immune nucleic acid sensors. Moreover, we also focus on innovative antibody engineering with the aim of exploiting immune checkpoints to improve cancer immunotherapy. Read more...

Selected Publications

Structural mechanism of cytosolic DNA sensing by cGAS.
Civril F, Deimling T, de Oliveira Mann CC, Ablasser A, Moldt M, Witte G, Hornung V, Hopfner KP.
Nature. 2013 Jun 20;498(7454):332-7. PubMed

Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex.
Tosi A, Haas C, Herzog F, Gilmozzi A, Berninghausen O, Ungewickell C, Gerhold CB, Lakomek K, Aebersold R, Beckmann R, Hopfner KP.
Cell. 2013 Sep 12;154(6):1207-19. PubMed

The Mre11:Rad50 structure shows an ATP-dependent molecular clamp in DNA double-strand break repair.
Lammens K, Bemeleit DJ, Möckel C, Clausing E, Schele A, Hartung S, Schiller CB, Lucas M, Angermüller C, Söding J, Strässer K, Hopfner KP.
Cell. 2011 Apr 1;145(1):54-66. PubMed

SIRPα-antibody fusion proteins stimulate phagocytosis and promote elimination of acute myeloid leukemia cells.
Ponce LP, Fenn NC, Moritz N, Krupka C, Kozik JH, Lauber K, Subklewe M, Hopfner KP.
Oncotarget. 2017 Feb 14;8(7):11284-11301. PubMed

More publications

Lab News

01.12.2017 - New member

Matthias Rotheneder joined our lab in Dezember 2017.

01.12.2017 - New member

Stephan Woike joined our lab in Dezember 2017.

13.09.2017  - New Publication

cGAS senses long and HMGB/ TFAM-bound U-turn DNA by forming protein-DNA ladders.

08.12.2016 - Leibniz Prize

Karl-Peter Hopfner is one of the 2017 Gottfried Wilhelm Leibniz prize winners.