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Stigler Lab - Biophysics of Structural Dynamics in Chromosomes

stigler_mainResearch Topics

  • Mechanics of Intrachromosomal Crosslinks
  • Establishment of Hierarchically Structured Chromosomes





Dr. Johannes Stigler

phone: +49 (0)89 - 2180 76962
stigler@genzentrum.lmu.de

Chromosomes provide the fundamental scaffold for the maintenance, regulation and propagation of genetic information. Recent experimental findings have shown that eukaryotic chromosomes are highly structured and that the three-dimensional folding of chromosomes is directly linked to gene regulation. Our lab uses biophysical single molecule techniques to determine the processes that lead to the three-dimensional folding of chromosomes. Read more...

Selected Publications

Single-Molecule Imaging Reveals a Collapsed Conformational State for DNA-Bound Cohesin.
Stigler J, Çamdere GÖ, Koshland DE, Greene EC.
Cell Rep. 2016 May 3;15(5):988-998. doi: 10.1016/j.celrep.2016.04.003. Epub 2016 Apr 21. PubMed

Sequence-resolved free energy profiles of stress-bearing vimentin intermediate filaments.
Ramm B, Stigler J, Hinczewski M, Thirumalai D, Herrmann H, Woehlke G, Rief M.
Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11359-64. doi: 10.1073/pnas.1403122111. Epub 2014 Jul 21. PubMed

The complex folding network of single calmodulin molecules.
Stigler J, Ziegler F, Gieseke A, Gebhardt JC, Rief M.
Science. 2011 Oct 28;334(6055):512-6. doi: 10.1126/science.1207598. PubMed

More publications

News

New member in our lab

Jonas Huber joined our lab as a PhD student in April 2018.

New member in our lab

We're growing. Isabel Aly joined our lab in February 2018.

New member in our lab

Marvin Freitag joined our lab in December 2017.
Welcome!

Open Position

We are seeking motivated PhD students to join our lab. Please send your applications to Johannes Stigler.