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Adler Lab - Biology of Cytomegaloviruses

adler_mainResearch Topics

  • Virus Entry and Cell Tropism
  • Modulation of Antiviral Immune Responses
  • CMV Vectors for Immune Therapy

 

 

 

PD Dr. Barbara Adler

phone: +49 (0)89 - 2180 76863
adler@genzentrum.lmu.de

Infections with human cytomegalovirus (HCMV) are a major cause of mortality in immunocompromised humans and of childhood disabilities. We are interested in the role of cytomegalovirus envelope glycoprotein complexes in cell entry and in shaping the antiviral immune response with the aim to design vaccines protecting from HCMV infection and CMV vectors for immune therapy of infectious diseases and tumors. Read more...

Selected Publications

Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry.
Wu Y, Prager A, Boos S, Resch M, Brizic I, Mach M, Wildner S, Scrivano L, Adler B.
PLoS Pathog. 2017 Apr 12;13(4):e1006281. doi: 10.1371/journal.ppat.1006281. PubMed

Structural Basis of Vesicle Formation at the Inner Nuclear Membrane.
Hagen C, Dent KC, Zeev-Ben-Mordehai T, Grange M, Bosse JB, Whittle C, Klupp BG, Siebert CA, Vasishtan D, Bäuerlein FJ, Cheleski J, Werner S, Guttmann P, Rehbein S, Henzler K, Demmerle J, Adler B, Koszinowski U, Schermelleh L, Schneider G, Enquist LW, Plitzko JM, Mettenleiter TC, Grünewald K.
Cell. 2015 Dec 17;163(7):1692-701. doi: 10.1016/j.cell.2015.11.029. PubMed

Non-redundant and redundant roles of cytomegalovirus gH/gL complexes in host organ entry and intra-tissue spread.
Lemmermann NA, Krmpotic A, Podlech J, Brizic I, Prager A, Adler H, Karbach A, Wu Y, Jonjic S, Reddehase MJ, Adler B.
PLoS Pathog. 2015 Feb 6;11(2):e1004640. doi: 10.1371/journal.ppat.1004640. eCollection 2015 Feb. PubMed

HCMV spread and cell tropism are determined by distinct virus populations.
Scrivano L, Sinzger C, Nitschko H, Koszinowski UH, Adler B.
PLoS Pathog. 2011 Jan 13;7(1):e1001256. doi: 10.1371/journal.ppat.1001256. PubMed

More Publications