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Adler Lab - Publications

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2018




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2017

Differences in Growth Properties among Two Human Cytomegalovirus Glycoprotein O Genotypes.
Kalser J, Adler B, Mach M, Kropff B, Puchhammer-Stöckl E, Gärzer I.
Front Microbiol
. 2017 Aug 22;8:1609. doi: 10.3389/fmicb.2017.01609. eCollection 2017. PubMed 

Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry.
Wu Y, Prager A, Boos S, Resch M, Brizic I, Mach M, Wildner S, Scrivano L, Adler B.
PLoS Pathog
. 2017 Apr 12;13(4):e1006281. doi: 10.1371/journal.ppat.1006281. eCollection 2017 Apr. PubMed

Herpesviruses and Their Host Cells: A Successful Liaison.
Adler B, Sattler C, Adler H.
Trends Microbiol
. 2017 Mar;25(3):229-241. doi: 10.1016/j.tim.2016.11.009. Epub 2016 Dec 9. Review. PubMed

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2016

The contribution of pUL74 to growth of human cytomegalovirus is masked in the presence of RL13 and UL128 expression.
Laib Sampaio K, Stegmann C, Brizic I, Adler B, Stanton RJ, Sinzger C.
J Gen Virol
. 2016 Aug;97(8):1917-27. doi: 10.1099/jgv.0.000475. Epub 2016 Apr 6. PubMed

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2015

Structural Basis of Vesicle Formation at the Inner Nuclear Membrane.
Hagen C, Dent KC, Zeev-Ben-Mordehai T, Grange M, Bosse JB, Whittle C, Klupp BG, Siebert CA, Vasishtan D, Bäuerlein FJ, Cheleski J, Werner S, Guttmann P, Rehbein S, Henzler K, Demmerle J, Adler B, Koszinowski U, Schermelleh L, Schneider G, Enquist LW, Plitzko JM, et al.
Cell
. 2015 Dec 17;163(7):1692-701. doi: 10.1016/j.cell.2015.11.029. PubMed

A Viral Pilot for HCMV Navigation?
Adler B.
Viruses. 2015 Jul 15;7(7):3857-62. doi: 10.3390/v7072801. PubMed

Principles for studying in vivo attenuation of virus mutants: defining the role of the cytomegalovirus gH/gL/gO complex as a paradigm.
Podlech J, Reddehase MJ, Adler B, Lemmermann NA.
Med Microbiol Immunol. 2015 Jun;204(3):295-305. doi: 10.1007/s00430-015-0405-2. Epub 2015 Mar 18. Review. PubMed

Non-redundant and redundant roles of cytomegalovirus gH/gL complexes in host organ entry and intra-tissue spread.
Lemmermann NA, Krmpotic A, Podlech J, Brizic I, Prager A, Adler H, Karbach A, Wu Y, Jonjic S, Reddehase MJ, Adler B.
PLoS
Pathog. 2015 Feb 6;11(2):e1004640. doi: 10.1371/journal.ppat.1004640. eCollection 2015 Feb. PubMed

Cytomegalovirus-Based Vaccine Expressing a Modified Tumor Antigen Induces Potent Tumor-Specific CD8(+) T-cell Response and Protects Mice from Melanoma.
Qiu Z, Huang H, Grenier JM, Perez OA, Smilowitz HM, Adler B, Khanna KM.
Cancer Immunol Res
. 2015 May;3(5):536-46. doi: 10.1158/2326-6066.CIR-14-0044. Epub 2015 Jan 29. PubMed

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2014

HCMV infection of human trophoblast progenitor cells of the placenta is neutralized by a human monoclonal antibody to glycoprotein B and not by antibodies to the pentamer complex.
Zydek M, Petitt M, Fang-Hoover J, Adler B, Kauvar LM, Pereira L, Tabata T.
Viruses
. 2014 Mar 19;6(3):1346-64. doi: 10.3390/v6031346. PubMed

Reversible silencing of cytomegalovirus genomes by type I interferon governs virus latency.
Dag F, Dölken L, Holzki J, Drabig A, Weingärtner A, Schwerk J, Lienenklaus S, Conte I, Geffers R, Davenport C, Rand U, Köster M, Wieß S, Adler B, Wirth D, Messerle M, Hauser H, Cicin-Sain L.
PLoS Pathog
. 2014 Feb 20;10(2):e1003962. doi: 10.1371/journal.ppat.1003962. eCollection 2014 Feb. PubMed

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2013

The viral chemokine MCK-2 of murine cytomegalovirus promotes infection as part of a gH/gL/MCK-2 complex.
Wagner FM, Brizic I, Prager A, Trsan T, Arapovic M, Lemmermann NA, Podlech J, Reddehase MJ, Lemnitzer F, Bosse JB, Gimpfl M, Marcinowski L, MacDonald M, Adler H, Koszinowski UH, Adler B.
PLoS Pathog
. 2013;9(7):e1003493. doi: 10.1371/journal.ppat.1003493. Epub 2013 Jul 25. PubMed

A new reporter mouse cytomegalovirus reveals maintained immediate-early gene expression but poor virus replication in cycling liver sinusoidal endothelial cells.
Dag F, Weingärtner A, Butueva M, Conte I, Holzki J, May T, Adler B, Wirth D, Cicin-Sain L.
Virol J
. 2013 Jun 17;10:197. doi: 10.1186/1743-422X-10-197. PubMed

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2012

Cytomegalovirus replicon-based regulation of gene expression in vitro and in vivo.
Mohr H, Mohr CA, Schneider MR, Scrivano L, Adler B, Kraner-Schreiber S, Schnieke A, Dahlhoff M, Wolf E, Koszinowski UH, Ruzsics Z.
PLoS Pathog. 2012;8(6):e1002728. doi: 10.1371/journal.ppat.1002728. Epub 2012 Jun 7. PubMed

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2011

Virus progeny of murine cytomegalovirus bacterial artificial chromosome pSM3fr show reduced growth in salivary Glands due to a fixed mutation of MCK-2.
Jordan S, Krause J, Prager A, Mitrovic M, Jonjic S, Koszinowski UH, Adler B.
J Virol
. 2011 Oct;85(19):10346-53. doi: 10.1128/JVI.00545-11. Epub 2011 Aug 3. PubMed

HCMV spread and cell tropism are determined by distinct virus populations.
Scrivano L, Sinzger C, Nitschko H, Koszinowski UH, Adler B.
PLoS Pathog
. 2011 Jan 13;7(1):e1001256. doi: 10.1371/journal.ppat.1001256. PubMed

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2010

A gammaherpesvirus complement regulatory protein promotes initiation of infection by activation of protein kinase Akt/PKB.
Steer B, Adler B, Jonjic S, Stewart JP, Adler H.
PLoS One
. 2010 Jul 21;5(7):e11672. doi: 10.1371/journal.pone.0011672. PubMed

The m74 gene product of murine cytomegalovirus (MCMV) is a functional homolog of human CMV gO and determines the entry pathway of MCMV.
Scrivano L, Esterlechner J, Mühlbach H, Ettischer N, Hagen C, Grünewald K, Mohr CA, Ruzsics Z, Koszinowski U, Adler B.
J Virol. 2010 May;84(9):4469-80. doi: 10.1128/JVI.02441-09. Epub 2010 Feb 24. PubMed

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2009

Endothelial cells in human cytomegalovirus infection: one host cell out of many or a crucial target for virus spread?
Adler B, Sinzger C.
Thromb Haemost
. 2009 Dec;102(6):1057-63. doi: 10.1160/TH09-04-0213. Review. PubMed

H2O2 inhibits BCR-dependent immediate early induction of EBV genes in Burkitt's lymphoma cells.
Osipova-Goldberg HI, Turchanowa LV, Adler B, Pfeilschifter JM.
Free Radic Biol Med
. 2009 Oct 15;47(8):1120-9. doi: 10.1016/j.freeradbiomed.2009.06.019. Epub 2009 Jun 21. PubMed

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2008

Cloning and sequencing of a highly productive, endotheliotropic virus strain derived from human cytomegalovirus TB40/E.
Sinzger C, Hahn G, Digel M, Katona R, Sampaio KL, Messerle M, Hengel H, Koszinowski U, Brune W, Adler B.
J Gen Virol
. 2008 Feb;89(Pt 2):359-68. doi: 10.1099/vir.0.83286-0. PubMed

UL74 of human cytomegalovirus contributes to virus release by promoting secondary envelopment of virions.
Jiang XJ, Adler B, Sampaio KL, Digel M, Jahn G, Ettischer N, Stierhof YD, Scrivano L, Koszinowski U, Mach M, Sinzger C.
J Virol
. 2008 Mar;82(6):2802-12. doi: 10.1128/JVI.01550-07. Epub 2008 Jan 9. PubMed

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2007

Random screening for dominant-negative mutants of the cytomegalovirus nuclear egress protein M50.
Rupp B, Ruzsics Z, Buser C, Adler B, Walther P, Koszinowski UH.
J Virol. 2007 Jun;81(11):5508-17. Epub 2007 Mar 21. PubMed

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2006

Role of human cytomegalovirus UL131A in cell type-specific virus entry and release.
Adler B, Scrivano L, Ruzcics Z, Rupp B, Sinzger C, Koszinowski U.
J Gen Virol. 2006 Sep;87(Pt 9):2451-60. PubMed

IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression.
Brand S, Beigel F, Olszak T, Zitzmann K, Eichhorst ST, Otte JM, Diebold J, Diepolder H, Adler B, Auernhammer CJ, Göke B, Dambacher J.
Am J Physiol Gastrointest Liver Physiol
. 2005 Nov;289(5):G960-8. Epub 2005 Jul 28. PubMed

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2005

Epstein-Barr virus latent membrane protein 2A mimics B-cell receptor-dependent virus reactivation.
Schaadt E, Baier B, Mautner J, Bornkamm GW, Adler B.
J Gen Virol
. 2005 Mar;86(Pt 3):551-9. PubMed

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2004

Persistent hypogammaglobulinemia following mononucleosis in boys is highly suggestive of X-linked lymphoproliferative disease - report of three cases.
Hügle B, Suchowerskyj P, Hellebrand H, Adler B, Borte M, Sack U, Overberg-Schmidt US, Strnad N, Otto J, Meindl A, Schuster V.
J Clin Immunol
. 2004 Sep;24(5):515-22. PubMed

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2003

Functional analysis of the mutated Epstein-Barr virus oncoprotein LMP1(69del): implications for a new role of naturally occurring LMP1 variants.
Larcher C, Bernhard D, Schaadt E, Adler B, Ausserlechner MJ, Mitterer M, Huemer HP.
Haematologica
. 2003 Dec;88(12):1324-35. PubMed

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2002

Control of Epstein-Barr virus reactivation by activated CD40 and viral latent membrane protein 1.
Adler B, Schaadt E, Kempkes B, Zimber-Strobl U, Baier B, Bornkamm GW.
Proc Natl Acad Sci U S A
. 2002 Jan 8;99(1):437-42. Epub 2001 Dec 18. PubMed

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2001

Costimulation by extracellular matrix proteins determines the response to TCR ligation.
Adler B
, Ashkar S, Cantor H, Weber GF.
Cell Immunol
. 2001 May 25 PubMed

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2000 and before

Activation of T cells by superantigen: cytokine production but not apoptosis depends on MEK-1 activity.
Adler B
, Weber GF, Cantor H.
Eur J Immunol. 1998 Nov PubMed

Macrophages infected with cytopathic bovine viral diarrhea virus release a factor(s) capable of priming uninfected macrophages for activation-induced apoptosis.
Adler B, Adler H, Pfister H, Jungi TW, Peterhans E.
J Virol
. 1997 Apr;71(4):3255-8. PubMed

Identification of latent membrane protein 2A (LMP2A) domains essential for the LMP2A dominant-negative effect on B-lymphocyte surface immunoglobulin signal transduction.
Fruehling S, Lee SK, Herrold R, Frech B, Laux G, Kremmer E, Grässer FA, Longnecker R.
J Virol. 1996 Sep PubMed

Interferon-alpha primes macrophages for lipopolysaccharide-induced apoptosis.
Adler B
, Adler H, Jungi TW, Peterhans E.
Biochem Biophys Res Commun. 1995 Oct 24;215(3):921-7. PubMed

RT-PCR: 'background priming' during reverse transcription.
Frech B
, Peterhans E.
Nucleic Acids Res. 1994 Oct 11 PubMed

Inducible nitric oxide synthase in cattle. Differential cytokine regulation of nitric oxide synthase in bovine and murine macrophages.
Adler H, Frech B, Thöny M, Pfister H, Peterhans E, Jungi TW.
J Immunol. 1995 May 1 PubMed

Noncytopathic strains of bovine viral diarrhea virus prime bovine bone marrow-derived macrophages for enhanced generation of nitric oxide.
Adler H, Frech B, Meier P, Jungi TW, Peterhans E.
Biochem Biophys Res Commun
. 1994 Aug 15 PubMed

Characterization of the antibody response to the latent infection terminal proteins of Epstein-Barr virus in patients with nasopharyngeal carcinoma.
Frech B
, Zimber-Strobl U, Yip TT, Lau WH, Müller-Lantzsch N.
J Gen Virol. 1993 May PubMed

Down-regulation of integrated Epstein-Barr virus nuclear antigen 1 and 2 genes in a Burkitt lymphoma cell line after somatic cell fusion with autologous EBV-immortalized lymphoblastoid cells.
Wolf J, Pawlita M, Klevenz B, Frech B, Freese UK, Müller-Lantzsch N, Diehl V, zur Hausen H.
Int J Cancer
. 1993 Feb 20 PubMed

Identification of Epstein-Barr virus terminal protein 1 (TP1) in extracts of four lymphoid cell lines, expression in insect cells, and detection of antibodies in human sera.
Frech B
, Zimber-Strobl U, Suentzenich KO, Pavlish O, Lenoir GM, Bornkamm GW, Müller-Lantzsch.
J Virol
. 1990 Jun PubMed

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