Gene Center Munich

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Hopfner Lab - Research

We want to understand the molecular and structural mechanisms how the cellular DNA repair and antiviral RNA sensing protein machineries detect, signal and repair or remove malignant nucleic acids such as damaged DNA and viral RNA. To investigate these processes, our lab uses a variety of techniques such as X-ray crystallography, Cryo-EM, SAXS, CX-MS and biophysical/biochemical methods.