Gene Center Munich

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Proteomics comprises a set of technologies for separation, identification and quantification of proteins from complex mixtures like cells or tissues. The LAFUGA proteomics platform offers state-of-the-art instrumentation for discovery proteomics using nano-HPLC and high resolution FT mass spectrometers. Absolute protein quantification down to the attomolar range is achieved by targeted mass spectrometry performing selected reaction monitoring (SRM) approaches on nano-LC-QTRAP mass spectrometers.

Structural proteomics approaches at the Gene Center (Herzog Lab) includes mass spectrometric identification of chemical crosslinks indicating the subunit connectivity of protein complexes and protein-protein binding interfaces.