Fröhlich Lab - Proteomics
- Mammalian Embryo and Germ Cell Proteomics
- Proteomics of Animal Disease Models
- Proteomic Approach to Testicular Ageing
Our research activity comprises proteome analysis during early embryogenesis in mammals, proteomic characterization of large animal disease models for molecular biomedical research (Diabetes, Duchenne muscular dystrophy), and secretome analysis of human testicular peritubular cells (HTPC) in the context of spermatogenesis. We perform holistic as well as targeted proteomic approaches using latest mass spectrometry instrumentation. Read more...
Progressive muscle proteome changes in a clinically relevant pig model of Duchenne muscular dystrophy.
Fröhlich T, Kemter E, Flenkenthaler F, Klymiuk N, Otte KA, Blutke A, Krause S, Walter MC, Wanke R, Wolf E, Arnold GJ.
Sci Rep. 2016 Sep 16;6:33362. doi: 10.1038/srep33362. PubMed
Proteome analysis of early lineage specification in bovine embryos.
Demant M, Deutsch DR, Fröhlich T, Wolf E, Arnold GJ.
Proteomics. 2015 Feb;15(4):688-701. doi: 10.1002. Epub 2014 Oct 9. PubMed
Stage-specific proteome signatures in early bovine embryo development.
Deutsch DR, Fröhlich T, Otte KA, Beck A, Habermann FA, Wolf E, Arnold GJ.
J Proteome Res. 2014 Oct 3;13(10):4363-76. doi: 10.1021. Epub 2014 Sep 10. PubMed
Secretome analysis of testicular peritubular cells: a window into the human testicular microenvironment and the spermatogonial stem cell niche in man.
Flenkenthaler F, Windschüttl S, Fröhlich T, Schwarzer JU, Mayerhofer A, Arnold GJ.
J Proteome Res. 2014 Mar 7;13(3):1259-69. doi: 10.1021. Epub 2014 Jan 30. PubMed
1.1.2019: New DFG funded project
Within the SFB 1357 “MICROPLASTICS: Understanding the mechanisms and processes of biological effects, transport and formation (Speaker Prof. Laforsch; University of Bayreuth)” we successfully applied for a grant. In our subproject, we will study effects of microplastics on the model organism Daphnia at the proteome level. We are happy to contribute to the solution of the important and socially relevant issue of microplastics in the environment.