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Fröhlich Lab - Proteomics

froehlich_mainResearch Topics

  • Proteomics of Animal Disease Models
  • Mammalian Embryo and Germ Cell Proteomics
  • Proteomics of Human Testicular Peritubular Cells (HTPC)

Dr. Thomas Fröhlich

phone: +49 (0)89 - 2180 76755

Our research activity comprises proteomic characterization of large animal disease models for molecular biomedical research (Diabetes, Duchenne muscular dystrophy), proteome analysis during early embryogenesis in mammals and secretome analysis of human testicular peritubular cells (HTPC) in the context of spermatogenesis. We perform holistic as well as targeted proteomic approaches using latest mass spectrometry instrumentation. Read more...

Selected Publications

Progressive Proteome Changes in the Myocardium of a Pig Model for Duchenne Muscular Dystrophy.
Tamiyakul H, Kemter E, Kösters M, Ebner S, Blutke A, Klymiuk N, Flenkenthaler F, Wolf E, Arnold GJ, Fröhlich T.
. 2020 Sep 1;23(9):101516. doi: 10.1016/j.isci.2020.101516. PMID: 32927262 PubMed

Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy. Moretti A, Fonteyne L, Giesert F, Hoppmann P, Meier AB, Bozoglu T, Baehr A, Schneider CM, Sinnecker D, Klett K, Fröhlich T, Rahman FA, Haufe T, Sun S, Jurisch V, Kessler B, Hinkel R, Dirschinger R, Martens E, Jilek C, Graf A, Krebs S, Santamaria G, Kurome M, Zakhartchenko V, Campbell B, Voelse K, Wolf A, Ziegler T, Reichert S, Lee S, Flenkenthaler F, Dorn T, Jeremias I, Blum H, Dendorfer A, Schnieke A, Krause S, Walter MC, Klymiuk N, Laugwitz KL, Wolf E, Wurst W, Kupatt C.
Nat Med.
2020 Feb;26(2):207-214. doi: 10.1038/s41591-019-0738-2. PubMed

Detection of collagens by multispectral optoacoustic tomography as an imaging biomarker for Duchenne muscular dystrophy.
Regensburger AP, Fonteyne LM, Jüngert J, Wagner AL, Gerhalter T, Nagel AM, Heiss R, Flenkenthaler F, Qurashi M, Neurath MF, Klymiuk N, Kemter E, Fröhlich T, Uder M, Woelfle J, Rascher W, Trollmann R, Wolf E, Waldner MJ, Knieling F.
Nat Med. 2019 25(12):1905-1915. doi: 10.1038/s41591-019-0669-y.  PubMed

Functional changes of the liver in the absence of growth hormone (GH) action - Proteomic and metabolomic insights from a GH receptor deficient pig model. Riedel EO, Hinrichs A, Kemter E, Dahlhoff M, Backman M, Rathkolb B, Prehn C, Adamski J, Renner S, Blutke A, de Angelis MH, Bidlingmaier M, Schopohl J, Arnold GJ, Fröhlich T*, Wolf E*.
Mol Metab. 2020 Mar 18:100978. doi: 10.1016/j.molmet.2020.100978. [Epub ahead of print] * contributed equally PubMed

The impact of transcription inhibition during in vitro maturation on the proteome of bovine oocytes.
Gegenfurtner K, Flenkenthaler F, Fröhlich T, Wolf E, Arnold GJ. Biol Reprod. 2020 Aug 28:ioaa149. doi: 10.1093/biolre/ioaa149. Online ahead of print. PMID: 32856698 PubMed

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Lab News

1.3.2020: New EU funded project

Within the EU funded Marie Sklodowska-Curie Innovative Training Network “DohART-NET” we received a grant for an Early Stage Researcher (ESR). The ESR will investigate effects of maternal diabetes at the proteome level using transgenic pig models for diabetes and pre-diabetes developed by the Wolf lab.

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