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Fröhlich Lab - Proteomics

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Proteomics and disease network associations evaluation of environmentally relevant Bisphenol A concentrations in a human 3D neural stem cell model.
Horánszky A, Shashikadze B, Elkhateib R, Lombardo SD, Lamberto F, Zana M, Menche J, Fröhlich T, Dinnyés A. Front Cell Dev Biol. 2023 Aug 16;11:1236243. doi: 10.3389/fcell.2023.1236243. eCollection 2023. PMID: 37664457 PubMed

TRPV2, a novel player in the human ovary and human granulosa cells.
Eubler K, Caban KM, Dissen GA, Berg U, Berg D, Herrmann C, Kreitmair N, Tiefenbacher A, Fröhlich T, Mayerhofer A. Mol Hum Reprod. 2023 Aug 23:gaad029. doi: 10.1093/molehr/gaad029. Online ahead of print. PMID: 37610352 PubMed

Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model.
Lamberto F, Shashikadze B, Elkhateib R, Lombardo SD, Horánszky A, Balogh A, Kistamás K, Zana M, Menche J, Fröhlich T, Dinnyés A. Environ Pollut. 2023 Aug 9;335:122359. doi: 10.1016/j.envpol.2023.122359. Online ahead of print. PMID: 3756740 PubMed

An ovarian phenotype of alpha 7 nicotinic receptor knock-out mice.
Seßenhausen P*, Caban KM*, Kreitmair N, Peitzsch M, Stöckl JB, Meinsohn MC, Pepin D, Popper B, Fröhlich T, Mayerhofer A. Reproduction. 2023 Jul 1:REP-23-0123. doi: 10.1530/REP-23-0123. Online ahead of print. PMID: 37432973 * joint first authors ** joint senior authors PubMed

Systemic deletion of DMD exon 51 rescues clinically severe Duchenne muscular dystrophy in a pig model lacking DMD exon 52.
Stirm M, Shashikadze B, Blutke A, Kemter E, Lange A, Stöckl JB, Jaudas F, Laane L, Kurome M, Keßler B, Zakhartchenko V, Bähr A, Klymiuk N, Nagashima H, Walter MC, Wurst W, Kupatt C, Fröhlich T, Wolf E. Proc Natl Acad Sci U S A. 2023 Jul 18;120(29):e2301250120. doi: 10.1073/pnas.2301250120. Epub 2023 Jul 10. PMID: 37428903 PubMed

Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model.
Shashikadze B, Valla L, Lombardo SD, Prehn C, Haid M, Riols F, Stöckl JB, Elkhateib R, Renner S, Rathkolb B, Menche J, Hrabĕ de Angelis M, Wolf E, Kemter E, Fröhlich T. Mol Metab. 2023 Jul 4:101768. doi: 10.1016/j.molmet.2023.101768. Online ahead of print. PMID: 37414142 PubMed

Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2.
Ikeuchi K, Ivic N, Buschauer R, Cheng J, Fröhlich T, Matsuo Y, Berninghausen O, Inada T, Becker T, Beckmann R. Nat Commun. 2023 May 12;14(1):2730. doi: 10.1038/s41467-023-38161-w. PMID: 37169754 PubMed

Structural and proteomic repercussions of growth hormone receptor deficiency on the pituitary gland: Lessons from a translational pig model.
Shashikadze B, Franzmeier S, Hofmann I, Kraetzl M, Flenkenthaler F, Blutke A, Fröhlich T, Wolf E, Hinrichs A. J Neuroendocrinol. 2023 Apr 15:e13277. doi: 10.1111/jne.13277. Online ahead of print. PMID: 37160285 PubMed

Proteomics- and Metabolomics-Based Analysis of Metabolic Changes in a Swine Model of Pulmonary Hypertension.
Sen P, Shashikadze B, Flenkenthaler F, Van de Kamp E, Tian S, Meng C, Gigl M, Fröhlich T, Merkus D. Int J Mol Sci. 2023 Mar 2;24(5):4870. doi: 10.3390/ijms24054870. PMID: 36902298 PubMed

The platelet transcriptome and proteome in Alzheimer's disease and aging: an exploratory cross-sectional study.
de Sousa DMB, Poupardin R, Villeda SA, Schroer AB, Fröhlich T, Frey V, Staffen W, Mrowetz H, Altendorfer B, Unger MS, Iglseder B, Paulweber B, Trinka E, Cadamuro J, Drerup M, Schallmoser K, Aigner L, Kniewallner KM. Front Mol Biosci. 2023 Jun 30;10:1196083. doi: 10.3389/fmolb.2023.1196083. eCollection 2023. PMID: 37457829 PubMed


Combating Drug Resistance by Exploiting miRNA-200c-Controlled Phase II Detoxification.
Köhler B, Dubovik S, Hörterer E, Wilk U, Stöckl JB, Tekarslan-Sahin H, Ljepoja B, Paulitschke P, Fröhlich T, Wagner E, Roidl A. Cancers (Basel). 2022 Nov 11;14(22):5554. doi: 10.3390/cancers14225554. PMID: 36428646 PubMed

Changes of Protein Expression after CRISPR/Cas9 Knockout of miRNA-142 in Cell Lines Derived from Diffuse Large B-Cell Lymphoma. Menegatti J, Nakel J, Stepanov YK, Caban KM, Ludwig N, Nord R, Pfitzner T, Yazdani M, Vilimova M, Kehl T, Lenhof HP, Philipp SE, Meese E, Fröhlich T, Grässer FA, Hart M. Cancers (Basel). 2022 Oct 14;14(20):5031. doi: 10.3390/cancers14205031. PMID: 36291816 PubMed

Profound Effects of Dexamethasone on the Immunological State, Synthesis and Secretion Capacity of Human Testicular Peritubular Cells. Stepanov YK, Speidel JD, Herrmann C, Schmid N, Behr R, Köhn FM, Stöckl JB, Pickl U, Trottmann M, Fröhlich T**, Mayerhofer A**, Welter H**. Cells. 2022 Oct 9;11(19):3164. doi: 10.3390/cells11193164. PMID: 36231125. PubMed.  ** equal last author contribution.

Tailor-Made Protein Corona Formation on Polystyrene Microparticles and its Effect on Epithelial Cell Uptake.
Jasinski J, Wilde MV, Voelkl M, Jérôme V, Fröhlich T, Freitag R, Scheibel T. ACS Appl Mater Interfaces. 2022 Oct 4. doi: 10.1021/acsami.2c13987. Online ahead of print. PMID: 36194482 PubMed

Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation.
Stafford CA, Gassauer AM, de Oliveira Mann CC, Tanzer MC, Fessler E, Wefers B, Nagl D, Kuut G, Sulek K, Vasilopoulou C, Schwojer SJ, Wiest A, Pfautsch MK, Wurst W, Yabal M, Fröhlich T, Mann M, Gisch N, Jae LT, Hornung V. Nature. 2022 Aug 24. doi: 10.1038/s41586-022-05125-x. Online ahead of print. PMID: 36002575 PubMed

In-depth characterization revealed polymer type and chemical content specific effects of microplastic on Dreissena bugensis.
Brehm J, Wilde MV, Reiche L, Leitner LC, Petran B, Meinhart M, Wieland S, Ritschar S, Schott M, Boos JP, Frei S, Kress H, Senker J, Greiner A, Fröhlich T, Laforsch C. J Hazard Mater. 2022 Jun 13;437:129351. doi: 10.1016/j.jhazmat.2022.129351. Online ahead of print. PMID: 35728319 PubMed

Pig models for Duchenne muscular dystrophy - from disease mechanisms to validation of new diagnostic and therapeutic concepts. Stirm M, Fonteyne LM, Shashikadze B, Stöckl JB, Kurome M, Keßler B, Zakhartchenko V, Kemter E, Blum H, Arnold GJ, Matiasek K, Wanke R, Wurst W, Nagashima H, Knieling F, Walter MC, Kupatt C, Fröhlich T, Klymiuk N, Blutke A, Wolf E. Neuromuscul Disord. 2022 Apr 25:S0960-8966(22)00116-X. doi: 10.1016/j.nmd.2022.04.005 PubMed

Improving the proteome coverage of Daphnia magna - implications for future ecotoxicoproteomics studies. Wilde MV, Brehm J, Schwarzer M, Stöckl JB, Laforsch C, Fröhlich T.
Proteomics. 2022 Feb 10:e2100289. doi: 10.1002/pmic.202100289. Online ahead of print.
PMID: 35143708 PubMed

Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells.
Siow WX, Kabiri Y, Tang R, Chao YK, Plesch E, Eberhagen C, Flenkenthaler F, Fröhlich T, Bracher F, Grimm C, Biel M, Zischka H, Vollmar AM, Bartel K. J Cell Sci. 2022 Mar 11:jcs.259455. doi: 10.1242/jcs.259455. Online ahead of print. PMID: 35274126 PubMed

Valosin-containing protein-regulated endoplasmic reticulum stress causes NOD2-dependent inflammatory responses. Ghalandary M, Li Y, Fröhlich T, Magg T, Liu Y, Rohlfs M, Hollizeck S, Conca R, Schwerd T, Uhlig HH, Bufler P, Koletzko S, Muise AM, Snapper SB, Hauck F, Klein C, Kotlarz D. Sci Rep. 2022 Mar 10;12(1):3906. doi: 10.1038/s41598-022-07804-1. PMID: 35273242 PubMed

Book chapter: Meyer H.E., Fröhlich T.*, Nordhoff E., Kuhlmann K. (2022) Massenspektrometrie. In: Kurreck J., Engels J.W., Lottspeich F. (eds) Bioanalytik. Springer Spektrum, Berlin, Heidelberg.; * Corresponding author, Springer Link

Shape, size, and polymer dependent effects of microplastics on Daphnia magna.
Schwarzer M, Brehm J, Vollmer M, Jasinski J, Xu C, Zainuddin S, Fröhlich T, Schott M, Greiner A, Scheibel T, Laforsch C. J Hazard Mater. 2022 Mar 15;426:128136. doi: 10.1016/j.jhazmat.2021.128136. Epub 2021 Dec 24. PMID: 3497438 PubMed

Dynamic regulation of the transcriptome and proteome of the equine embryo during maternal recognition of pregnancy.
Vegas AR, Podico G, Canisso IF, Bollwein H, Fröhlich T, Bauersachs S, Almiñana C. FASEB Bioadv. 2022 Oct 18;4(12):775-797. doi: 10.1096/fba.2022-00063. eCollection 2022 Dec. PMID: 36479207 PubMed

Uterine extracellular vesicles as multi-signal messengers during maternal recognition of pregnancy in the mare.
Rudolf Vegas A, Hamdi M, Podico G, Bollwein H, Fröhlich T, Canisso IF, Bauersachs S, Almiñana C. Sci Rep. 2022 Sep 16;12(1):15616. doi: 10.1038/s41598-022-19958-z. PMID: 3611435 PubMed


Developmental Effects of (Pre-)Gestational Diabetes on Offspring: Systematic Screening Using Omics Approaches.
Shashikadze B, Flenkenthaler F, Stöckl JB, Valla L, Renner S, Kemter E, Wolf E, Fröhlich T. Genes (Basel). 2021 Dec 15;12(12):1991. doi: 10.3390/genes12121991. PMID: 34946940 PubMed

Differential Effects of Insulin-Deficient Diabetes Mellitus on Visceral vs. Subcutaneous Adipose Tissue-Multi-omics Insights From the Munich MIDY Pig Model.
Flenkenthaler F, Ländström E, Shashikadze B, Backman M, Blutke A, Philippou-Massier J, Renner S, Hrabe de Angelis M, Wanke R, Blum H, Arnold GJ, Wolf E*, Fröhlich T*. Front Med (Lausanne). 2021 Nov 23;8:751277. doi: 10.3389/fmed.2021.751277. eCollection 2021. PMID: 34888323 * Corresponding authors  PubMed

A scalable, clinically severe pig model for Duchenne muscular dystrophy.
Stirm M, Fonteyne LM, Shashikadze B, Lindner M, Chirivi M, Lange A, Kaufhold C, Mayer C, Medugorac I, Kessler B, Kurome M, Zakhartchenko V, Hinrichs A, Kemter E, Krause S, Wanke R, Arnold GJ, Wess G, Nagashima H, de Angelis MH, Flenkenthaler F, Kobelke LA, Bearzi C, Rizzi R, Bähr A, Reese S, Matiasek K, Walter MC, Kupatt C, Ziegler S, Bartenstein P, Fröhlich T, Klymiuk N, Blutke A, Wolf E. Dis Model Mech. 2021 Nov 19:dmm.049285. doi: 10.1242/dmm.049285. Online ahead of print. PMID: 34796900 PubMed

Long-term exposure of Daphnia magna to polystyrene microplastic (PS-MP) leads to alterations of the proteome, morphology and life-history.
Trotter B*, Wilde MV*, Brehm J*, Dafni E, Aliu A, Arnold GJ, Fröhlich T**, Laforsch C**. Sci Total Environ.  2021 Jul 3;795:148822. doi: 10.1016/j.scitotenv.2021.148822. Online ahead of print. PMID: 34328913 * Authors contributed equally, ** Corresponding authors PubMed

Age-Related Alterations in the Testicular Proteome of a Non-Human Primate.
Stöckl JB, Schmid N, Flenkenthaler F, Drummer C, Behr R, Mayerhofer A, Arnold GJ, Fröhlich T. Cells. 2021 May 24;10(6):1306. doi: 10.3390/cells10061306. PMID: 34074003 PubMed

Growth hormone receptor knockout to reduce the size of donor pigs for preclinical xenotransplantation studies.
Hinrichs A*, Riedel EO*, Klymiuk N, Blutke A, Kemter E, Längin M, Dahlhoff M, Keßler B, Kurome M, Zakhartchenko V, Jemiller EM, Ayares D, Bidlingmaier M, Flenkenthaler F, Hrabĕ de Angelis M, Arnold GJ, Reichart B, Fröhlich T**, Wolf E**. Xenotransplantation. 2021 Mar;28(2):e12664. doi: 10.1111/xen.12664. PMID: 33241624 PubMed; * equal first author contribution, ** equal last author contribution. The manuscript was awarded with the Carl-Gustav Groth Xeno Prize!

Comparative proteomic analysis reveals the importance of the protective role of ovarian fluid over eggs during the reproduction of pikeperch.
Nyncaa J, Żarski D, Fröhlich T, Köster M, Bobe J, Ciereszkoa A, Aquaculture, Volume 548, Part 2, 15 February 2022, 737656 ScienceDirect

Neurodevelopment vs. the immune system: Complementary contributions of maternally-inherited gene transcripts and proteins to successful embryonic development in fish.
Żarski D, Le Cam A, Frohlich T, Kösters M, Klopp C, Nynca J, Ciesielski S, Sarosiek B, Dryl K, Montfort J, Król J, Fontaine P, Ciereszko A, Bobe J. Genomics. 2021 Sep 8:S0888-7543(21)00345-1. doi: 10.1016/j.ygeno.2021.09.003. Online ahead of print. PMID: 34508856 PubMed.

The transmembrane protein LRIG1 triggers melanocytic tumor development following chemically induced skin carcinogenesis.
Hoesl C, Fröhlich T, Posch C, Kneitz H, Goebeler M, Schneider MR, Dahlhoff M. Mol Oncol. 2021 Mar 31. doi: 10.1002/1878-0261.12945. Online ahead of print. PMID: 33786987 PubMed

Isolation and Characterization of Equine Uterine Extracellular Vesicles: A Comparative Methodological Study.
Almiñana C, Rudolf Vegas A, Tekin M, Hassan M, Uzbekov R, Fröhlich T, Bollwein H, Bauersachs S. Int J Mol Sci. 2021 Jan 19;22(2):979. doi: 10.3390/ijms22020979. PMID: 33478136 PubMed


Filamin A Orchestrates Cytoskeletal Structure, Cell Migration and Stem Cell Characteristics in Human Seminoma TCam-2 Cells.
Welter H, Herrmann C, Fröhlich T, Flenkenthaler F, Eubler K, Schorle H, Nettersheim D, Mayerhofer A, Müller-Taubenberger A. Cells. 2020 Nov 30;9(12):E2563. doi: 10.3390/cells9122563. PMID: 33266100 PubMed

Proteomic Insights into Senescence of Testicular Peritubular Cells from a Nonhuman Primate Model.
Stöckl JB, Schmid N, Flenkenthaler F, Drummer C, Behr R, Mayerhofer A, Arnold GJ, Fröhlich T. Cells. 2020 Nov 17;9(11):E2498. doi: 10.3390/cells9112498. PMID: 33213088 PubMed

A decade of experience with genetically tailored pig models for diabetes and metabolic research.
Zettler S, Renner S, Kemter E, Hinrichs A, Klymiuk N, Backman M, Riedel EO, Mueller C, Streckel E, Braun-Reichhart C, Martins AS, Kurome M, Keßler B, Zakhartchenko V, Flenkenthaler F, Arnold GJ, Fröhlich T, Blum H, Blutke A, Wanke R, Wolf E. Anim Reprod. 2020 Aug 26;17(3):e20200064. doi: 10.1590/1984-3143-AR2020-0064. PMID: 33029223 PubMed

Progressive Proteome Changes in the Myocardium of a Pig Model for Duchenne Muscular Dystrophy.
Tamiyakul H, Kemter E, Kösters M, Ebner S, Blutke A, Klymiuk N, Flenkenthaler F, Wolf E, Arnold GJ, Fröhlich T. iScience. 2020 Sep 1;23(9):101516. doi: 10.1016/j.isci.2020.101516. PMID: 32927262 PubMed

The impact of transcription inhibition during in vitro maturation on the proteome of bovine oocytes.
Gegenfurtner K, Flenkenthaler F, Fröhlich T, Wolf E, Arnold GJ. Biol Reprod. 2020 Aug 28:ioaa149. doi: 10.1093/biolre/ioaa149. Online ahead of print. PMID: 32856698 PubMed

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Thoms M, Buschauer R, Ameismeier M, Koepke L, Denk T, Hirschenberger M, Kratzat H, Hayn M, Mackens-Kiani T, Cheng J, Straub JH, Stürzel CM, Fröhlich T, Berninghausen O, Becker T, Kirchhoff F, Sparrer K, Beckmann R.
Science. 2020 Jul 17:eabc8665. doi: 10.1126/science.abc8665. PubMed

Metabolic implication of tigecycline as an efficacious second-line treatment for sorafenib-resistant hepatocellular carcinoma.
Meßner M, Schmitt S, Ardelt MA, Fröhlich T, Müller M, Pein H, Huber-Cantonati P, Ortler C, Koenig LM, Zobel L, Koeberle A, Arnold GJ, Rothenfußer S, Kiemer AK, Gerbes AL, Zischka H, Vollmar AM, Pachmayr J. FASEB J. 2020 Jul 11. doi: 10.1096/fj.202001128R. Online ahead of print. PubMed

A translational cellular model for the study of peritubular cells of the testis. Schmid N, Missel A, Petkov S, Stöckl JB, Flenkenthaler F, Arnold GJ, Fröhlich T, Behr R, Mayerhofer A. Reproduction. 2020 May 1:REP-20-0100.R2. doi: 10.1530/REP-20-0100. Online ahead of print. PubMed

Functional changes of the liver in the absence of growth hormone (GH) action - Proteomic and metabolomic insights from a GH receptor deficient pig model. Riedel EO, Hinrichs A, Kemter E, Dahlhoff M, Backman M, Rathkolb B, Prehn C, Adamski J, Renner S, Blutke A, de Angelis MH, Bidlingmaier M, Schopohl J, Arnold GJ, Fröhlich T*, Wolf E*. Mol Metab. 2020 Mar 18:100978. doi: 10.1016/j.molmet.2020.100978. [Epub ahead of print] * contributed equally PubMed

The secretome of skin cancer cells activates the mTOR/MYC pathway in healthy keratinocytes and induces tumorigenic properties. Hoesl C, Zanuttigh E, Fröhlich T, Philippou-Massier J, Krebs S, Blum H, Dahlhoff M. Biochim Biophys Acta Mol Cell Res. 2020 Apr 10:118717. doi: 10.1016/j.bbamcr.2020.118717. [Epub ahead of print] PubMed

Trafficking of siRNA precursors by the dsRBD protein Blanks in Drosophila. Nitschko V, Kunzelmann S, Fröhlich T, Arnold GJ, Förstemann K. Nucleic Acids Res. 2020 Feb 6. pii: gkaa072. doi: 10.1093/nar/gkaa072. [Epub ahead of print] PubMed

Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy. Moretti A, Fonteyne L, Giesert F, Hoppmann P, Meier AB, Bozoglu T, Baehr A, Schneider CM, Sinnecker D, Klett K, Fröhlich T, Rahman FA, Haufe T, Sun S, Jurisch V, Kessler B, Hinkel R, Dirschinger R, Martens E, Jilek C, Graf A, Krebs S, Santamaria G, Kurome M, Zakhartchenko V, Campbell B, Voelse K, Wolf A, Ziegler T, Reichert S, Lee S, Flenkenthaler F, Dorn T, Jeremias I, Blum H, Dendorfer A, Schnieke A, Krause S, Walter MC, Klymiuk N, Laugwitz KL, Wolf E, Wurst W, Kupatt C. Nat Med. 2020 Jan 27. doi: 10.1038/s41591-019-0738-2. [Epub ahead of print] PubMed

Genetic merit for fertility alters the bovine uterine luminal fluid proteome. Gegenfurtner K, Fröhlich T, Flenkenthaler F, Kösters M, Fritz S, Desnoës O, Bourhis DL, Salvetti P, Sandra O, Charpigny G, Mermillod P, Lonergan P, Wolf E, Arnold GJ. Biol Reprod. 2020 Mar 13;102(3):730-739. doi: 10.1093/biolre/ioz216. PubMed

Tolerance of Stored Boar Spermatozoa to Autologous Seminal Plasma: A Proteomic and Lipidomic Approach.
Höfner L, Luther AM, Palladini A, Fröhlich T, Waberski D. Int J Mol Sci. 2020;21(18):E6474. doi: 10.3390/ijms21186474. PMID: 32899843 PubMed

Novel sampling procedure to characterize bovine subclinical endometritis by uterine secretions and tissue. Helfrich AL, Reichenbach HD, Meyerholz MM, Schoon HA, Arnold GJ, Fröhlich T, Weber F, Zerbe H. Theriogenology. 2020 Jan 1;141:186-196. doi: 10.1016/j.theriogenology.2019.09.016. Epub 2019 Sep 16. PubMed



Detection of collagens by multispectral optoacoustic tomography as an imaging biomarker for Duchenne muscular dystrophy. Regensburger AP, Fonteyne LM, Jüngert J, Wagner AL, Gerhalter T, Nagel AM, Heiss R, Flenkenthaler F, Qurashi M, Neurath MF, Klymiuk N, Kemter E, Fröhlich T, Uder M, Woelfle J, Rascher W, Trollmann R, Wolf E, Waldner MJ, Knieling F. Nat Med. 2019 Dec;25(12):1905-1915. doi: 10.1038/s41591-019-0669-y. Epub 2019 Dec 2. PubMed

Downregulation of GRK5 hampers the migration of breast cancer cells. Sommer AK, Falcenberg M, Ljepoja B, Fröhlich T, Arnold GJ, Wagner E, Roidl A. Sci Rep. 2019 Oct 29;9(1):15548. doi: 10.1038/s41598-019-51923-1. PubMed

Insights into replicative senescence of human testicular peritubular cells. Schmid N, Flenkenthaler F, Stöckl JB, Dietrich KG, Köhn FM, Schwarzer JU, Kunz L, Luckner M, Wanner G, Arnold GJ, Fröhlich T, Mayerhofer A. Sci Rep. 2019 Oct 21;9(1):15052. doi: 10.1038/s41598-019-51380-w. PubMed

The transmembrane protein LRIG2 increases tumor progression in skin carcinogenesis. Hoesl C, Fröhlich T, Hundt JE, Kneitz H, Goebeler M, Wolf R, Schneider MR, Dahlhoff M. Mol Oncol. 2019 Nov;13(11):2476-2492. doi: 10.1002/1878-0261.12579. Epub 2019 Oct 21. PubMed

Influence of metabolic status and genetic merit for fertility on proteomic composition of bovine oviduct fluid. Gegenfurtner K, Fröhlich T, Kösters M, Mermillod P, Locatelli Y, Fritz S, Salvetti P, Forde N N, Lonergan P, Wolf E, Arnold GJ. Biol Reprod. 2019 Jul 26. pii: ioz142. doi: 10.1093/biolre/ioz142. [Epub ahead of print] PubMed

Multi-omics insights into functional alterations of the liver in insulin-deficient diabetes mellitus.
Backman M*, Flenkenthaler F*, Blutke A, Dahlhoff M, Ländström E, Renner S, Philippou-Massier J, Krebs S, Rathkolb B, Prehn C, Grzybek M, Coskun Ü, Rothe M, Adamski J, de Angelis MH, Wanke R, Fröhlich T, Arnold GJ, Blum H, Wolf E. Mol Metab. 2019 Jun 4. pii: S2212-8778(19)30186-3. doi: 10.1016/j.molmet.2019.05.011. [Epub ahead of print] * contributed equally PubMed

Uterine fluid proteome changes during diapause and resumption of embryo development in roe deer. van der Weijden VA, Bick J, Bauersachs S, Arnold GJ, Fröhlich T, Drews B, Ulbrich SE. Reproduction. 2019 Apr 1. pii: REP-19-0022.R1. doi: 10.1530/REP-19-0022. [Epub ahead of print] PubMed

A novel approach to study the bovine oviductal fluid proteome using transvaginal endoscopy. Papp SM, Fröhlich T, Radefeld K, Havlicek V, Kösters M, Yu H, Mayrhofer C, Brem G, Arnold GJ, Besenfelder U. Theriogenology. 2019 Jul 1;132:53-61. doi: 10.1016/j.theriogenology.2019.04.009. Epub 2019 Apr 8. PubMed

Anti α-enolase antibody is a novel autoimmune biomarker for unexplained recurrent miscarriages. Ye Y, Kuhn C, Kösters M, Arnold GJ, Ishikawa-Ankerhold H, Schulz C, Rogenhofer N, Thaler CJ, Mahner S, Fröhlich T, Jeschke U, von Schönfeldt V. EBioMedicine. 2019 Feb 28. pii: S2352-3964(19)30104-5. PubMed

Necroptosis in primate luteolysis: a role for ceramide. Bagnjuk K, Stöckl JB, Fröhlich T, Arnold GJ, Behr R, Berg U, Berg D, Kunz L, Bishop C, Xu J, Mayerhofer A. Cell Death Discov. 2019 Feb 11;5:67. doi: 10.1038/s41420-019-0149-7. eCollection 2019.  PubMed

CD36-triggered cell invasion and persistent tissue colonization by tumor microvesicles during metastasis. Pfeiler S, Thakur M, Grünauer P, Megens RTA, Joshi U, Coletti R, Samara V, Müller-Stoy G, Ishikawa-Ankerhold H, Stark K, Klingl A, Fröhlich T, Arnold GJ, Wörmann S, Bruns CJ, Algül H, Weber C, Massberg S, Engelmann B. FASEB J. 2019 Feb;33(2):1860-1872. PubMed

Inhibition of Cyclin-dependent Kinase 5 - a Novel Strategy to Improve Sorafenib Response in HCC Therapy.
Ardelt MA, Fröhlich T, Martini E, Müller M, Kanitz V, Atzberger C, Cantonati P, Meßner M, Posselt L, Lehr T, Wojtyniak JG, Ulrich M, Arnold GJ, König L, Parazzoli D, Zahler S, Rothenfußer S, Mayr D, Gerbes A, Scita G, Vollmar AM, Pachmayr J.
Hepatology. 2019 Jan;69(1):376-393. PubMed



A proteomic analysis of chemoresistance development via sequential treatment with doxorubicin reveals novel players in MCF‑7 breast cancer cells. Sommer AK, Hermawan A, Ljepoja B, Fröhlich T, Arnold GJ, Wagner E, Roidl A. Int J Mol Med. 2018 Oct;42(4):1987-1997. PubMed

Insights into the role of androgen receptor in human testicular peritubular cells.
Mayer C, Adam M, Walenta L, Schmid N, Heikelä H, Schubert K, Flenkenthaler F, Dietrich KG, Gruschka S, Arnold GJ, Fröhlich T, Schwarzer JU, Köhn FM, Strauss L, Welter H, Poutanen M, Mayerhofer A. Andrology. 2018 JSep;6(5):756-765. PubMed

Characterization of a nonhuman primate model for the study of testicular peritubular cells - comparison with human testicular cells.
Schmid N, Stöckl JB, Flenkenthaler F, Dietrich KG, Schwarzer JU, Köhn FM, Drummer C, Fröhlich T, Arnold GJ, Behr R, Mayerhofer A.
Mol Hum Reprod. 2018 Aug 1;24(8):401-410. PubMed

A proteomic analysis of an in vitro knock-out of miR-200c.
Ljepoja B, García-Roman J, Sommer AK, Fröhlich T, Arnold GJ, Wagner E, Roidl A.
Sci Rep. 2018 May 2;8(1):6927. doi: 10.1038/s41598-018-25240-y. PubMed

ATP-mediated Events in Peritubular Cells Contribute to Sterile Testicular Inflammation.
Walenta L, Fleck D, Fröhlich T, Eysmondt H, Arnold GJ, Spehr J, Schwarzer JU, Köhn FM, Spehr M, Mayerhofer A.
Sci Rep. 2018 Jan 23;8(1):1431. doi: 10.1038/s41598-018-19624-3. PubMed



The Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes.
Blutke A, Renner S, Flenkenthaler F, Backman M, Haesner S, Kemter E, Ländström E, Braun-Reichhart C, Albl B, Streckel E, Rathkolb B, Prehn C, Palladini A, Grzybek M, Krebs S, Bauersachs S, Bähr A, Brühschwein A, Deeg CA, De Monte E, Dmochewitz M, Eberle C, Emrich D, Fux R, Groth F, Gumbert S, Heitmann A, Hinrichs A, Keßler B, Kurome M, Leipig-Rudolph M, Matiasek K, Öztürk H, Otzdorff C, Reichenbach M, Reichenbach HD, Rieger A, Rieseberg B, Rosati M, Saucedo MN, Schleicher A, Schneider MR, Simmet K, Steinmetz J, Übel N, Zehetmaier P, Jung A, Adamski J, Coskun Ü, Hrabě de Angelis M, Simmet C, Ritzmann M, Meyer-Lindenberg A, Blum H, Arnold GJ, Fröhlich T, Wanke R, Wolf E.
Mol Metab. 2017 Jun 13;6(8):931-940. doi: 10.1016/j.molmet.2017.06.004. eCollection 2017 Aug. PubMed

Antibodies against the mono-methylated arginine-glycine repeat (MMA-RG) of the Epstein-Barr virus nuclear antigen 2 (EBNA2) identify potential cellular proteins targeted in viral transformation.
Ayoubian H, Fröhlich T, Pogodski D, Flatley A, Kremmer E, Schepers A, Feederle R, Arnold GJ, Grässer FA.
J Gen Virol. 2017 Aug;98(8):2128-2142. doi: 10.1099/jgv.0.000870. Epub 2017 Jul 28. PubMed

Proteomic identification of turkey (Meleagris gallopavo) seminal plasma proteins.
Slowinska M, Nynca J, Arnold GJ, Fröhlich T, Jankowski J, Kozlowski K, Mostek A, Ciereszko A.
Poult Sci. 2017 Sep 1;96(9):3422-3435. doi: 10.3382/ps/pex132. PubMed

Proteomic identification of rainbow trout blood plasma proteins and their relationship to seminal plasma proteins.
Nynca J, Arnold GJ, Fröhlich T, Ciereszko A.
Proteomics. 2017 Jun;17(11). doi: 10.1002/pmic.20160046 PubMed

Mitochondrial Dysregulation Secondary to Endoplasmic Reticulum Stress in Autosomal Dominant Tubulointerstitial Kidney Disease - UMOD (ADTKD-UMOD).
Kemter E, Fröhlich T, Arnold GJ, Wolf E, Wanke R.
Sci Rep
. 2017 Feb 21;7:42970. doi: 10.1038/srep42970. PubMed

ADNP Is a Therapeutically Inducible Repressor of WNT Signaling in Colorectal Cancer. 
Blaj C, Bringmann A, Schmidt EM, Urbischek M, Lamprecht S, Fröhlich TArnold GJ, Krebs S, Blum H, Hermeking H, Jung A, Kirchner T, Horst D. 
Clin Cancer Res. 2017 Jun 1;23(11):2769-2780. doi: 10.1158/1078-0432.CCR-16-1604. Epub 2016 Nov 30. PubMed



ROS-Mediated Inhibition of S-nitrosoglutathione Reductase Contributes to the Activation of Anti-oxidative Mechanisms.
Kovacs I, Holzmeister C, Wirtz M, Geerlof A, Fröhlich T, Römling G, Kuruthukulangarakoola GT, Linster E, Hell R, Arnold GJ, Durner J, Lindermayr C.
Front Plant Sci
. 2016 Nov 10;7:1669. eCollection 2016. PubMed

Improved cryotolerance and developmental potential of in vitro and in vivo matured mouse oocytes by supplementing with a glutathione donor prior to vitrification.
Trapphoff T, Heiligentag M, Simon J, Staubach N, Seidel T, Otte K, Fröhlich T, Arnold GJ, Eichenlaub-Ritter U.
Mol Hum Reprod
. 2016 Dec;22(12):867-881. Epub 2016 Sep 7. PubMed

Modelling oviduct fluid formation in vitro.
Simintiras CA, Fröhlich T, Sathyapalan T, Arnold GJ, Ulbrich SE, Leese HJ, Sturmey RG.
. 2016 Oct 13. pii: REP-15-0508. PubMed

Progressive muscle proteome changes in a clinically relevant pig model of Duchenne muscular dystrophy.
Fröhlich T, Kemter E, Flenkenthaler F, Klymiuk N, Otte KA, Blutke A, Krause S, Walter MC, Wanke R, Wolf E, Arnold GJ.
Sci Rep. 2016 Sep 16;6:33362. doi: 10.1038/srep33362. PubMed

Cyclin-dependent kinase 5 stabilizes hypoxia-inducible factor-1α: a novel approach for inhibiting angiogenesis in hepatocellular carcinoma.
Herzog J, Ehrlich SM, Pfitzer L, Liebl J, Fröhlich T, Arnold GJ, Mikulits W, Haider C, Vollmar AM, Zahler S.
Oncotarget. 2016 May 10;7(19):27108-21. doi: 10.18632/oncotarget.8342. PubMed

Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes.
Trapphoff T, Heiligentag M, Dankert D, Demond H, Deutsch D, Fröhlich TArnold GJ, Grümmer R, Horsthemke B, Eichenlaub-Ritter U.
Hum Reprod. 2016 Jan;31(1):133-49. doi: 10.1093/humrep/dev279. Epub 2015 Nov 17. PubMed

LC-MS/MS analysis reveals a broad functional spectrum of proteins in the secretome of sebocytes. 
Dahlhoff M, Fröhlich TArnold GJ, Zouboulis CC, Schneider MR. 
Exp Dermatol
. 2016 Jan;25(1):66-7. doi: 10.1111/exd.12867. Epub 2015 Nov 23. No abstract available. PubMed



The influence of simulated microgravity on the proteome of Daphnia magna.
Trotter B, Otte KA, Schoppmann K, Hemmersbach R, Fröhlich T, Arnold GJ, Laforsch C.
NPJ Microgravity. 2015 Sep 24;1:15016. doi: 10.1038/npjmgrav.2015.16. eCollection 2015.PMID:28725717 PubMed

Human testicular peritubular cells secrete pigment epithelium-derived factor (PEDF), which may be responsible for the avascularity of the seminiferous tubules.
Windschüttl S, Kampfer C, Mayer C, Flenkenthaler F, Fröhlich T, Schwarzer JU, Köhn FM, Urbanski H, Arnold GJ, Mayerhofer A.
Sci Rep. 2015 Sep 3;5:12820. doi: 10.1038/srep12820. PubMed

Proteomic analysis of extracellular medium of cryopreserved carp (Cyprinus carpio L.) semen.
Dietrich MA, Arnold GJ, Fröhlich T, Otte KA, Dietrich GJ, Ciereszko A.
Comp Biochem Physiol Part D Genomics Proteomics
. 2015 Sep;15:49-57. doi: 10.1016/j.cbd.2015.05.003. Epub 2015 Jun 6. PubMed

Interclonal proteomic responses to predator exposure in Daphnia magna may depend on predator composition of habitats.
Otte KA, Schrank I, Fröhlich T, Arnold GJ, Laforsch C.
Mol Ecol
. 2015 Aug;24(15):3901-17. doi: 10.1111/mec.13287. Epub 2015 Jul 20. PubMed

Betacellulin transgenic mice develop urothelial hyperplasia and show sex-dependent reduction in urinary major urinary protein content. Schulz H, Dahlhoff M, Glogowska A, Zhang L, Arnold GJ, Fröhlich T, Schneider MR, Klonisch T. Exp Mol Pathol. 2015 Aug;99(1):33-8. doi: 10.1016/j.yexmp.2015.05.002. Epub 2015 May 2. PubMed

Cryopreservation-induced alterations in protein composition of rainbow trout semen.
Nynca J, Arnold GJ, Fröhlich T, Ciereszko A.
. 2015 Aug;15(15):2643-54. doi: 10.1002 Epub 2015 Apr 29. PubMed

Shotgun proteomics of rainbow trout ovarian fluid.
Nynca J, Arnold GJ, Fröhlich T, Ciereszko A.
Reprod Fertil Dev
. 2015 Mar;27(3):504-12. doi: 10.1071/RD13224. PubMed

Readthrough acetylcholinesterase (AChE-R) and regulated necrosis: pharmacological targets for the regulation of ovarian functions?
Blohberger J, Kunz L, Einwang D, Berg U, Berg D, Ojeda SR, Dissen GA, Fröhlich T, Arnold GJ, Soreq H, Lara H, Mayerhofer A.
Cell Death Dis. 2015 Mar 12;6:e1685. doi: 10.1038/cddis.2015.51. PubMed

Characterization of the sebocyte lipid droplet proteome reveals novel potential regulators of sebaceous lipogenesis.
Dahlhoff M, Fröhlich TArnold GJ, Müller U, Leonhardt H, Zouboulis CC, Schneider MR. 
Exp Cell Res
. 2015 Mar 1;332(1):146-55. doi: 10.1016/j.yexcr.2014.12.004. Epub 2014 Dec 16. PubMed



In-depth proteomic analysis of carp (Cyprinus carpio L) spermatozoa.
Dietrich MA, Arnold GJ, Fröhlich T, Ciereszko A.
Comp Biochem Physiol Part D Genomics Proteomics
. 2014 Dec;12:10-5. doi: 10.1016/j.cbd.2014.09.003. Epub 2014 Sep 28. PubMed

Proteome analysis of early lineage specification in bovine embryos.
Demant M, Deutsch DR, Fröhlich T, Wolf E, Arnold GJ.
. 2015 Feb;15(4):688-701. doi: 10.1002. Epub 2014 Oct 9. PubMed

Stage-specific proteome signatures in early bovine embryo development.
Deutsch DR, Fröhlich T, Otte KA, Beck A, Habermann FA, Wolf E, Arnold GJ.
J Proteome Res
. 2014 Oct 3;13(10):4363-76. doi: 10.1021. Epub 2014 Sep 10. PubMed

Proteomic analysis of Daphnia magna hints at molecular pathways involved in defensive plastic responses.
Otte KA, Fröhlich T, Arnold GJ, Laforsch C.
BMC Genomics
. 2014 Apr 24;15:306. doi: 10.1186/1471-2164-15-306. PubMed

Proteomic identification of rainbow trout sperm proteins.
Nynca J, Arnold GJ, Fröhlich T, Otte K, Ciereszko A.
Proteomics. 2014 Jun;14(12):1569-73. doi: 10.1002. Epub 2014 May 12. PubMed

Characterization of carp seminal plasma proteome in relation to blood plasma.
Dietrich MA, Arnold GJ, Nynca J, Fröhlich T, Otte K, Ciereszko A.
J Proteomics
. 2014 Feb 26;98:218-32. doi: 10.1016/j.jprot.2014.01.005. Epub 2014 Jan 13. PubMed

Secretome analysis of testicular peritubular cells: a window into the human testicular microenvironment and the spermatogonial stem cell niche in man.
Flenkenthaler F, Windschüttl S, Fröhlich T, Schwarzer JU, Mayerhofer A, Arnold GJ.
J Proteome Res
. 2014 Mar 7;13(3):1259-69. doi: 10.1021. Epub 2014 Jan 30. PubMed

Proteomic identification of rainbow trout seminal plasma proteins.
Nynca J, Arnold GJ, Fröhlich T, Otte K, Flenkenthaler F, Ciereszko A.
. 2014 Jan;14(1):133-40. doi: 10.1002. Epub 2013 Dec 11. PubMed



V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activation in vivo.
Kubisch R, Fröhlich T, Arnold GJ, Schreiner L, von Schwarzenberg K, Roidl A, Vollmar AM, Wagner E.
Int J Cancer. 2014 May 15;134(10):2478-88. doi: 10.1002/ijc.28562. Epub 2013 Nov 14. PubMed

iTRAQ proteome analysis reflects a progressed differentiation state of epiblast derived versus inner cell mass derived murine embryonic stem cells.
Fröhlich T, Kösters M, Graf A, Wolf E, Kobolak J, Brochard V, Dinnyés A, Jouneau A, Arnold GJ.
J Proteomics
. 2013 Sep 2;90:38-51. doi: 10.1016/j.jprot.2013.03.015. Epub 2013 Apr 18. PubMed

Promiscuous behaviour of archaeal ribosomal proteins: implications for eukaryotic ribosome evolution.
Armache JP, Anger AM, Márquez V, Franckenberg S, Fröhlich T, Villa E, Berninghausen O, Thomm M, Arnold GJ, Beckmann R, Wilson DN.
Nucleic Acids Res. 2013 Jan;41(2):1284-93. doi: 10.1093/nar/gks1259. Epub 2012 Dec 6. PubMed

ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions. A method to directly monitor the active conformation of LRRK2?
Gillardon F, Kremmer E, Froehlich T, Ueffing M, Hengerer B, Gloeckner CJ.
J Neurosci Methods. 2013 Mar 30;214(1):62-8. doi: 10.1016/j.jneumeth.2012.12.015. Epub 2013 Jan 12

2D DIGE analysis of the bursa of Fabricius reveals characteristic proteome profiles for different stages of chicken B-cell development.
Korte J, Fröhlich T, Kohn M, Kaspers B, Arnold GJ, Härtle S.
. 2013 Jan;13(1):119-33. doi: 10.1002. Epub 2012 Dec 5. PubMed



2D DIGE saturation labeling for minute sample amounts.
Arnold GJ
, Fröhlich T.
Methods Mol Biol
. 2012;854:89-112. doi: 10.1007/978-1-61779-573-2_7. PubMed

Vitrification at the pre-antral stage transiently alters inner mitochondrial membrane potential but proteome of in vitro grown and matured mouse oocytes appears unaffected.
Demant M, Trapphoff T, Fröhlich T, Arnold GJ, Eichenlaub-Ritter U.
Hum Reprod
. 2012 Apr;27(4):1096-111. doi: 10.1093/humrep/der453. Epub 2012 Jan 18. PubMed

First inducible transgene expression in porcine large animal models.
Klymiuk N, Böcker W, Schönitzer V, Bähr A, Radic T, Fröhlich T, Wünsch A, Keßler B, Kurome M, Schilling E, Herbach N, Wanke R, Nagashima H, Mutschler W, Arnold GJ, Schwinzer R, Schieker M, Wolf E.
FASEB J. 2012 Mar;26(3):1086-99. doi: 10.1096/fj.11-185041. Epub 2011 Dec 1. PubMed



Quantifying attomole amounts of proteins from complex samples by nano-LC and selected reaction monitoring. Fröhlich T, Arnold GJ.
Methods Mol Biol. 2011;790:141-64. doi: 10.1007/978-1-61779-319-6_11. PubMed

Human tryptase cleaves pro-nerve growth factor (pro-NGF): hints of local, mast cell-dependent regulation of NGF action.
Spinnler K, Fröhlich T, Arnold GJ, Kunz L, Mayerhofer A.
J Biol Chem
. 2011 Sep 9;286(36):31707-13. doi: 10.1074/jbc.M111.233486. Epub 2011 Jul 18. PubMed

Differential glomerular proteome analysis of two murine nephropathy models at onset of albuminuria.
Blutke A, Block C, Berendt F, Herbach N, Kemter E, Amann K, Fröhlich T, Arnold GJ, Wanke R.
Proteomics Clin Appl
. 2011 Jun;5(5-6):375-81. doi: 10.1002. Epub 2011 Apr 29. PubMed

Dynamic proteome signatures in gametes, embryos and their maternal environment.
Arnold GJ
, Frohlich T.
Reprod Fertil Dev
. 2011;23(1):81-93. doi: 10.1071/RD10223. Review. PubMed

The ecoresponsive genome of Daphnia pulex.
Colbourne JK, Pfrender ME, Gilbert D, Thomas WK, Tucker A, Oakley TH, Tokishita S, Aerts A, Arnold GJ, Basu MK, Bauer DJ, Cáceres CE, Carmel L, Casola C, Choi JH, Detter JC, Dong Q, Dusheyko S, Eads BD, Fröhlich T, Geiler-Samerotte KA, Gerlach D, et al.
. 2011 Feb 4;331(6017):555-61. doi: 10.1126/science.1197761. PubMed

Proteomic characterization of archaeal ribosomes reveals the presence of novel archaeal-specific ribosomal proteins.
Márquez V, Fröhlich T, Armache JP, Sohmen D, Dönhöfer A, Mikolajka A, Berninghausen O, Thomm M, Beckmann R, Arnold GJ, Wilson DN.
J Mol Biol
. 2011 Feb 4;405(5):1215-32. doi: 10.1016/j.jmb.2010.11.055. Epub 2010 Dec 4. PubMed

Bovine endometrial metallopeptidases MMP14 and MMP2 and the metallopeptidase inhibitor TIMP2 participate in maternal preparation of pregnancy.
Ulbrich SE, Meyer SU, Zitta K, Hiendleder S, Sinowatz F, Bauersachs S, Büttner M, Fröhlich T, Arnold GJ, Reichenbach HD, Wolf E, Meyer HH.
Mol Cell Endocrinol
. 2011 Jan 30;332(1-2):48-57. doi: 10.1016/j.mce.2010.09.009. Epub 2010 Sep 29. PubMed



In vivo chemoresistance of prostate cancer in metronomic cyclophosphamide therapy.
Thoenes L, Hoehn M, Kashirin R, Ogris M, Arnold GJ, Wagner E, Guenther M.
J Proteomics
. 2010 May 7;73(7):1342-54. doi: 10.1016/j.jprot.2010.02.019. Epub 2010 Feb 25. PubMed

Identification of novel downstream targets of platelet glycoprotein VI activation by differential proteome analysis: implications for thrombus formation.
Schulz C, Leuschen NV, Fröhlich T, Lorenz M, Pfeiler S, Gleissner CA, Kremmer E, Kessler M, Khandoga AG, Engelmann B, Ley K, Massberg S, Arnold GJ.
. 2010 May 20;115(20):4102-10. doi: 10.1182/blood-2009-07-230268. Epub 2010 Jan 27. PubMed

Creating new knowledge for ruminant reproduction from rapidly expanding and evolving scientific databases.
Bauersachs S, Blum H, Krebs S, Fröhlich T, Arnold GJ, Wolf E.
Soc Reprod Fertil Suppl. 2010;67:29-40. Review.



A newcomer's guide to nano-liquid-chromatography of peptides.
Fröhlich T, Arnold GJ.
Methods Mol Biol
. 2009;564:123-41. doi: 10.1007/978-1-60761-157-8_7. PubMed

Evidence for estrogen-dependent uterine serpin (SERPINA14) expression during estrus in the bovine endometrial glandular epithelium and lumen.
Ulbrich SE, Frohlich T, Schulke K, Englberger E, Waldschmitt N, Arnold GJ, Reichenbach HD, Reichenbach M, Wolf E, Meyer HH, Bauersachs S.
Biol Reprod
. 2009 Oct;81(4):795-805. doi: 10.1095/biolreprod.108.075184. Epub 2009 Jun 3. PubMed

LC-MS/MS-based proteome profiling in Daphnia pulex and Daphnia longicephala: the Daphnia pulex genome database as a key for high throughput proteomics in Daphnia.
Fröhlich T, Arnold GJ, Fritsch R, Mayr T, Laforsch C.
BMC Genomics
. 2009 Apr 21;10:171. doi: 10.1186/1471-2164-10-171. PubMed

Highly sensitive saturation labeling reveals changes in abundance of cell cycle-associated proteins and redox enzyme variants during oocyte maturation in vitro.
Berendt FJ, Fröhlich T, Bolbrinker P, Boelhauve M, Güngör T, Habermann FA, Wolf E, Arnold GJ.
. 2009 Feb;9(3):550-64. doi: 10.1002. PubMed



The brain proteome profile is highly conserved between Prnp-/- and Prnp+/+ mice.
Crecelius AC, Helmstetter D, Strangmann J, Mitteregger G, Fröhlich T, Arnold GJ, Kretzschmar HA.
Neuroreport. 2008 Jul 2;19(10):1027-31. doi: 10.1097/WNR.0b013e3283046157. PubMed

Invasion of tumorigenic HT1080 cells is impeded by blocking or downregulating the 37-kDa/67-kDa laminin receptor.
Zuber C, Knackmuss S, Zemora G, Reusch U, Vlasova E, Diehl D, Mick V, Hoffmann K, Nikles D, Fröhlich T, Arnold GJ, Brenig B, Wolf E, Lahm H, Little M, Weiss S.
J Mol Biol
. 2008 May 2;378(3):530-9. doi: 10.1016/j.jmb.2008.02.004. Epub 2008 Feb 12. PubMed

Assessing quantitative post-mortem changes in the gray matter of the human frontal cortex proteome by 2-D DIGE.
Crecelius A, Götz A, Arzberger T, Fröhlich T, Arnold GJ, Ferrer I, Kretzschmar HA.
. 2008 Mar;8(6):1276-91. doi: 10.1002. PubMed



Dual specificities of the glyoxysomal/peroxisomal processing protease Deg15 in higher plants.
Helm M, Lück C, Prestele J, Hierl G, Huesgen PF, Fröhlich T, Arnold GJ, Adamska I, Görg A, Lottspeich F, Gietl C.
Proc Natl Acad Sci U S A
. 2007 Jul 3;104(27):11501-6. Epub 2007 Jun 25. PubMed

Single chain Fv antibodies directed against the 37 kDa/67 kDa laminin receptor as therapeutic tools in prion diseases.
Zuber C, Knackmuss S, Rey C, Reusch U, Röttgen P, Fröhlich T, Arnold GJ, Pace C, Mitteregger G, Kretzschmar HA, Little M, Weiss S.
Mol Immunol
. 2008 Jan;45(1):144-51. Epub 2007 Jun 18. PubMed



Analysis of the HUPO Brain Proteome reference samples using 2-D DIGE and 2-D LC-MS/MS. Fröhlich T, Helmstetter D, Zobawa M, Crecelius AC, Arzberger T, Kretzschmar HA, Arnold GJ.
. 2006 Sep;6(18):4950-66. PubMed

Methods for transcriptome and proteome research: applications for studying the biology of reproduction in cattle.
Wolf E, Hiendleder S, Bauersachs S, Fröhlich T, Sinowatz F, Blum H, Arnold GJ.
Berl Munch Tierarztl Wochenschr
. 2006 Jan-Feb;119(1-2):7-16. Review. German. PubMed

Proteome research based on modern liquid chromatography--tandem mass spectrometry: separation, identification and quantification.
Fröhlich T, Arnold GJ.
J Neural Transm (Vienna). 2006 Aug;113(8):973-94. Epub 2006 Jul 13. Review. PubMed



Holistic differential analysis of embryo-induced alterations in the proteome of bovine endometrium in the preattachment period.
Berendt FJ, Fröhlich T, Schmidt SE, Reichenbach HD, Wolf E, Arnold GJ.
. 2005 Jul;5(10):2551-60. PubMed

Functional genomics: tools for improving farm animal health and welfare.
Hiendleder S, Bauersachs S, Boulesteix A, Blum H, Arnold GJ, Fröhlich T, Wolf E.
Rev Sci Tech. 2005 Apr;24(1):355-77. Review. PubMed

Holistic differential analysis of embryo-induced alterations in the proteome of bovine endometrium in the preattachment period.
Berendt FJ, Fröhlich T, Schmidt SE, Reichenbach HD, Wolf E, Arnold GJ.
Proteomics. 2005 Jul;5(10):2551-60. PubMed



Detection of wild type and deleted latent membrane protein 1 (LMP1) of Epstein-Barr virus in clinical biopsy material.
Nicholls J, Hahn P, Kremmer E, Fröhlich T, Arnold GJ, Sham J, Kwong D, Grässer FA.
J Virol Methods. 2004 Mar 1;116(1):79-88. PubMed



Embryo-maternal communication in bovine - strategies for deciphering a complex cross-talk.
Wolf E, Arnold GJ, Bauersachs S, Beier HM, Blum H, Einspanier R, Fröhlich T, Herrler A, Hiendleder S, Kölle S, Prelle K, Reichenbach HD, Stojkovic M, Wenigerkind H, Sinowatz F.
Reprod Domest Anim
. 2003 Aug;38(4):276-89. Review. PubMed