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Conzelmann - Molecular Biology of Negative Strand RNA Viruses

Research Topics

  • Rabies Virus Neuron-Biology
  • Trans-synaptic Tracing of Neurons
  • Innate Immune Response to RNA Viruses

We are studying negative strand RNA viruses like rabies and measles virus to learn how they exploit and trick the cellular machineries. Key technologies include genetic engineering of RNA viruses (reverse genetics) and CRISPR-based editing of entire host cell genomes. The knowledge of details of virus replication and host-cell interplay is required to develop novel antiviral strategies to exploit viruses as biomedical tools or vaccines. Read more...

Selected Publications

Transplanted embryonic neurons integrate into adult neocortical circuits.
Falkner S, Grade S, Dimou L, Conzelmann KK, Bonhoeffer T, Götz M, Hübener M.
Nature. 2016 Nov 10;539(7628):248-253. doi: 10.1038/nature20113. Epub 2016 Oct 26. Erratum in: Nature. 2017 Jan 5;541(7635):122. PubMed

Measles virus C protein interferes with Beta interferon transcription in the nucleus.
Sparrer KM, Pfaller CK, Conzelmann KK.
J Virol. 2012 Jan;86(2):796-805. doi: 10.1128/JVI.05899-11. Epub 2011 Nov 9. PubMed

Budding of rabies virus particles in the absence of the spike glycoprotein.
Mebatsion T, Konig M, Conzelmann KK.
Cell. 1996 Mar 22;84(6):941-51. PubMed

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