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Herzog Lab - Publications

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Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading.
Böttcher RT, Veelders M, Rombaut P, Faix J, Theodosiou M, Stradal TE, Rottner K, Zent R, Herzog F, Fässler R.
J Cell Biol. 2017 Nov 6;216(11):3785-3798. doi: 10.1083/jcb.201701176. Epub 2017 Sep 14. PubMed

The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding.
Ye Q, Kim DH, Dereli I, Rosenberg SC, Hagemann G, Herzog F, Tóth A, Cleveland DW, Corbett KD.
EMBO J. 2017 Aug 15;36(16):2419-2434. doi: 10.15252/embj.201797291. Epub 2017 Jun 28. PubMed

compleXView: a server for the interpretation of protein abundance and connectivity information to identify protein complexes.
Solis-Mezarino V, Herzog F.
Nucleic Acids Res
. 2017 May 12. doi: 10.1093/nar/gkx411. [Epub ahead of print] PubMed

Structure of the RZZ complex and molecular basis of its interaction with Spindly.
Mosalaganti S, Keller J, Altenfeld A, Winzker M, Rombaut P, Saur M, Petrovic A, Wehenkel A, Wohlgemuth S, Müller F, Maffini S, Bange T, Herzog F, Waldmann H, Raunser S, Musacchio A.
J Cell Biol. 2017 Apr 3;216(4):961-981. doi: 10.1083/jcb.201611060. Epub 2017 Mar 20. PubMed



Structural basis for the disaggregase activity and regulation of Hsp104.
Heuck A, Schitter-Sollner S, Suskiewicz MJ, Kurzbauer R, Kley J, Schleiffer A, Rombaut P, Herzog F, Clausen T.
Elife. 2016 Nov 30;5. pii: e21516. doi: 10.7554/eLife.21516. PubMed

Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores.
Petrovic A, Keller J, Liu Y, Overlack K, John J, Dimitrova YN, Jenni S, van Gerwen S, Stege P, Wohlgemuth S, Rombaut P, Herzog F, Harrison SC, Vetter IR, Musacchio A.
. 2016 Nov 3;167(4):1028-1040.e15. doi: 10.1016/j.cell.2016.10.005. Epub 2016 Oct 27. PubMed

Determination of local chromatin composition by CasID.
Schmidtmann E, Anton T, Rombaut P, Herzog F, Leonhardt H.
Nucleus. 2016 Sep 2;7(5):476-484. Epub 2016 Sep 27. PubMed 

Structural mechanism for the recognition and ubiquitination of a single nucleosome residue by Rad6-Bre1.
Gallego LD, Ghodgaonkar Steger M, Polyansky AA, Schubert T, Zagrovic B, Zheng N, Clausen T, Herzog F, Köhler A.
Proc Natl Acad Sci U S A
. 2016 Sep 20;113(38):10553-8. doi: 10.1073. Epub 2016 Sep 6. PubMed

Insights from biochemical reconstitution into the architecture of human kinetochores.
Weir JR, Faesen AC, Klare K, Petrovic A, Basilico F, Fischböck J, Pentakota S, Keller J, Pesenti ME, Pan D, Vogt D, Wohlgemuth S, Herzog F, Musacchio A.
Nature. 2016 Sep 8;537(7619):249-253. doi: 10.1038/nature19333. Epub 2016 Aug 31. PubMed

Topology and structure of an engineered human cohesin complex bound to Pds5B.
Hons MT, Huis In 't Veld PJ, Kaesler J, Rombaut P, Schleiffer A, Herzog F, Stark H, Peters JM.
Nat Commun. 2016 Aug 23;7:12523. doi: 10.1038/ncomms12523. PubMed

CCAN Assembly Configures Composite Binding Interfaces to Promote Cross-Linking of Ndc80 Complexes at the Kinetochore.
Pekgöz Altunkaya G, Malvezzi F, Demianova Z, Zimniak T, Litos G, Weissmann F, Mechtler K, Herzog F, Westermann S.
Curr Biol. 2016 Sep 12;26(17):2370-8. doi: 10.1016/j.cub.2016.07.005. Epub 2016 Aug 11. PubMed

Architecture and RNA binding of the human negative elongation factor.
Vos SM, Pöllmann D, Caizzi L, Hofmann KB, Rombaut P, Zimniak T, Herzog F, Cramer P.
Elife. 2016 Jun 10;5. pii: e14981. doi: 10.7554/eLife.14981. PubMed

Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and Astrin.
Friese A, Faesen AC, Huis in 't Veld PJ, Fischböck J, Prumbaum D, Petrovic A, Raunser S, Herzog F, Musacchio A.
Nat Commun. 2016 Apr 20;7:11407. doi: 10.1038/ncomms11407. PubMed

Insights from the reconstitution of the divergent outer kinetochore of Drosophila melanogaster.
Liu Y, Petrovic A, Rombaut P, Mosalaganti S, Keller J, Raunser S, Herzog F, Musacchio A.
Open Biol. 2016 Feb;6(2):150236. doi: 10.1098/rsob.150236. PubMed

Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress.
Poli J, Gerhold CB, Tosi A, Hustedt N, Seeber A, Sack R, Herzog F, Pasero P, Shimada K, Hopfner KP, Gasser SM.
Genes Dev. 2016 Feb 1;30(3):337-54. doi: 10.1101/gad.273813.115. Epub 2016 Jan 21. PubMed

Structure of transcribing mammalian RNA polymerase II.
Bernecky C, Herzog F, Baumeister W, Plitzko JM, Cramer P.
Nature. 2016 Jan 28;529(7587):551-4. doi: 10.1038/nature16482. Epub 2016 Jan 20. PubMed

Structural and functional insights into the fly microRNA biogenesis factor Loquacious.
Jakob L, Treiber T, Treiber N, Gust A, Kramm K, Hansen K, Stotz M, Wankerl L, Herzog F, Hannus S, Grohmann D, Meister G.
RNA. 2016 Mar;22(3):383-96. doi: 10.1261/rna.055426.115. Epub 2016 Jan 14. PubMed



CENP-C is a blueprint for constitutive centromere-associated network assembly within human kinetochores.
Klare K, Weir JR, Basilico F, Zimniak T, Massimiliano L, Ludwigs N, Herzog F, Musacchio A.
J Cell Biol. 2015 Jul 6;210(1):11-22. doi: 10.1083/jcb.201412028. Epub 2015 Jun 29. PubMed

A modular open platform for systematic functional studies under physiological conditions.
Mulholland CB, Smets M, Schmidtmann E, Leidescher S, Markaki Y, Hofweber M, Qin W, Manzo M, Kremmer E, Thanisch K, Bauer C, Rombaut P, Herzog F, Leonhardt H, Bultmann S.
Nucleic Acids Res. 2015 Sep 30;43(17):e112. doi: 10.1093/nar/gkv550. Epub 2015 May 24. PubMed

Molecular Basis of Transcription-Coupled Pre-mRNA Capping.
Martinez-Rucobo FW, Kohler R, van de Waterbeemd M, Heck AJ, Hemann M, Herzog F, Stark H, Cramer P.
Mol Cell. 2015 Jun 18;58(6):1079-89. doi: 10.1016/j.molcel.2015.04.004. Epub 2015 May 7. PubMed

xVis: a web server for the schematic visualization and interpretation of crosslink-derived spatial restraints.
Grimm M, Zimniak T, Kahraman A, Herzog F.
Nucleic Acids Res. 2015 Jul 1;43(W1):W362-9. doi: 10.1093/nar/gkv463. Epub 2015 May 8. PubMed

Proteasome assembly from 15S precursors involves major conformational changes and recycling of the Pba1-Pba2 chaperone.
Kock M, Nunes MM, Hemann M, Kube S, Dohmen RJ, Herzog F, Ramos PC, Wendler P.
Nat Commun. 2015 Jan 22;6:6123. doi: 10.1038/ncomms7123. PubMed



Characterization of a DNA exit gate in the human cohesin ring.
Huis in 't Veld PJ, Herzog F, Ladurner R, Davidson IF, Piric S, Kreidl E, Bhaskara V, Aebersold R, Peters JM.
Science. 2014 Nov 21;346(6212):968-72. doi: 10.1126/science.1256904. PubMed

A cooperative mechanism drives budding yeast kinetochore assembly downstream of CENP-A.
Hornung P, Troc P, Malvezzi F, Maier M, Demianova Z, Zimniak T, Litos G, Lampert F, Schleiffer A, Brunner M, Mechtler K, Herzog F, Marlovits TC, Westermann S.
J Cell Biol. 2014 Aug 18;206(4):509-24. doi: 10.1083/jcb.201403081. PubMed

Conserved architecture of the core RNA polymerase II initiation complex.
Mühlbacher W, Sainsbury S, Hemann M, Hantsche M, Neyer S, Herzog F, Cramer P.
Nat Commun. 2014 Jul 10;5:4310. doi: 10.1038/ncomms5310. PubMed

The pseudo GTPase CENP-M drives human kinetochore assembly.
Basilico F, Maffini S, Weir JR, Prumbaum D, Rojas AM, Zimniak T, De Antoni A, Jeganathan S, Voss B, van Gerwen S, Krenn V, Massimiliano L, Valencia A, Vetter IR, Herzog F, Raunser S, Pasqualato S, Musacchio A.
Elife. 2014 Jul 8;3:e02978. doi: 10.7554/eLife.02978. PubMed

Structure of the VipA/B type VI secretion complex suggests a contraction-state-specific recycling mechanism.
Kube S, Kapitein N, Zimniak T, Herzog F, Mogk A, Wendler P.
Cell Rep
. 2014 Jul 10;8(1):20-30. doi: 10.1016/j.celrep.2014.05.034. Epub 2014 Jun 19. PubMed

Modulation of the chromatin phosphoproteome by the Haspin protein kinase.
Maiolica A, de Medina-Redondo M, Schoof EM, Chaikuad A, Villa F, Gatti M, Jeganathan S, Lou HJ, Novy K, Hauri S, Toprak UH, Herzog F, Meraldi P, Penengo L, Turk BE, Knapp S, Linding R, Aebersold R.
Mol Cell Proteomics. 2014 Jul;13(7):1724-40. doi: 10.1074/mcp.M113.034819. Epub 2014 Apr 14. PubMed

Measuring spatial restraints on native protein complexes using isotope-tagged chemical cross-linking and mass spectrometry.
Herzog F.
Methods Mol Biol. 2014;1091:259-73. doi: 10.1007/978-1-62703-691-7_19. PubMed



Cross-link guided molecular modeling with ROSETTA.
Kahraman A, Herzog F, Leitner A, Rosenberger G, Aebersold R, Malmström L.
PLoS One. 2013 Sep 17;8(9):e73411. doi: 10.1371/journal.pone.0073411. eCollection 2013. PubMed

Structural features of Argonaute-GW182 protein interactions.
Pfaff J, Hennig J, Herzog F, Aebersold R, Sattler M, Niessing D, Meister G.
Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3770-9. doi: 10.1073. Epub 2013 Sep 16. PubMed

Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex.
Tosi A, Haas C, Herzog F, Gilmozzi A, Berninghausen O, Ungewickell C, Gerhold CB, Lakomek K, Aebersold R, Beckmann R, Hopfner KP.
Cell. 2013 Sep 12;154(6):1207-19. doi: 10.1016/j.cell.2013.08.016. PubMed



RNA polymerase III subunit architecture and implications for open promoter complex formation.
Wu CC, Herzog F, Jennebach S, Lin YC, Pai CY, Aebersold R, Cramer P, Chen HT.
Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19232-7. doi: 10.1073. Epub 2012 Nov 6. PubMed

Molecular architecture of human polycomb repressive complex 2.
Ciferri C, Lander GC, Maiolica A, Herzog F, Aebersold R, Nogales E.
Elife. 2012 Oct 30;1:e00005. doi: 10.7554/eLife.00005. PubMed

Structural probing of a protein phosphatase 2A network by chemical cross-linking and mass spectrometry.
Herzog F, Kahraman A, Boehringer D, Mak R, Bracher A, Walzthoeni T, Leitner A, Beck M, Hartl FU, Ban N, Malmström L, Aebersold R.
. 2012 Sep 14;337(6100):1348-52. doi: 10.1126/science.1221483. PubMed

False discovery rate estimation for cross-linked peptides identified by mass spectrometry.
Walzthoeni T, Claassen M, Leitner A, Herzog F, Bohn S, Förster F, Beck M, Aebersold R.
Nat Methods
. 2012 Sep;9(9):901-3. doi: 10.1038/nmeth.2103. Epub 2012 Jul 8. PubMed

Using iRT, a normalized retention time for more targeted measurement of peptides.
Escher C, Reiter L, MacLean B, Ossola R, Herzog F, Chilton J, MacCoss MJ, Rinner O.
Proteomics. 2012 Apr;12(8):1111-21. doi: 10.1002. PubMed

Crosslinking-MS analysis reveals RNA polymerase I domain architecture and basis of rRNA cleavage.
Jennebach S, Herzog F, Aebersold R, Cramer P.
Nucleic Acids Res
. 2012 Jul;40(12):5591-601. doi: 10.1093/nar/gks220. Epub 2012 Mar 6. PubMed

Expanding the chemical cross-linking toolbox by the use of multiple proteases and enrichment by size exclusion chromatography.
Leitner A, Reischl R, Walzthoeni T, Herzog F, Bohn S, Förster F, Aebersold R.
Mol Cell Proteomics. 2012 Mar;11(3):M111.014126. doi: 10.1074/mcp.M111.014126. Epub 2012 Jan 27. PubMed



The quantitative proteome of a human cell line.
Beck M, Schmidt A, Malmstroem J, Claassen M, Ori A, Szymborska A, Herzog F, Rinner O, Ellenberg J, Aebersold R.
Mol Syst Biol. 2011 Nov 8;7:549. doi: 10.1038/msb.2011.82. PubMed

Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth.
Blattner C, Jennebach S, Herzog F, Mayer A, Cheung AC, Witte G, Lorenzen K, Hopfner KP, Heck AJ, Aebersold R, Cramer P.
Genes Dev. 2011 Oct 1;25(19):2093-105. doi: 10.1101/gad.17363311. Epub 2011 Sep 22. PubMed



Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1.
Buschhorn BA, Petzold G, Galova M, Dube P, Kraft C, Herzog F, Stark H, Peters JM.
Nat Struct Mol Biol. 2011 Jan;18(1):6-13. doi: 10.1038/nsmb.1979. Epub 2010 Dec 26. PubMed

Probing native protein structures by chemical cross-linking, mass spectrometry, and bioinformatics.
Leitner A, Walzthoeni T, Kahraman A, Herzog F, Rinner O, Beck M, Aebersold R.
Mol Cell Proteomics. 2010 Aug;9(8):1634-49. doi: 10.1074/mcp.R000001-MCP201. Epub 2010 Mar 31. Review. PubMed



Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex.
Herzog F, Primorac I, Dube P, Lenart P, Sander B, Mechtler K, Stark H, Peters JM.
Science. 2009 Mar 13;323(5920):1477-81. doi: 10.1126/science.1163300. PubMed



GraFix: sample preparation for single-particle electron cryomicroscopy.
Kastner B, Fischer N, Golas MM, Sander B, Dube P, Boehringer D, Hartmuth K, Deckert J, Hauer F, Wolf E, Uchtenhagen H, Urlaub H, Herzog F, Peters JM, Poerschke D, Löhrmann R, Stark H.
Nat Methods. 2008 Jan;5(1):53-5. Epub 2007 Dec 23. PubMed



Titanium dioxide as a chemo-affinity solid phase in offline phosphopeptide chromatography prior to HPLC-MS/MS analysis.
Mazanek M, Mituloviae G, Herzog F, Stingl C, Hutchins JR, Peters JM, Mechtler K.
Nat Protoc
. 2007;2(5):1059-69. Epub 2006 Dec 14. PubMed



Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.
Dube P, Herzog F, Gieffers C, Sander B, Riedel D, Müller SA, Engel A, Peters JM, Stark H.
Mol Cell. 2005 Dec 22;20(6):867-79. PubMed

Identification of cell cycle-dependent phosphorylation sites on the anaphase-promoting complex/cyclosome by mass spectrometry.
Herzog F
, Mechtler K, Peters JM.
Methods Enzymol
. 2005;398:231-45. PubMed

Large-scale purification of the vertebrate anaphase-promoting complex/cyclosome.
Herzog F
, Peters JM.
Methods Enzymol. 2005;398:175-95. PubMed



The anaphase promoting complex/cyclosome is recruited to centromeres by the spindle assembly checkpoint.
Acquaviva C, Herzog F, Kraft C, Pines J.
Nat Cell Biol
. 2004 Sep;6(9):892-8. Epub 2004 Aug 22. Erratum in: Nat Cell Biol. 2004 Oct;6(10):1010. PubMed



Mitotic regulation of the human anaphase-promoting complex by phosphorylation.
Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J, Peters JM.
EMBO J. 2003 Dec 15;22(24):6598-609. PubMed