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Wolf Lab - Publications

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2018

Release of pig leukocytes and reduced human NK cell recruitment during ex vivo perfusion of HLA-E/human CD46 double-transgenic pig limbs with human blood.
Puga Yung G, Bongoni AK, Pradier A, Madelon N, Papaserafeim M, Sfriso R, Ayares DL, Wolf E, Klymiuk N, Bähr A, Constantinescu MA, Voegelin E, Kiermeir D, Jenni H, Rieben R, Seebach JD.
Xenotransplantation. 2018 Jan;25(1). doi: 10.1111/xen.12357. Epub 2017 Oct 22. PubMed

Modeling lethal X-linked genetic disorders in pigs with ensured fertility.
Matsunari H, Watanabe M, Nakano K, Enosawa S, Umeyama K, Uchikura A, Yashima S, Fukuda T, Klymiuk N, Kurome M, Kessler B, Wuensch A, Zakhartchenko V, Wolf E, Hanazono Y, Nagaya M, Umezawa A, Nakauchi H, Nagashima H.
Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):708-713. doi: 10.1073/pnas.1715940115. Epub 2018 Jan 8. PubMed

Identification of genetic elements in metabolism by high-throughput mouse phenotyping.
Rozman J, Rathkolb B, Oestereicher MA, Schütt C, Ravindranath AC, Leuchtenberger S, Sharma S, Kistler M, Willershäuser M, Brommage R, Meehan TF, Mason J, Haselimashhadi H; IMPC Consortium, Hough T, Mallon AM, Wells S, Santos L, Lelliott CJ, White JK, Sorg T, Champy MF, Bower LR, Reynolds CL, Flenniken AM, Murray SA, Nutter LMJ, Svenson KL, West D, Tocchini-Valentini GP, Beaudet AL, Bosch F, Braun RB, Dobbie MS, Gao X, Herault Y, Moshiri A, Moore BA, Kent Lloyd KC, McKerlie C, Masuya H, Tanaka N, Flicek P, Parkinson HE, Sedlacek R, Seong JK, Wang CL, Moore M, Brown SD, Tschöp MH, Wurst W, Klingenspor M, Wolf E, Beckers J, Machicao F, Peter A, Staiger H, Häring HU, Grallert H, Campillos M, Maier H, Fuchs H, Gailus-Durner V, Werner T, Hrabe de Angelis M.
Nat Commun. 2018 Jan 18;9(1):288. doi: 10.1038/s41467-017-01995-2. PubMed

Animal models of obesity and diabetes mellitus.
Kleinert M, Clemmensen C, Hofmann SM, Moore MC, Renner S, Woods SC, Huypens P,
Beckers J, de Angelis MH, Schürmann A, Bakhti M, Klingenspor M, Heiman M, Cherrington AD, Ristow M, Lickert H, Wolf E, Havel PJ, Müller TD, Tschöp MH.
Nat Rev Endocrinol. 2018 Mar;14(3):140-162. doi: 10.1038/nrendo.2017.161. Epub 2018 Jan 19. PubMed

Strong xenoprotective function by single-copy transgenes placed sequentially at a permissive locus.
Rieblinger B, Fischer K, Kind A, Saller BS, Baars W, Schuster M, Wolf-van Buerck L, Schäffler A, Flisikowska T, Kurome M, Zakhartchenko V, Kessler B, Flisikowski K, Wolf E, Seissler J, Schwinzer R, Schnieke A.
Xenotransplantation. 2018 Jan 23. doi: 10.1111/xen.12382. [Epub ahead of print] PubMed

Distribution of porcine cytomegalovirus in infected donor pigs and in baboon recipients of pig heart transplantation.
Fiebig U, Abicht JM, Mayr T, Längin M, Bähr A, Guethoff S, Falkenau A, Wolf E,
Reichart B, Shibahara T, Denner J.
Viruses. 2018 Feb 6;10(2). pii: E66. doi: 10.3390/v10020066. PubMed

Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice.
Xie K, Ryan DP, Pearson BL, Henzel KS, Neff F, Vidal RO, Hennion M, Lehmann I, Schleif M, Schröder S, Adler T, Rathkolb B, Rozman J, Schütz AL, Prehn C, Mickael ME, Weiergräber M, Adamski J, Busch DH, Ehninger G, Matynia A, Jackson WS, Wolf E, Fuchs H, Gailus-Durner V, Bonn S, Hrabě de Angelis M, Ehninger D.
Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2348-E2357. doi: 0.1073/pnas.1707337115. Epub 2018 Feb 21. PubMed

OCT4/POU5F1 is required for NANOG expression in bovine blastocysts.
Simmet K, Zakhartchenko V, Philippou-Massier J, Blum H, Klymiuk N, Wolf E.
Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2770-2775. doi: 10.1073/pnas.1718833115. Epub 2018 Feb 26. PubMed

Single-cell RNA sequencing reveals developmental heterogeneity of blastomeres during major genome activation in bovine embryos.
Lavagi I, Krebs S, Simmet K, Beck A, Zakhartchenko V, Wolf E, Blum H.
Sci Rep. 2018 Mar 6;8(1):4071. doi: 10.1038/s41598-018-22248-2. PubMed

Multiple genetically modified GTKO/hCD46/HLA-E/hβ2-mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood.
Abicht JM, Sfriso R, Reichart B, Längin M, Gahle K, Puga Yung GL, Seebach JD, Rieben R, Ayares D, Wolf E, Klymiuk N, Baehr A, Kind A, Mayr T, Bauer A.
Xenotransplantation. 2018 Mar 14. doi: 10.1111/xen.12390. [Epub ahead of print] PubMed

2017

 Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice.
Xie K, Neff F, Markert A, Rozman J, Aguilar-Pimentel JA, Amarie OV, Becker L, Brommage R, Garrett L, Henzel KS, Hölter SM, Janik D, Lehmann I, Moreth K, Pearson BL, Racz I, Rathkolb B, Ryan DP, Schröder S, Treise I, Bekeredjian R, Busch DH, Graw J, Ehninger G, Klingenspor M, Klopstock T, Ollert M, Sandholzer M, Schmidt-Weber C, Weiergräber M, Wolf E, Wurst W, Zimmer A, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Ehninger D.
Nat Commun. 2017 Jul 24;8(1):155. doi: 10.1038/s41467-017-00178-3. PubMed

Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 (I27N) mutant mice.
Kumar S, Rathkolb B, Sabrautzki S, Krebs S, Kemter E, Becker L, Beckers J, Bekeredjian R, Brommage R, Calzada-Wack J, Garrett L, Hölter SM, Horsch M, Klingenspor M, Klopstock T, Moreth K, Neff F, Rozman J, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Wolf E, Aigner B.
J Biomed Sci. 2017 Aug 17;24(1):57. doi: 10.1186/s12929-017-0365-5. PubMed

Assessment of the anticoagulant and anti-inflammatory properties of endothelial cells using 3D cell culture and non-anticoagulated whole blood.Sfriso R, Bongoni A, Banz Y, Klymiuk N, Wolf E, Rieben R.
J Vis Exp. 2017 Sep 5;(127). doi: 10.3791/56227. PubMed

Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic.
Fuchs H, Aguilar-Pimentel JA, Amarie OV, Becker L, Calzada-Wack J, Cho YL, Garrett L, Hölter SM, Irmler M, Kistler M, Kraiger M, Mayer-Kuckuk P, Moreth K, Rathkolb B, Rozman J, da Silva Buttkus P, Treise I, Zimprich A, Gampe K, Hutterer C, Stöger C, Leuchtenberger S, Maier H, Miller M, Scheideler A, Wu M, Beckers J, Bekeredjian R, Brielmeier M, Busch DH, Klingenspor M, Klopstock T, Ollert M, Schmidt-Weber C, Stöger T, Wolf E, Wurst W, Yildirim AÖ, Zimmer A, Gailus-Durner V, Hrabě de Angelis M.
Behav Brain Res. 2017 Sep 29. pii: S0166-4328(17)30931-2. doi: 10.1016/j.bbr.2017.09.048. [Epub ahead of print]. PubMed

Photorhabdus luminescens lectin A (PllA): A new probe for detecting α-galactoside-terminating glycoconjugates.
Beshr G, Sikandar A, Jemiller EM, Klymiuk N, Hauck D, Wagner S, Wolf E, Koehnke J, Titz A.
J Biol Chem. 2017 Dec 1;292(48):19935-19951. doi: 10.1074/jbc.M117.812792. Epub 2017 Sep 28. PubMed

Effect of metabolic status on conceptus-maternal interactions on day 19 in dairy cattle: II. Effects on the endometrial transcriptome.
Bauersachs S, Simintiras CA, Sturmey RG, Krebs S, Bick J, Blum H, Wolf E, Lonergan P, Forde N.
Biol Reprod. 2017 Sep 1;97(3):413-425. doi: 10.1093/biolre/iox095. PubMed

Effect of lactation on conceptus-maternal interactions at the initiation of implantation in cattle: I. Effects on the conceptus transcriptome and amino acid composition of the uterine luminal fluid.
Forde N, Simintiras CA, Sturmey RG, Graf A, Wolf E, Blum H, Lonergan P.
Biol Reprod. 2017 Jan 1;97(6):798-809. doi: 10.1093/biolre/iox135. PubMed

Design and validation of a disease network of inflammatory processes in the NSG-UC mouse model.
Jodeleit H, Palamides P, Beigel F, Mueller T,Wolf E, Siebeck M, Gropp R.
J Transl Med. 2017 Dec 28;15(1):265. doi: 10.1186/s12967-017-1368-4. PubMed

Corpuls CPR generates higher mean arterial pressure than LUCAS II in a pig model of cardiac arrest.
Eichhorn S, Mendoza A, Prinzing A, Stroh A, Xinghai L, Polski M, Heller M, Lahm H, Wolf E, Lange R, Krane M.
Biomed Res Int. 2017;2017:5470406. doi: 10.1155/2017/5470406. Epub 2017 Dec 17.  PubMed

The Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes.
Blutke A, Renner S, Flenkenthaler F, Backman M, Haesner S, Kemter E, Ländström E, Braun-Reichhart C, Albl B, Streckel E, Rathkolb B, Prehn C, Palladini A, Grzybek M, Krebs S, Bauersachs S, Bähr A, Brühschwein A, Deeg CA, De Monte E, Dmochewitz M, Eberle C, Emrich D, Fux R, Groth F, Gumbert S, Heitmann A, Hinrichs A, Keßler B, Kurome M, Leipig-Rudolph M, Matiasek K, Öztürk H, Otzdorff C, Reichenbach M, Reichenbach HD, Rieger A, Rieseberg B, Rosati M, Saucedo MN, Schleicher A, Schneider MR, Simmet K, Steinmetz J, Übel N, Zehetmaier P, Jung A, Adamski J, Coskun Ü, Hrabě de Angelis M, Simmet C, Ritzmann M, Meyer-Lindenberg A, Blum H, Arnold GJ, Fröhlich T, Wanke R, Wolf E.
Mol Metab. 2017 Jun 13;6(8):931-940. doi: 10.1016/j.molmet.2017.06.004. eCollection 2017 Aug. PubMed

Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression.
Kaklamanos A, Rozman J, Roulis M, Karagianni N, Armaka M, Wu M, Brachthäuser L, Calzada-Wack J, Horsch M, Beckers J, Rathkolb B, Adler T, Neff F, Wolf E, Gailus-Durner V, Fuchs H, de Angelis MH, Kollias G.
Sci Rep. 2017 May 25;7(1):2397. doi: 10.1038/s41598-017-02581-8. PubMed 

Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016.
van den Bruck R, Weil PP, Ziegenhals T, Schreiner P, Juranek S, Gödde D, Vogel S, Schuster F, Orth V, Dörner J, Pembaur D, Wolf E, Röper M, Störkel S, Zirngibl H, Wirth S, Jenke ACW, Postberg J, Boy N, Heringer J, Haege G, Glahn EM, Hoffmann GF, et al.
Mol Cell Pediatr. 2017 May;4(Suppl 1):5. doi: 10.1186/s40348-017-0071-0. No abstract available. PubMed 

Retinopathy with central oedema in an INS (C94Y) transgenic pig model of long-term diabetes.
Kleinwort KJH, Amann B, Hauck SM, Hirmer S, Blutke A, Renner S, Uhl PB, Lutterberg K, Sekundo W, Wolf E, Deeg CA.
Diabetologia. 2017 May 8. doi: 10.1007/s00125-017-4290-7.  PubMed 

Chromatin-remodeling factor SMARCD2 regulates transcriptional networks controlling differentiation of neutrophil granulocytes.
Witzel M, Petersheim D, Fan Y, Bahrami E, Racek T, Rohlfs M, Puchalka J, Mertes C, Gagneur J, Ziegenhain C, Enard W, Stray-Pedersen A, Arkwright PD, Abboud MR, Pazhakh V, Lieschke GJ, Krawitz PM, Dahlhoff M, Schneider MR, Wolf E, Horny HP, Schmidt H, et al.
Nat Genet. 2017 May;49(5):742-752. doi: 10.1038/ng.3833. Epub 2017 Apr 3. PubMed 

Vessel network architecture of adult human islets promotes distinct cell-cell interactions in situ and is altered after transplantation.
Cohrs CM, Chen C, Jahn SR, Stertmann J, Chmelova H, Weitz J, Bähr A, Klymiuk N, Steffen A, Ludwig B, Kamvissi V, Wolf E, Bornstein SR, Solimena M, Speier S.
Endocrinology. 2017 Jan 27. doi: 10.1210/en.2016-1184. PubMed 

INS-eGFP transgenic pigs: a novel reporter system for studying maturation, growth and vascularisation of neonatal islet-like cell clusters.
Kemter E, Cohrs CM, Schäfer M, Schuster M, Steinmeyer K, Wolf-van Buerck L, Wolf A, Wuensch A, Kurome M, Kessler B, Zakhartchenko V, Loehn M, Ivashchenko Y, Seissler J, Schulte AM, Speier S, Wolf E.
Diabetologia. 2017 Jun;60(6):1152-1156. doi: 10.1007/s00125-017-4250-2. Epub 2017 Mar 18. PubMed 

Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice.
Franko A, Neschen S, Rozman J, Rathkolb B, Aichler M, Feuchtinger A, Brachthäuser L, Neff F, Kovarova M, Wolf E, Fuchs H, Häring HU, Peter A, Hrabé de Angelis M.
Mol Metab. 2017 Jan 6;6(3):256-266. doi: 10.1016/j.molmet.2016.12.007. eCollection 2017 Mar. PubMed 

Modification of the fatty acid composition of an obesogenic diet improves the maternal and placental metabolic environment in obese pregnant mice.
Gimpfl M, Rozman J, Dahlhoff M, Kübeck R, Blutke A, Rathkolb B, Klingenspor M, Hrabé de Angelis M, Öner-Sieben S, Seibt A, Roscher AA, Wolf E, Ensenauer R.
Biochim Biophys Acta. 2017 Feb 21;1863(6):1605-1614. doi: 10.1016/j.bbadis.2017.02.021. PubMed 

Mitochondrial Dysregulation Secondary to Endoplasmic Reticulum Stress in Autosomal Dominant Tubulointerstitial Kidney Disease - UMOD (ADTKD-UMOD).
Kemter E, Fröhlich T, Arnold GJ, Wolf E, Wanke R.
Sci Rep. 2017 Feb 21;7:42970. doi: 10.1038/srep42970. PubMed 

Diabetes Mellitus-Induced Microvascular Destabilization in the Myocardium.
Hinkel R, Hoewe A, Renner S, Ng J, Lee S, Klett K, Kaczmarek V, Moretti A, Laugwitz KL, Skroblin P, Mayr M, Milting H, Dendorfer A, Reichart B, Wolf E, Kupatt C.
J Am Coll Cardiol. 2017 Jan 17;69(2):131-143. doi: 10.1016/j.jacc.2016.10.058. PubMed 

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2016

Direct introduction of gene constructs into the pronucleus-like structure of cloned embryos: a new strategy for the generation of genetically modified pigs.
Kurome M, Leuchs S, Kessler B, Kemter E, Jemiller EM, Foerster B, Klymiuk N, Zakhartchenko V, Wolf E.
Transgenic Res. 2017 Apr;26(2):309-318. doi: 10.1007/s11248-016-0004-z. Epub 2016 Dec 10. PubMed 

Serum Response Factor (SRF) Ablation Interferes with Acute Stress-Associated Immediate and Long-Term Coping Mechanisms.
Zimprich A, Mroz G, Meyer Zu Reckendorf C, Anastasiadou S, Förstner P, Garrett L, Hölter SM, Becker L, Rozman J, Prehn C, Rathkolb B, Moreth K, Wurst W, Klopstock T, Klingenspor M, Adamski J, Wolf E, Bekeredjian R, Fuchs H, Gailus-Durner V, de Angelis MH, Knöll B.
Mol Neurobiol. 2016 Dec 2. PubMed 

The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.
Fuchs H, Sabrautzki S, Przemeck GK, Leuchtenberger S, Lorenz-Depiereux B, Becker L, Rathkolb B, Horsch M, Garrett L, Östereicher MA, Hans W, Wolf E, Abe K, Sagawa N, Rozman J, Vargas-Panesso IL, Sandholzer M, Lisse TS, Adler T, Aguilar-Pimentel JA, Calzada-Wack J, Ehrhard N, Elvert R, et al.
G3 (Bethesda). 2016 Dec 7;6(12):4035-4046. doi: 10.1534/g3.116.033670. PubMed 

Progress in Clinical Encapsulated Islet Xenotransplantation.
Cooper DK, Matsumoto S, Abalovich A, Itoh T, Mourad NI, Gianello PR, Wolf E, Cozzi E.
Transplantation. 2016 Nov;100(11):2301-2308. Review. PubMed 

Viable Ednra (Y129F) mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation.
Sabrautzki S, Sandholzer MA, Lorenz-Depiereux B, Brommage R, Przemeck G, Vargas Panesso IL, Vernaleken A, Garrett L, Baron K, Yildirim AO, Rozman J, Rathkolb B, Gau C, Hans W, Hoelter SM, Marschall S, Stoeger C, Becker L, Fuchs H, Wolf E, Gailus-Durner V, Klingenspor M, Klopstock T, et al.
Mamm Genome. 2016 Dec;27(11-12):587-598. Epub 2016 Sep 26. PubMed 

Loss of DRO1/CCDC80 results in obesity and promotes adipocyte differentiation.
Grill JI, Neumann J, Herbst A, Ofner A, Hiltwein F, Marschall MK, Zierahn H, Wolf E, Schneider MR, Kolligs FT.
Mol Cell Endocrinol. 2017 Jan 5;439:286-296. doi: 10.1016/j.mce.2016.09.014. Epub 2016 Sep 16. PubMed 

Progressive muscle proteome changes in a clinically relevant pig model of Duchenne muscular dystrophy.
Fröhlich T, Kemter E, Flenkenthaler F, Klymiuk N, Otte KA, Blutke A, Krause S, Walter MC, Wanke R, Wolf E, Arnold GJ.
Sci Rep. 2016 Sep 16;6:33362. doi: 10.1038/srep33362. PubMed 

A mouse model for ulcerative colitis based on NOD-scid IL2R γnull mice reconstituted with peripheral blood mononuclear cells from affected individuals.
Palamides P, Jodeleit H, Föhlinger M, Beigel F, Herbach N, Mueller T, Wolf E, Siebeck M, Gropp R.
Dis Model Mech. 2016 Sep 1;9(9):985-97. doi: 10.1242/dmm.025452. Epub 2016 Aug 4. PubMed 

Clinical Chemistry Reference Intervals for C57BL/6J, C57BL/6N, and C3HeB/FeJ Mice (Mus musculus).
Otto GP, Rathkolb B, Oestereicher MA, Lengger CJ, Moerth C, Micklich K, Fuchs H, Gailus-Durner V, Wolf E, Hrabé de Angelis M.
J Am Assoc Lab Anim Sci. 2016;55(4):375-86. PubMed 

Missense Mutation of POU Domain Class 3 Transcription Factor 3 in Pou3f3L423P Mice Causes Reduced Nephron Number and Impaired Development of the Thick Ascending Limb of the Loop of Henle.
Rieger A, Kemter E, Kumar S, Popper B, Aigner B, Wolf E, Wanke R, Blutke A.
PLoS One. 2016 Jul 15;11(7):e0158977. doi: 10.1371/journal.pone.0158977. eCollection 2016. PubMed 

Efficient production of multi-modified pigs for xenotransplantation by 'combineering', gene stacking and gene editing.
Fischer K, Kraner-Scheiber S, Petersen B, Rieblinger B, Buermann A, Flisikowska T, Flisikowski K, Christan S, Edlinger M, Baars W, Kurome M, Zakhartchenko V, Kessler B, Plotzki E, Szczerbal I, Switonski M, Denner J, Wolf E, Schwinzer R, Niemann H, Kind A, Schnieke A.
Sci Rep. 2016 Jun 29;6:29081. doi: 10.1038/srep29081. PubMed 

Bezafibrate Improves Insulin Sensitivity and Metabolic Flexibility in STZ-Induced Diabetic Mice.
Franko A, Huypens P, Neschen S, Irmler M, Rozman J, Rathkolb B, Neff F, Prehn C, Dubois G, Baumann M, Massinger R, Gradinger D, Przemeck GK, Repp B, Aichler M, Feuchtinger A, Schommers P, Stöhr O, Sanchez-Lasheras C, Adamski J, Peter A, Wolf E, Prokisch H, et al.
Diabetes. 2016 Sep;65(9):2540-52. doi: 10.2337/db15-1670. Epub 2016 Jun 9. PubMed 

Comparative aspects of rodent and nonrodent animal models for mechanistic and translational diabetes research.
Renner S, Dobenecker B, Blutke A, Zöls S, Wanke R, Ritzmann M, Wolf E.
Theriogenology. 2016 Jul 1;86(1):406-21. doi: 10.1016/j.theriogenology.2016.04.055. Epub 2016 Apr 21. Review. PubMed 

Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs.
Bähr A, Käser T, Kemter E, Gerner W, Kurome M, Baars W, Herbach N, Witter K, Wünsch A, Talker SC, Kessler B, Nagashima H, Saalmüller A, Schwinzer R, Wolf E, Klymiuk N.
PLoS One. 2016 May 13;11(5):e0155676. doi: 10.1371/journal.pone.0155676. eCollection 2016. PubMed 

Transgenic Expression of Human Thrombomodulin Inhibits HMGB1-Induced Porcine Aortic Endothelial Cell Activation.
Bongoni AK, Klymiuk N, Wolf E, Ayares D, Rieben R, Cowan PJ.
Transplantation. 2016 Sep;100(9):1871-9. doi: 10.1097/TP.0000000000001188. PubMed 

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft.
Mohiuddin MM, Singh AK, Corcoran PC, Thomas ML 3rd, Clark T, Lewis BG, Hoyt RF, Eckhaus M, Pierson RN 3rd, Belli AJ, Wolf E, Klymiuk N, Phelps C, Reimann KA, Ayares D, Horvath KA.
Nat Commun. 2016 Apr 5;7:11138. doi: 10.1038/ncomms11138. PubMed 

Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice.
Kumar S, Rathkolb B, Kemter E, Sabrautzki S, Michel D, Adler T, Becker L, Beckers J, Busch DH, Garrett L, Hans W, Hölter SM, Horsch M, Klingenspor M, Klopstock T, Rá¡cz I, Wolf E, Rozman J, Vargas Panesso IL, Vernaleken A, Zimmer A, Fuchs H, Gailus-Durner V, et al.
PLoS One. 2016 Mar 22;11(3):e0150472. doi: 10.1371/journal.pone.0150472. eCollection 2016. PubMed 

Growth hormone (GH)-transgenic insulin-like growth factor 1 (IGF1)-deficient mice allow dissociation of excess GH and IGF1 effects on glomerular and tubular growth.
Blutke A, Schneider MR, Wolf E, Wanke R.
Physiol Rep. 2016 Mar;4(5). pii: e12709. doi: 10.14814https://www.ncbi.nlm.nih.gov/phy2.12709. PubMed 

First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--Chapter 2b: genetically modified source pigs.
Cowan PJ, Ayares D, Wolf E, Cooper DK.
Xenotransplantation. 2016 Jan-Feb;23(1):32-7. doi: 10.1111/xen.12224. Epub 2016 Mar 1. PubMed 

Tissue Sampling Guides for Porcine Biomedical Models.
Albl B, Haesner S, Braun-Reichhart C, Streckel E, Renner S, Seeliger F, Wolf E, Wanke R, Blutke A.
Toxicol Pathol. 2016 Apr;44(3):414-20. doi: 10.1177/0192623316631023. Epub 2016 Feb 16. PubMed 

Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice.
Korner G, Scherer T, Adamsen D, Rebuffat A, Crabtree M, Rassi A, Scavelli R, Homma D, Ledermann B, Konrad D, Ichinose H, Wolfrum C, Horsch M, Rathkolb B, Klingenspor M, Beckers J, Wolf E, Gailus-Durner V, Fuchs H, Hrabé de Angelis M, Blau N, Rozman J, et al.
J Inherit Metab Dis. 2016 Mar;39(2):309-19. doi: 10.1007/s10545-015-9909-6. Epub 2016 Feb 1. PubMed 

Exome sequencing identifies a nonsense mutation in Fam46a associated with bone abnormalities in a new mouse model for skeletal dysplasia.
Diener S, Bayer S, Sabrautzki S, Wieland T, Mentrup B, Przemeck GK, Rathkolb B, Graf E, Hans W, Fuchs H, Horsch M, Schwarzmayr T, Wolf E, Klopocki E, Jakob F, Strom TM, Hrabé de Angelis M, Lorenz-Depiereux B.
Mamm Genome. 2016 Apr;27(3-4):111-21. doi: 10.1007/s00335-016-9619-x. Epub 2016 Jan 23. PubMed 

Inhibition of complement component C5 prevents clotting in an ex vivo model of xenogeneic activation of coagulation.
Rataj D, Werwitzke S, Haarmeijer B, Winkler M, Ramackers W, Petersen B, Niemann H, Wünsch A, Bähr A, Klymiuk N, Wolf E, Abicht JM, Ayares D, Tiede A.
Xenotransplantation. 2016 Mar;23(2):117-27. doi: 10.1111/xen.12218. Epub 2016 Jan 16. PubMed 

Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice.
Mulay SR, Eberhard JN, Pfann V, Marschner JA, Darisipudi MN, Daniel C, Romoli S, Desai J, Grigorescu M, Kumar SV, Rathkolb B, Wolf E, Hrabé de Angelis M, Bäuerle T, Dietel B, Wagner CA, Amann K, Eckardt KU, Aronson PS, Anders HJ, Knauf F.
Am J Physiol Renal Physiol. 2016 Apr 15;310(8):F785-F795. doi: 10.1152/ajprenal.00488.2015. Epub 2016 Jan 13. PubMed 

Pillars Article: CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs.
Cell. 1999. 99: 23-33.
Förster R, Schubel A, Breitfeld D, Kremmer E, Renner-Müller I, Wolf E, Lipp M.
J Immunol. 2016 Jan 1;196(1):5-15. No abstract available. PubMed 

Developmental endothelial locus-1 modulates platelet-monocyte interactions and instant blood-mediated inflammatory reaction in islet transplantation.
Kourtzelis I, Kotlabova K, Lim JH, Mitroulis I, Ferreira A, Chen LS, Gercken B, Steffen A, Kemter E, Klotzsche-von Ameln A, Waskow C, Hosur K, Chatzigeorgiou A, Ludwig B, Wolf E, Hajishengallis G, Chavakis T.
Thromb Haemost. 2016 Apr;115(4):781-8. doi: 10.1160/TH15-05-0429. Epub 2015 Dec 17. PubMed 

Stage-dependent remodeling of the nuclear envelope and lamina during rabbit early embryonic development.
Popken J, Schmid VJ, Strauss A, Guengoer T, Wolf E, Zakhartchenko V.
J Reprod Dev. 2016 Apr 22;62(2):127-35. doi: 10.1262/jrd.2015-100. Epub 2015 Dec 4. PubMed 

3D structured illumination microscopy of mammalian embryos and spermatozoa.
Popken J, Dahlhoff M, Guengoer T, Wolf E, Zakhartchenko V.
BMC Dev Biol. 2015 Nov 26;15:46. doi: 10.1186/s12861-015-0092-7. PubMed 

Pre-clinical heterotopic intrathoracic heart xenotransplantation: a possibly useful clinical technique.
Abicht JM, Mayr T, Reichart B, Buchholz S, Werner F, Lutzmann I, Schmoeckel M, Bauer A, Thormann M, Langenmayer M, Herbach N, Pohla H, Herzog R, McGregor CG, Ayares D, Wolf E, Klymiuk N, Baehr A, Kind A, Hagl C, Ganswindt U, Belka C, et al.
Xenotransplantation. 2015 Nov-Dec;22(6):427-42. doi: 10.1111/xen.12213. Epub 2015 Nov 25. PubMed 

Computed Tomography (CT) Scanning Facilitates Early Identification of Neonatal Cystic Fibrosis Piglets.
Guillon A, Chevaleyre C, Barc C, Berri M, Adriaensen H, Lecompte F, Villemagne T, Pezant J, Delaunay R, Moënne-Loccoz J, Berthon P, Bähr A, Wolf E, Klymiuk N, Attucci S, Ramphal R, Sarradin P, Buzoni-Gatel D, Si-Tahar M, Caballero I.
PLoS One. 2015 Nov 23;10(11):e0143459. doi: 10.1371/journal.pone.0143459. eCollection 2015. PubMed 

MFAP4 Promotes Vascular Smooth Muscle Migration, Proliferation and Accelerates Neointima Formation.
Schlosser A, Pilecki B, Hemstra LE, Kejling K, Kristmannsdottir GB, Wulf-Johansson H, Moeller JB, Füchtbauer EM, Nielsen O, Kirketerp-Møller K, Dubey LK, Hansen PB, Stubbe J, Wrede C, Hegermann J, Ochs M, Rathkolb B, Schrewe A, Bekeredjian R, Wolf E, Gailus-Durner V, Fuchs H, et al.
Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):122-33. doi: 10.1161/ATVBAHA.115.306672. Epub 2015 Nov 12. PubMed 

Tailored Pig Models for Preclinical Efficacy and Safety Testing of Targeted Therapies.
Klymiuk N, Seeliger F, Bohlooly-Y M, Blutke A, Rudmann DG, Wolf E.
Toxicol Pathol. 2016 Apr;44(3):346-57. doi: 10.1177/0192623315609688. Epub 2015 Oct 27. Review. PubMed 

Dissociation of somatic growth, time of sexual maturity, and life expectancy by overexpression of an RGD-deficient IGFBP-2 variant in female transgenic mice.
Hoeflich A, Reyer A, Ohde D, Schindler N, Brenmoehl J, Spitschak M, Langhammer M, Tuchscherer A, Wirthgen E, Renner-Müller I, Wanke R, Metzger F, Bielohuby M, Wolf E.
Aging Cell. 2016 Feb;15(1):111-7. doi: 10.1111/acel.12413. Epub 2015 Oct 28. PubMed 

Engraftment and reversal of diabetes after intramuscular transplantation of neonatal porcine islet-like clusters.
Wolf-van Buerck L, Schuster M, Baehr A, Mayr T, Guethoff S, Abicht J, Reichart B, Nam-Apostolopoulos YC, Klymiuk N, Wolf E, Seissler J.
Xenotransplantation. 2015 Nov-Dec;22(6):443-50. doi: 10.1111/xen.12201. Epub 2015 Oct 21. PubMed 

Pigs pave a way to de novo formation of functional human kidneys.
Kemter E, Wolf E.
Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):12905-6. doi: 10.1073https://www.ncbi.nlm.nih.gov/pnas.1517582112. Epub 2015 Oct 12. No abstract available. PubMed 

Incretin actions and consequences of incretin-based therapies: lessons from complementary animal models.
Renner S, Blutke A, Streckel E, Wanke R, Wolf E.
J Pathol. 2016 Jan;238(2):345-58. doi: 10.1002https://www.ncbi.nlm.nih.gov/path.4655. Epub 2015 Nov 30. Review. PubMed 

Metamizol Relieves Pain Without Interfering With Cerulein-Induced Acute Pancreatitis in Mice.
Stumpf F, Algül H, Thoeringer CK, Schmid RM, Wolf E, Schneider MR, Dahlhoff M.
Pancreas
. 2016 Apr;45(4):572-8. doi: 10.1097/MPA.0000000000000483. PubMed 

Efavirenz Causes Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy in Endothelial Cells.
Weiß M, Kost B, Renner-Müller I, Wolf E, Mylonas I, Brüning A.
Cardiovasc Toxicol. 2016 Jan;16(1):90-9. doi: 10.1007/s12012-015-9314-2. PubMed 

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2015

Phytohemagglutinin facilitates the aggregation of blastomere pairs from Day 5 donor embryos with Day 4 host embryos for chimeric bovine embryo multiplication.
Simmet K, Reichenbach M, Reichenbach HD, Wolf E.
Theriogenology. 2015 Dec;84(9):1603-10. doi: 10.1016/j.theriogenology.2015.08.012. Epub 2015 Aug 29. PubMed 

eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription.
Brina D, Miluzio A, Ricciardi S, Clarke K, Davidsen PK, Viero G, Tebaldi T, Offenhäuser N, Rozman J, Rathkolb B, Neschen S, Klingenspor M, Wolf E, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Quattrone A, Falciani F, Biffo S.
Nat Commun. 2015 Sep 18;6:8261. doi: 10.1038/ncomms9261. PubMed 

Xenotransplantation of Cells, Tissues, Organs and the German Research Foundation Transregio Collaborative Research Centre 127.
Reichart B, Guethoff S, Brenner P, Poettinger T, Wolf E, Ludwig B, Kind A, Mayr T, Abicht JM.
Adv Exp Med Biol. 2015;865:143-55. doi: 10.1007/978-3-319-18603-0_9. Review. PubMed 

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.
Hrabé de Angelis M, Nicholson G, Selloum M, White JK, Morgan H, Wolf E, Ramirez-Solis R, Sorg T, Wells S, Fuchs H, Fray M, Adams DJ, Adams NC, Adler T, Aguilar-Pimentel A, Ali-Hadji D, Amann G, André P, Atkins S, Auburtin A, Ayadi A, Becker J, Becker L, et al.
Nat Genet. 2015 Sep;47(9):969-78. doi: 10.1038/ng.3360. Epub 2015 Jul 27. PubMed 

Functional compensation among HMGN variants modulates the DNase I hypersensitive sites at enhancers.
Deng T, Zhu ZI, Zhang S, Postnikov Y, Huang D, Horsch M, Furusawa T, Beckers J, Rozman J, Klingenspor M, Amarie O, Graw J, Rathkolb B, Wolf E, Adler T, Busch DH, Gailus-Durner V, Fuchs H, Hrabé de Angelis M, van der Velde A, Tessarollo L, Ovcherenko I, et al.
Genome Res. 2015 Sep;25(9):1295-308. doi: 10.1101/gr.192229.115. Epub 2015 Jul 8. PubMed 

Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy.
Simon CM, Rauskolb S, Gunnersen JM, Holtmann B, Drepper C, Dombert B, Braga M, Wiese S, Jablonka S, Pühringer D, Zielasek J, Hoeflich A, Silani V, Wolf E, Kneitz S, Sommer C, Toyka KV, Sendtner M.
Acta Neuropathol. 2015 Sep;130(3):373-87. doi: 10.1007/s00401-015-1446-8. Epub 2015 May 30. PubMed 

Transgenic Expression of Human CD46 on Porcine Endothelium: Effect on Coagulation and Fibrinolytic Cascades During Ex Vivo Human-to-Pig Limb Xenoperfusions.
Bongoni AK, Kiermeir D, Schnider J, Jenni H, Garimella P, Bähr A, Klymiuk N, Wolf E, Ayares D, Voegelin E, Constantinescu MA, Seebach JD, Rieben R.
Transplantation. 2015 Oct;99(10):2061-9. doi: 10.1097/TP.0000000000000746. PubMed 

Virus safety of islet cell transplantation from transgenic pigs to marmosets.
Plotzki E, Wolf-van Buerck L, Knauf Y, Becker T, Maetz-Rensing K, Schuster M, Baehr A, Klymiuk N, Wolf E, Seissler J, Denner J.
Virus Res. 2015 Jun 2;204:95-102. doi: 10.1016/j.virusres.2015.04.016. Epub 2015 May 6. PubMed 

Remodeling of the Nuclear Envelope and Lamina during Bovine Preimplantation Development and Its Functional Implications.
Popken J, Graf A, Krebs S, Blum H, Schmid VJ, Strauss A, Guengoer T, Zakhartchenko V, Wolf E, Cremer T.
PLoS One. 2015 May 1;10(5):e0124619. doi: 10.1371/journal.pone.0124619. eCollection 2015. PubMed 

Effects of the glucagon-like peptide-1 receptor agonist liraglutide in juvenile transgenic pigs modeling a pre-diabetic condition.
Streckel E, Braun-Reichhart C, Herbach N, Dahlhoff M, Kessler B, Blutke A, Bähr A, Übel N, Eddicks M, Ritzmann M, Krebs S, Göke B, Blum H, Wanke R, Wolf E, Renner S.
J Transl Med. 2015 Feb 25;13:73. doi: 10.1186/s12967-015-0431-2. PubMed 

Inactivation of Itf2 promotes intestinal tumorigenesis in Apc(Min/+) mice.
Grill JI, Herbst A, Brandl L, Kong L, Schneider MR, Kirchner T, Wolf E, Kolligs FT.
Biochem Biophys Res Commun. 2015 May 29;461(2):249-53. doi: 10.1016/j.bbrc.2015.04.009. Epub 2015 Apr 11. PubMed 

Pig-to-baboon heterotopic heart transplantation--exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens.
Iwase H, Ekser B, Satyananda V, Bhama J, Hara H, Ezzelarab M, Klein E, Wagner R, Long C, Thacker J, Li J, Zhou H, Jiang M, Nagaraju S, Zhou H, Veroux M, Bajona P, Wijkstrom M, Wang Y, Phelps C, Klymiuk N, Wolf E, et al.
Xenotransplantation. 2015 May-Jun;22(3):211-20. doi: 10.1111/xen.12167. Epub 2015 Apr 3. PubMed 

Glucose tolerance tests for systematic screening of glucose homeostasis in mice.
Rozman J, Rathkolb B, Neschen S, Fuchs H, Gailus-Durner V, Klingenspor M, Wolf E, Hrabé de Angelis M.
Curr Protoc Mouse Biol. 2015 Mar 2;5(1):65-84. doi: 10.1002/9780470942390.mo140111. PubMed 

Viable pigs with a conditionally-activated oncogenic KRAS mutation.
Li S, Edlinger M, Saalfrank A, Flisikowski K, Tschukes A, Kurome M, Zakhartchenko V, Kessler B, Saur D, Kind A, Wolf E, Schnieke A, Flisikowska T.
Transgenic Res. 2015 Jun;24(3):509-17. doi: 10.1007/s11248-015-9866-8. Epub 2015 Feb 26. PubMed 

Commentary on "Meta-analysis of the independent and cumulative effects of multiple genetic modifications on pig lung xenograft performance during ex vivo perfusion with human blood" (by Harris et al.): tailoring donor pigs for xenotransplantation-how to find the right combination of genetic modifica...
Wolf E, Reichart B.
Xenotransplantation. 2015 Mar-Apr;22(2):112-3. doi: 10.1111/xen.12159. Epub 2015 Feb 25. No abstract available. PubMed 

Screen for alterations of iron related parameters in N-ethyl-N-nitrosourea-treated mice identified mutant lines with increased plasma ferritin levels.
Rathkolb B, Klempt M, Sabrautzki S, Michel D, Klaften M, Laufs J, Sedlmeier R, Hans W, Fuchs H, Muckenthaler MU, Horsch M, Campagna DR, Fleming M, Hrabé de Angelis M, Wolf E, Aigner B.
Biometals. 2015 Apr;28(2):293-306. doi: 10.1007/s10534-015-9824-1. Epub 2015 Jan 31. PubMed 

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2014

Genome activation in bovine embryos: review of the literature and new insights from RNA sequencing experiments.
Graf A, Krebs S, Heininen-Brown M, Zakhartchenko V, Blum H, Wolf E.
Anim Reprod Sci. 2014a. 149: 46-58. PubMed

Stage-specific proteome signatures in early bovine embryo development.
Deutsch DR, Frohlich T, Otte KA, Beck A, Habermann FA, Wolf E, Arnold GJ.
J Proteome Res. 2014. 13: 4363-76. PubMed 

DRO1 inactivation drives colorectal carcinogenesis in ApcMin/+ mice.
Grill JI, Neumann J, Herbst A, Hiltwein F, Ofner A, Marschall MK, Wolf E, Kirchner T, Goke B, Schneider MR, Kolligs FT.
Mol Cancer Res. 2014. 12: 1655-62. PubMed 

Complement dependent early immunological responses during ex vivo xenoperfusion of hCD46/HLA-E double transgenic pig forelimbs with human blood.
Bongoni AK, Kiermeir D, Jenni H, Bahr A, Ayares D, Klymiuk N, Wolf E, Voegelin E, Constantinescu MA, Seebach JD, Rieben R.
Xenotransplantation. 2014. 21: 230-43. PubMed 

Homologous recombination contributes to the repair of zinc-finger-nuclease induced double strand breaks in pig primary cells and facilitates recombination with exogenous DNA.
Klymiuk N, Fezert P, Wunsch A, Kurome M, Kessler B, Wolf E. J Biotechnol. 2014. 177: 74-81. PubMed 

Fine mapping of genome activation in bovine embryos by RNA sequencing.
Graf A, Krebs S, Zakhartchenko V, Schwalb B, Blum H, Wolf E.
Proc Natl Acad Sci U S A. 2014b. 111: 4139-44. PubMed 

Comparative and retrospective molecular analysis of Parapoxvirus (PPV) isolates.
Friederichs S, Krebs S, Blum H, Wolf E, Lang H, von Buttlar H, Buttner M.
Virus Res
. 2014. 181: 11-21. PubMed 

Uniformity of nucleosome preservation pattern in Mammalian sperm and its connection to repetitive DNA elements.
Samans B, Yang Y, Krebs S, Sarode GV, Blum H, Reichenbach M, Wolf E, Steger K, Dansranjavin T, Schagdarsurengin U.
Dev Cell. 2014. 30: 23-35. PubMed 

Regulatory sequences of the porcine THBD gene facilitate endothelial-specific expression of bioactive human thrombomodulin in single- and multitransgenic pigs.
Wuensch A, Baehr A, Bongoni AK, Kemter E, Blutke A, Baars W, Haertle S, Zakhartchenko V, Kurome M, Kessler B, Faber C, Abicht JM, Reichart B, Wanke R, Schwinzer R, Nagashima H, Rieben R, Ayares D, Wolf E, Klymiuk N.
Transplantation. 2014. 97: 138-47. PubMed 

Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring.
Dahlhoff M, Pfister S, Blutke A, Rozman J, Klingenspor M, Deutsch MJ, Rathkolb B, Fink B, Gimpfl M, Hrabe de Angelis M, Roscher AA, Wolf E, Ensenauer R.
Biochim Biophys Acta. 2014. 1842: 304-17. PubMed 

One-year heterotopic cardiac xenograft survival in a pig to baboon model.
Mohiuddin MM, Singh AK, Corcoran PC, Hoyt RF, Thomas ML, 3rd, Lewis BG, Eckhaus M, Reimann KA, Klymiuk N, Wolf E, Ayares D, Horvath KA.
Am J Transplant. 2014. 14: 488-9. PubMed 

Genetically engineered pig models for diabetes research.
Wolf E, Braun-Reichhart C, Streckel E, Renner S.
Transgenic Res. 2014. 23: 27-38. PubMed 

Genetic dissection of IGF1-dependent and -independent effects of permanent GH excess on postnatal growth and organ pathology of mice.
Blutke A, Schneider MR, Renner-Muller I, Herbach N, Wanke R, Wolf E.
Mol Cell Endocrinol. 2014. 394: 88-98. PubMed 

No amelioration of uromodulin maturation and trafficking defect by sodium 4-phenylbutyrate in vivo: studies in mouse models of uromodulin-associated kidney disease.
Kemter E, Sklenak S, Rathkolb B, Hrabe de Angelis M, Wolf E, Aigner B, Wanke R.
J Biol Chem. 2014. 289: 10715-26. PubMed 

Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.
Stribl C, Samara A, Trumbach D, Peis R, Neumann M, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Rathkolb B, Wolf E, Beckers J, Horsch M, Neff F, Kremmer E, Koob S, Reichert AS, Hans W, Rozman J, Klingenspor M, Aichler M, et al.
J Biol Chem. 2014. 289: 10769-84. PubMed 

The ABC of BTC: structural properties and biological roles of betacellulin.
Dahlhoff M, Wolf E, Schneider MR.
Semin Cell Dev Biol. 2014. 28: 42-8. PubMed 

Uromodulin retention in thick ascending limb of Henle's loop affects SCD1 in neighboring proximal tubule: renal transcriptome studies in mouse models of uromodulin-associated kidney disease.
Horsch M, Beckers J, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Rathkolb B, Wolf E, Aigner B, Kemter E.
PLoS One. 2014. 9: e113125. PubMed 

Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts.
Keller J, Catala-Lehnen P, Huebner AK, Jeschke A, Heckt T, Lueth A, Krause M, Koehne T, Albers J, Schulze J, Schilling S, Haberland M, Denninger H, Neven M, Hermans-Borgmeyer I, Streichert T, Breer S, Barvencik F, Levkau B, Rathkolb B, Wolf E et al.
Nat Commun. 2014. 5: 5215. PubMed 

Standardized, systemic phenotypic analysis of Slc12a1I299F mutant mice.
Kemter E, Rathkolb B, Becker L, Bolle I, Busch DH, Dalke C, Elvert R, Favor J, Graw J, Hans W, Ivandic B, Kalaydjiev S, Klopstock T, Racz I, Rozman J, Schrewe A, Schulz H, Zimmer A, Fuchs H, Gailus-Durner V, Wolf E et al.
J Biomed Sci. 2014. 21: 68. PubMed 

Pleiotropic functions for transcription factor zscan10.
Kraus P, V S, Yu HB, Xing X, Lim SL, Adler T, Pimentel JA, Becker L, Bohla A, Garrett L, Hans W, Holter SM, Janas E, Moreth K, Prehn C, Puk O, Rathkolb B, Rozman J, Adamski J, Bekeredjian R, Wolf E et al.
PLoS One. 2014. 9: e104568. PubMed 

Dual fluorescent reporter pig for Cre recombination: transgene placement at the ROSA26 locus.
Li S, Flisikowska T, Kurome M, Zakhartchenko V, Kessler B, Saur D, Kind A, Wolf E, Flisikowski K, Schnieke A.
PLoS One. 2014. 9: e102455. PubMed 

Reprogramming of fibroblast nuclei in cloned bovine embryos involves major structural remodeling with both striking similarities and differences to nuclear phenotypes of in vitro fertilized embryos.
Popken J, Brero A, Koehler D, Schmid VJ, Strauss A, Wuensch A, Guengoer T, Graf A, Krebs S, Blum H, Zakhartchenko V, Wolf E, Cremer T.
Nucleus. 2014. 5: 555-89. PubMed 

Positional changes of a pluripotency marker gene during structural reorganization of fibroblast nuclei in cloned early bovine embryos.
Popken J, Koehler D, Brero A, Wuensch A, Guengoer T, Thormeyer T, Wolf E, Cremer T, Zakhartchenko V.
Nucleus
. 2014. 5: 542-54. PubMed 

Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments.
Zumbrennen-Bullough KB, Becker L, Garrett L, Holter SM, Calzada-Wack J, Mossbrugger I, Quintanilla-Fend L, Racz I, Rathkolb B, Klopstock T, Wurst W, Zimmer A, Wolf E, Fuchs H, Gailus-Durner V, de Angelis MH, Romney SJ, Leibold EA.
PLoS One. 2014. 9: e98072. PubMed 

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2013

iTRAQ proteome analysis reflects a progressed differentiation state of epiblast derived versus inner cell mass derived murine embryonic stem cells.
Frohlich T, Kosters M, Graf A, Wolf E, Kobolak J, Brochard V, Dinnyes A, Jouneau A, Arnold GJ.
J Proteomics. 2013. 90: 38-51. PubMed 

Type of uromodulin mutation and allelic status influence onset and severity of uromodulin-associated kidney disease in mice.
Kemter E, Prueckl P, Sklenak S, Rathkolb B, Habermann FA, Hans W, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Wolf E, Aigner B, Wanke R.
Hum Mol Genet. 2013. 22: 4148-63. PubMed 

Ligand-independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice.
Dahlhoff M, de Angelis MH, Wolf E, Schneider MR.
Exp Dermatol. 2013. 22: 667-9. PubMed 

Activation of the lectin pathway of complement in pig-to-human xenotransplantation models.
Bongoni AK, Kiermeir D, Jenni H, Wunsch A, Bahr A, Ayares D, Seebach JD, Wolf E, Klymiuk N, Constantinescu MA, Vogelin E, Rieben R.
Transplantation. 2013. 96: 791-9. PubMed 

Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle.
Klymiuk N, Blutke A, Graf A, Krause S, Burkhardt K, Wuensch A, Krebs S, Kessler B, Zakhartchenko V, Kurome M, Kemter E, Nagashima H, Schoser B, Herbach N, Blum H, Wanke R, Aartsma-Rus A, Thirion C, Lochmuller H, Walter MC, Wolf E et al.
Hum Mol Genet. 2013. 22: 4368-82. PubMed 

SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities.
Ju L, Wing J, Taylor E, Brandt R, Slijepcevic P, Horsch M, Rathkolb B, Racz I, Becker L, Hans W, Adler T, Beckers J, Rozman J, Klingenspor M, Wolf E, Zimmer A, Klopstock T, Busch DH, Gailus-Durner V, Fuchs H et al.
DNA Repair (Amst). 2013. 12: 356-66. PubMed 

Oxazolone and ethanol induce colitis in non-obese diabetic-severe combined immunodeficiency interleukin-2Rgamma(null) mice engrafted with human peripheral blood mononuclear cells.
Nolte T, Zadeh-Khorasani M, Safarov O, Rueff F, Gulberg V, Herbach N, Wollenberg A, Mueller T, Siebeck M, Wolf E, Gropp R.
Clin Exp Immunol. 2013a. 172: 349-62. PubMed 

Permanent neonatal diabetes in INS(C94Y) transgenic pigs.
Renner S, Braun-Reichhart C, Blutke A, Herbach N, Emrich D, Streckel E, Wunsch A, Kessler B, Kurome M, Bahr A, Klymiuk N, Krebs S, Puk O, Nagashima H, Graw J, Blum H, Wanke R, Wolf E.
Diabetes. 2013. 62: 1505-11. PubMed 

Immune aspects of embryo-maternal cross-talk in the bovine uterus.
Bauersachs S, Wolf E.
J Reprod Immunol. 2013. 97: 20-6. PubMed 

High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner.
Kugler JE, Horsch M, Huang D, Furusawa T, Rochman M, Garrett L, Becker L, Bohla A, Holter SM, Prehn C, Rathkolb B, Racz I, Aguilar-Pimentel JA, Adler T, Adamski J, Beckers J, Busch DH, Eickelberg O, Klopstock T, Ollert M, Wolf E et al.
J Biol Chem. 2013. 288: 16690-703. PubMed 

Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rgamma(null) mice engrafted with human peripheral blood mononuclear cells.
Nolte T, Zadeh-Khorasani M, Safarov O, Rueff F, Varga R, Herbach N, Wanke R, Wollenberg A, Mueller T, Gropp R, Wolf E, Siebeck M.
Dis Model Mech. 2013b. 6: 125-34. PubMed 

Genetic deletion of the EGFR ligand epigen does not affect mouse embryonic development and tissue homeostasis.
Dahlhoff M, Schafer M, Wolf E, Schneider MR.
Exp Cell Res. 2013. 319: 529-35. PubMed 

Protein O-mannosylation is crucial for E-cadherin-mediated cell adhesion.
Lommel M, Winterhalter PR, Willer T, Dahlhoff M, Schneider MR, Bartels MF, Renner-Muller I, Ruppert T, Wolf E, Strahl S.
Proc Natl Acad Sci U S A. 2013. 110: 21024-9. PubMed 

Increased activation of the epidermal growth factor receptor in transgenic mice overexpressing epigen causes peripheral neuropathy.
Dahlhoff M, Emrich D, Wolf E, Schneider MR.
Biochim Biophys Acta. 2013. 1832: 2068-76. PubMed 

Modeling hepatic osteodystrophy in Abcb4 deficient mice.
Hochrath K, Ehnert S, Ackert-Bicknell CL, Lau Y, Schmid A, Krawczyk M, Hengstler JG, Dunn J, Hiththetiya K, Rathkolb B, Micklich K, Hans W, Fuchs H, Gailus-Durner V, Wolf E, de Angelis MH, Dooley S, Paigen B, Wildemann B, Lammert F et al.
Bone. 2013. 55: 501-11. PubMed

Rapamycin extends murine lifespan but has limited effects on aging.
Neff F, Flores-Dominguez D, Ryan DP, Horsch M, Schroder S, Adler T, Afonso LC, Aguilar-Pimentel JA, Becker L, Garrett L, Hans W, Hettich MM, Holtmeier R, Holter SM, Moreth K, Prehn C, Puk O, Racz I, Rathkolb B, Rozman J, Wol E et al.
J Clin Invest. 2013. 123: 3272-91. PubMed 

Cytoplasmic mislocalization of POU3F4 due to novel mutations leads to deafness in humans and mice.
Parzefall T, Shivatzki S, Lenz DR, Rathkolb B, Ushakov K, Karfunkel D, Shapira Y, Wolf M, Mohr M, Wolf E, Sabrautzki S, de Angelis MH, Frydman M, Brownstein Z, Avraham KB.
Hum Mutat. 2013. 34: 1102-10. PubMed 

An ENU mutagenesis-derived mouse model with a dominant Jak1 mutation resembling phenotypes of systemic autoimmune disease.
Sabrautzki S, Janas E, Lorenz-Depiereux B, Calzada-Wack J, Aguilar-Pimentel JA, Rathkolb B, Adler T, Cohrs C, Hans W, Diener S, Fuchs H, Gailus-Durner V, Busch DH, Hofler H, Ollert M, Strom TM, Wolf E, Neff F, Hrabe de Angelis M.
Am J Pathol. 2013. 183: 352-68. PubMed 

Tissue-specific and minor inter-individual variation in imprinting of IGF2R is a common feature of Bos taurus Concepti and not correlated with fetal weight.
Bebbere D, Bauersachs S, Furst RW, Reichenbach HD, Reichenbach M, Medugorac I, Ulbrich SE, Wolf E, Ledda S, Hiendleder S.
PLoS One. 2013. 8: e59564. PubMed 

A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice.
Holter SM, Stromberg M, Kovalenko M, Garrett L, Glasl L, Lopez E, Guide J, Gotz A, Hans W, Becker L, Rathkolb B, Rozman J, Schrewed A, Klingenspor M, Klopstock T, Schulz H, Wolf E, Wursta W, Gillis T, Wakimoto H et al.
PLoS One. 2013. 8: e80923. PubMed 

Phenotypic comparison of common mouse strains developing high-fat diet-induced hepatosteatosis.
Kahle M, Horsch M, Fridrich B, Seelig A, Schultheiss J, Leonhardt J, Irmler M, Beckers J, Rathkolb B, Wolf E, Franke N, Gailus-Durner V, Fuchs H, de Angelis MH, Neschen S.
Mol Metab. 2013. 2: 435-46. PubMed 

Standardized, systemic phenotypic analysis of Umod(C93F) and Umod(A227T) mutant mice.
Kemter E, Pruckl P, Rathkolb B, Micklich K, Adler T, Becker L, Beckers J, Busch DH, Gotz AA, Hans W, Horsch M, Ivandic B, Klingenspor M, Klopstock T, Rozman J, Schrewe A, Schulz H, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Wolf E et al.
PLoS One. 2013. 8: e78337. PubMed

Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set.
Kurome M, Geistlinger L, Kessler B, Zakhartchenko V, Klymiuk N, Wuensch A, Richter A, Baehr A, Kraehe K, Burkhardt K, Flisikowski K, Flisikowska T, Merkl C, Landmann M, Durkovic M, Tschukes A, Kraner S, Schindelhauer D, Petri T, Kind A, Wolf E et al.
BMC Biotechnol
. 2013. 13: 43. PubMed 

Mouse nuclear myosin I knock-out shows interchangeability and redundancy of myosin isoforms in the cell nucleus.
Venit T, Dzijak R, Kalendova A, Kahle M, Rohozkova J, Schmidt V, Rulicke T, Rathkolb B, Hans W, Bohla A, Eickelberg O, Stoeger T, Wolf E, Yildirim AO, Gailus-Durner V, Fuchs H, de Angelis MH, Hozak P.
PLoS One. 2013. 8: e61406. PubMed 

NOD-scid IL2R gammanull mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways.
Zadeh-Khorasani M, Nolte T, Mueller TD, Pechlivanis M, Rueff F, Wollenberg A, Fricker G, Wolf E, Siebeck M, Gropp R.
J Transl Med. 2013. 11: 4. PubMed 

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2012

Transcriptome analyses of bovine, porcine and equine endometrium during the pre-implantation phase.
Bauersachs S, Wolf E.
Anim Reprod Sci. 2012. 134: 84-94. PubMed 

Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology.
Huttemann M, Lee I, Gao X, Pecina P, Pecinova A, Liu J, Aras S, Sommer N, Sanderson TH, Tost M, Neff F, Aguilar-Pimentel JA, Becker L, Naton B, Rathkolb B, Rozman J, Favor J, Hans W, Prehn C, Puk O, Wolf E et al.
FASEB J. 2012. 26: 3916-30. PubMed 

In-vivo biodegradation of extruded lipid implants in rabbits.
Sax G, Kessler B, Wolf E, Winter G.
J Control Release. 2012. 163: 195-202. PubMed 

Enhanced oxidative stress and endocrine pancreas alterations are linked to a novel glucokinase missense mutation in ENU-derived Munich Gck(D217V) mutants.
van Buerck L, Schuster M, Rathkolb B, Sabrautzki S, Hrabe de Angelis M, Wolf E, Aigner B, Wanke R, Herbach N.
Mol Cell Endocrinol. 2012. 362: 139-48. PubMed 

Innovations in phenotyping of mouse models in the German Mouse Clinic.
Fuchs H, Gailus-Durner V, Neschen S, Adler T, Afonso LC, Aguilar-Pimentel JA, Becker L, Bohla A, Calzada-Wack J, Cohrs C, Dewert A, Fridrich B, Garrett L, Glasl L, Gotz A, Hans W, Holter SM, Horsch M, Hurt A, Janas E, Wolf E et al.
Mamm Genome. 2012. 23: 611-22. PubMed 

A porcine model of familial adenomatous polyposis.
Flisikowska T, Merkl C, Landmann M, Eser S, Rezaei N, Cui X, Kurome M, Zakhartchenko V, Kessler B, Wieland H, Rottmann O, Schmid RM, Schneider G, Kind A, Wolf E, Saur D, Schnieke A.
Gastroenterology. 2012. 143: 1173-5 e1-7. PubMed 

A transgenic mouse line expressing cre recombinase in pancreatic beta-cells.
Dahlhoff M, Grzech M, Habermann FA, Wolf E, Schneider MR.
Genesis. 2012. 50: 437-42. PubMed 

Sequential targeting of CFTR by BAC vectors generates a novel pig model of cystic fibrosis.
Klymiuk N, Mundhenk L, Kraehe K, Wuensch A, Plog S, Emrich D, Langenmayer MC, Stehr M, Holzinger A, Kroner C, Richter A, Kessler B, Kurome M, Eddicks M, Nagashima H, Heinritzi K, Gruber AD, Wolf E.
J Mol Med (Berl). 2012. 90: 597-608. PubMed 

First inducible transgene expression in porcine large animal models.
Klymiuk N, Bocker W, Schonitzer V, Bahr A, Radic T, Frohlich T, Wunsch A, Kessler B, Kurome M, Schilling E, Herbach N, Wanke R, Nagashima H, Mutschler W, Arnold GJ, Schwinzer R, Schieker M, Wolf E.
FASEB J. 2012. 26: 1086-99. PubMed 

Truncation of MIMT1 gene in the PEG3 domain leads to major changes in placental gene expression and stillbirth in cattle.
Flisikowski K, Venhoranta H, Bauersachs S, Hanninen R, Furst RW, Saalfrank A, Ulbrich SE, Taponen J, Lohi H, Wolf E, Kind A, Andersson M, Schnieke A.
Biol Reprod. 2012. 87: 140. PubMed 

Xenografted islet cell clusters from INSLEA29Y transgenic pigs rescue diabetes and prevent immune rejection in humanized mice.
Klymiuk N, van Buerck L, Bahr A, Offers M, Kessler B, Wuensch A, Kurome M, Thormann M, Lochner K, Nagashima H, Herbach N, Wanke R, Seissler J, Wolf E.
Diabetes. 2012. 61: 1527-32. PubMed 

Human TNF-related apoptosis-inducing ligand-expressing dendritic cells from transgenic pigs attenuate human xenogeneic T cell responses.
Kemter E, Lieke T, Kessler B, Kurome M, Wuensch A, Summerfield A, Ayares D, Nagashima H, Baars W, Schwinzer R, Wolf E.
Xenotransplantation. 2012. 19: 40-51. PubMed 

Gene expression profiling of bovine peripartal placentomes: detection of molecular pathways potentially involved in the release of foetal membranes.
Streyl D, Kenngott R, Herbach N, Wanke R, Blum H, Sinowatz F, Wolf E, Zerbe H, Bauersachs S.
Reproduction. 2012. 143: 85-105. PubMed 

Normal epidermal growth factor receptor signaling is dispensable for bone anabolic effects of parathyroid hormone.
Schneider MR, Dahlhoff M, Andrukhova O, Grill J, Glosmann M, Schuler C, Weber K, Wolf E, Erben RG.
Bone. 2012. 50: 237-44. PubMed 

Lack of Pur-alpha alters postnatal brain development and causes megalencephaly.
Hokkanen S, Feldmann HM, Ding H, Jung CK, Bojarski L, Renner-Muller I, Schuller U, Kretzschmar H, Wolf E, Herms J.
Hum Mol Genet. 2012. 21: 473-84. PubMed 

Comparison of the effects of early pregnancy with human interferon, alpha 2 (IFNA2), on gene expression in bovine endometrium.
Bauersachs S, Ulbrich SE, Reichenbach HD, Reichenbach M, Buttner M, Meyer HH, Spencer TE, Minten M, Sax G, Winter G, Wolf E.
Biol Reprod. 2012. 86: 46. PubMed

Early insulin therapy prevents beta cell loss in a mouse model for permanent neonatal diabetes (Munich Ins2(C95S)).
Kautz S, van Burck L, Schuster M, Wolf E, Wanke R, Herbach N.
Diabetologia. 2012. 55: 382-91. PubMed 

The hepatic phosphatidylcholine transporter ABCB4 as modulator of glucose homeostasis.
Hochrath K, Krawczyk M, Goebel R, Langhirt M, Rathkolb B, Micklich K, Rozman J, Horsch M, Beckers J, Klingenspor M, Fuchs H, Gailus-Durner V, Wolf E, Acalovschi M, Volmer DA, Hrabe de Angelis M, Lammert F.
FASEB J. 2012. 26: 5081-91. PubMed 

Domestic animal models for biomedical research.
Bahr A, Wolf E.
Reprod Domest Anim. 2012. 47 Suppl 4: 59-71. PubMed 

A new mouse model for studying EGFR-dependent gastric polyps.
Dahlhoff M, Gerhard M, Rad R, Linden S, Wolf E, Schneider MR.
Biochim Biophys Acta. 2012. 1822: 1293-9. PubMed 

Does enamelin have pleiotropic effects on organs other than the teeth? Lessons from a phenotyping screen of two enamelin-mutant mouse lines.
Fuchs H, Sabrautzki S, Seedorf H, Rathkolb B, Rozman J, Hans W, Schneider R, Klaften M, Holter SM, Becker L, Klempt M, Elvert R, Wurst W, Klopstock T, Klingenspor M, Wolf E, Gailus-Durner V, de Angelis MH.
Eur J Oral Sci. 2012. 120: 269-77. PubMed 

Changing metabolic signatures of amino acids and lipids during the prediabetic period in a pig model with impaired incretin function and reduced beta-cell mass.
Renner S, Romisch-Margl W, Prehn C, Krebs S, Adamski J, Goke B, Blum H, Suhre K, Roscher AA, Wolf E.
Diabetes. 2012. 61: 2166-75. PubMed 

New mouse models for metabolic bone diseases generated by genome-wide ENU mutagenesis.
Sabrautzki S, Rubio-Aliaga I, Hans W, Fuchs H, Rathkolb B, Calzada-Wack J, Cohrs CM, Klaften M, Seedorf H, Eck S, Benet-Pages A, Favor J, Esposito I, Strom TM, Wolf E, Lorenz-Depiereux B, Hrabe de Angelis M.
Mamm Genome. 2012. 23: 416-30. PubMed 

Negative feedback mechanisms surpass the effect of intrinsic EGFR activation during skin chemical carcinogenesis.
Dahlhoff M, Rose C, de Angelis MH, Wolf E, Schneider MR.
Am J Pathol. 2012. 180: 1378-85. PubMed 

Clinical chemistry of human FcRn transgenic mice.
Stein C, Kling L, Proetzel G, Roopenian DC, de Angelis MH, Wolf E, Rathkolb B.
Mamm Genome. 2012. 23: 259-69. PubMed 

Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs.
Leuchs S, Saalfrank A, Merkl C, Flisikowska T, Edlinger M, Durkovic M, Rezaei N, Kurome M, Zakhartchenko V, Kessler B, Flisikowski K, Kind A, Wolf E, Schnieke A.
PLoS One. 2012. 7: e43323. PubMed 

Cytomegalovirus replicon-based regulation of gene expression in vitro and in vivo.
Mohr H, Mohr CA, Schneider MR, Scrivano L, Adler B, Kraner-Schreiber S, Schnieke A, Dahlhoff M, Wolf E, Koszinowski UH, Ruzsics Z.
PLoS Pathog. 2012. 8: e1002728. PubMed 

Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans.
Olszewski PK, Rozman J, Jacobsson JA, Rathkolb B, Stromberg S, Hans W, Klockars A, Alsio J, Riserus U, Becker L, Holter SM, Elvert R, Ehrhardt N, Gailus-Durner V, Fuchs H, Fredriksson R, Wolf E, Klopstock T, Wurst W, Levine AS et al.
PLoS Genet. 2012. 8: e1002568. PubMed 

The endocytic adaptor Eps15 controls marginal zone B cell numbers.
Pozzi B, Amodio S, Lucano C, Sciullo A, Ronzoni S, Castelletti D, Adler T, Treise I, Betsholtz IH, Rathkolb B, Busch DH, Wolf E, Fuchs H, Gailus-Durner V, de Angelis MH, Betsholtz C, Casola S, Di Fiore PP, Offenhauser N.
PLoS One. 2012. 7: e50818. PubMed 

Potential of primary kidney cells for somatic cell nuclear transfer mediated transgenesis in pig. Richter A, Kurome M, Kessler B, Zakhartchenko V, Klymiuk N, Nagashima H, Wolf E, Wuensch A.
BMC Biotechnol. 2012. 12: 84. PubMed 

Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system.
Staropoli JF, Haliw L, Biswas S, Garrett L, Holter SM, Becker L, Skosyrski S, Da Silva-Buttkus P, Calzada-Wack J, Neff F, Rathkolb B, Rozman J, Schrewe A, Adler T, Puk O, Sun M, Favor J, Racz I, Bekeredjian R, Busch DH, Wolf E et al.
PLoS One. 2012. 7: e38310. PubMed 

Hosting the preimplantation embryo: potentials and limitations of different approaches for analysing embryo-endometrium interactions in cattle.
Ulbrich SE, Wolf E, Bauersachs S.
Reprod Fertil Dev. 2012. 25: 62-70. PubMed 

Completion of the swine genome will simplify the production of swine as a large animal biomedical model.
Walters EM, Wolf E, Whyte JJ, Mao J, Renner S, Nagashima H, Kobayashi E, Zhao J, Wells KD, Critser JK, Riley LK, Prather RS.
BMC Med Genomics. 2012. 5: 55. PubMed 

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2011

Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in hematological parameters. Aigner B, Rathkolb B, Klempt M, Wagner S, Michel D, Klaften M, Laufs J, Schneider B, Sedlmeier R, Hrabe de Angelis M, Wolf E. Mamm Genome. 2011. 22: 495-505. PubMed 

Reduced amino acids in the bovine uterine lumen of cloned versus in vitro fertilized pregnancies prior to implantation.
Groebner AE, Zakhartchenko V, Bauersachs S, Rubio-Aliaga I, Daniel H, Buttner M, Reichenbach HD, Meyer HH, Wolf E, Ulbrich SE.
Cell Reprogram. 2011. 13: 403-10. PubMed 

In vivo evidence for epidermal growth factor receptor (EGFR)-mediated release of prolactin from the pituitary gland.
Dahlhoff M, Blutke A, Wanke R, Wolf E, Schneider MR.
J Biol Chem. 2011. 286: 39297-306. PubMed 

Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice.
Horsch M, Seeburg PH, Adler T, Aguilar-Pimentel JA, Becker L, Calzada-Wack J, Garrett L, Gotz A, Hans W, Higuchi M, Holter SM, Naton B, Prehn C, Puk O, Racz I, Rathkolb B, Rozman J, Schrewe A, Adamski J, Busch DH, Wolf E et al.
J Biol Chem. 2011. 286: 18614-22. PubMed 

A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cgamma2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model.
Abe K, Fuchs H, Boersma A, Hans W, Yu P, Kalaydjiev S, Klaften M, Adler T, Calzada-Wack J, Mossbrugger I, Rathkolb B, Rozman J, Prehn C, Maraslioglu M, Kametani Y, Shimada S, Adamski J, Busch DH, Esposito I, Klingenspor M, Wolf E et al.
Arthritis Rheum. 2011. 63: 1301-11. PubMed 

Increase of essential amino acids in the bovine uterine lumen during preimplantation development.
Groebner AE, Rubio-Aliaga I, Schulke K, Reichenbach HD, Daniel H, Wolf E, Meyer HH, Ulbrich SE.
Reproduction. 2011. 141: 685-95. PubMed 

Decreased incidence of papillomas in mice with impaired EGFR function during multi-stage skin carcinogenesis.
Dahlhoff M, Rose C, Wolf E, Schneider MR.
Exp Dermatol. 2011. 20: 290-3. PubMed 

Exploration of relationships between production and fertility traits in dairy cattle via association studies of SNPs within candidate genes derived by expression profiling.
Pimentel EC, Bauersachs S, Tietze M, Simianer H, Tetens J, Thaller G, Reinhardt F, Wolf E, Konig S.
Anim Genet. 2011. 42: 251-62. PubMed 

Bovine endometrial metallopeptidases MMP14 and MMP2 and the metallopeptidase inhibitor TIMP2 participate in maternal preparation of pregnancy.
Ulbrich SE, Meyer SU, Zitta K, Hiendleder S, Sinowatz F, Bauersachs S, Buttner M, Frohlich T, Arnold GJ, Reichenbach HD, Wolf E, Meyer HH.
Mol Cell Endocrinol. 2011. 332: 48-57. PubMed 

Utilization of a mutagenesis screen to generate mouse models of hyperaldosteronism.
Spyroglou A, Wagner S, Gomez-Sanchez C, Rathkolb B, Wolf E, Manolopoulou J, Reincke M, Bidlingmaier M, Hrabe de Angelis M, Beuschlein F.
Endocrinology. 2011. 152: 326-31. PubMed 

Mouse phenotyping.
Fuchs H, Gailus-Durner V, Adler T, Aguilar-Pimentel JA, Becker L, Calzada-Wack J, Da Silva-Buttkus P, Neff F, Gotz A, Hans W, Holter SM, Horsch M, Kastenmuller G, Kemter E, Lengger C, Maier H, Matloka M, Moller G, Naton B, Prehn C, Wolf E et al.
Methods. 2011. 53: 120-35. PubMed 

Genomic integration of adenoviral gene transfer vectors following transduction of fertilized mouse oocytes.
Larochelle N, Stucka R, Rieger N, Schermelleh L, Schiedner G, Kochanek S, Wolf E, Lochmuller H.
Transgenic Res. 2011. 20: 123-35. PubMed 

Cell-mediated transgenesis in rabbits: chimeric and nuclear transfer animals.
Zakhartchenko V, Flisikowska T, Li S, Richter T, Wieland H, Durkovic M, Rottmann O, Kessler B, Gungor T, Brem G, Kind A, Wolf E, Schnieke A.
Biol Reprod. 2011. 84: 229-37. PubMed 

Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia.
Saarikangas J, Mattila PK, Varjosalo M, Bovellan M, Hakanen J, Calzada-Wack J, Tost M, Jennen L, Rathkolb B, Hans W, Horsch M, Hyvonen ME, Perala N, Fuchs H, Gailus-Durner V, Esposito I, Wolf E, de Angelis MH, Frilander MJ, Savilahti H et al.
J Cell Sci. 2011. 124: 1245-55. PubMed 

Formation of nucleoli in interspecies nuclear transfer embryos derived from bovine, porcine, and rabbit oocytes and nuclear donor cells of various species.
Lagutina I, Zakhartchenko V, Fulka H, Colleoni S, Wolf E, Fulka J, Jr., Lazzari G, Galli C.
Reproduction. 2011. 141: 453-65. PubMed 

Immunological mechanisms to establish embryo tolerance in early bovine pregnancy.
Groebner AE, Schulke K, Schefold JC, Fusch G, Sinowatz F, Reichenbach HD, Wolf E, Meyer HH, Ulbrich SE.
Reprod Fertil Dev. 2011. 23: 619-32. PubMed 

Postnatal development of numbers and mean sizes of pancreatic islets and beta-cells in healthy mice and GIPR(dn) transgenic diabetic mice.
Herbach N, Bergmayr M, Goke B, Wolf E, Wanke R.
PLoS One. 2011. 6: e22814. PubMed 

Cell arrest and cell death in mammalian preimplantation development: lessons from the bovine model.
Leidenfrost S, Boelhauve M, Reichenbach M, Gungor T, Reichenbach HD, Sinowatz F, Wolf E, Habermann FA.
PLoS One. 2011. 6: e22121. PubMed 

Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells.
Raab M, Kappel S, Kramer A, Sanhaji M, Matthess Y, Kurunci-Csacsko E, Calzada-Wack J, Rathkolb B, Rozman J, Adler T, Busch DH, Esposito I, Fuchs H, Gailus-Durner V, Klingenspor M, Wolf E, Sanger N, Prinz F, Angelis MH, Seibler J et al.
Nat Commun. 2011. 2: 395. PubMed 

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2010

AKT/GSK-3beta/beta-catenin signalling within hippocampus and amygdala reflects genetically determined differences in posttraumatic stress disorder like symptoms.
Dahlhoff M, Siegmund A, Golub Y, Wolf E, Holsboer F, Wotjak CT.
Neuroscience. 2010. 169: 1216-26. PubMed 

Canine embryonic stem cells: state of the art.
Schneider MR, Wolf E, Braun J, Kolb HJ, Adler H.
Theriogenology. 2010. 74: 492-7. PubMed 

Actions and interactions of progesterone and estrogen on transcriptome profiles of the bovine endometrium.
Shimizu T, Krebs S, Bauersachs S, Blum H, Wolf E, Miyamoto A.
Physiol Genomics. 2010. 42A: 290-300. PubMed 

Microarray analysis of equine endometrium at days 8 and 12 of pregnancy.
Merkl M, Ulbrich SE, Otzdorff C, Herbach N, Wanke R, Wolf E, Handler J, Bauersachs S.
Biol Reprod. 2010. 83: 874-86. PubMed 

Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function.
Renner S, Fehlings C, Herbach N, Hofmann A, von Waldthausen DC, Kessler B, Ulrichs K, Chodnevskaja I, Moskalenko V, Amselgruber W, Goke B, Pfeifer A, Wanke R, Wolf E.
Diabetes. 2010. 59: 1228-38. PubMed 

Enhanced proapoptotic gene expression of XAF1, CASP8 and TNFSF10 in the bovine endometrium during early pregnancy is not correlated with augmented apoptosis.
Groebner AE, Schulke K, Unterseer S, Reichenbach HD, Reichenbach M, Buttner M, Wolf E, Meyer HH, Ulbrich SE.
Placenta. 2010. 31: 168-77. PubMed 

Genetic modification of pigs as organ donors for xenotransplantation.
Klymiuk N, Aigner B, Brem G, Wolf E.
Mol Reprod Dev. 2010. 77: 209-21. PubMed 

Phenotypic and pathomorphological characteristics of a novel mutant mouse model for maturity-onset diabetes of the young type 2 (MODY 2).
van Burck L, Blutke A, Kautz S, Rathkolb B, Klaften M, Wagner S, Kemter E, Hrabe de Angelis M, Wolf E, Aigner B, Wanke R, Herbach N.
Am J Physiol Endocrinol Metab. 2010. 298: E512-23. PubMed 

Mutation of the Na(+)-K(+)-2Cl(-) cotransporter NKCC2 in mice is associated with severe polyuria and a urea-selective concentrating defect without hyperreninemia.
Kemter E, Rathkolb B, Bankir L, Schrewe A, Hans W, Landbrecht C, Klaften M, Ivandic B, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Wolf E, Wanke R, Aigner B.
Am J Physiol Renal Physiol. 2010. 298: F1405-15. PubMed 

Transgenic pigs as models for translational biomedical research.
Aigner B, Renner S, Kessler B, Klymiuk N, Kurome M, Wunsch A, Wolf E.
J Mol Med (Berl). 2010. 88: 653-64. PubMed 

Specific transgene expression in mouse pancreatic beta-cells under the control of the porcine insulin promoter.
Grzech M, Dahlhoff M, Herbach N, Habermann FA, Renner-Muller I, Wanke R, Flaswinkel H, Wolf E, Schneider MR.
Mol Cell Endocrinol. 2010. 315: 219-24. PubMed 

Epigen transgenic mice develop enlarged sebaceous glands.
Dahlhoff M, Muller AK, Wolf E, Werner S, Schneider MR.
J Invest Dermatol. 2010. 130: 623-6. PubMed 

Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice.
Rosemann M, Ivashkevich A, Favor J, Dalke C, Holter SM, Becker L, Racz I, Bolle I, Klempt M, Rathkolb B, Kalaydjiev S, Adler T, Aguilar A, Hans W, Horsch M, Rozman J, Calzada-Wack J, Kunder S, Naton B, Gailus-Durner V, Wolf E et al.
Mamm Genome. 2010. 21: 13-27. PubMed 

EGFR ligands exert diverging effects on male reproductive organs.
Schneider MR, Gratao AA, Dahlhoff M, Boersma A, Hrabe de Angelis M, Hoang-Vu C, Wolf E, Klonisch T.
Exp Mol Pathol. 2010. 88: 216-8. PubMed

Differential endometrial gene expression in pregnant and nonpregnant sows.
Ostrup E, Bauersachs S, Blum H, Wolf E, Hyttel P.
Biol Reprod. 2010. 83: 277-85. PubMed 

Germ-line transmission of lentiviral PGK-EGFP integrants in transgenic cattle: new perspectives for experimental embryology.
Reichenbach M, Lim T, Reichenbach HD, Guengoer T, Habermann FA, Matthiesen M, Hofmann A, Weber F, Zerbe H, Grupp T, Sinowatz F, Pfeifer A, Wolf E.
Transgenic Res. 2010. 19: 549-56. PubMed 

In vitro systems for intercepting early embryo-maternal cross-talk in the bovine oviduct.
Ulbrich SE, Zitta K, Hiendleder S, Wolf E.
Theriogenology. 2010. 73: 802-16. PubMed 

Transgenic pigs for xenotransplantation: selection of promoter sequences for reliable transgene expression.
Aigner B, Klymiuk N, Wolf E.
Curr Opin Organ Transplant. 2010. 15: 201-6. PubMed 

Betacellulin protects from pancreatitis by activating stress-activated protein kinase.
Dahlhoff M, Algul H, Siveke JT, Lesina M, Wanke R, Wartmann T, Halangk W, Schmid RM, Wolf E, Schneider MR.
Gastroenterology. 2010. 138: 1585-94, 1594 e1-3. PubMed 

Quantification of leukocyte genomic 5-methylcytosine levels reveals epigenetic plasticity in healthy adult cloned cattle.
de Montera B, El Zeihery D, Muller S, Jammes H, Brem G, Reichenbach HD, Scheipl F, Chavatte-Palmer P, Zakhartchenko V, Schmitz OJ, Wolf E, Renard JP, Hiendleder S.
Cell Reprogram. 2010. 12: 175-81. PubMed 

Creating new knowledge for ruminant reproduction from rapidly expanding and evolving scientific databases.
Bauersachs S, Blum H, Krebs S, Frohlich T, Arnold GJ, Wolf E.
Soc Reprod Fertil Suppl. 2010. 67: 29-40. PubMed 

FISH on 3D preserved bovine and murine preimplantation embryos.
Koehler D, Zakhartchenko V, Ketterl N, Wolf E, Cremer T, Brero A.
Methods Mol Biol. 2010. 659: 437-45. PubMed 

Escherichia coli infection induces distinct local and systemic transcriptome responses in the mammary gland.
Mitterhuemer S, Petzl W, Krebs S, Mehne D, Klanner A, Wolf E, Zerbe H, Blum H.
BMC Genomics. 2010. 11: 138. PubMed 

A key role for E-cadherin in intestinal homeostasis and Paneth cell maturation.
Schneider MR, Dahlhoff M, Horst D, Hirschi B, Trulzsch K, Muller-Hocker J, Vogelmann R, Allgauer M, Gerhard M, Steininger S, Wolf E, Kolligs FT.
PLoS One. 2010. 5: e14325. PubMed 

Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice.
Tocchetti A, Soppo CB, Zani F, Bianchi F, Gagliani MC, Pozzi B, Rozman J, Elvert R, Ehrhardt N, Rathkolb B, Moerth C, Horsch M, Fuchs H, Gailus-Durner V, Beckers J, Klingenspor M, Wolf E, Hrabe de Angelis M, Scanziani E, Tacchetti C et al.
PLoS One. 2010. 5: e9468. PubMed 

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2009

A new Fgf10 mutation in the mouse leads to atrophy of the harderian gland and slit-eye phenotype in heterozygotes: a novel model for dry-eye disease?
Puk O, Esposito I, Soker T, Loster J, Budde B, Nurnberg P, Michel-Soewarto D, Fuchs H, Wolf E, Hrabe de Angelis M, Graw J.
Invest Ophthalmol Vis Sci. 2009. 50: 4311-8. PubMed

Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection.
Rathkolb B, Noyes HA, Brass A, Dark P, Fuchs H, Gailus-Durner V, Gibson J, de Angelis MH, Ogugo M, Iraqi F, Kemp SJ, Naessens J, Pope ME, Wolf E, Agaba M.
Infect Immun. 2009. 77: 3948-57. PubMed 

Maternal inexperience as a risk factor of innate fear and PTSD-like symptoms in mice.
Siegmund A, Dahlhoff M, Habersetzer U, Mederer A, Wolf E, Holsboer F, Wotjak CT.
J Psychiatr Res. 2009. 43: 1156-65. PubMed 

Evidence for estrogen-dependent uterine serpin (SERPINA14) expression during estrus in the bovine endometrial glandular epithelium and lumen.
Ulbrich SE, Frohlich T, Schulke K, Englberger E, Waldschmitt N, Arnold GJ, Reichenbach HD, Reichenbach M, Wolf E, Meyer HH, Bauersachs S.
Biol Reprod. 2009. 81: 795-805. PubMed 

Novel missense mutation of uromodulin in mice causes renal dysfunction with alterations in urea handling, energy, and bone metabolism.
Kemter E, Rathkolb B, Rozman J, Hans W, Schrewe A, Landbrecht C, Klaften M, Ivandic B, Fuchs H, Gailus-Durner V, Klingenspor M, de Angelis MH, Wolf E, Wanke R, Aigner B.
Am J Physiol Renal Physiol. 2009. 297: F1391-8. PubMed 

A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice.
Enard W, Gehre S, Hammerschmidt K, Holter SM, Blass T, Somel M, Bruckner MK, Schreiweis C, Winter C, Sohr R, Becker L, Wiebe V, Nickel B, Giger T, Muller U, Groszer M, Adler T, Aguilar A, Bolle I, Calzada-Wack J, Wolf E et al.
Cell. 2009. 137: 961-71. PubMed 

Scrapie-infected transgenic mice expressing a laminin receptor decoy mutant reveal a prolonged incubation time associated with low levels of PrPres.
Pflanz H, Vana K, Mitteregger G, Renner-Muller I, Pace C, Kuchenhoff H, Kretzschmar HA, Wolf E, Weiss S.
J Mol Biol. 2009. 388: 721-9. PubMed 

IGFBP-2 overexpression reduces the appearance of dysplastic aberrant crypt foci and inhibits growth of adenomas in chemically induced colorectal carcinogenesis.
Diehl D, Hessel E, Oesterle D, Renner-Muller I, Elmlinger M, Langhammer M, Gottlicher M, Wolf E, Lahm H, Hoeflich A.
Int J Cancer. 2009. 124: 2220-5. PubMed 

Distribution and expression of porcine endogenous retroviruses in multi-transgenic pigs generated for xenotransplantation.
Dieckhoff B, Kessler B, Jobst D, Kues W, Petersen B, Pfeifer A, Kurth R, Niemann H, Wolf E, Denner J.
Xenotransplantation. 2009. 16: 64-73. PubMed 

Decreased p44/42 mitogen-activated protein kinase phosphorylation in gender- or hormone-related but not during age-related adrenal gland growth in mice.
Bielohuby M, Sawitzky M, Johnsen I, Wittenburg D, Beuschlein F, Wolf E, Hoeflich A.
Endocrinology. 2009. 150: 1269-77. PubMed 

High cortical bone mass phenotype in betacellulin transgenic mice is EGFR dependent.
Schneider MR, Mayer-Roenne B, Dahlhoff M, Proell V, Weber K, Wolf E, Erben RG.
J Bone Miner Res. 2009. 24: 455-67. PubMed 

The epidermal growth factor receptor ligands at a glance.
Schneider MR, Wolf E.
J Cell Physiol. 2009. 218: 460-6. PubMed 

Reprogramming of active and repressive histone modifications following nuclear transfer with rabbit mesenchymal stem cells and adult fibroblasts.
Brero A, Hao R, Schieker M, Wierer M, Wolf E, Cremer T, Zakhartchenko V.
Cloning Stem Cells. 2009. 11: 319-29. PubMed 

Changes of higher order chromatin arrangements during major genome activation in bovine preimplantation embryos.
Koehler D, Zakhartchenko V, Froenicke L, Stone G, Stanyon R, Wolf E, Cremer T, Brero A.
Exp Cell Res. 2009. 315: 2053-63. PubMed 

HLA-E/human beta2-microglobulin transgenic pigs: protection against xenogeneic human anti-pig natural killer cell cytotoxicity.
Weiss EH, Lilienfeld BG, Muller S, Muller E, Herbach N, Kessler B, Wanke R, Schwinzer R, Seebach JD, Wolf E, Brem G.
Transplantation. 2009. 87: 35-43. PubMed 

Betacellulin overexpression in transgenic mice improves glucose tolerance and enhances insulin secretion by isolated islets in vitro.
Dahlhoff M, Dames PM, Lechner A, Herbach N, van Burck L, Wanke R, Wolf E, Schneider MR.
Mol Cell Endocrinol. 2009. 299: 188-93. PubMed 

Highly sensitive saturation labeling reveals changes in abundance of cell cycle-associated proteins and redox enzyme variants during oocyte maturation in vitro.
Berendt FJ, Frohlich T, Bolbrinker P, Boelhauve M, Gungor T, Habermann FA, Wolf E, Arnold GJ.
Proteomics. 2009. 9: 550-64. PubMed 

The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models.
Fuchs H, Gailus-Durner V, Adler T, Pimentel JA, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Dalke C, Ehrhardt N, Fasnacht N, Ferwagner B, Frischmann U, Hans W, Holter SM, Holzlwimmer G, Horsch M, Javaheri A, Kallnik M, Kling E, Wolf E et al.
Curr Pharm Biotechnol. 2009. 10: 236-43. PubMed 

Chronic growth hormone excess is associated with increased aldosterone: a study in patients with acromegaly and in growth hormone transgenic mice.
Bielohuby M, Roemmler J, Manolopoulou J, Johnsen I, Sawitzky M, Schopohl J, Reincke M, Wolf E, Hoeflich A, Bidlingmaier M.
Exp Biol Med (Maywood). 2009. 234: 1002-9. PubMed 

The C-terminal cytoplasmic domain of human proEGF is a negative modulator of body and organ weights in transgenic mice.
Klonisch T, Glogowska A, Gratao AA, Grzech M, Nistor A, Torchia M, Weber E, de Angelis MH, Rathkolb B, Cuong HV, Wolf E, Schneider MR.
FEBS Lett. 2009. 583: 1349-57. PubMed 

The endometrium responds differently to cloned versus fertilized embryos. Bauersachs S, Ulbrich SE, Zakhartchenko V, Minten M, Reichenbach M, Reichenbach HD, Blum H, Spencer TE, Wolf E.
Proc Natl Acad Sci U S A. 2009. 106: 5681-6. PubMed 

Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in plasma enzyme activities as novel organ-specific disease models.
Aigner B, Rathkolb B, Klaften M, Sedlmeier R, Klempt M, Wagner S, Michel D, Mayer U, Klopstock T, de Angelis MH, Wolf E.
Exp Physiol. 2009a. 94: 412-21. PubMed 

Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis.
Herbach N, Schairer I, Blutke A, Kautz S, Siebert A, Goke B, Wolf E, Wanke R.
Am J Physiol Renal Physiol. 2009. 296: F819-29. PubMed 

N-ethyl-N-nitrosourea mutagenesis produced a small number of mice with altered plasma electrolyte levels.
Aigner B, Rathkolb B, Klempt M, Wagner S, Michel D, de Angelis MH, Wolf E.
J Biomed Sci. 2009b. 16: 53. PubMed 

Systemic first-line phenotyping.
Gailus-Durner V, Fuchs H, Adler T, Aguilar Pimentel A, Becker L, Bolle I, Calzada-Wack J, Dalke C, Ehrhardt N, Ferwagner B, Hans W, Holter SM, Holzlwimmer G, Horsch M, Javaheri A, Kallnik M, Kling E, Lengger C, Morth C, Mossbrugger I, Wolf E et al.
Methods Mol Biol. 2009. 530: 463-509. PubMed 

Mechanisms controlling anaemia in Trypanosoma congolense infected mice.
Noyes HA, Alimohammadian MH, Agaba M, Brass A, Fuchs H, Gailus-Durner V, Hulme H, Iraqi F, Kemp S, Rathkolb B, Wolf E, de Angelis MH, Roshandel D, Naessens J.
PLoS One. 2009. 4: e5170. PubMed 

Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes.
Rubio-Aliaga I, Przemeck GK, Fuchs H, Gailus-Durner V, Adler T, Hans W, Horsch M, Rathkolb B, Rozman J, Schrewe A, Wagner S, Hoelter SM, Becker L, Klopstock T, Wurst W, Wolf E, Klingenspor M, Ivandic BT, Busch DH, Beckers J et al.
PLoS One. 2009. 4: e6054. PubMed 

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2008

Correlation of in vivo and in vitro release data for rh-INFalpha lipid implants.
Schwab M, Kessler B, Wolf E, Jordan G, Mohl S, Winter G.
Eur J Pharm Biopharm. 2008. 70: 690-4. PubMed 

Effects of genetic background, gender, and early environmental factors on isolation-induced ultrasonic calling in mouse pups: an embryo-transfer study.
Wohr M, Dahlhoff M, Wolf E, Holsboer F, Schwarting RK, Wotjak CT.
Behav Genet. 2008. 38: 579-95. PubMed 

Invasion of tumorigenic HT1080 cells is impeded by blocking or downregulating the 37-kDa/67-kDa laminin receptor.
Zuber C, Knackmuss S, Zemora G, Reusch U, Vlasova E, Diehl D, Mick V, Hoffmann K, Nikles D, Frohlich T, Arnold GJ, Brenig B, Wolf E, Lahm H, Little M, Weiss S.
J Mol Biol. 2008. 378: 530-9. PubMed 

Cortical bone loss in androgen-deficient aged male rats is mainly caused by increased endocortical bone remodeling.
Reim NS, Breig B, Stahr K, Eberle J, Hoeflich A, Wolf E, Erben RG.
J Bone Miner Res. 2008. 23: 694-704. PubMed 

Betacellulin regulates hair follicle development and hair cycle induction and enhances angiogenesis in wounded skin.
Schneider MR, Antsiferova M, Feldmeyer L, Dahlhoff M, Bugnon P, Hasse S, Paus R, Wolf E, Werner S.
J Invest Dermatol. 2008. 128: 1256-65. PubMed 

Transcriptome studies of bovine endometrium reveal molecular profiles characteristic for specific stages of estrous cycle and early pregnancy. Bauersachs S, Mitko K, Ulbrich SE, Blum H, Wolf E.
Exp Clin Endocrinol Diabetes. 2008. 116: 371-84. PubMed 

Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology.
Schneider MR, Werner S, Paus R, Wolf E.
Am J Pathol. 2008. 173: 14-24. PubMed 

Betacellulin overexpression in the mouse ovary leads to MAPK3/MAPK1 hyperactivation and reduces litter size by impairing fertilization.
Gratao AA, Dahlhoff M, Sinowatz F, Wolf E, Schneider MR.
Biol Reprod. 2008. 78: 43-52. PubMed 

Diets influence the diabetic phenotype of transgenic mice expressing a dominant negative glucose-dependent insulinotropic polypeptide receptor (GIPRdn).
Herbach N, Goke B, Wolf E, Wanke R.
Regul Pept. 2008. 146: 260-70. PubMed 

Concise classification of the genomic porcine endogenous retroviral gamma1 load to defined lineages.
Klymiuk N, Wolf E, Aigner B.
Virology. 2008. 371: 175-84. PubMed 

Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects.
Aigner B, Rathkolb B, Herbach N, Hrabe de Angelis M, Wanke R, Wolf E.
Am J Physiol Endocrinol Metab. 2008. 294: E232-40. PubMed 

ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta.
Lisse TS, Thiele F, Fuchs H, Hans W, Przemeck GK, Abe K, Rathkolb B, Quintanilla-Martinez L, Hoelzlwimmer G, Helfrich M, Wolf E, Ralston SH, Hrabe de Angelis M.
PLoS Genet. 2008. 4: e7. PubMed 

A highly sensitive immunofluorometric assay for the measurement of aldosterone in small sample volumes: validation in mouse serum.
Manolopoulou J, Bielohuby M, Caton SJ, Gomez-Sanchez CE, Renner-Mueller I, Wolf E, Lichtenauer UD, Beuschlein F, Hoeflich A, Bidlingmaier M.
J Endocrinol. 2008. 196: 215-24. PubMed 

Dynamic changes in messenger RNA profiles of bovine endometrium during the oestrous cycle.
Mitko K, Ulbrich SE, Wenigerkind H, Sinowatz F, Blum H, Wolf E, Bauersachs S.
Reproduction. 2008. 135: 225-40. PubMed 

Genes involved in conceptus-endometrial interactions in ruminants: insights from reductionism and thoughts on holistic approaches.
Spencer TE, Sandra O, Wolf E.
Reproduction. 2008. 135: 165-79. PubMed 

Betacellulin stimulates growth of the mouse intestinal epithelium and increases adenoma multiplicity in Apc+/Min mice.
Dahlhoff M, Horst D, Gerhard M, Kolligs FT, Wolf E, Schneider MR.
FEBS Lett. 2008. 582: 2911-5. PubMed 

Systemic overexpression of growth hormone (GH) in transgenic FVB/N inbred mice: an optimized model for holistic studies of molecular mechanisms underlying GH-induced kidney pathology.
von Waldthausen DC, Schneider MR, Renner-Muller I, Rauleder DN, Herbach N, Aigner B, Wanke R, Wolf E.
Transgenic Res. 2008. 17: 479-88. PubMed 

Canine embryo-derived stem cells and models for human diseases.
Schneider MR, Wolf E, Braun J, Kolb HJ, Adler H.
Hum Mol Genet. 2008. 17: R42-7. PubMed 

Mutation in a novel connexin-like gene (Gjf1) in the mouse affects early lens development and causes a variable small-eye phenotype.
Puk O, Loster J, Dalke C, Soewarto D, Fuchs H, Budde B, Nurnberg P, Wolf E, de Angelis MH, Graw J.
Invest Ophthalmol Vis Sci. 2008. 49: 1525-32. PubMed 

The epidermal growth factor receptor and its ligands in female reproduction: insights from rodent models.
Schneider MR, Wolf E.
Cytokine Growth Factor Rev. 2008. 19: 173-81. PubMed 

Evidence for conserved DNA and histone H3 methylation reprogramming in mouse, bovine and rabbit zygotes. Lepikhov K, Zakhartchenko V, Hao R, Yang F, Wrenzycki C, Niemann H, Wolf E, Walter J.
Epigenetics Chromatin. 2008. 1: 8. PubMed 

Pleiotropic effects in Eya3 knockout mice.
Soker T, Dalke C, Puk O, Floss T, Becker L, Bolle I, Favor J, Hans W, Holter SM, Horsch M, Kallnik M, Kling E, Moerth C, Schrewe A, Stigloher C, Topp S, Gailus-Durner V, Naton B, Beckers J, Fuchs H, Wolf E et al.
BMC Dev Biol. 2008. 8: 118. PubMed 

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2007

Effect of macrophage ApoE on atherosclerosis in LDL-receptor deficient mice.
Tennert C, Teupser D, Mueller MA, Wilfert W, Renner-Muller I, Stein O, Stein Y, Sippel AE, Wolf E, Thiery J.
Biochem Biophys Res Commun. 2007. 361: 574-9. PubMed 

Reporter genes for embryogenesis research in livestock species.
Habermann FA, Wuensch A, Sinowatz F, Wolf E.
Theriogenology. 2007. 68 Suppl 1: S116-24. PubMed 

Technical note: Bovine oviduct and endometrium array version 1: a tailored tool for studying bovine endometrium biology and pathophysiology.
Bauersachs S, Mitko K, Blum H, Wolf E.
J Dairy Sci. 2007. 90: 4420-3. PubMed 

Physiologic systemic iron metabolism in mice deficient for duodenal Hfe.
Vujic Spasic M, Kiss J, Herrmann T, Kessler R, Stolte J, Galy B, Rathkolb B, Wolf E, Stremmel W, Hentze MW, Muckenthaler MU.
Blood. 2007. 109: 4511-7. PubMed 

Screening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project reveals kidney disease models.
Aigner B, Rathkolb B, Herbach N, Kemter E, Schessl C, Klaften M, Klempt M, de Angelis MH, Wanke R, Wolf E.
Am J Physiol Renal Physiol. 2007a. 292: F1560-7. PubMed 

Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice.
Herbach N, Rathkolb B, Kemter E, Pichl L, Klaften M, de Angelis MH, Halban PA, Wolf E, Aigner B, Wanke R.
Diabetes. 2007. 56: 1268-76. PubMed 

Leptin promotes meiotic progression and developmental capacity of bovine oocytes via cumulus cell-independent and -dependent mechanisms.
Paula-Lopes FF, Boelhauve M, Habermann FA, Sinowatz F, Wolf E.
Biol Reprod. 2007. 76: 532-41. PubMed 

A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse.
Rubio-Aliaga I, Soewarto D, Wagner S, Klaften M, Fuchs H, Kalaydjiev S, Busch DH, Klempt M, Rathkolb B, Wolf E, Abe K, Zeiser S, Przemeck GK, Beckers J, de Angelis MH.
Genetics. 2007. 175: 1451-63. PubMed 

Quantitative monitoring of pluripotency gene activation after somatic cloning in cattle.
Wuensch A, Habermann FA, Kurosaka S, Klose R, Zakhartchenko V, Reichenbach HD, Sinowatz F, McLaughlin KJ, Wolf E.
Biol Reprod. 2007. 76: 983-91. PubMed 

Growth analysis of the mouse adrenal gland from weaning to adulthood: time- and gender-dependent alterations of cell size and number in the cortical compartment.
Bielohuby M, Herbach N, Wanke R, Maser-Gluth C, Beuschlein F, Wolf E, Hoeflich A.
Am J Physiol Endocrinol Metab. 2007. 293: E139-46. PubMed 

Canine embryo-derived stem cells--toward clinically relevant animal models for evaluating efficacy and safety of cell therapies.
Schneider MR, Adler H, Braun J, Kienzle B, Wolf E, Kolb HJ.
Stem Cells. 2007. 25: 1850-1. PubMed 

Postnatally elevated levels of insulin-like growth factor (IGF)-II fail to rescue the dwarfism of IGF-I-deficient mice except kidney weight.
Moerth C, Schneider MR, Renner-Mueller I, Blutke A, Elmlinger MW, Erben RG, Camacho-Hubner C, Hoeflich A, Wolf E.
Endocrinology. 2007. 148: 441-51. PubMed 

Rabbit somatic cell cloning: effects of donor cell type, histone acetylation status and chimeric embryo complementation.
Yang F, Hao R, Kessler B, Brem G, Wolf E, Zakhartchenko V.
Reproduction. 2007. 133: 219-30. PubMed 

The bioactive lipid sphingosylphosphorylcholine induces differentiation of mouse embryonic stem cells and human promyelocytic leukaemia cells.
Kleger A, Busch T, Liebau S, Prelle K, Paschke S, Beil M, Rolletschek A, Wobus A, Wolf E, Adler G, Seufferlein T.
Cell Signal. 2007. 19: 367-77. PubMed 

Generation of ENU-induced mouse mutants with hypocholesterolemia: novel tools for dissecting plasma lipoprotein homeostasis.
Aigner B, Rathkolb B, Mohr M, Klempt M, Hrabe de Angelis M, Wolf E.
Lipids. 2007b. 42: 731-7. PubMed 

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2006

Peroxiredoxin 6 is a potent cytoprotective enzyme in the epidermis.
Kumin A, Huber C, Rulicke T, Wolf E, Werner S.
Am J Pathol. 2006. 169: 1194-205. PubMed 

A bovine oviduct epithelial cell suspension culture system suitable for studying embryo-maternal interactions: morphological and functional characterization.
Rottmayer R, Ulbrich SE, Kolle S, Prelle K, Neumueller C, Sinowatz F, Meyer HH, Wolf E, Hiendleder S.
Reproduction. 2006. 132: 637-48. PubMed 

Generation and characterization of dickkopf3 mutant mice.
Barrantes Idel B, Montero-Pedrazuela A, Guadano-Ferraz A, Obregon MJ, Martinez de Mena R, Gailus-Durner V, Fuchs H, Franz TJ, Kalaydjiev S, Klempt M, Holter S, Rathkolb B, Reinhard C, Morreale de Escobar G, Bernal J, Busch DH, Wurst W, Wolf E, Schulz H, Shtrom S et al.
Mol Cell Biol. 2006. 26: 2317-26. PubMed 

Phenotype analysis of mice deficient in the peptide transporter PEPT2 in response to alterations in dietary protein intake.
Frey IM, Rubio-Aliaga I, Klempt M, Wolf E, Daniel H.
Pflugers Arch. 2006. 452: 300-6. PubMed 

Tissue-specific effects of in vitro fertilization procedures on genomic cytosine methylation levels in overgrown and normal sized bovine fetuses.
Hiendleder S, Wirtz M, Mund C, Klempt M, Reichenbach HD, Stojkovic M, Weppert M, Wenigerkind H, Elmlinger M, Lyko F, Schmitz OJ, Wolf E.
Biol Reprod. 2006. 75: 17-23. PubMed 

Methods for transcriptome and proteome research: applications for studying the biology of reproduction in cattle.
Wolf E, Hiendleder S, Bauersachs S, Frohlich T, Sinowatz F, Blum H, Arnold GJ.
Berl Munch Tierarztl Wochenschr. 2006. 119: 7-16. PubMed

Epigenetic regulation of lentiviral transgene vectors in a large animal model.
Hofmann A, Kessler B, Ewerling S, Kabermann A, Brem G, Wolf E, Pfeifer A.
Mol Ther. 2006. 13: 59-66. PubMed 

Monozygotic twin model reveals novel embryo-induced transcriptome changes of bovine endometrium in the preattachment period.
Klein C, Bauersachs S, Ulbrich SE, Einspanier R, Meyer HH, Schmidt SE, Reichenbach HD, Vermehren M, Sinowatz F, Blum H, Wolf E.
Biol Reprod. 2006. 74: 253-64. PubMed 

Genotype-specific environmental impact on the variance of blood values in inbred and F1 hybrid mice.
Klempt M, Rathkolb B, Fuchs E, de Angelis MH, Wolf E, Aigner B.
Mamm Genome. 2006. 17: 93-102. PubMed 

The variability of ovum pick-up response and in vitro embryo production from monozygotic twin cows.
Machado SA, Reichenbach HD, Weppert M, Wolf E, Goncalves PB.
Theriogenology. 2006. 65: 573-83. PubMed 

Region-specific expression of nitric oxide synthases in the bovine oviduct during the oestrous cycle and in vitro.
Ulbrich SE, Rehfeld S, Bauersachs S, Wolf E, Rottmayer R, Hiendleder S, Vermehren M, Sinowatz F, Meyer HH, Einspanier R.
J Endocrinol. 2006. 188: 205-13. PubMed 

Embryo-induced transcriptome changes in bovine endometrium reveal species-specific and common molecular markers of uterine receptivity.
Bauersachs S, Ulbrich SE, Gross K, Schmidt SE, Meyer HH, Wenigerkind H, Vermehren M, Sinowatz F, Blum H, Wolf E.
Reproduction. 2006. 132: 319-31. PubMed 

Evaluation of laser-assisted lentiviral transgenesis in bovine.
Ewerling S, Hofmann A, Klose R, Weppert M, Brem G, Rink K, Pfeifer A, Wolf E.
Transgenic Res. 2006. 15: 447-54. PubMed 

IGF-II transgenic mice display increased aberrant colon crypt multiplicity and tumor volume after 1,2-dimethylhydrazine treatment.
Diehl D, Oesterle D, Elmlinger MW, Hoeflich A, Wolf E, Lahm H.
J Carcinog. 2006. 5: 24. PubMed 

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2005

Genotyping of transgenic mice: old principles and recent developments.
Schneider MR, Wolf E.
Anal Biochem. 2005. 344: 1-7. PubMed 

Maturation of bovine oocytes in the presence of leptin improves development and reduces apoptosis of in vitro-produced blastocysts.
Boelhauve M, Sinowatz F, Wolf E, Paula-Lopes FF.
Biol Reprod. 2005. 73: 737-44. PubMed 

Functional consequences of IGFBP excess-lessons from transgenic mice.
Wolf E, Schneider MR, Zhou R, Fisch TM, Herbach N, Dahlhoff M, Wanke R, Hoeflich A.
Pediatr Nephrol. 2005. 20: 269-78. PubMed 

Gene expression profiling of bovine endometrium during the oestrous cycle: detection of molecular pathways involved in functional changes.
Bauersachs S, Ulbrich SE, Gross K, Schmidt SE, Meyer HH, Einspanier R, Wenigerkind H, Vermehren M, Blum H, Sinowatz F, Wolf E.
J Mol Endocrinol. 2005. 34: 889-908. PubMed 

Introducing the German Mouse Clinic: open access platform for standardized phenotyping.
Gailus-Durner V, Fuchs H, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Elvert R, Ehrhardt N, Dalke C, Franz TJ, Grundner-Culemann E, Hammelbacher S, Holter SM, Holzlwimmer G, Horsch M, Javaheri A, Kalaydjiev SV, Klempt M, Kling E, Kunder S, Wolf E et al.
Nat Methods. 2005. 2: 403-4. PubMed 

Expression of biologically active human TRAIL in transgenic pigs.
Klose R, Kemter E, Bedke T, Bittmann I, Kelsser B, Endres R, Pfeffer K, Schwinzer R, Wolf E.
Transplantation. 2005. 80: 222-30. PubMed 

Holistic differential analysis of embryo-induced alterations in the proteome of bovine endometrium in the preattachment period.
Berendt FJ, Frohlich T, Schmidt SE, Reichenbach HD, Wolf E, Arnold GJ.
Proteomics. 2005. 5: 2551-60. PubMed 

Insulin-like growth factor (IGF)-I stimulates cell proliferation and induces IGF binding protein (IGFBP)-3 and IGFBP-5 gene expression in cultured growth plate chondrocytes via distinct signaling pathways.
Kiepe D, Ciarmatori S, Hoeflich A, Wolf E, Tonshoff B.
Endocrinology. 2005. 146: 3096-104. PubMed 

CARP, a cardiac ankyrin repeat protein, is up-regulated during wound healing and induces angiogenesis in experimental granulation tissue.
Shi Y, Reitmaier B, Regenbogen J, Slowey RM, Opalenik SR, Wolf E, Goppelt A, Davidson JM.
Am J Pathol. 2005. 166: 303-12. PubMed 

Overexpression of a dominant negative GIP receptor in transgenic mice results in disturbed postnatal pancreatic islet and beta-cell development.
Herbach N, Goeke B, Schneider M, Hermanns W, Wolf E, Wanke R.
Regul Pept. 2005. 125: 103-17. PubMed 

Transcriptome analysis of a human colorectal cancer cell line shows molecular targets of insulin-like growth factor-binding protein-4 overexpression.
Diehl D, Lahm H, Wolf E, Bauersachs S.
Int J Cancer. 2005. 113: 588-99. PubMed 

Three novel Pax6 alleles in the mouse leading to the same small-eye phenotype caused by different consequences at target promoters.
Graw J, Loster J, Puk O, Munster D, Haubst N, Soewarto D, Fuchs H, Meyer B, Nurnberg P, Pretsch W, Selby P, Favor J, Wolf E, Hrabe de Angelis M.
Invest Ophthalmol Vis Sci. 2005. 46: 4671-83. PubMed 

Betacellulin overexpression in transgenic mice causes disproportionate growth, pulmonary hemorrhage syndrome, and complex eye pathology.
Schneider MR, Dahlhoff M, Herbach N, Renner-Mueller I, Dalke C, Puk O, Graw J, Wanke R, Wolf E.
Endocrinology. 2005. 146: 5237-46. PubMed 

Functional genomics: tools for improving farm animal health and welfare.
Hiendleder S, Bauersachs S, Boulesteix A, Blum H, Arnold GJ, Frohlich T, Wolf E.
Rev Sci Tech. 2005. 24: 355-77. PubMed 

Mitochondria and the success of somatic cell nuclear transfer cloning: from nuclear-mitochondrial interactions to mitochondrial complementation and mitochondrial DNA recombination.
Hiendleder S, Zakhartchenko V, Wolf E.
Reprod Fertil Dev. 2005. 17: 69-83. PubMed 

Molecular cloning, expression analysis and assignment of the porcine tumor necrosis factor superfamily member 10 gene (TNFSF10) to SSC13q34-->q36 by fluorescence in situ hybridization and radiation hybrid mapping.
Kemter E, Philipp U, Klose R, Kuiper H, Boelhauve M, Distl O, Wolf E, Leeb T.
Cytogenet Genome Res. 2005. 111: 74-8. PubMed 

Large-scale albuminuria screen for nephropathy models in chemically induced mouse mutants.
Rathkolb B, Tran TV, Klempt M, Hrabe de Angelis M, Wanke R, Wolf E, Aigner B.
Nephron Exp Nephrol. 2005. 100: e143-9. PubMed 

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2004

Targeted disruption of the Walker-Warburg syndrome gene Pomt1 in mouse results in embryonic lethality.
Willer T, Prados B, Falcon-Perez JM, Renner-Muller I, Przemeck GK, Lommel M, Coloma A, Valero MC, de Angelis MH, Tanner W, Wolf E, Strahl S, Cruces J.
Proc Natl Acad Sci U S A. 2004. 101: 14126-31. PubMed 

Peri/nuclear localization of intact insulin-like growth factor binding protein-2 and a distinct carboxyl-terminal IGFBP-2 fragment in vivo.
Hoeflich A, Reisinger R, Schuett BS, Elmlinger MW, Russo VC, Vargas GA, Jehle PM, Lahm H, Renner-Muller I, Wolf E.
Biochem Biophys Res Commun. 2004. 324: 705-10. PubMed 

Hypercholesterolemia in ENU-induced mouse mutants.
Mohr M, Klempt M, Rathkolb B, de Angelis MH, Wolf E, Aigner B.
J Lipid Res. 2004. 45: 2132-7. PubMed 

Cloned transgenic farm animals produce a bispecific antibody for T cell-mediated tumor cell killing.
Grosse-Hovest L, Muller S, Minoia R, Wolf E, Zakhartchenko V, Wenigerkind H, Lassnig C, Besenfelder U, Muller M, Lytton SD, Jung G, Brem G.
Proc Natl Acad Sci U S A. 2004. 101: 6858-63. PubMed 

Longitudinal in vivo effects of growth hormone overexpression on bone in transgenic mice.
Eckstein F, Weusten A, Schmidt C, Wehr U, Wanke R, Rambeck W, Wolf E, Mohan S.
J Bone Miner Res. 2004. 19: 802-10. PubMed 

Insulin-like growth factor (IGF)-binding protein-4 inhibits colony formation of colorectal cancer cells by IGF-independent mechanisms.
Diehl D, Hoeflich A, Wolf E, Lahm H.
Cancer Res. 2004. 64: 1600-3. PubMed 

Transgenic mice reveal novel activities of growth hormone in wound repair, angiogenesis, and myofibroblast differentiation.
Thorey IS, Hinz B, Hoeflich A, Kaesler S, Bugnon P, Elmlinger M, Wanke R, Wolf E, Werner S.
J Biol Chem. 2004. 279: 26674-84. PubMed 

Role of the insulin-like growth factor system in adrenocortical growth control and carcinogenesis.
Fottner C, Hoeflich A, Wolf E, Weber MM.
Horm Metab Res. 2004. 36: 397-405. PubMed 

Tissue-specific elevated genomic cytosine methylation levels are associated with an overgrowth phenotype of bovine fetuses derived by in vitro techniques.
Hiendleder S, Mund C, Reichenbach HD, Wenigerkind H, Brem G, Zakhartchenko V, Lyko F, Wolf E.
Biol Reprod. 2004. 71: 217-23. PubMed 

Effects of growth hormone on the ultrastructure of bovine preimplantation embryos.
Kolle S, Stojkovic M, Reese S, Reichenbach HD, Wolf E, Sinowatz F.
Cell Tissue Res. 2004. 317: 101-8. PubMed

Methylation reprogramming and chromosomal aneuploidy in in vivo fertilized and cloned rabbit preimplantation embryos.
Shi W, Dirim F, Wolf E, Zakhartchenko V, Haaf T.
Biol Reprod. 2004. 71: 340-7. PubMed 

Knock-down of the 37-kDa/67-kDa laminin receptor in mouse brain by transgenic expression of specific antisense LRP RNA.
Leucht C, Vana K, Renner-Muller I, Dormont D, Lasmezas CI, Wolf E, Weiss S.
Transgenic Res. 2004. 13: 81-5. PubMed 

Activities of the matrix metalloproteinase stromelysin-2 (MMP-10) in matrix degradation and keratinocyte organization in wounded skin.
Krampert M, Bloch W, Sasaki T, Bugnon P, Rulicke T, Wolf E, Aumailley M, Parks WC, Werner S.
Mol Biol Cell. 2004. 15: 5242-54. PubMed 

Generation of transgenic cattle by lentiviral gene transfer into oocytes.
Hofmann A, Zakhartchenko V, Weppert M, Sebald H, Wenigerkind H, Brem G, Wolf E, Pfeifer A.
Biol Reprod. 2004. 71: 405-9. PubMed 

Monitoring gene expression changes in bovine oviduct epithelial cells during the oestrous cycle.
Bauersachs S, Rehfeld S, Ulbrich SE, Mallok S, Prelle K, Wenigerkind H, Einspanier R, Blum H, Wolf E.
J Mol Endocrinol. 2004. 32: 449-66. PubMed 

Nuclear-cytoplasmic interactions affect in utero developmental capacity, phenotype, and cellular metabolism of bovine nuclear transfer fetuses.
Hiendleder S, Prelle K, Bruggerhoff K, Reichenbach HD, Wenigerkind H, Bebbere D, Stojkovic M, Muller S, Brem G, Zakhartchenko V, Wolf E.
Biol Reprod. 2004. 70: 1196-205. PubMed 

Growth selection in mice reveals conserved and redundant expression patterns of the insulin-like growth factor system.
Hoeflich A, Bunger L, Nedbal S, Renne U, Elmlinger MW, Blum WF, Bruley C, Kolb HJ, Wolf E.
Gen Comp Endocrinol. 2004. 136: 248-59. PubMed 

Insulin-like growth factor-binding protein-4 inhibits growth of the thymus in transgenic mice.
Zhou R, Flaswinkel H, Schneider MR, Lahm H, Hoeflich A, Wanke R, Wolf E.
J Mol Endocrinol. 2004. 32: 349-64. PubMed 

Maternal-fetal transplacental leakage of mitochondrial DNA in bovine nuclear transfer pregnancies: potential implications for offspring and recipients.
Hiendleder S, Bebbere D, Zakhartchenko V, Reichenbach HD, Wenigerkind H, Ledda S, Wolf E.
Cloning Stem Cells. 2004. 6: 150-6. PubMed 

Tumor galectinology: insights into the complex network of a family of endogenous lectins.
Lahm H, Andre S, Hoeflich A, Kaltner H, Siebert HC, Sordat B, von der Lieth CW, Wolf E, Gabius HJ.
Glycoconj J. 2004. 20: 227-38. PubMed 

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2003

Increased activity of catalase in tumor cells overexpressing IGFBP-2.
Hoeflich A, Fettscher O, Preta G, Lahm H, Kolb HJ, Wolf E, Weber MM.
Horm Metab Res. 2003. 35: 816-21. PubMed 

Efficient transgenesis in farm animals by lentiviral vectors.
Hofmann A, Kessler B, Ewerling S, Weppert M, Vogg B, Ludwig H, Stojkovic M, Boelhauve M, Brem G, Wolf E, Pfeifer A.
EMBO Rep. 2003. 4: 1054-60. PubMed 

Polyclonal anti-PrP auto-antibodies induced with dimeric PrP interfere efficiently with PrPSc propagation in prion-infected cells.
Gilch S, Wopfner F, Renner-Muller I, Kremmer E, Bauer C, Wolf E, Brem G, Groschup MH, Schatzl HM.
J Biol Chem. 2003. 278: 18524-31. PubMed 

Growth hormone-related effects on apoptosis, mitosis, and expression of connexin 43 in bovine in vitro maturation cumulus-oocyte complexes.
Kolle S, Stojkovic M, Boie G, Wolf E, Sinowatz F.
Biol Reprod. 2003. 68: 1584-9. PubMed 

Nucleolar proteins and ultrastructure in bovine in vivo developed, in vitro produced, and parthenogenetic cleavage-stage embryos.
Laurincik J, Schmoll F, Mahabir E, Schneider H, Stojkovic M, Zakhartchenko V, Prelle K, Hendrixen PJ, Voss PL, Moeszlacher GG, Avery B, Dieleman SJ, Besenfelder U, Muller M, Ochs RL, Wolf E, Schellander K, Maddox-Hyttel P.
Mol Reprod Dev. 2003. 65: 73-85. PubMed 

Epigenetic reprogramming in mammalian nuclear transfer.
Shi W, Zakhartchenko V, Wolf E.
Differentiation. 2003. 71: 91-113. PubMed 

Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor.
Zeitz U, Weber K, Soegiarto DW, Wolf E, Balling R, Erben RG.
FASEB J. 2003. 17: 509-11. PubMed 

Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos.
Santos F, Zakhartchenko V, Stojkovic M, Peters A, Jenuwein T, Wolf E, Reik W, Dean W.
Curr Biol. 2003. 13: 1116-21. PubMed

Expression of dystrophin driven by the 1.35-kb MCK promoter ameliorates muscular dystrophy in fast, but not in slow muscles of transgenic mdx mice.
Dunant P, Larochelle N, Thirion C, Stucka R, Ursu D, Petrof BJ, Wolf E, Lochmuller H.
Mol Ther. 2003. 8: 80-9. PubMed 

Induction of a senescent-like phenotype does not confer the ability of bovine immortal cells to support the development of nuclear transfer embryos.
Shi W, Hoeflich A, Flaswinkel H, Stojkovic M, Wolf E, Zakhartchenko V.
Biol Reprod. 2003. 69: 301-9. PubMed 

Heteroplasmy in bovine fetuses produced by intra- and inter-subspecific somatic cell nuclear transfer: neutral segregation of nuclear donor mitochondrial DNA in various tissues and evidence for recipient cow mitochondria in fetal blood.
Hiendleder S, Zakhartchenko V, Wenigerkind H, Reichenbach HD, Bruggerhoff K, Prelle K, Brem G, Stojkovic M, Wolf E.
Biol Reprod. 2003. 68: 159-66. PubMed 

Developmental regulation of hyaluronan-binding protein (RHAMM/IHABP) expression in early bovine embryos. Stojkovic M, Krebs O, Kolle S, Prelle K, Assmann V, Zakhartchenko V, Sinowatz F, Wolf E. Biol Reprod. 2003. 68: 60-6. PubMed 

Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect.
Leheste JR, Melsen F, Wellner M, Jansen P, Schlichting U, Renner-Muller I, Andreassen TT, Wolf E, Bachmann S, Nykjaer A, Willnow TE.
FASEB J. 2003. 17: 247-9. PubMed 

Replicated anterior zeugopod (raz): a polydactylous mouse mutant with lowered Shh signaling in the limb bud.
Krebs O, Schreiner CM, Scott WJ, Jr., Bell SM, Robbins DJ, Goetz JA, Alt H, Hawes N, Wolf E, Favor J.
Development. 2003. 130: 6037-47. PubMed 

The mitochondrial genome in embryo technologies.
Hiendleder S, Wolf E.
Reprod Domest Anim. 2003. 38: 290-304. PubMed 

Embryo-maternal communication in bovine - strategies for deciphering a complex cross-talk.
Wolf E, Arnold GJ, Bauersachs S, Beier HM, Blum H, Einspanier R, Frohlich T, Herrler A, Hiendleder S, Kolle S, Prelle K, Reichenbach HD, Stojkovic M, Wenigerkind H, Sinowatz F.
Reprod Domest Anim. 2003. 38: 276-89. PubMed 

IGF-binding protein-4: biochemical characteristics and functional consequences.
Zhou R, Diehl D, Hoeflich A, Lahm H, Wolf E.
J Endocrinol. 2003. 178: 177-93. PubMed 

Regulation of ipsilateral and contralateral bovine oviduct epithelial cell function in the postovulation period: a transcriptomics approach.
Bauersachs S, Blum H, Mallok S, Wenigerkind H, Rief S, Prelle K, Wolf E.
Biol Reprod. 2003. 68: 1170-7. PubMed 

Molecular biological fingerprinting of human lectin expression by RT-PCR. Lahm H, Andre S, Hoeflich A, Fischer JR, Sordat B, Kaltner H, Wolf E, Gabius HJ.
Methods Enzymol. 2003. 362: 287-97. PubMed 

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2002

Effects of a novel co-culture system on development, metabolism and gene expression of bovine embryos produced in vitro.
Rief S, Sinowatz F, Stojkovic M, Einspanier R, Wolf E, Prelle K.
Reproduction. 2002. 124: 543-56. PubMed 

Insulin-like growth factor binding protein 2 (IGFBP-2) separates hypertrophic and hyperplastic effects of growth hormone (GH)/IGF-I excess on adrenocortical cells in vivo.
Hoeflich A, Weber MM, Fisch T, Nedbal S, Fottner C, Elmlinger MW, Wanke R, Wolf E.
FASEB J. 2002. 16: 1721-31. PubMed 

Expression of the vascular endothelial growth factor and its receptors and effects of VEGF during in vitro maturation of bovine cumulus-oocyte complexes (COC).
Einspanier R, Schonfelder M, Muller K, Stojkovic M, Kosmann M, Wolf E, Schams D.
Mol Reprod Dev. 2002. 62: 29-36. PubMed 

IGF-binding protein-5: flexible player in the IGF system and effector on its own.
Schneider MR, Wolf E, Hoeflich A, Lahm H.
J Endocrinol. 2002. 172: 423-40. PubMed 

Effects of bovine serum albumin and estrous cow serum on development and ultrastructure of in vitro-produced porcine embryos. Ott M, Schernthaner W, Sinowatz F, Wolf E.
Anat Histol Embryol. 2002. 31: 151-7. PubMed 

Pluripotent stem cells--model of embryonic development, tool for gene targeting, and basis of cell therapy.
Prelle K, Zink N, Wolf E.
Anat Histol Embryol. 2002. 31: 169-86. PubMed 

Mutation of the RGD sequence does not affect plasma membrane association and growth inhibitory effects of elevated IGFBP-2 in vivo.
Hoeflich A, Reisinger R, Vargas GA, Elmlinger MW, Schuett B, Jehle PM, Renner-Muller I, Lahm H, Russo VC, Wolf E.
FEBS Lett. 2002. 523: 63-7. PubMed 

Application of stem cell technology and nuclear transfer in animal models.
Prelle K, Zakhartchenko V, Wolf E.
Z Arztl Fortbild Qualitatssich. 2002. 96: 434-40. PubMed 

Effects of high concentrations of hyaluronan in culture medium on development and survival rates of fresh and frozen-thawed bovine embryos produced in vitro.
Stojkovic M, Kolle S, Peinl S, Stojkovic P, Zakhartchenko V, Thompson JG, Wenigerkind H, Reichenbach HD, Sinowatz F, Wolf E.
Reproduction. 2002. 124: 141-53. PubMed 

Bovine somatic cell nuclear transfer using recipient oocytes recovered by ovum pick-up: effect of maternal lineage of oocyte donors.
Bruggerhoff K, Zakhartchenko V, Wenigerkind H, Reichenbach HD, Prelle K, Schernthaner W, Alberio R, Kuchenhoff H, Stojkovic M, Brem G, Hiendleder S, Wolf E.
Biol Reprod. 2002. 66: 367-73. PubMed 

Growth hormone inhibits apoptosis in in vitro produced bovine embryos.
Kolle S, Stojkovic M, Boie G, Wolf E, Sinowatz F.
Mol Reprod Dev. 2002. 61: 180-6. PubMed

Diethylnitrosamine induces long-lasting re-expression of insulin-like growth factor II during early stages of liver carcinogenesis in mice.
Lahm H, Gittner K, Krebs O, Sprague L, Deml E, Oesterle D, Hoeflich A, Wanke R, Wolf E.
Growth Horm IGF Res. 2002. 12: 69-79. PubMed 

Insulin-like growth factor-binding protein-2 (IGFBP-2) overexpression negatively regulates bone size and mass, but not density, in the absence and presence of growth hormone/IGF-I excess in transgenic mice.
Eckstein F, Pavicic T, Nedbal S, Schmidt C, Wehr U, Rambeck W, Wolf E, Hoeflich A.
Anat Embryol (Berl). 2002. 206: 139-48. PubMed 

V76D mutation in a conserved gD-crystallin region leads to dominant cataracts in mice.
Graw J, Loster J, Soewarto D, Fuchs H, Reis A, Wolf E, Balling R, Hrabe de Angelis M.
Mamm Genome. 2002. 13: 452-5. PubMed 

Cloning of animals--perspectives for biomedical research.
Wolf E.
Exp Toxicol Pathol. 2002. 54: 161-2. PubMed 

Body composition, bone mass and microstructural analysis in GH-transgenic mice reveals that skeletal changes are specific to bone compartment and gender.
Eckstein F, Lochmuller EM, Koller B, Wehr U, Weusten A, Rambeck W, Hoeflich A, Wolf E.
Growth Horm IGF Res. 2002. 12: 116-25. PubMed 

Nucleolar protein allocation and ultrastructure in bovine embryos produced by nuclear transfer from granulosa cells.
Laurincik J, Zakhartchenko V, Stojkovic M, Brem G, Wolf E, Muller M, Ochs RL, Maddox-Hyttel P.
Mol Reprod Dev. 2002. 61: 477-87. PubMed 

The effect of activation of Mammalian oocytes on remodeling of donor nuclei after nuclear transfer.
Motlik J, Alberio R, Zakhartchenko V, Stojkovic M, Kubelka M, Wolf E.
Cloning Stem Cells. 2002. 4: 245-52. PubMed 

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2001

The Ca2+-binding proteins S100A8 and S100A9 are encoded by novel injury-regulated genes.
Thorey IS, Roth J, Regenbogen J, Halle JP, Bittner M, Vogl T, Kaesler S, Bugnon P, Reitmaier B, Durka S, Graf A, Wockner M, Rieger N, Konstantinow A, Wolf E, Goppelt A, Werner S.
J Biol Chem. 2001. 276: 35818-25. PubMed 

Energy status of nonmatured and in vitro-matured domestic cat oocytes and of different stages of in vitro-produced embryos: enzymatic removal of the zona pellucida increases adenosine triphosphate content and total cell number of blastocysts.
Freistedt P, Stojkovic P, Wolf E, Stojkovic M.
Biol Reprod. 2001a. 65: 793-8. PubMed 

Insulin-like growth factor-binding protein-5 inhibits growth and induces differentiation of mouse osteosarcoma cells. Schneider MR, Zhou R, Hoeflich A, Krebs O, Schmidt J, Mohan S, Wolf E, Lahm H.
Biochem Biophys Res Commun. 2001. 288: 435-42. PubMed 

Impaired wound healing in transgenic mice overexpressing the activin antagonist follistatin in the epidermis.
Wankell M, Munz B, Hubner G, Hans W, Wolf E, Goppelt A, Werner S.
EMBO J. 2001. 20: 5361-72. PubMed 

Mammalian oocyte activation: lessons from the sperm and implications for nuclear transfer.
Alberio R, Zakhartchenko V, Motlik J, Wolf E.
Int J Dev Biol. 2001. 45: 797-809. PubMed 

Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos.
Dean W, Santos F, Stojkovic M, Zakhartchenko V, Walter J, Wolf E, Reik W.
Proc Natl Acad Sci U S A. 2001. 98: 13734-8. PubMed 

Characterization of a new, dominant V124E mutation in the mouse alphaA-crystallin-encoding gene.
Graw J, Loster J, Soewarto D, Fuchs H, Meyer B, Reis A, Wolf E, Balling R, Hrabe de Angelis M.
Invest Ophthalmol Vis Sci. 2001a. 42: 2909-15. PubMed 

Nuclear transfer in cattle with non-transfected and transfected fetal or cloned transgenic fetal and postnatal fibroblasts.
Zakhartchenko V, Mueller S, Alberio R, Schernthaner W, Stojkovic M, Wenigerkind H, Wanke R, Lassnig C, Mueller M, Wolf E, Brem G.
Mol Reprod Dev. 2001. 60: 362-9. PubMed 

Growth inhibition in giant growth hormone transgenic mice by overexpression of insulin-like growth factor-binding protein-2.
Hoeflich A, Nedbal S, Blum WF, Erhard M, Lahm H, Brem G, Kolb HJ, Wanke R, Wolf E.
Endocrinology. 2001. 142: 1889-98. PubMed 

Muscle-specific overexpression of the adenovirus primary receptor CAR overcomes low efficiency of gene transfer to mature skeletal muscle.
Nalbantoglu J, Larochelle N, Wolf E, Karpati G, Lochmuller H, Holland PC.
J Virol. 2001. 75: 4276-82. PubMed 

Ethylnitrosourea-induced mutation in mice leads to the expression of a novel protein in the eye and to dominant cataracts.
Graw J, Klopp N, Loster J, Soewarto D, Fuchs H, Becker-Follmann J, Reis A, Wolf E, Balling R, Habre de Angelis M.
Genetics. 2001. 157: 1313-20. PubMed 

Insulin-like growth factor I (IGF-I) and long R(3)IGF-I differently affect development and messenger ribonucleic acid abundance for IGF-binding proteins and type I IGF receptors in in vitro produced bovine embryos.
Prelle K, Stojkovic M, Boxhammer K, Motlik J, Ewald D, Arnold GJ, Wolf E.
Endocrinology. 2001. 142: 1309-16. PubMed 

Mitochondrial distribution and adenosine triphosphate content of bovine oocytes before and after in vitro maturation: correlation with morphological criteria and developmental capacity after in vitro fertilization and culture.
Stojkovic M, Machado SA, Stojkovic P, Zakhartchenko V, Hutzler P, Goncalves PB, Wolf E.
Biol Reprod. 2001. 64: 904-9. PubMed 

Aey2, a new mutation in the betaB2-crystallin-encoding gene of the mouse.
Graw J, Loster J, Soewarto D, Fuchs H, Reis A, Wolf E, Balling R, Hrabe de Angelis M.
Invest Ophthalmol Vis Sci. 2001b. 42: 1574-80. PubMed 

Growth hormone (GH)/GH receptor expression and GH-mediated effects during early bovine embryogenesis.
Kolle S, Stojkovic M, Prelle K, Waters M, Wolf E, Sinowatz F.
Biol Reprod. 2001. 64: 1826-34. PubMed 

Efficient in vitro production of cat embryos in modified synthetic oviduct fluid medium: effects of season and ovarian status.
Freistedt P, Stojkovic M, Wolf E.
Biol Reprod. 2001b. 65: 9-13. PubMed 

Enu mouse mutagenesis: generation of mouse mutants with aberrant plasma IgE levels.
Alessandrini F, Jakob T, Wolf A, Wolf E, Balling R, Hrabe de Angelis M, Ring J, Behrendt H.
Int Arch Allergy Immunol. 2001. 124: 25-8. PubMed 

Objectively measured sperm motility and sperm head morphometry in boars (Sus scrofa): relation to fertility and seminal plasma growth factors.
Hirai M, Boersma A, Hoeflich A, Wolf E, Foll J, Aumuller TR, Braun J.
J Androl. 2001. 22: 104-10. PubMed 

Precision of high-resolution dual energy X-ray absorptiometry of bone mineral status and body composition in small animal models.
Lochmuller EM, Jung V, Weusten A, Wehr U, Wolf E, Eckstein F.
Eur Cell Mater. 2001. 1: 43-51. PubMed 

Insulin-like growth factor-binding protein 2 in tumorigenesis: protector or promoter?
Hoeflich A, Reisinger R, Lahm H, Kiess W, Blum WF, Kolb HJ, Weber MM, Wolf E.
Cancer Res. 2001. 61: 8601-10. PubMed 

Characterization of a mutation in the lens-specific MP70 encoding gene of the mouse leading to a dominant cataract.
Graw J, Loster J, Soewarto D, Fuchs H, Meyer B, Reis A, Wolf E, Balling R, Hrabe de Angelis M.
Exp Eye Res. 2001c. 73: 867-76. PubMed 

Remodeling of donor nuclei, DNA-synthesis, and ploidy of bovine cumulus cell nuclear transfer embryos: effect of activation protocol.
Alberio R, Brero A, Motlik J, Cremer T, Wolf E, Zakhartchenko V.
Mol Reprod Dev. 2001. 59: 371-9. PubMed 

Genome-wide search for loci controlling serum IGF binding protein levels of mice.
Brockmann GA, Haley CS, Wolf E, Karle S, Kratzsch J, Renne U, Schwerin M, Hoeflich A.
FASEB J. 2001. 15: 978-87. PubMed 

Nucleolar protein allocation and ultrastructure in bovine embryos produced by nuclear transfer from embryonic cells.
Hyttel P, Laurincik J, Zakhartchenko V, Stojkovic M, Wolf E, Muller M, Ochs RL, Brem G.
Cloning. 2001. 3: 69-82. PubMed 

Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
Lahm H, Andre S, Hoeflich A, Fischer JR, Sordat B, Kaltner H, Wolf E, Gabius HJ.
J Cancer Res Clin Oncol. 2001. 127: 375-86. PubMed 

Role of podocyte damage in the pathogenesis of glomerulosclerosis and tubulointerstitial lesions: findings in the growth hormone transgenic mouse model of progressive nephropathy.
Wanke R, Wolf E, Brem G, Hermanns W.
Verh Dtsch Ges Pathol. 2001. 85: 250-6. PubMed 

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2000 and before

Behavior of M-phase synchronized blastomeres after nuclear transfer in cattle.
Alberio R, Motlik J, Stojkovic M, Wolf E, Zakhartchenko V. Mol Reprod Dev. 2000. 57: 37-47. PubMed 

Gene expression of galectin-9/ecalectin, a potent eosinophil chemoattractant, and/or the insertional isoform in human colorectal carcinoma cell lines and detection of frame-shift mutations for protein sequence truncations in the second functional lectin domain.
Lahm H, Hoeflich A, Andre S, Sordat B, Kaltner H, Wolf E, Gabius HJ.
Int J Oncol
. 2000. 17: 519-24. PubMed 

Functional organization of secondary lymphoid organs by homeostatic chemokines.
Lipp M, Forster R, Schubel A, Burgstahler R, Muller G, Breitfeld D, Kremmer E, Wolf E.
Eur Cytokine Netw
. 2000. 11: 504-5. PubMed 

Intracytoplasmic sperm injection in bovine: effects of oocyte activation, sperm pretreatment and injection technique.
Suttner R, Zakhartchenko V, Stojkovic P, Muller S, Alberio R, Medjugorac I, Brem G, Wolf E, Stojkovic M.
Theriogenology
. 2000. 54: 935-48. PubMed 

Overexpression of insulin-like growth factor-II in mouse embryonic stem cells promotes myogenic differentiation. Prelle K, Wobus AM, Krebs O, Blum WF, Wolf E.
Biochem Biophys Res Commun
. 2000. 277: 631-8. PubMed 

Large-scale N-ethyl-N-nitrosourea mutagenesis of mice-from phenotypes to genes.
Rathkolb B, Fuchs E, Kolb HJ, Renner-Muller I, Krebs O, Balling R, Hrabe de Angelis M, Wolf E.
Exp Physiol
. 2000. 85: 635-44. PubMed 

Transgenic technology in farm animals--progress and perspectives.
Wolf E
, Schernthaner W, Zakhartchenko V, Prelle K, Stojkovic M, Brem G.
Exp Physiol
. 2000. 85: 615-25. PubMed 

Partial leptin receptor gene deletion in transgenic mice prevents expression of the membrane-bound isoforms except for Ob-Rc. Reichart U, Kappler R, Scherthan H, Wolf E, Muller M, Brem G, Aigner B.
Biochem Biophys Res Commun. 2000. 269: 496-501. PubMed 

Contrasting obesity phenotypes uncovered by partial leptin receptor gene deletion in transgenic mice.
Reichart U, Renner-Muller I, Hoflich A, Muller OJ, Franz WM, Wolf E, Muller M, Brem G, Aigner B.
Biochem Biophys Res Commun. 2000. 269: 502-7. PubMed 

Activation of ribosomal RNA genes in preimplantation cattle and swine embryos. Hyttel P, Laurincik J, Viuff D, Fair T, Zakhartchenko V, Rosenkranz C, Avery B, Rath D, Niemann H, Thomsen PD, Schellander K, Callesen H, Wolf E, Ochs RL, Greve T. Anim Reprod Sci. 2000. 60-61: 49-60. PubMed 

Identification of immunological relevant phenotypes in ENU mutagenized mice.
Flaswinkel H, Alessandrini F, Rathkolb B, Decker T, Kremmer E, Servatius A, Jakob T, Soewarto D, Marschall S, Fella C, Behrendt H, Ring J, Wolf E, Balling R, Hrabe de Angelis M, Pfeffer K.
Mamm Genome
. 2000. 11: 526-7. PubMed 

Screening for dysmorphological abnormalities--a powerful tool to isolate new mouse mutants.
Fuchs H, Schughart K, Wolf E, Balling R, Hrabe de Angelis M.
Mamm Genome. 2000. 11: 528-30. PubMed

The clinical-chemical screen in the Munich ENU Mouse Mutagenesis Project: screening for clinically relevant phenotypes.
Rathkolb B, Decker T, Fuchs E, Soewarto D, Fella C, Heffner S, Pargent W, Wanke R, Balling R, Hrabe de Angelis M, Kolb HJ, Wolf E.
Mamm Genome
. 2000. 11: 543-6. PubMed

The biochemical metabolite screen in the Munich ENU Mouse Mutagenesis Project: determination of amino acids and acylcarnitines by tandem mass spectrometry.
Rolinski B, Arnecke R, Dame T, Kreischer J, Olgemoller B, Wolf E, Balling R, Hrabe de Angelis M, Roscher AA. Mamm Genome. 2000. 11: 547-51. PubMed

The large-scale Munich ENU-mouse-mutagenesis screen.
Soewarto D, Fella C, Teubner A, Rathkolb B, Pargent W, Heffner S, Marschall S, Wolf E, Balling R, Hrabe de Angelis M.
Mamm Genome. 2000. 11: 507-10. PubMed

Mitochondrial DNA heteroplasmy in cloned cattle produced by fetal and adult cell cloning.
Steinborn R, Schinogl P, Zakhartchenko V, Achmann R, Schernthaner W, Stojkovic M, Wolf E, Muller M, Brem G.
Nat Genet
. 2000. 25: 255-7. PubMed

Effects of IGFBP-2 overexpression in vitro and in vivo.
Wolf E
, Lahm H, Wu M, Wanke R, Hoeflich A.
Pediatr Nephrol
. 2000. 14: 572-8. PubMed

Overexpression of insulin-like growth factor-binding protein-2 results in increased tumorigenic potential in Y-1 adrenocortical tumor cells.
Hoeflich A, Fettscher O, Lahm H, Blum WF, Kolb HJ, Engelhardt D, Wolf E, Weber MM.
Cancer Res. 2000. 60: 834-8. PubMed

The role of the insulin-like growth factor system in adrenocortical tumourigenesis.
Weber MM, Fottner C, Wolf E.
Eur J Clin Invest
. 2000. 30 Suppl 3: 69-75. PubMed

Insulin-like growth factor-I is an autocrine regulator of chromogranin A secretion and growth in human neuroendocrine tumor cells.
von Wichert G, Jehle PM, Hoeflich A, Koschnick S, Dralle H, Wolf E, Wiedenmann B, Boehm BO, Adler G, Seufferlein T.
Cancer Res
. 2000. 60: 4573-81. PubMed

Genome-wide, large-scale production of mutant mice by ENU mutagenesis.
Hrabe de Angelis MH, Flaswinkel H, Fuchs H, Rathkolb B, Soewarto D, Marschall S, Heffner S, Pargent W, Wuensch K, Jung M, Reis A, Richter T, Alessandrini F, Jakob T, Fuchs E, Kolb H, Kremmer E, Wolf E, Schaeble K, Rollinski B, Roscher A et al.
Nat Genet
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Interleukin-6 stimulates clonogenic growth of primary and metastatic human colon carcinoma cells.
Schneider MR, Hoeflich A, Fischer JR, Wolf E, Sordat B, Lahm H.
Cancer Lett
. 2000. 151: 31-8. PubMed

Activation of bovine oocytes by specific inhibition of cyclin-dependent kinases.
Alberio R, Kubelka M, Zakhartchenko V, Hajduch M, Wolf E, Motlik J.
Mol Reprod Dev. 2000. 55: 422-32. PubMed

Transgenic mouse models for studying the functions of insulin-like growth factor-binding proteins.
Schneider MR, Lahm H, Wu M, Hoeflich A, Wolf E.
FASEB J
. 2000. 14: 629-40. PubMed

Functional organization of secondary lymphoid organs by the chemokine system.
Lipp M, Burgstahler R, Muller G, Pevzner V, Kremmer E, Wolf E, Forster R.
Curr Top Microbiol Immunol
. 2000. 251: 173-9. PubMed

Embryonic stem cells and nuclear transfer strategies. Present state and future prospects.
Wobus AM, Wolf E, Beier HM.
Cells Tissues Organs. 2000. 166: 1-5. PubMed

CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Forster R, Schubel A, Breitfeld D, Kremmer E, Renner-Muller I, Wolf E, Lipp M.
Cell
. 1999. 99: 23-33. PubMed

Mutation in the betaA3/A1-crystallin encoding gene Cryba1 causes a dominant cataract in the mouse.
Graw J, Jung M, Loster J, Klopp N, Soewarto D, Fella C, Fuchs H, Reis A, Wolf E, Balling R, Hrabe de Angelis M.
Genomics. 1999. 62: 67-73. PubMed

Chimeric pigs following blastocyst injection of transgenic porcine primordial germ cells.
Mueller S, Prelle K, Rieger N, Petznek H, Lassnig C, Luksch U, Aigner B, Baetscher M, Wolf E, Mueller M, Brem G. Mol Reprod Dev. 1999. 54: 244-54. PubMed

Adult cloning in cattle: potential of nuclei from a permanent cell line and from primary cultures.
Zakhartchenko V, Alberio R, Stojkovic M, Prelle K, Schernthaner W, Stojkovic P, Wenigerkind H, Wanke R, Duchler M, Steinborn R, Mueller M, Brem G, Wolf E.
Mol Reprod Dev
. 1999. 54: 264-72. PubMed

Factors affecting proliferation and dedifferentiation of primary bovine oviduct epithelial cells in vitro.
Reischl J, Prelle K, Schol H, Neumuller C, Einspanier R, Sinowatz F, Wolf E.
Cell Tissue Res
. 1999. 296: 371-83. PubMed

A non-destructive technique for 3-D microstructural phenotypic characterisation of bones in genetically altered mice: preliminary data in growth hormone transgenic animals and normal controls.
Graichen H, Lochmuller EM, Wolf E, Langkabel B, Stammberger T, Haubner M, Renner-Muller I, Englmeier KH, Eckstein F.
Anat Embryol (Berl)
. 1999. 199: 239-48. PubMed

Sex-specific analysis of bone mass in normal and growth hormone transgenic mice using dual energy x-ray absorptiometry (DXA).
Lochmuller EM, Weusten A, Wolf E, Cindik E, Renner-Muller I, Eikmeier T, Eckstein F.
Ann Anat
. 1999. 181: 191-8. PubMed

Effects of serum starvation and re-cloning on the efficiency of nuclear transfer using bovine fetal fibroblasts.
Zakhartchenko V, Durcova-Hills G, Stojkovic M, Schernthaner W, Prelle K, Steinborn R, Muller M, Brem G, Wolf E.
J Reprod Fertil
. 1999a. 115: 325-31. PubMed

Insulin-like growth factors and IGF-binding proteins in bovine seminal plasma. Hoeflich A, Reichenbach HD, Schwartz J, Grupp T, Weber MM, Foll J, Wolf E.
Domest Anim Endocrinol
. 1999. 17: 39-51. PubMed

Differential autocrine regulation of intestine epithelial cell proliferation and differentiation by insulin-like growth factor (IGF) system components.
Jehle PM, Fussgaenger RD, Blum WF, Angelus NK, Hoeflich A, Wolf E, Jungwirth RJ.
Horm Metab Res
. 1999. 31: 97-102. PubMed

Proinsulin-like growth factor-II overexpression does not alter monoallelic H19 gene expression in transfected human embryonic kidney fibroblasts.
Kiess W, Paquette J, Koepf G, Wolf E, Deal C.
Biochem Biophys Res Commun
. 1999. 255: 226-30. PubMed

Pregnancy rate after ultrasound-guided follicle aspiration in nonlactating cows from different breeds.
Schernthaner W, Wenigerkind H, Stojkovic M, Palma GA, Modl J, Wolf E, Brem G.
Zentralbl Veterinarmed A
. 1999. 46: 33-7. PubMed

Overexpression of insulin-like growth factor-binding protein-2 in transgenic mice reduces postnatal body weight gain.
Hoeflich A, Wu M, Mohan S, Foll J, Wanke R, Froehlich T, Arnold GJ, Lahm H, Kolb HJ, Wolf E.
Endocrinology
. 1999. 140: 5488-96. PubMed

Overgrowth of skin in growth hormone transgenic mice depends on the presence of male gonads.
Wanke R, Milz S, Rieger N, Ogiolda L, Renner-Muller I, Brem G, Hermanns W, Wolf E.
J Invest Dermatol
. 1999. 113: 967-71. PubMed

Coenzyme Q(10) in submicron-sized dispersion improves development, hatching, cell proliferation, and adenosine triphosphate content of in vitro-produced bovine embryos.
Stojkovic M, Westesen K, Zakhartchenko V, Stojkovic P, Boxhammer K, Wolf E.
Biol Reprod
. 1999. 61: 541-7. PubMed

Secretion of interferon-tau by bovine embryos in long-term culture: comparison of in vivo derived, in vitro produced, nuclear transfer and demi-embryos.
Stojkovic M, Buttner M, Zakhartchenko V, Riedl J, Reichenbach HD, Wenigerkind H, Brem G, Wolf E.
Anim Reprod Sci
. 1999. 55: 151-62. PubMed

Species-specific alternative splicing of transgenic RNA in the mammary glands of pigs, rabbits, and mice.
Aigner B, Pambalk K, Reichart U, Besenfelder U, Bosze Z, Renner M, Gunzburg WH, Wolf E, Muller M, Brem G.
Biochem Biophys Res Commun. 1999. 257: 843-50. PubMed

Postnatal overexpression of insulin-like growth factor II in transgenic mice is associated with adrenocortical hyperplasia and enhanced steroidogenesis.
Weber MM, Fottner C, Schmidt P, Brodowski KM, Gittner K, Lahm H, Engelhardt D, Wolf E.
Endocrinology
. 1999. 140: 1537-43. PubMed

Potential of fetal germ cells for nuclear transfer in cattle.
Zakhartchenko V, Durcova-Hills G, Schernthaner W, Stojkovic M, Reichenbach HD, Mueller S, Steinborn R, Mueller M, Wenigerkind H, Prelle K, Wolf E, Brem G.
Mol Reprod Dev
. 1999b. 52: 421-6. PubMed

Establishment of pluripotent cell lines from vertebrate species--present status and future prospects.
Prelle K, Vassiliev IM, Vassilieva SG, Wolf E, Wobus AM.
Cells Tissues Organs
. 1999. 165: 220-36. PubMed

Xenotransplantation. Possibilities of animal breeding.
Wolf E
, Schernthaner W, Muller S, Brem G.
Zentralbl Chir
. 1999. 124: 585-90. PubMed

Effect of chronic GH overproduction on cardiac ANP expression and circulating ANP levels.
Dirsch VM, Wolf E, Wanke R, Schulz R, Hermanns W, Vollmar AM.
Mol Cell Endocrinol
. 1998. 144: 109-18. PubMed

Insulin-like growth factor-binding protein-2 inhibits proliferation of human embryonic kidney fibroblasts and of IGF-responsive colon carcinoma cell lines.
Hoflich A, Lahm H, Blum W, Kolb H, Wolf E.
FEBS Lett
. 1998. 434: 329-34. PubMed

Nuclear transfer in mammals: recent developments and future perspectives.
Wolf E
, Zakhartchenko V, Brem G.
J Biotechnol. 1998. 65: 99-110. PubMed

Stable production of human insulin-like growth factor 1 (IGF-1) in the milk of hemi- and homozygous transgenic rabbits over several generations.
Zinovieva N, Lassnig C, Schams D, Besenfelder U, Wolf E, Muller S, Frenyo L, Seregi J, Muller M, Brem G.
Transgenic Res. 1998. 7: 437-47. PubMed

Identification of transgenic mice by direct PCR analysis of lysates of epithelial cells obtained from the inner surface of the rectum.
Lahm H, Hoeflich A, Rieger N, Wanke R, Wolf E.
Transgenic Res. 1998. 7: 131-4. PubMed

Intestinal dimensions of mice divergently selected for body weight.
Ogiolda L, Wanke R, Rottmann O, Hermanns W, Wolf E.
Anat Rec
. 1998. 250: 292-9. PubMed

What is the function of IGF-II in postnatal life? Answers from transgenic mouse models.
Wolf E
, Hoeflich A, Lahm H.
Growth Horm IGF Res
. 1998. 8: 185-93. PubMed

Comparison of ultrasound-guided vs laparoscopic transvaginal ovum pick-up (OPU) in simmental heifers.
Santl B, Wenigerkind H, Schernthaner W, Modl J, Stojkovic M, Prelle K, Holtz W, Brem G, Wolf E.
Theriogenology. 1998. 50: 89-100. PubMed

The use of transgenic animals in the European Union: the report and recommendations of ECVAM Workshop 28.
Mepham TB, Combes RD, Balls M, Barbieri O, Blokhuis HJ, Costa P, Crilly RE, de Cock Buning T, Delpire VC, O'Hare MJ, Houdebine LM, van Kreijl CF, van der Meer M, Reinhardt CA, Wolf E, van Zeller AM.
Altern Lab Anim
. 1998. 26: 21-43. PubMed

A reliable procedure for differential staining of in vitro produced bovine blastocysts: comparison of tissue culture medium 199 and Menezo's B2 medium.
Stojkovic M, Buttner M, Zakhartchenko V, Brem G, Wolf E.
Anim Reprod Sci
. 1998. 50: 1-9. PubMed

Primary culture of porcine PGCs requires LIF and porcine membrane-bound stem cell factor.
Durcova-Hills G, Prelle K, Muller S, Stojkovic M, Motlik J, Wolf E, Brem G.
Zygote
. 1998. 6: 271-5. PubMed

Composition of parental mitochondrial DNA in cloned bovine embryos.
Steinborn R, Zakhartchenko V, Jelyazkov J, Klein D, Wolf E, Muller M, Brem G.
FEBS Lett
. 1998a. 426: 352-6. PubMed

Non-balanced mix of mitochondrial DNA in cloned cattle produced by cytoplast-blastomere fusion.
Steinborn R, Zakhartchenko V, Wolf E, Muller M, Brem G.
FEBS Lett
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Altered growth of mice divergently selected for body weight is associated with complex changes in the growth hormone/insulin-like growth factor system.
Hoeflich A, Schmidt P, Foll J, Rottmann O, Weber MM, Kolb HJ, Pirchner F, Wolf E.
Growth Horm IGF Res
. 1998. 8: 113-23. PubMed

Topography of growth hormone receptor expression in the bovine embryo.
Kolle S, Sinowatz F, Boie G, Lincoln D, Palma G, Stojkovic M, Wolf E.
Histochem Cell Biol
. 1998. 109: 417-9. PubMed

Lessons from gene knockouts.
Osterrieder N, Wolf E.
Rev Sci Tech
. 1998. 17: 351-64. PubMed

Correlations between chemical parameters, mitogenic activity and embryotrophic activity of bovine oviduct-conditioned medium.
Stojkovic M, Wolf E, Van Langendonckt A, Vansteenbrugge A, Charpigny G, Reinaud P, Gandolfi F, Brevini TA, Mermillod P, Terqui M, Brem G, Massip A.
Theriogenology
. 1997. 48: 659-73. PubMed

Support for the development of bovine embryos in vitro by secretions of bovine trophoblastic vesicles derived in vitro.
Stojkovic M, Zakhartchenko V, Brem G, Wolf E.
J Reprod Fertil
. 1997. 111: 191-6. PubMed

Karyoplast-cytoplast volume ratio in bovine nuclear transfer embryos: effect on developmental potential.
Zakhartchenko V, Stojkovic M, Brem G, Wolf E.
Mol Reprod Dev. 1997. 48: 332-8. PubMed

Actions and interactions of growth hormone and insulin-like growth factor-II: body and organ growth of transgenic mice.
Blackburn A, Schmitt A, Schmidt P, Wanke R, Hermanns W, Brem G, Wolf E.
Transgenic Res
. 1997. 6: 213-22. PubMed

Human insulin-like growth factor I (IGF-I) produced in the mammary glands of transgenic rabbits: yield, receptor binding, mitogenic activity, and effects on IGF-binding proteins.
Wolf E
, Jehle PM, Weber MM, Sauerwein H, Daxenberger A, Breier BH, Besenfelder U, Frenyo L, Brem G.
Endocrinology. 1997. 138: 307-13. PubMed

Interactions of insulin-like growth factor (IGF)-II and growth hormone in vivo: circulating levels of IGF-I and IGF-binding proteins in transgenic mice.
Blackburn A, Dressendorfer RA, Blum WF, Erhard M, Brem G, Strasburger CJ, Wolf E.
Eur J Endocrinol
. 1997. 137: 701-8. PubMed

Cryptic physiological trophic support of motoneurons by LIF revealed by double gene targeting of CNTF and LIF. Sendtner M, Gotz R, Holtmann B, Escary JL, Masu Y, Carroll P, Wolf E, Brem G, Brulet P, Thoenen H.
Curr Biol
. 1996. 6: 686-94. PubMed

Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation.
Airaksinen MS, Koltzenburg M, Lewin GR, Masu Y, Helbig C, Wolf E, Brem G, Toyka KV, Thoenen H, Meyer M.
Neuron
. 1996. 16: 287-95. PubMed

A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen.
Forster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M.
Cell
. 1996. 87: 1037-47. PubMed

Development of frozen-thawed porcine blastocysts in vitro and in vivo.
Modl J, Reichenbach HD, Wolf E, Brem G.
Vet Rec
. 1996. 139: 208-10. PubMed

Nuclear transfer in cattle using in vivo-derived vs. in vitro-produced donor embryos: effect of developmental stage.
Zakhartchenko V, Reichenbach HD, Riedl J, Palma GA, Wolf E, Brem G.
Mol Reprod Dev
. 1996. 44: 493-8. PubMed

The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6.
Peters M, Jacobs S, Ehlers M, Vollmer P, Mullberg J, Wolf E, Brem G, Meyer zum Buschenfelde KH, Rose-John S.
J Exp Med
. 1996. 183: 1399-406. PubMed

Effect of donor embryo cell number and cell size on the efficiency of bovine embryo cloning.
Zakhartchenko V, Wolf E, Palma GA, Brem G.
Mol Reprod Dev
. 1995. 42: 53-7. PubMed

Secretion of biologically active interferon tau by in vitro-derived bovine trophoblastic tissue.
Stojkovic M, Wolf E, Buttner M, Berg U, Charpigny G, Schmitt A, Brem G.
Biol Reprod
. 1995. 53: 1500-7. PubMed

Skeletal growth of transgenic mice with elevated levels of circulating insulin-like growth factor-II.
Wolf E
, Rapp K, Blum WF, Kolb H, Brem G.
Growth Regul
. 1995. 5: 177-83. PubMed

Effects of growth hormone overproduction on grip strength of transgenic mice.
Wolf E
, Wanke R, Schenck E, Hermanns W, Brem G.
Eur J Endocrinol
. 1995. 133: 735-40. PubMed

Does the overexpression of pro-insulin-like growth factor-II in transfected human embryonic kidney fibroblasts increase the secretion of lysosomal enzymes?
Hoeflich A, Wolf E, Braulke T, Koepf G, Kessler U, Brem G, Rascher W, Blum W, Kiess W.
Eur J Biochem
. 1995. 232: 172-8. PubMed

Expression of synthetic cDNA sequences encoding human insulin-like growth factor-1 (IGF-1) in the mammary gland of transgenic rabbits.
Brem G, Hartl P, Besenfelder U, Wolf E, Zinovieva N, Pfaller R.
Gene. 1994. 149: 351-5. PubMed

Consequences of postnatally elevated insulin-like growth factor-II in transgenic mice: endocrine changes and effects on body and organ growth.
Wolf E, Kramer R, Blum WF, Foll J, Brem G.
Endocrinology
. 1994a. 135: 1877-86. PubMed

Efficient generation of chimaeric mice using embryonic stem cells after long-term culture in the presence of ciliary neurotrophic factor.
Wolf E
, Kramer R, Polejaeva I, Thoenen H, Brem G.
Transgenic Res. 1994b. 3: 152-8. PubMed

Disruption of the CNTF gene results in motor neuron degeneration.
Masu Y, Wolf E, Holtmann B, Sendtner M, Brem G, Thoenen H.
Nature. 1993. 365: 27-32. PubMed

Effects of long-term elevated serum levels of growth hormone on life expectancy of mice: lessons from transgenic animal models.
Wolf E
, Kahnt E, Ehrlein J, Hermanns W, Brem G, Wanke R.
Mech Ageing Dev
. 1993. 68: 71-87. PubMed

The GH-transgenic mouse as an experimental model for growth research: clinical and pathological studies.
Wanke R, Wolf E, Hermanns W, Folger S, Buchmuller T, Brem G.
Horm Res
. 1992. 37 Suppl 3: 74-87. PubMed

Growth characteristics of metallothionein-human growth hormone transgenic mice as compared to mice selected for high eight-week body weight and unselected controls. II. Skeleton.
Wolf E
, Rapp K, Wanke R, Hermanns W, Pirchner F, von Butler-Wemken I, Brem G.
Growth Dev Aging
. 1991a. 55: 237-48. PubMed

Growth characteristics of metallothionein-human growth hormone transgenic mice as compared to mice selected for high eight-week body weight and unselected controls. I. Body weight gain and external body dimensions.
Wolf E, Wanke R, Hermanns W, Brem G, Pirchner F, von Butler-Wemken I.
Growth Dev Aging
. 1991. 55: 225-35. PubMed

Expression of metallothionein-human growth hormone fusion genes in transgenic mice results in disproportionate skeletal gigantism.
Wolf E
, Rapp K, Brem G.
Growth Dev Aging
. 1991b. 55: 117-27. PubMed

"High-dose hook effect" as a pitfall in quantifying transgene expression in metallothionein-human growth hormone (MT-hGH) transgenic mice.
Wolf E
, Brem G.
Clin Chem
. 1991. 37: 763-5. PubMed

Accelerated growth and visceral lesions in transgenic mice expressing foreign genes of the growth hormone family: an overview.
Wanke R, Hermanns W, Folger S, Wolf E, Brem G.
Pediatr Nephrol. 1991. 5: 513-21. PubMed

Unexpected transgene expression of a mammary-specific growth hormone gene construct in Bergmann glial cells of the mouse.
Brem G, Brenig B, Salmons B, Wolf E, Muller M, Erfle V, Gunzburg WH, Dahme E.
Tierarztl Prax. 1991. 19: 345-50. PubMed

Multiple consequences of human growth hormone expression in transgenic mice.
Brem G, Wanke R, Wolf E, Buchmuller T, Muller M, Brenig B, Hermanns W.
Mol Biol Med. 1989. 6: 531-47. PubMed