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Beckmann Lab - Publications

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2018


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2017

Interdependent action of KH domain proteins Krr1 and Dim2 drive the 40S platform assembly.
Sturm M, Cheng J, Baßler J, Beckmann R, Hurt E.
Nat Commun. 2017 Dec 20;8(1):2213. doi: 10.1038/s41467-017-02199-4. PubMed

Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes.
Kater L, Thoms M, Barrio-Garcia C, Cheng J, Ismail S, Ahmed YL, Bange G, Kressler D, Berninghausen O, Sinning I, Hurt E, Beckmann R.
Cell. 2017 Dec 14;171(7):1599-1610.e14. doi: 10.1016/j.cell.2017.11.039. PubMed

Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae.
Heuer A, Thomson E, Schmidt C, Berninghausen O, Becker T, Hurt E, Beckmann R.
Nat Struct Mol Biol. 2017 Dec;24(12):1107-1115. doi: 10.1038/nsmb.3495 PubMed

Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P.
Huter P, Arenz S, Bock LV, Graf M, Frister JO, Heuer A, Peil L, Starosta AL, Wohlgemuth I, Peske F, Nováček J, Berninghausen O, Grubmüller H, Tenson T, Beckmann R, Rodnina MV, Vaiana AC, Wilson DN.
Mol Cell. 2017 Nov 2;68(3):515-527.e6. doi: 10.1016/j.molcel.2017.10.014. PubMed

Preribosomes escaping from the nucleus are caught during translation by cytoplasmic quality control.
Sarkar A, Thoms M, Barrio-Garcia C, Thomson E, Flemming D, Beckmann R, Hurt E
Nat Struct Mol Biol. 2017 Dec;24(12):1107-1115. doi: 10.1038/nsmb.3495 PubMed

3.2-Å-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.
Cheng J, Kellner N, Berninghausen O, Hurt E, Beckmann R.
Nat Struct Mol Biol. 2017 Nov;24(11):954-964. doi: 10.1038/nsmb.3476 PubMed

Ubiquitination of stalled ribosome triggers ribosome-associated quality control.
Matsuo Y, Ikeuchi K, Saeki Y, Iwasaki S, Schmidt C, Udagawa T, Sato F, Tsuchiya H, Becker T, Tanaka K, Ingolia NT, Beckmann R, Inada T
Nat Commun. 2017 Jul 31;8(1):159. doi: 10.1038/s41467-017-00188-1 PubMed

 An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome.
Florin T, Maracci C, Graf M, Karki P, Klepacki D, Berninghausen O, Beckmann R, Vázquez-Laslop N, Wilson DN, Rodnina MV, Mankin AS.
Nat Struct Mol Biol. 2017 Sep;24(9):752-757. doi: 10.1038/nsmb.3439 PubMed

The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling.
Su T, Cheng J, Sohmen D, Hedman R, Berninghausen O, von Heijne G, Wilson DN, Beckmann R.
Elife. 2017 May 30;6. pii: e25642. doi: 10.7554/eLife.25642. PubMed

Structure of the Bacillus subtilis hibernating 100S ribosome reveals the basis for 70S dimerization.
Beckert B, Abdelshahid M, Schäfer H, Steinchen W, Arenz S, Berninghausen O, Beckmann R, Bange G, Turgay K, Wilson DN.
EMBO J
. 2017 May 3. pii: e201696189. doi: 10.15252/embj.201696189. PubMed

Sucrose sensing through nascent peptide-meditated ribosome stalling at the stop codon of Arabidopsis bZIP11 uORF2.
Yamashita Y, Takamatsu S, Glasbrenner M, Becker T, Naito S, Beckmann R.
FEBS Lett
. 2017 May;591(9):1266-1277. doi: 10.1002/1873-3468.12634. Epub 2017 Apr 10. PubMed

Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation.
Heuer A, Gerovac M, Schmidt C, Trowitzsch S, Preis A, Kötter P, Berninghausen O, Becker T, Beckmann R, Tampé R.
Nat Struct Mol Biol
. 2017 May;24(5):453-460. doi: 10.1038/nsmb.3396. Epub 2017 Apr 3. PubMed

Cotranslational folding of spectrin domains via partially structured states.
Nilsson OB, Nickson AA, Hollins JJ, Wickles S, Steward A, Beckmann R, von Heijne G, Clarke J.
Nat Struct Mol Biol. 2017 Mar;24(3):221-225. doi: 10.1038/nsmb.3355. Epub 2017 Jan 23. PubMed

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2016

The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex.
Schmidt C, Kowalinski E, Shanmuganathan V, Defenouillère Q, Braunger K, Heuer A, Pech M, Namane A, Berninghausen O, Fromont-Racine M, Jacquier A, Conti E, Becker T, Beckmann R.
Science. 2016 Dec 16;354(6318):1431-1433. PubMed

Structural Dynamics of the YidC:Ribosome Complex during Membrane Protein Biogenesis.
Kedrov A, Wickles S, Crevenna AH, van der Sluis EO, Buschauer R, Berninghausen O, Lamb DC, Beckmann R.
Cell Rep. 2016 Dec 13;17(11):2943-2954. doi: 10.1016/j.celrep.2016.11.059. PubMed

Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons.
Huter P, Müller C, Beckert B, Arenz S, Berninghausen O, Beckmann R, Wilson DN.
Nature
. 2017 Jan 26;541(7638):546-549. doi: 10.1038/nature20821. Epub 2016 Dec 1. PubMed

Structure of the ribosome post-recycling complex probed by chemical cross-linking and mass spectrometry.
Kiosze-Becker K, Ori A, Gerovac M, Heuer A, Närenberg-Goloub E, Rashid UJ, Becker T, Beckmann R, Beck M, Tampé R.
Nat Commun
. 2016 Nov 8;7:13248. doi: 10.1038/ncomms13248. PubMed

Ribosome-stalk biogenesis is coupled with recruitment of nuclear-export factor to the nascent 60S subunit.
Sarkar A, Pech M, Thoms M, Beckmann R, Hurt E.
Nat Struct Mol Biol
. 2016 Dec;23(12):1074-1082. doi: 10.1038/nsmb.3312. Epub 2016 Oct 24. PubMed

Architecture of the 90S Pre-ribosome: A Structural View on the Birth of the Eukaryotic Ribosome.
Kornprobst M, Turk M, Kellner N, Cheng J, Flemming D, Koš-Braun I, Koš M, Thoms M, Berninghausen O, Beckmann R, Hurt E.
Cell
. 2016 Jul 14;166(2):380-93. doi: 10.1016/j.cell.2016.06.014. PubMed

Dynamic Behavior of Trigger Factor on the Ribosome.
Deeng J, Chan KY, van der Sluis EO, Berninghausen O, Han W, Gumbart J, Schulten K, Beatrix B, Beckmann R.
J Mol Biol. 2016 Sep 11;428(18):3588-602. doi: 10.1016/j.jmb.2016.06.007. PubMed

A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest.
Arenz S, Bock LV, Graf M, Innis CA, Beckmann R, Grubmüller H, Vaiana AC, Wilson DN.
Nat Commun
. 2016 Jul 6;7:12026. doi: 10.1038/ncomms12026. PubMed

The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis.
Arenz S, Abdelshahid M, Sohmen D, Payoe R, Starosta AL, Berninghausen O, Hauryliuk V, Beckmann R, Wilson DN.
Nucleic Acids Res
. 2016 Jul 27;44(13):6471-81. doi: 10.1093/nar/gkw470. Epub 2016 May 25. PubMed

Correction: ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.
Lässig C, Matheisl S, Sparrer KM, de Oliveira Mann CC, Moldt M, Patel JR, Goldeck M, Hartmann G, García-Sastre A, Hornung V, Conzelmann KK, Beckmann R, Hopfner KP.
Elife
. 2016 Mar 2;5. pii: e14954. doi: 10.7554/eLife.14954. No abstract available. PubMed

Small protein domains fold inside the ribosome exit tunnel.
Marino J, von Heijne G, Beckmann R.
FEBS Lett. 2016 Mar;590(5):655-60. doi: 10.1002/1873-3468.12098. Epub 2016 Feb 25. PubMed

Translation regulation via nascent polypeptide-mediated ribosome stalling.
Wilson DN, Arenz S, Beckmann R.
Curr Opin Struct Biol. 2016 Apr;37:123-33. doi: 10.1016/j.sbi.2016.01.008. Epub 2016 Feb 7. Review. PubMed

Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome.
Schmidt C, Becker T, Heuer A, Braunger K, Shanmuganathan V, Pech M, Berninghausen O, Wilson DN, Beckmann R.
Nucleic Acids Res. 2016 Feb 29;44(4):1944-51. doi: 10.1093/nar/gkv1517. Epub 2015 Dec 28. PubMed

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2015

Architecture of the Rix1-Rea1 checkpoint machinery during pre-60S-ribosome remodeling.
Barrio-Garcia C, Thoms M, Flemming D, Kater L, Berninghausen O, Baßler J, Beckmann R, Hurt E.
Nat Struct Mol Biol
. 2016 Jan;23(1):37-44. doi: 10.1038/nsmb.3132. Epub 2015 Nov 30. PubMed

ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.
Lässig C, Matheisl S, Sparrer KM, de Oliveira Mann CC, Moldt M, Patel JR, Goldeck M, Hartmann G, Garcí­a-Sastre A, Hornung V, Conzelmann KK, Beckmann R, Hopfner KP.
Elife
. 2015 Nov 26;4. pii: e10859. doi: 10.7554/eLife.10859. Erratum in: Elife. 2016;5. pii: e14954. doi: 10.7554/eLife.14954. PubMed 

Structure of the native Sec61 protein-conducting channel.
Pfeffer S, Burbaum L, Unverdorben P, Pech M, Chen Y, Zimmermann R, Beckmann R, Förster F.
Nat Commun
. 2015 Sep 28;6:8403. doi: 10.1038/ncomms9403. PubMed

Structure of a human translation termination complex.
Matheisl S, Berninghausen O, Becker T, Beckmann R.
Nucleic Acids Res
. 2015 Oct 15;43(18):8615-26. doi: 10.1093/nar/gkv909. Epub 2015 Sep 17. PubMed

Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions.
Beckert B, Kedrov A, Sohmen D, Kempf G, Wild K, Sinning I, Stahlberg H, Wilson DN, Beckmann R.
Nat Struct Mol Biol
. 2015 Oct;22(10):767-73. doi: 10.1038/nsmb.3086. Epub 2015 Sep 7. PubMed

Cotranslational Protein Folding inside the Ribosome Exit Tunnel.
Nilsson OB, Hedman R, Marino J, Wickles S, Bischoff L, Johansson M, Müller-Lucks A, Trovato F, Puglisi JD, O'Brien EP, Beckmann R, von Heijne G.
Cell Rep
. 2015 Sep 8;12(10):1533-40. doi: 10.1016/j.celrep.2015.07.065. Epub 2015 Aug 28. PubMed

A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation.
Baßler J, Paternoga H, Holdermann I, Thoms M, Granneman S, Barrio-Garcia C, Nyarko A, Lee W, Stier G, Clark SA, Schraivogel D, Kallas M, Beckmann R, Tollervey D, Barbar E, Sinning I, Hurt E.
J Cell Biol
. 2015 Jul 6;210(1):169-70. doi: 10.1083/jcb.20140811106112015c. No abstract available. PubMed

Role of the Cytosolic Loop C2 and the C Terminus of YidC in Ribosome Binding and Insertion Activity.
Geng Y, Kedrov A, Caumanns JJ, Crevenna AH, Lamb DC, Beckmann R, Driessen AJ.
J Biol Chem
. 2015 Jul 10;290(28):17250-61. doi: 10.1074/jbc.M115.650309. Epub 2015 May 28. PubMed

Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stalling.
Sohmen D, Chiba S, Shimokawa-Chiba N, Innis CA, Berninghausen O, Beckmann R, Ito K, Wilson DN.
Nat Commun
. 2015 Apr 23;6:6941. doi: 10.1038/ncomms7941. PubMed

Structural biology. Mitoribosome oddities.
Beckmann R, Herrmann JM.
Science
. 2015 Apr 17;348(6232):288-9. doi: 10.1126/science.aab1054. Epub 2015 Apr 16. No abstract available. PubMed

Cryo-EM structure of the tetracycline resistance protein TetM in complex with a translating ribosome at 3.9-Å… resolution.
Arenz S, Nguyen F, Beckmann R, Wilson DN.
Proc Natl Acad Sci U S A
. 2015 Apr 28;112(17):5401-6. doi: 10.1073. Epub 2015 Apr 13. PubMed

Parallel Structural Evolution of Mitochondrial Ribosomes and OXPHOS Complexes.
van der Sluis EO, Bauerschmitt H, Becker T, Mielke T, Frauenfeld J, Berninghausen O, Neupert W, Herrmann JM, Beckmann R.
Genome Biol Evol
. 2015 Apr 9;7(5):1235-51. doi: 10.1093/gbe/evv061. PubMed

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2014

A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation.
Baßler J, Paternoga H, Holdermann I, Thoms M, Granneman S, Barrio-Garcia C, Nyarko A, Lee W, Stier G, Clark SA, Schraivogel D, Kallas M, Beckmann R, Tollervey D, Barbar E, Sinning I, Hurt E.
J Cell Biol
. 2014 Nov 24;207(4):481-98. doi: 10.1083/jcb.201408111. Epub 2014 Nov 17. Erratum in: J Cell Biol. 2015 Jul 6;210(1):169-70. Lee, Woonghee [added]. PubMed

Molecular basis for the ribosome functioning as an L-tryptophan sensor.
Bischoff L, Berninghausen O, Beckmann R.
Cell Rep
. 2014 Oct 23;9(2):469-75. doi: 10.1016/j.celrep.2014.09.011. Epub 2014 Oct 9. PubMed

Drug sensing by the ribosome induces translational arrest via active site perturbation.
Arenz S, Meydan S, Starosta AL, Berninghausen O, Beckmann R, Vázquez-Laslop N, Wilson DN.
Mol Cell
. 2014 Nov 6;56(3):446-52. doi: 10.1016/j.molcel.2014.09.014. Epub 2014 Oct 8. PubMed

A structural model of the active ribosome-bound membrane protein insertase YidC.
Wickles S, Singharoy A, Andreani J, Seemayer S, Bischoff L, Berninghausen O, Soeding J, Schulten K, van der Sluis EO, Beckmann R.
Elife
. 2014 Jul 10;3:e03035. doi: 10.7554/eLife.03035. PubMed

Cryoelectron microscopic structures of eukaryotic translation termination complexes containing eRF1-eRF3 or eRF1-ABCE1.
Preis A, Heuer A, Barrio-Garcia C, Hauser A, Eyler DE, Berninghausen O, Green R, Becker T, Beckmann R.
Cell Rep. 2014 Jul 10;8(1):59-65. doi: 10.1016/j.celrep.2014.04.058. Epub 2014 Jul 4. PubMed

Visualization of a polytopic membrane protein during SecY-mediated membrane insertion.
Bischoff L, Wickles S, Berninghausen O, van der Sluis EO, Beckmann R.
Nat Commun
. 2014 Jun 10;5:4103. doi: 10.1038/ncomms5103. PubMed

Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide. Arenz S, Ramu H, Gupta P, Berninghausen O, Beckmann R, Vázquez-Laslop N, Mankin AS, Wilson DN.
Nat Commun. 2014 Mar 24;5:3501. doi: 10.1038/ncomms4501. PubMed

60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle.
Leidig C, Thoms M, Holdermann I, Bradatsch B, Berninghausen O, Bange G, Sinning I, Hurt E, Beckmann R.
Nat Commun. 2014 Mar 24;5:3491. doi: 10.1038/ncomms4491. PubMed

A new system for naming ribosomal proteins.
Ban N, Beckmann R, Cate JH, Dinman JD, Dragon F, Ellis SR, Lafontaine DL, Lindahl L, Liljas A, Lipton JM, McAlear MA, Moore PB, Noller HF, Ortega J, Panse VG, Ramakrishnan V, Spahn CM, Steitz TA, Tchorzewski M, Tollervey D, Warren AJ, Williamson JR, et al.
Curr Opin Struct Biol
. 2014 Feb;24:165-9. doi: 10.1016/j.sbi.2014.01.002. Epub 2014 Feb 10. Review. PubMed 


Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion.
Gogala M, Becker T, Beatrix B, Armache JP, Barrio-Garcia C, Berninghausen O, Beckmann R.
Nature. 2014 Feb 6;506(7486):107-10. doi: 10.1038/nature12950. PubMed

Structure of the mammalian oligosaccharyl-transferase complex in the native ER protein translocon.
Pfeffer S, Dudek J, Gogala M, Schorr S, Linxweiler J, Lang S, Becker T, Beckmann R, Zimmermann R, Förster F.
Nat Commun. 2014;5:3072. doi: 10.1038/ncomms4072. PubMed

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2013

The C-terminal regions of YidC from Rhodopirellula baltica and Oceanicaulis alexandrii bind to ribosomes and partially substitute for SRP receptor function in Escherichia coli.
Seitl I, Wickles S, Beckmann R, Kuhn A, Kiefer D. Mol Microbiol. 2014 Jan;91(2):408-21. doi: 10.1111/mmi.12465. Epub 2013 Dec 12. PubMed

Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex.
Tosi A, Haas C, Herzog F, Gilmozzi A, Berninghausen O, Ungewickell C, Gerhold CB, Lakomek K, Aebersold R, Beckmann R, Hopfner KP.
Cell
. 2013 Sep 12;154(6):1207-19. doi: 10.1016/j.cell.2013.08.016. PubMed

Structures of the human and Drosophila 80S ribosome.
Anger AM, Armache JP, Berninghausen O, Habeck M, Subklewe M, Wilson DN, Beckmann R.
Nature
. 2013 May 2;497(7447):80-5. doi: 10.1038/nature12104. PubMed

Automatic post-picking using MAPPOS improves particle image detection from cryo-EM micrographs.
Norousi R, Wickles S, Leidig C, Becker T, Schmid VJ, Beckmann R, Tresch A.
J Struct Biol
. 2013 May;182(2):59-66. doi: 10.1016/j.jsb.2013.02.008. Epub 2013 Feb 21. PubMed

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2012

Promiscuous behaviour of archaeal ribosomal proteins: implications for eukaryotic ribosome evolution.
Armache JP, Anger AM, Márquez V, Franckenberg S, Fröhlich T, Villa E, Berninghausen O, Thomm M, Arnold GJ, Beckmann R, Wilson DN.
Nucleic Acids Res
. 2013 Jan;41(2):1284-93. doi: 10.1093/nar/gks1259. Epub 2012 Dec 6. PubMed

Structural characterization of a eukaryotic chaperone--the ribosome-associated complex.
Leidig C, Bange G, Kopp J, Amlacher S, Aravind A, Wickles S, Witte G, Hurt E, Beckmann R, Sinning I.
Nat Struct Mol Biol. 2013 Jan;20(1):23-8. doi: 10.1038/nsmb.2447. Epub 2012 Dec 2. PubMed

Structure of the pre-60S ribosomal subunit with nuclear export factor Arx1 bound at the exit tunnel.
Bradatsch B, Leidig C, Granneman S, Gnädig M, Tollervey D, Böttcher B, Beckmann R, Hurt E.
Nat Struct Mol Biol
. 2012 Dec;19(12):1234-41. doi: 10.1038/nsmb.2438. Epub 2012 Nov 11. PubMed

Structural view on recycling of archaeal and eukaryotic ribosomes after canonical termination and ribosome rescue.
Franckenberg S, Becker T, Beckmann R.
Curr Opin Struct Biol
. 2012 Dec;22(6):786-96. doi: 10.1016/j.sbi.2012.08.002. Epub 2012 Sep 29. Review. PubMed

Structural basis for TetM-mediated tetracycline resistance.
Dönhöfer A, Franckenberg S, Wickles S, Berninghausen O, Beckmann R, Wilson DN.
Proc Natl Acad Sci U S A
. 2012 Oct 16;109(42):16900-5. doi: 10.1073https://www.ncbi.nlm.nih.gov/pnas.1208037109. Epub 2012 Oct 1. PubMed

Mechanisms of SecM-mediated stalling in the ribosome.
Gumbart J, Schreiner E, Wilson DN, Beckmann R, Schulten K.
Biophys J
. 2012 Jul 18;103(2):331-41. doi: 10.1016/j.bpj.2012.06.005. Epub 2012 Jul 17. PubMed

Solution structure of the natively assembled yeast ribosomal stalk determined by small-angle X-ray scattering.
Grela P, Gajda MJ, Armache JP, Beckmann R, Krokowski D, Svergun DI, Grankowski N, Tchórzewski M.
Biochem J. 2012 Jun 1;444(2):205-9. doi: 10.1042/BJ20120115. PubMed

Structural basis of highly conserved ribosome recycling in eukaryotes and archaea.
Becker T, Franckenberg S, Wickles S, Shoemaker CJ, Anger AM, Armache JP, Sieber H, Ungewickell C, Berninghausen O, Daberkow I, Karcher A, Thomm M, Hopfner KP, Green R, Beckmann R.
Nature. 2012 Feb 22;482(7386):501-6. doi: 10.1038/nature10829. PubMed

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2011

The DARC site: a database of aligned ribosomal complexes.
Jarasch A, Dziuk P, Becker T, Armache JP, Hauser A, Wilson DN, Beckmann R.
Nucleic Acids Res
. 2012 Jan;40(Database issue):D495-500. doi: 10.1093/nar/gkr824. Epub 2011 Oct 18. PubMed

Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex with its substrate TBP.
Wollmann P, Cui S, Viswanathan R, Berninghausen O, Wells MN, Moldt M, Witte G, Butryn A, Wendler P, Beckmann R, Auble DT, Hopfner KP.
Nature
. 2011 Jul 6;475(7356):403-7. doi: 10.1038/nature10215. PubMed

Structure of the no-go mRNA decay complex Dom34-Hbs1 bound to a stalled 80S ribosome.
Becker T, Armache JP, Jarasch A, Anger AM, Villa E, Sieber H, Motaal BA, Mielke T, Berninghausen O, Beckmann R.
Nat Struct Mol Biol
. 2011 Jun;18(6):715-20. doi: 10.1038/nsmb.2057. Epub 2011 May 29. PubMed

Signal sequence-independent SRP-SR complex formation at the membrane suggests an alternative targeting pathway within the SRP cycle.
Braig D, Mircheva M, Sachelaru I, van der Sluis EO, Sturm L, Beckmann R, Koch HG.
Mol Biol Cell
. 2011 Jul 1;22(13):2309-23. doi: 10.1091/mbc.E11-02-0152. Epub 2011 May 5. PubMed

Cryo-EM structure of the ribosome-SecYE complex in the membrane environment. Frauenfeld J, Gumbart J, Sluis EO, Funes S, Gartmann M, Beatrix B, Mielke T, Berninghausen O, Becker T, Schulten K, Beckmann R.
Nat Struct Mol Biol. 2011 May;18(5):614-21. doi: 10.1038/nsmb.2026. Epub 2011 Apr 17. PubMed

The ribosomal tunnel as a functional environment for nascent polypeptide folding and translational stalling.
Wilson DN, Beckmann R.
Curr Opin Struct Biol
. 2011 Apr;21(2):274-82. doi: 10.1016/j.sbi.2011.01.007. Review. PubMed

SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase center.
Bhushan S, Hoffmann T, Seidelt B, Frauenfeld J, Mielke T, Berninghausen O, Wilson DN, Beckmann R.
PLoS Biol
. 2011 Jan 18;9(1):e1000581. doi: 10.1371/journal.pbio.1000581. PubMed

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2010

Proteomic characterization of archaeal ribosomes reveals the presence of novel archaeal-specific ribosomal proteins.
Márquez V, Fröhlich T, Armache JP, Sohmen D, Dönhöfer A, Mikolajka A, Berninghausen O, Thomm M, Beckmann R, Arnold GJ, Wilson DN.
J Mol Biol
. 2011 Feb 4;405(5):1215-32. doi: 10.1016/j.jmb.2010.11.055. Epub 2010 Dec 4. PubMed

Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.
Armache JP, Jarasch A, Anger AM, Villa E, Becker T, Bhushan S, Jossinet F, Habeck M, Dindar G, Franckenberg S, Marquez V, Mielke T, Thomm M, Berninghausen O, Beatrix B, Söding J, Westhof E, Wilson DN, Beckmann R.
Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19748-53. doi: 10.1073https://www.ncbi.nlm.nih.gov/pnas.1009999107. Epub 2010 Oct 27. PubMed

Localization of eukaryote-specific ribosomal proteins in a 5.5-Ã… cryo-EM map of the 80S eukaryotic ribosome. Armache JP, Jarasch A, Anger AM, Villa E, Becker T, Bhushan S, Jossinet F, Habeck M, Dindar G, Franckenberg S, Marquez V, Mielke T, Thomm M, Berninghausen O, Beatrix B, Söding J, Westhof E, Wilson DN, Beckmann R.
Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19754-9. doi: 10.1073https://www.ncbi.nlm.nih.gov/pnas.1010005107. Epub 2010 Oct 25. PubMed

Structural basis for translational stalling by human cytomegalovirus and fungal arginine attenuator peptide.
Bhushan S, Meyer H, Starosta AL, Becker T, Mielke T, Berninghausen O, Sattler M, Wilson DN, Beckmann R.
Mol Cell
. 2010 Oct 8;40(1):138-46. doi: 10.1016/j.molcel.2010.09.009. PubMed

Dual binding mode of the nascent polypeptide-associated complex reveals a novel universal adapter site on the ribosome.
Pech M, Spreter T, Beckmann R, Beatrix B.
J Biol Chem
. 2010 Jun 18;285(25):19679-87. doi: 10.1074/jbc.M109.092536. Epub 2010 Apr 21. PubMed

Mechanism of eIF6-mediated inhibition of ribosomal subunit joining.
Gartmann M, Blau M, Armache JP, Mielke T, Topf M, Beckmann R.
J Biol Chem. 2010 May 14;285(20):14848-51. doi: 10.1074/jbc.C109.096057. Epub 2010 Mar 31. PubMed

alpha-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnel.
Bhushan S, Gartmann M, Halic M, Armache JP, Jarasch A, Mielke T, Berninghausen O, Wilson DN, Beckmann R.
Nat Struct Mol Biol. 2010 Mar;17(3):313-7. doi: 10.1038/nsmb.1756. Epub 2010 Feb 7. PubMed

Coupled chaperone action in folding and assembly of hexadecameric Rubisco.
Liu C, Young AL, Starling-Windhof A, Bracher A, Saschenbrecker S, Rao BV, Rao KV, Berninghausen O, Mielke T, Hartl FU, Beckmann R, Hayer-Hartl M.
Nature. 2010 Jan 14;463(7278):197-202. doi: 10.1038/nature08651. PubMed

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2009

Structural insight into nascent polypeptide chain-mediated translational stalling.
Seidelt B, Innis CA, Wilson DN, Gartmann M, Armache JP, Villa E, Trabuco LG, Becker T, Mielke T, Schulten K, Steitz TA, Beckmann R.
Science
. 2009 Dec 4;326(5958):1412-5. doi: 10.1126/science.1177662. Epub 2009 Oct 29. PubMed

Structure of monomeric yeast and mammalian Sec61 complexes interacting with the translating ribosome.
Becker T, Bhushan S, Jarasch A, Armache JP, Funes S, Jossinet F, Gumbart J, Mielke T, Berninghausen O, Schulten K, Westhof E, Gilmore R, Mandon EC, Beckmann R.
Science
. 2009 Dec 4;326(5958):1369-73. doi: 10.1126/science.1178535. Epub 2009 Oct 29. PubMed

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2007

Structure of an archaeal RNA polymerase.
Kusser AG, Bertero MG, Naji S, Becker T, Thomm M, Beckmann R, Cramer P.
J Mol Biol
. 2008 Feb 15;376(2):303-7. doi: 10.1016/j.jmb.2007.08.066. Epub 2007 Sep 5. PubMed

Functional architecture of RNA polymerase I.
Kuhn CD, Geiger SR, Baumli S, Gartmann M, Gerber J, Jennebach S, Mielke T, Tschochner H, Beckmann R, Cramer P.
Cell. 2007 Dec 28;131(7):1260-72. PubMed

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2006

Following the signal sequence from ribosomal tunnel exit to signal recognition particle.
Halic M, Blau M, Becker T, Mielke T, Pool MR, Wild K, Sinning I, Beckmann R.
Nature
. 2006 Nov 23;444(7118):507-11. Epub 2006 Oct 29. PubMed

Structure of eEF3 and the mechanism of transfer RNA release from the E-site.
Andersen CB, Becker T, Blau M, Anand M, Halic M, Balar B, Mielke T, Boesen T, Pedersen JS, Spahn CM, Kinzy TG, Andersen GR, Beckmann R.
Nature
. 2006 Oct 12;443(7112):663-8. Epub 2006 Aug 23. PubMed

Signal recognition particle receptor exposes the ribosomal translocon binding site.
Halic M, Gartmann M, Schlenker O, Mielke T, Pool MR, Sinning I, Beckmann R.
Science
. 2006 May 5;312(5774):745-7. PubMed

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2005

ERj1p uses a universal ribosomal adaptor site to coordinate the 80S ribosome at the membrane.
Blau M, Mullapudi S, Becker T, Dudek J, Zimmermann R, Penczek PA, Beckmann R.
Nat Struct Mol Biol
. 2005 Nov;12(11):1015-6. PubMed

Localization and dynamic behavior of ribosomal protein L30e.
Halic M, Becker T, Frank J, Spahn CM, Beckmann R.
Nat Struct Mol Biol
. 2005 May;12(5):467-8. Epub 2005 May 1. PubMed

The signal recognition particle and its interactions during protein targeting.
Halic M, Beckmann R.
Curr Opin Struct Biol. 2005 Feb;15(1):116-25. Review. PubMed

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2004

SRP meets the ribosome.
Wild K, Halic M, Sinning I, Beckmann R.
Nat Struct Mol Biol. 2004 Nov;11(11):1049-53. Review. PubMed

Rearrangement of the 16S precursor subunits is essential for the formation of the active 20S proteasome.
Mullapudi S, Pullan L, Bishop OT, Khalil H, Stoops JK, Beckmann R, Kloetzel PM, Krüger E, Penczek PA.
Biophys J
. 2004 Dec;87(6):4098-105. Epub 2004 Sep 10. PubMed

Structure of the signal recognition particle interacting with the elongation-arrested ribosome.
Halic M, Becker T, Pool MR, Spahn CM, Grassucci RA, Frank J, Beckmann R.
Nature
. 2004 Feb 26;427(6977):808-14. PubMed

Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation.
Spahn CM, Gomez-Lorenzo MG, Grassucci RA, Jörgensen R, Andersen GR, Beckmann R, Penczek PA, Ballesta JP, Frank J.
EMBO J
. 2004 Mar 10;23(5):1008-19. Epub 2004 Feb 19. PubMed

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2003

A band 3-based macrocomplex of integral and peripheral proteins in the RBC membrane.
Bruce LJ, Beckmann R, Ribeiro ML, Peters LL, Chasis JA, Delaunay J, Mohandas N, Anstee DJ, Tanner MJ.
Blood. 2003 May 15;101(10):4180-8. Epub 2003 Jan 16. PubMed

Structure of the filamentous phage pIV multimer by cryo-electron microscopy.
Opalka N, Beckmann R, Boisset N, Simon MN, Russel M, Darst SA.
J Mol Biol. 2003 Jan 17;325(3):461-70. PubMed

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2002

An N-terminal GFP tag does not alter the functional expression to the plasma membrane of red cell and kidney anion exchanger (AE1) in mammalian cells.
Beckmann R, Toye AM, Smythe JS, Anstee DJ, Tanner MJ.
Mol Membr Biol. 2002 Jul-Sep;19(3):187-200. PubMed

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2001

The active 80S ribosome-Sec61 complex, in: The Ribosome, Symposia on Quantitative Biology.
Beckmann R, Spahn CMT, Frank J, Blobel G.
Cold Spring Harbor Lab Press. 2002 Vol LXVI, 543-554. PubMed

Structure of the 80S Ribosome from Saccharomyces cerevisiae-tRNA-Ribosome and Subunit-Subunit Interactions.
Spahn CM, Beckmann R, Eswar N, Penczek PA, Sali A, Blobel G, Frank J.
Cell. 2001 Nov 2;107(3):373-86. PubMed

Architecture of the Protein-Conducting Channel Associated with the Translating 80S Ribosome.
Beckmann R, Spahn CM, Eswar N, Helmers J, Penczek PA, Sali A, Frank J, Blobel G.
Cell. 2001 Nov 2;107(3):361-72. PubMed

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2000 and before

Crystal Structures of Ribosome Anti-Association Factor IF6.
Groft CM, Beckmann R, Sali A, Burley SK.
Nat Struct Biol. 2000 Dec;7(12):1156-64. PubMed

Alignment of Conduits for the Nascent Polypeptide Chain in the Ribosome-Sec61 Complex.
Beckmann R, Bubeck D, Grassucci R, Penczek P, Verschoor A, Blobel G, Frank J.
Science. 1997 Dec 19;278(5346):2123-6. PubMed

Large-conductance cation channels in the envelope of nuclei from rat cerebral cortex.
Draguhn A, Börner G, Beckmann R, Buchner K, Heinemann U, Hucho F.
J Membr Biol. 1997 Jul 15;158(2):159-66. PubMed

Bradykinin Induces Rise of Free Calcium in Nuclei of Neuroblastoma X Glioma Hybrid Ng 108-15 Cells.
Beckmann R, Lindschau C, Haller H, Buchner K.
J Neurosci Res. 1995 Apr 1;40(5):571-8. PubMed

Differential Nuclear Localization of Protein Kinase C Isoforms in Neuroblastoma X Glioma Hybrid Cells.
Beckmann R, Lindschau C, Haller H, Hucho F, Buchner K.
Eur J Biochem. 1994; 222, 335-343. PubMed

Nuclear Substrates of Protein Kinase C.
Beckmann R, Buchner K, Jungblut PR, Eckerskorn C, Weise C, Hilbert R and Hucho F.
Eur J Biochem. 1992; 210, 45-51. PubMed

GTP-Binding Proteins in Bovine Brain Nuclear Membranes.
Otto H, Buchner K, Beckmann R, Hilbert R, Hucho F.
Neurochem Int. 1992 Oct;21(3):409-14. PubMed