Hornung Lab - Publications
2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001
2023
Nanoscale organization of the endogenous ASC speck.
Glück IM, Mathias GP, Strauss S, Rat V, Gialdini I, Ebert TS, Stafford C, Agam G, Manley S, Hornung V, Jungmann R, Sieben C, Lamb DC. iScience. 2023 Nov 2;26(12):108382. doi: 10.1016/j.isci.2023.108382. eCollection 2023 Dec 15. Pubmed
E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation.
Pruenster M, Immler R, Roth J, Kuchler T, Bromberger T, Napoli M, Nussbaumer K, Rohwedder I, Wackerbarth LM, Piantoni C, Hennis K, Fink D, Kallabis S, Schroll T, Masgrau-Alsina S, Budke A, Liu W, Vestweber D, Wahl-Schott C, Roth J, Meissner F, Moser M, Vogl T, Hornung V, Broz P, Sperandio M. Nat Immunol. 2023 Dec;24(12):2021-2031. doi: 10.1038/s41590-023-01656-1. Epub 2023 Oct 30. Pubmed
β1 integrin signaling governs necroptosis via the chromatin-remodeling factor CHD4.
Sun Z, Cernilogar FM, Horvatic H, Yeroslaviz A, Abdullah Z, Schotta G, Hornung V. Cell Rep. 2023 Nov 28;42(11):113322. doi: 10.1016/j.celrep.2023.113322. Epub 2023 Oct 25. Pubmed
Systematic P2Y receptor survey identifies P2Y11 as modulator of immune responses and virus replication in macrophages.
Andersen LL, Huang Y, Urban C, Oubraham L, Winheim E, Stafford C, Nagl D, O'Duill F, Ebert T, Engleitner T, Paludan SR, Krug A, Rad R, Hornung V, Pichlmair A. EMBO J. 2023 Dec 1;42(23):e113279. doi: 10.15252/embj.2022113279. Epub 2023 Oct 26. Pubmed
A prospective longitudinal cohort study on risk factors for COVID-19 vaccination failure (RisCoin): methods, procedures and characterization of the cohort.
Koletzko S, Le Thi TG, Zhelyazkova A, Osterman A, Wichert SP, Breiteneicher S, Koletzko L, Schwerd T, Völk S, Jebrini T, Horak J, Tuschen M, Choukér A, Hornung V, Keppler OT, Koletzko B, Török HP, Adorjan K; Members of Riscoin Study Group. Clin Exp Med. 2023 Dec;23(8):4901-4917. doi: 10.1007/s10238-023-01170-6. Epub 2023 Sep 2. Pubmed
Hemophagocytic lymphohistiocytosis-like hyperinflammation due to a de novo mutation in DPP9.
Wolf C, Fischer H, Kühl JS, Koss S, Jamra RA, Starke S, Schultz J, Ehl S, Neumann K, Schuetz C, Huber R, Hornung V, Lee-Kirsch MA. J Allergy Clin Immunol. 2023 Nov;152(5):1336-1344.e5. doi: 10.1016/j.jaci.2023.07.013. Epub 2023 Aug 5. Pubmed
STING agonism turns human T cells into interferon-producing cells but impedes their functionality.
Kuhl N, Linder A, Philipp N, Nixdorf D, Fischer H, Veth S, Kuut G, Xu TT, Theurich S, Carell T, Subklewe M, Hornung V.
EMBO Rep. 2023 Jan 27:e55536. doi: 10.15252/embr.202255536. Online ahead of print. Pubmed
2022
A novel NINJ1-mediated regulatory step is essential for active membrane rupture and common to different cell death pathways.
Dias C, Hornung V, Nylandsted J.
Fac Rev. 2022 Dec 30;11:41. doi: 10.12703/r-01-0000021. eCollection 2022. Pubmed
Tumor necrosis factor is a necroptosis-associated alarmin.
Pinci F, Gaidt MM, Jung C, Nagl D, Kuut G, Hornung V.
Front Immunol. 2022 Dec 12;13:1074440. doi: 10.3389/fimmu.2022.1074440. eCollection 2022. Pubmed
IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network.
Schmacke NA, O'Duill F, Gaidt MM, Szymanska I, Kamper JM, Schmid-Burgk JL, Mädler SC, Mackens-Kiani T, Kozaki T, Chauhan D, Nagl D, Stafford CA, Harz H, Fröhlich AL, Pinci F, Ginhoux F, Beckmann R, Mann M, Leonhardt H, Hornung V.
Immunity. 2022 Dec 13;55(12):2271-2284.e7. doi: 10.1016/j.immuni.2022.10.021. Epub 2022 Nov 15. Pubmed
Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever.
Mangan MSJ, Gorki F, Krause K, Heinz A, Pankow A, Ebert T, Jahn D, Hiller K, Hornung V, Maurer M, Schmidt FI, Gerhard R, Latz E.
PLoS Biol. 2022 Nov 7;20(11):e3001351. doi: 10.1371/journal.pbio.3001351. eCollection 2022 Nov. Pubmed
Myoglobin regulates fatty acid trafficking and lipid metabolism in mammary epithelial cells.
Armbruster J, Aboouf MA, Gassmann M, Egert A, Schorle H, Hornung V, Schmidt T, Schmid-Burgk JL, Kristiansen G, Bicker A, Hankeln T, Zhu H, Gorr TA. PLoS One. 2022 Oct 12;17(10):e0275725. doi: 10.1371/journal.pone.0275725. eCollection 2022. Pubmed
Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation.
Stafford CA, Gassauer AM, de Oliveira Mann CC, Tanzer MC, Fessler E, Wefers B, Nagl D, Kuut G, Sulek K, Vasilopoulou C, Schwojer SJ, Wiest A, Pfautsch MK, Wurst W, Yabal M, Fröhlich T, Mann M, Gisch N, Jae LT, Hornung V.
Nature. 2022 Aug 24. doi: 10.1038/s41586-022-05125-x. Online ahead of print. Pubmed
Novel Poxin Stable cGAMP-Derivatives Are Remarkable STING Agonists.
Stazzoni S, Böhmer DFR, Hernichel F, Özdemir D, Pappa A, Drexler D, Bauernfried S, Witte G, Wagner M, Veth S, Hopfner KP, Hornung V, König LM, Carell T.
Angew Chem Int Ed Engl. 2022 Jul 25:e202207175. doi: 10.1002/anie.202207175. Online ahead of print. Pubmed
ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome.
Robinson KS, Toh GA, Rozario P, Chua R, Bauernfried S, Sun Z, Firdaus MJ, Bayat S, Nadkarni R, Poh ZS, Tham KC, Harapas CR, Lim CK, Chu W, Tay CWS, Tan KY, Zhao T, Bonnard C, Sobota R, Connolly JE, Common J, Masters SL, Chen KW, Ho L, Wu B, Hornung V, Zhong FL.
Science. 2022 Jul 15;377(6603):328-335. doi: 10.1126/science.abl6324. Epub 2022 Jul 14. Pubmed
cGAS-STING signaling.
Sun Z, Hornung V.
Curr Biol. 2022 Jul 11;32(13):R730-R734. doi: 10.1016/j.cub.2022.05.027. Pubmed
Live Cell Imaging of T Cell Pyroptosis.
Linder A, Hornung V.
Methods Mol Biol. 2022;2523:303-315. doi: 10.1007/978-1-0716-2449-4_19. Pubmed
Genome Replication Is Associated With Release of Immunogenic DNA Waste.
Schubert N, Schumann T, Daum E, Flade K, Ge Y, Hagedorn L, Edelmann W, Müller L, Schmitz M, Kuut G, Hornung V, Behrendt R, Roers A.
Front Immunol. 2022 May 11;13:880413. doi: 10.3389/fimmu.2022.880413. eCollection 2022. Free PMC article. Pubmed
Molecular Signature of Astrocytes for Gene Delivery by the Synthetic Adeno-Associated Viral Vector rAAV9P1.
Bauer A, Puglisi M, Nagl D, Schick JA, Werner T, Klingl A, El Andari J, Hornung V, Kessler H, Götz M, Grimm D, Brack-Werner R.
Adv Sci (Weinh). 2022 May;9(16):e2104979. doi: 10.1002/advs.202104979. Epub 2022 Apr 10. Free PMC article. Pubmed
Homing in on gasdermins: How fungi regulate cell death.
Schmacke NA, Hornung V.
Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2201192119. doi: 10.1073/pnas.2201192119. Epub 2022 Mar 1. Pubmed
Three exposures to the spike protein of SARS-CoV-2 by either infection or vaccination elicit superior neutralizing immunity to all variants of concern.
Wratil PR, Stern M, Priller A, Willmann A, Almanzar G, Vogel E, Feuerherd M, Cheng CC, Yazici S, Christa C, Jeske S, Lupoli G, Vogt T, Albanese M, Mejías-Pérez E, Bauernfried S, Graf N, Mijocevic H, Vu M, Tinnefeld K, Wettengel J, Hoffmann D, Muenchhoff M, Daechert C, Mairhofer H, Krebs S, Fingerle V, Graf A, Steininger P, Blum H, Hornung V, Liebl B, Überla K, Prelog M, Knolle P, Keppler OT, Protzer U.
Nat Med. 2022 Jan 28. doi: 10.1038/s41591-022-01715-4. Online ahead of print. Pubmed
Human NLRP1: From the shadows to center stage.
Bauernfried S, Hornung V.
J Exp Med. 2022 Jan 3;219(1):e20211405. doi: 10.1084/jem.20211405. Epub 2021 Dec 15. Pubmed
Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4+ T cells allows complex functional analyses.
Albanese M, Ruhle A, Mittermaier J, Mejías-Pérez E, Gapp M, Linder A, Schmacke NA, Hofmann K, Hennrich AA, Levy DN, Humpe A, Conzelmann KK, Hornung V, Fackler OT, Keppler OT.
Nat Methods. 2022 Jan;19(1):81-89. doi: 10.1038/s41592-021-01328-8. Epub 2021 Dec 23. Pubmed
GGCX variants leading to biallelic deficiency to γ-carboxylate GRP cause skin laxity in VKCFD1 patients.
Ghosh S, Kraus K, Biswas A, Müller J, Forin F, Singer H, Höning K, Hornung V, Watzka M, Oldenburg J, Czogalla-Nitsche KJ.
Hum Mutat. 2022 Jan;43(1):42-55. doi: 10.1002/humu.24300. Epub 2021 Dec 2. Pubmed
2021
Evidence for increased SARS-CoV-2 susceptibility and COVID-19 severity related to pre-existing immunity to seasonal coronaviruses.
Wratil PR, Schmacke NA, Karakoc B, Dulovic A, Junker D, Becker M, Rothbauer U, Osterman A, Spaeth PM, Ruhle A, Gapp M, Schneider S, Muenchhoff M, Hellmuth JC, Scherer C, Mayerle J, Reincke M, Behr J, Kääb S, Zwissler B, von Bergwelt-Baildon M, Eberle J, Kaderali L, Schneiderhan-Marra N, Hornung V, Keppler OT.
Cell Rep. 2021 Dec 28;37(13):110169. doi: 10.1016/j.celrep.2021.110169. Epub 2021 Dec 7. Pubmed
Hepatitis-D Virus Infection Is Not Impaired by Innate Immunity but Increases Cytotoxic T-Cell Activity.
ltstetter SM, Quitt O, Pinci F, Hornung V, Lucko AM, Wisskirchen K, Jung S, Protzer U.
Cells. 2021 Nov 20;10(11):3253. doi: 10.3390/cells10113253. Pubmed
GGCX variants leading to biallelic deficiency to γ-carboxylate GRP cause skin laxity in VKCFD1 patients.
Ghosh S, Kraus K, Biswas A, Müller J, Forin F, Singer H, Höning K, Hornung V, Watzka M, Oldenburg J, Czogalla-Nitsche KJ.
Hum Mutat. 2021 Nov 24. doi: 10.1002/humu.24300. Epub ahead of print]. Pubmed
Phosphoproteome profiling uncovers a key role for CDKs in TNF signaling.
Tanzer MC, Bludau I, Stafford CA, Hornung V, Mann M.
Nat Commun. 2021 Oct 18;12(1):6053. doi: 10.1038/s41467-021-26289-6. Pubmed
Inflammasomes in T cells.
Linder A, Hornung V.
J Mol Biol. 2021 Sep 29:167275. doi: 10.1016/j.jmb.2021.167275. [Epub ahead of print]. Pubmed
In-depth profiling of COVID-19 risk factors and preventive measures in healthcare workers.
Wratil PR, Schmacke NA, Osterman A, Weinberger T, Rech J, Karakoc B, Zeilberger M, Steffen J, Mueller TT, Spaeth PM, Stern M, Albanese M, Thun H, Reinbold J, Sandmeyer B, Kressirer P, Grabein B, Falkai P, Adorjan K, Hornung V, Kaderali L, Klein M, Keppler OT.
Infection. 2021 Aug 11:1-14. doi: 10.1007/s15010-021-01672-z. [Epub ahead of print]. Pubmed
An autoimmune disease risk variant: A trans master regulatory effect mediated by IRF1 under immune stimulation?
Brandt M, Kim-Hellmuth S, Ziosi M, Gokden A, Wolman A, Lam N, Recinos Y, Daniloski Z, Morris JA, Hornung V, Schumacher J, Lappalainen T.
PLoS Genet. 2021 Jul 27;17(7):e1009684. doi: 10.1371/journal.pgen.1009684. [Epub ahead of print]. Pubmed
Molecular mechanisms of non-self nucleic acid recognition by the innate immune system.
de Oliveira Mann CC, Hornung V.
Eur J Immunol. 2021 Jun 17. doi: 10.1002/eji.202049116. Epub 2021 Jul 5. Pubmed
DPP9 restrains NLRP1 activation.
Bauernfried S, Hornung V.
Nat Struct Mol Biol. 2021 Mar 30. doi: 10.1038/s41594-021-00580-y. [Epub ahead of print]. Pubmed
Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade.
Roth S, Cao J, Singh V, Tiedt S, Hundeshagen G, Li T, Boehme JD, Chauhan D, Zhu J, Ricci A, Gorka O, Asare Y, Yang J, Lopez MS, Rehberg M, Bruder D, Zhang S, Groß O, Dichgans M, Hornung V, Liesz A.
Immunity. 2021 Mar 1. doi: 10.1016/j.immuni.2021.02.004. [Epub ahead of print]. Pubmed
GGCX mutations show different responses to vitamin K thereby determining the severity of the hemorrhagic phenotype in VKCFD1 patients.
Ghosh S, Kraus K, Biswas A, Müller J, Buhl AL, Forin F, Singer H, Höning K, Hornung V, Watzka M, Czogalla-Nitsche KJ, Oldenburg J.
J Thromb Haemost. 2021 Feb 15. doi: 10.1111/jth.15238. [Epub ahead of print]. Pubmed
Deletion of Alzheimer's disease-associated CD33 results in an inflammatory human microglia phenotype.
Wißfeld J, Nozaki I, Mathews M, Raschka T, Ebeling C, Hornung V, Brüstle O, Neumann H.
Glia. 2021 Feb 4. doi: 10.1002/glia.23968. [Epub ahead of print]. Pubmed
top2020
Human NLRP1 is a sensor for double-stranded RNA.
Bauernfried S, Scherr MJ, Pichlmair A, Duderstadt KE, Hornung V.
Science. 2020 Nov 26:eabd0811. doi: 10.1126/science.abd0811. [Epub ahead of print]. Pubmed
Irgm2 and Gate-16 put a break on non-canonical inflammasome activation.
Linder A, Hornung V.
EMBO Rep. 2020 Nov 1:e51787. doi: 10.15252/embr.202051787. Pubmed
C-tag TNF: a reporter system to study TNF shedding.
Pinci F, Gaidt MM, Jung C, Kuut G, Jackson MA, Bauernfried S, Hornung V.
J Biol Chem. 2020 Oct 20:jbc.RA120.015248. doi: 10.1074/jbc.RA120.015248. [Epub ahead of print] Pubmed
Structural basis for sequestration and autoinhibition of cGAS by chromatin.
Michalski S, de Oliveira Mann CC, Stafford C, Witte G, Bartho J, Lammens K, Hornung V, Hopfner KP.
Nature. 2020 Sep 10. doi: 10.1038/s41586-020-2748-0. Pubmed
CARD8 inflammasome activation triggers pyroptosis in human T cells
Linder A, Bauernfried S, Cheng Y, Albanese M, Jung C, Keppler OT, Hornung V.
EMBO J. 2020 Aug 25:e105071. doi: 10.15252/embj.2020105071. PubMed
Reduced Mitochondrial Resilience Enables Non-Canonical Induction of Apoptosis After TNF Receptor Signaling in Virus-Infected Hepatocytes.
Lampl S, Janas MK, Donakonda S, Brugger M, Lohr K, Schneider A, Manske K, Sperl LE, Wettmarshausen J, Müller C, Laschinger M, Hartmann D, Hüser N, Perrochi F, Schmitt-Kopplin P, Hagn F, Zender L, Hornung V, Borner C, Pichlmair A, Kashkar H, Klingenspor M, Prinz M, Schreiner S, Conrad M, Jost PJ, Zischka H, Steiger K, Krönke M, Zehn D, Protzer U, Heikenwälder M, Knolle PA, Wohlleber D.
J Hepatol. 2020 Jun 26:S0168-8278(20)30398-6. doi: 10.1016/j.jhep.2020.06.026. PubMed
Hepatitis B Virus DNA Is a Substrate for the cGAS/STING Pathway but Is Not Sensed in Infected Hepatocytes.
Lauterbach-Rivière L, Bergez M, Mönch S, Qu B, Riess M, Vondran FWR, Liese J, Hornung V, König SUAR.
Viruses. 2020 May 29;12(6):E592. doi: 10.3390/v12060592. [Free PMC article]. PubMed
Molecular Mechanisms and Cellular Functions of cGAS-STING Signalling.
Hopfner KP, Hornung V.
Nat Rev Mol Cell Biol. 2020 May 18. doi: 10.1038/s41580-020-0244-x. PubMed
Fourth Defence Molecule Completes Antiviral Line-Up.
Schmacke NA, Hornung V.
Nature. 2020 May;581(7808):266-267. doi: 10.1038/d41586-020-01336-2. PubMed
New Approaches for Absolute Quantification of Stable-Isotope-Labeled Peptide Standards for Targeted Proteomics based on a UV Active Tag.
Schnatbaum K, Solis-Mezarino V, Pokrovsky D, Schäfer F, Nagl D, Hornberger L, Zerweck J, Knaute T, Avramova-Nehmer J, Schutkowski M, Hornung V, Wenschuh H, Völker-Albert MC, Imhof A, Reimer U.
Proteomics. 2020 Apr 8:e2000007. doi: 10.1002/pmic.202000007. PubMed
Author Correction: AIM2 inflammasome-derived IL-1β induces postoperative ileus in mice.
Hupa KJ, Stein K, Schneider R, Lysson M, Schneiker B, Hornung V, Latz E, Iwakura Y, Kalff JC, Wehner S.
Sci Rep. 2020 Feb 21;10(1):3457. doi: 10.1038/s41598-020-60391-x. [Free PMC article]. PubMed
The NLRP3 inflammasome pathway is activated in sarcoidosis and involved in granuloma formation.
Huppertz C, Jäger B, Wieczorek G, Engelhard P, Oliver SJ, Bauernfeind FG, Littlewood-Evans A, Welte T, Hornung V, Prasse A.
Eur Respir J. 2020 Jan 16. pii: 1900119. doi: 10.1183/13993003.00119-2019. PubMed
2019
Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide.
Günther SD, Fritsch M, Seeger JM, Schiffmann LM, Snipas SJ, Coutelle M, Kufer TA, Higgins PG, Hornung V, Bernardini ML, Höning S, Krönke M, Salvesen GS, Kashkar H.
Nat Microbiol. 2019 Dec 23. doi: 10.1038/s41564-019-0620-5. [Epub ahead of print]. PubMed
Cytoplasmic RNA Sensor Pathways and Nitazoxanide Broadly Inhibit Intracellular Mycobacterium tuberculosis Growth.
Ranjbar S, Haridas V, Nambu A, Jasenosky LD, Sadhukhan S, Ebert TS, Hornung V, Cassell GH, Falvo JV, Goldfeld AE.
iScience. 2019 Nov 6;22:299-313. doi: 10.1016/j.isci.2019.11.001. [Epub ahead of print]. PubMed
Insights into Innate Sensing of Prototype Foamy Viruses in Myeloid Cells.
Bergez M, Weber J, Riess M, Erdbeer A, Seifried J, Stanke N, Munz C, Hornung V, König R, Lindemann D.
Viruses. 2019 Nov 26;11(12). pii: E1095. doi: 10.3390/v11121095. PubMed
TLR8 Is a Sensor of RNase T2 Degradation Products.
Greulich W, Wagner M, Gaidt MM, Stafford C, Cheng Y, Linder A, Carell T, Hornung V.
Cell. 2019 Nov 27;179(6):1264-1275.e13. doi: 10.1016/j.cell.2019.11.001. PubMed
AIM2 inflammasome-derived IL-1β induces postoperative ileus in mice.
Hupa KJ, Stein K, Schneider R, Lysson M, Schneiker B, Hornung V, Latz E, Iwakura Y, Kalff JC, Wehner S.
Sci Rep. 2019 Jul 22;9(1):10602. doi: 10.1038/s41598-019-46968-1. PubMed
Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis.
Fisch D, Bando H, Clough B, Hornung V, Yamamoto M, Shenoy AR, Frickel EM.
EMBO J. 2019 Jul 1;38(13):e100926. doi: 10.15252/embj.2018100926. Epub 2019 Jun 3. PubMEd
IRF1 inhibits antitumor immunity through the upregulation of PD-L1 in the tumor cell.
Shao L, Hou W, Scharping NE, Vendetti FP, Srivastava R, Roy CN, Menk AV, Wang Y, Chauvin JM, Karukonda P, Thorne SH, Hornung V, Zarour HM, Bakkenist CJ, Delgoffe GM, Sarkar SN.
Cancer Immunol Res. 2019 Jun 25. pii: canimm.0711.2018. doi: 10.1158/2326-6066.CIR-18-0711. [Epub ahead of print] PubMed
Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis.
Fisch D, Bando H, Clough B, Hornung V, Yamamoto M, Shenoy AR, Frickel EM.
EMBO J. 2019 May 31. pii: e100926. doi: 10.15252/embj.2018100926. [Epub ahead of print] PubMed
Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3.
von Gamm M, Schaub A, Jones AN, Wolf C, Behrens G, Lichti J, Essig K, Macht A, Pircher J, Ehrlich A, Davari K, Chauhan D, Busch B, Wurst W, Feederle R, Feuchtinger A, Tschöp MH, Friedel CC, Hauck SM, Sattler M, Geerlof A, Hornung V, Heissmeyer V, Schulz C, Heikenwalder M, Glasmacher E.
J Exp Med. 2019 Jul 1;216(7):1700-1723. doi: 10.1084/jem.20181762. Epub 2019 May 24. PubMed
KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells.
Metzger E, Wang S, Urban S, Willmann D, Schmidt A, Offermann A, Allen A, Sum M, Obier N, Cottard F, Ulferts S, Preca BT, Hermann B, Maurer J, Greschik H, Hornung V, Einsle O, Perner S, Imhof A, Jung M, Schüle R.
Nat Struct Mol Biol. 2019 May;26(5):361-371. doi: 10.1038/s41594-019-0219-9. Epub 2019 May 6. PubMed
DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer.
Paludan SR, Reinert LS, Hornung V.
Nat Rev Immunol. 2019 Jan 15. doi: 10.1038/s41577-018-0117-0. [Epub ahead of print] Review. PubMed
2018
Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases.
Li Y, Führer M, Bahrami E, Socha P, Klaudel-Dreszler M, Bouzidi A, Liu Y, Lehle AS, Magg T, Hollizeck S, Rohlfs M, Conca R, Field M, Warner N, Mordechai S, Shteyer E, Turner D, Boukari R, Belbouab R, Walz C, Gaidt MM, Hornung V, Baumann B, Pannicke U, Al Idrissi E, Ali Alghamdi H, Sepulveda FE, Gil M, de Saint Basile G, Hönig M, Koletzko S, Muise AM, Snapper SB, Schwarz K, Klein C, Kotlarz D.
Proc Natl Acad Sci U S A. 2018 Dec 27. pii: 201813582. doi: 10.1073/pnas.1813582116. [Epub ahead of print] PubMed
The antiviral activity of rodent and lagomorph SERINC3 and SERINC5 is counteracted by known viral antagonists.
de Sousa-Pereira P, Abrantes J, Bauernfried S, Pierini V, Esteves PJ, Keppler OT, Pizzato M, Hornung V, Fackler OT, Baldauf HM.
J Gen Virol. 2018 Dec 19. doi: 10.1099/jgv.0.001201. [Epub ahead of print] PubMed
BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages.
Chauhan D, Bartok E, Gaidt MM, Bock FJ, Herrmann J, Seeger JM, Broz P, Beckmann R, Kashkar H, Tait SWG, Müller R, Hornung V.
Cell Rep. 2018 Nov 27;25(9):2354-2368.e5. doi: 10.1016/j.celrep.2018.10.087. PubMed
Intestinal Inflammation and Dysregulated Immunity in Patients with Inherited Caspase-8 Deficiency.
Lehle AS, Farin HF, Marquardt B, Michels BE, Magg T, Li Y, Liu Y, Ghalandary M, Lammens K, Hollizeck S, Rohlfs M, Hauck F, Conca R, Walz C, Weiss B, Lev A, Simon AJ, Groß O, Gaidt MM, Hornung V, Clevers H, Yazbeck N, Hanna-Wakim R, Shouval DS, Warner N, Somech R, Muise AM, Snapper SS, Bufler P, Koletzko S, Klein C, Kotlarz D.
Gastroenterology. 2018 Sep 26. pii: S0016-5085(18)35036-4. doi: 10.1053/j.gastro.2018.09.041. [Epub ahead of print] PubMed
Mitochondrial dsRNA: A New DAMP for MDA5.
Linder A, Hornung V.
Dev Cell. 2018 Sep 10;46(5):530-532. doi: 10.1016/j.devcel.2018.08.019. PubMed
Activation of the NLRP3 Inflammasome by Hyaboron, a new Asymmetric Boron-Containing Macrodiolide from the Myxobacterium Hyalangium minutum.
Surup F, Chauhan D, Niggemann J, Bartok E, Herrmann J, Keck M, Zander W, Stadler M, Hornung V, Müller R.
ACS Chem Biol. 2018 Sep 5. doi: 10.1021/acschembio.8b00659. [Epub ahead of print] PubMed
Correction: AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis.
Jakobs C, Perner S, Hornung V.
PLoS One. 2018 Aug 9;13(8):e0202364. doi: 10.1371/journal.pone.0202364. eCollection 2018. PubMed
VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites.
Czogalla KJ, Liphardt K, Höning K, Hornung V, Biswas A, Watzka M, Oldenburg J.
Blood Adv. 2018 Mar 27;2(6):691-702. doi: 10.1182/bloodadvances.2017006775. PubMed
2017
ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect.
Zinecker H, Ouaret D, Ebner D, Gaidt MM, Taylor S, Aulicino A, Jagielowicz M, Hornung V, Simmons A.
Oncotarget. 2017 Nov 1;8(63):106764-106777. doi: 10.18632/oncotarget.22264. eCollection 2017 Dec 5. PubMed
Frequently used bioinformatics tools overestimate the damaging effect of allelic variants.
Andersen LL, Terczyńska-Dyla E, Mørk N, Scavenius C, Enghild JJ, Höning K, Hornung V, Christiansen M, Mogensen TH, Hartmann R.
Genes Immun. 2017 Dec 4. doi: 10.1038/s41435-017-0002-z. [Epub ahead of print]. PubMed
The NLRP3 inflammasome renders cell death pro-inflammatory.
Gaidt MM, Hornung V.
J Mol Biol. 2017 Dec 1. pii: S0022-2836(17)30563-6. doi: 10.1016/j.jmb.2017.11.013. [Epub ahead of print] Review. PubMed
Modeling Primary Human Monocytes with the Trans-Differentiation Cell Line BLaER1.
Gaidt MM, Rapino F, Graf T, Hornung V.
Methods Mol Biol. 2018;1714:57-66. doi: 10.1007/978-1-4939-7519-8_4. PubMed
Prolonged IKKβ Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells.
Heuser C, Gotot J, Piotrowski EC, Philipp MS, Courrèges CJF, Otte MS, Guo L, Schmid-Burgk JL, Hornung V, Heine A, Knolle PA, Garbi N, Serfling E, Evaristo C, Thaiss F, Kurts C.
Cell Rep. 2017 Oct 17;21(3):578-586. doi: 10.1016/j.celrep.2017.09.082. PubMed
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.
Gaidt MM, Ebert TS, Chauhan D, Ramshorn K, Pinci F, Zuber S, O'Duill F, Schmid-Burgk JL, Hoss F, Buhmann R, Wittmann G, Latz E, Subklewe M, Hornung V.
Cell. 2017 Nov 16;171(5):1110-1124.e18. doi: 10.1016/j.cell.2017.09.039. Epub 2017 Oct 12. PubMed
The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression.
Ghosh S, Wallerath C, Covarrubias S, Hornung V, Carpenter S, Fitzgerald KA.
J Immunol. 2017 Nov 1;199(9):3249-3260. doi: 10.4049/jimmunol.1700823. Epub 2017 Sep 20. PubMed
cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.
Andreeva L, Hiller B, Kostrewa D, Lässig C, de Oliveira Mann CC, Jan Drexler D, Maiser A, Gaidt M, Leonhardt H, Hornung V, Hopfner KP.
Nature. 2017 Sep 21;549(7672):394-398. doi: 10.1038/nature23890. Epub 2017 Sep 13. PubMed
Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations.
Kim-Hellmuth S, Bechheim M, Pütz B, Mohammadi P, Nédélec Y, Giangreco N, Becker J, Kaiser V, Fricker N, Beier E, Boor P, Castel SE, Nöthen MM, Barreiro LB, Pickrell JK, Müller-Myhsok B, Lappalainen T, Schumacher J, Hornung V.
Nat Commun. 2017 Aug 16;8(1):266. doi: 10.1038/s41467-017-00366-1. PubMed
Corrigendum: SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.
Schneider C, Oellerich T, Baldauf HM, Schwarz SM, Thomas D, Flick R, Bohnenberger H, Kaderali L, Stegmann L, Cremer A, Martin M, Lohmeyer J, Michaelis M, Hornung V, Schliemann C, Berdel WE, Hartmann W, Wardelmann E, Comoglio F, Hansmann ML, Yakunin AF, Geisslinger G, et al.
Nat Med. 2017 Jun 6;23(6):788. doi: 10.1038/nm0617-788a. No abstract available. PubMed
RIG-I Resists Hypoxia-Induced Immunosuppression and Dedifferentiation.
Engel C, Brügmann G, Lambing S, Mühlenbeck LH, Marx S, Hagen C, Horví¡th D, Goldeck M, Ludwig J, Herzner AM, Drijfhout JW, Wenzel D, Coch C, Tüting T, Schlee M, Hornung V, Hartmann G, Van den Boorn JG.
Cancer Immunol Res. 2017 Jun;5(6):455-467. doi: 10.1158/2326-6066.CIR-16-0129-T. Epub 2017 May 3. PubMed
Cyclic Dinucleotides in the Scope of the Mammalian Immune System.
Mankan AK, Müller M, Witte G, Hornung V.
Handb Exp Pharmacol. 2017;238:269-289. doi: 10.1007/164_2016_5002. PubMed
Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina.
Karlstetter M, Kopatz J, Aslanidis A, Shahraz A, Caramoy A, Linnartz-Gerlach B, Lin Y, Lückoff A, Fauser S, Düker K, Claude J, Wang Y, Ackermann J, Schmidt T, Hornung V, Skerka C, Langmann T, Neumann H.
EMBO Mol Med. 2017 Feb;9(2):154-166. doi: 10.15252/emmm.201606627. PubMed
SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.
Schneider C, Oellerich T, Baldauf HM, Schwarz SM, Thomas D, Flick R, Bohnenberger H, Kaderali L, Stegmann L, Cremer A, Martin M, Lohmeyer J, Michaelis M, Hornung V, Schliemann C, Berdel WE, Hartmann W, Wardelmann E, Comoglio F, Hansmann ML, Yakunin AF, Geisslinger G, et al.
Nat Med. 2017 Feb;23(2):250-255. doi: 10.1038/nm.4255. Epub 2016 Dec 19. PubMed
Warfarin and vitamin K compete for binding to Phe55 in human VKOR.
Czogalla KJ, Biswas A, Höning K, Hornung V, Liphardt K, Watzka M, Oldenburg J.
Nat Struct Mol Biol. 2017 Jan;24(1):77-85. doi: 10.1038/nsmb.3338. Epub 2016 Dec 12. PubMed
Alternative inflammasome activation enables IL-1β release from living cells. Gaidt MM, Hornung V.
Curr Opin Immunol. 2017 Feb;44:7-13. doi: 10.1016/j.coi.2016.10.007. Epub 2016 Nov 11. Review. PubMed
The Second-Generation Exportin-1 Inhibitor KPT-8602 Demonstrates Potent Activity against Acute Lymphoblastic Leukemia.
Vercruysse T, De Bie J, Neggers JE, Jacquemyn M, Vanstreels E, Schmid-Burgk JL, Hornung V, Baloglu E, Landesman Y, Senapedis W, Shacham S, Dagklis A, Cools J, Daelemans D.
Clin Cancer Res. 2017 May 15;23(10):2528-2541. doi: 10.1158/1078-0432.CCR-16-1580. Epub 2016 Oct 25. PubMed
Pore formation by GSDMD is the effector mechanism of pyroptosis.
Gaidt MM, Hornung V.
EMBO J. 2016 Oct 17;35(20):2167-2169. Epub 2016 Aug 29. No abstract available. PubMed
STING Contributes to Abnormal Bone Formation Induced by Deficiency of DNase II in Mice.
Baum R, Sharma S, Organ JM, Jakobs C, Hornung V, Burr DB, Marshak-Rothstein A, Fitzgerald KA, Gravallese EM.
Arthritis Rheumatol. 2017 Feb;69(2):460-471. doi: 10.1002/art.39863. PubMed
2016
cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites.
Xu S, Ducroux A, Ponnurangam A, Vieyres G, Franz S, Müsken M, Zillinger T, Malassa A, Ewald E, Hornung V, Barchet W, Häussler S, Pietschmann T, Goffinet C.
Cell Host Microbe. 2016 Oct 12;20(4):443-457. doi: 10.1016/j.chom.2016.09.003. PubMed
Aging-Associated TNF Production Primes Inflammasome Activation and NLRP3-Related Metabolic Disturbances.
Bauernfeind F, Niepmann S, Knolle PA, Hornung V.
J Immunol. 2016 Oct 1;197(7):2900-8. doi: 10.4049/jimmunol.1501336. Epub 2016 Aug 26. PubMed
CRISPaint allows modular base-specific gene tagging using a ligase-4-dependent mechanism.
Schmid-Burgk JL, Höning K, Ebert TS, Hornung V.
Nat Commun. 2016 Jul 28;7:12338. doi: 10.1038/ncomms12338. PubMed
Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production.
Andrade WA, Firon A, Schmidt T, Hornung V, Fitzgerald KA, Kurt-Jones EA, Trieu-Cuot P, Golenbock DT, Kaminski PA.
Cell Host Microbe. 2016 Jul 13;20(1):49-59. doi: 10.1016/j.chom.2016.06.003. PubMed
Inflammasome-Dependent Induction of Adaptive NK Cell Memory.
van den Boorn JG, Jakobs C, Hagen C, Renn M, Luiten RM, Melief CJ, Tüting T, Garbi N, Hartmann G, Hornung V.
Immunity. 2016 Jun 21;44(6):1406-21. doi: 10.1016/j.immuni.2016.05.008. Epub 2016 Jun 7. PubMed
Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4.
Andrade WA, Agarwal S, Mo S, Shaffer SA, Dillard JP, Schmidt T, Hornung V, Fitzgerald KA, Kurt-Jones EA, Golenbock DT.
Cell Rep. 2016 Jun 14;15(11):2438-48. doi: 10.1016/j.celrep.2016.05.030. Epub 2016 Jun 2. PubMed
An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice.
Ludwig-Portugall I, Bartok E, Dhana E, Evers BD, Primiano MJ, Hall JP, Franklin BS, Knolle PA, Hornung V, Hartmann G, Boor P, Latz E, Kurts C.
Kidney Int. 2016 Sep;90(3):525-39. doi: 10.1016/j.kint.2016.03.035. Epub 2016 Jun 2. PubMed
Measuring IL-1β Processing by Bioluminescence Sensors II: The iGLuc System.
Bartok E, Kampes M, Hornung V.
Methods Mol Biol. 2016;1417:97-113. doi: 10.1007/978-1-4939-3566-6_6. PubMed
Cre-dependent DNA recombination activates a STING-dependent innate immune response.
Pépin G, Ferrand J, Höning K, Jayasekara WS, Cain JE, Behlke MA, Gough DJ, G Williams BR, Hornung V, Gantier MP.
Nucleic Acids Res. 2016 Jun 20;44(11):5356-64. doi: 10.1093/nar/gkw405. Epub 2016 May 10. PubMed
Human plasmacytoid dentritic cells elicit a Type I Interferon response by sensing DNA via the cGAS-STING signaling pathway.
Bode C, Fox M, Tewary P, Steinhagen A, Ellerkmann RK, Klinman D, Baumgarten G, Hornung V, Steinhagen F.
Eur J Immunol. 2016 Jul;46(7):1615-21. doi: 10.1002/eji.201546113. Epub 2016 May 27. PubMed
NSs Virulence Factor of Rift Valley Fever Virus Engages the F-Box Proteins FBXW11 and β-TRCP1 To Degrade the Antiviral Protein Kinase PKR. Kainulainen M, Lau S, Samuel CE, Hornung V, Weber F.
J Virol. 2016 Jun 10;90(13):6140-7. doi: 10.1128/JVI.00016-16. Print 2016 Jul 1. PubMed
Recognition of Endogenous Nucleic Acids by the Innate Immune System.
Roers A, Hiller B, Hornung V.
Immunity. 2016 Apr 19;44(4):739-54. doi: 10.1016/j.immuni.2016.04.002. Review. PubMed
cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells. Paijo J, Döring M, Spanier J, Grabski E, Nooruzzaman M, Schmidt T, Witte G, Messerle M, Hornung V, Kaever V, Kalinke U.
PLoS Pathog. 2016 Apr 8;12(4):e1005546. doi: 10.1371/journal.ppat.1005546. eCollection 2016 Apr. PubMed
Human Monocytes Engage an Alternative Inflammasome Pathway.
Gaidt MM, Ebert TS, Chauhan D, Schmidt T, Schmid-Burgk JL, Rapino F, Robertson AA, Cooper MA, Graf T, Hornung V.
Immunity. 2016 Apr 19;44(4):833-46. doi: 10.1016/j.immuni.2016.01.012. Epub 2016 Mar 29. PubMed
MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction.
Cuevas RA, Ghosh A, Wallerath C, Hornung V, Coyne CB, Sarkar SN.
J Immunol. 2016 May 1;196(9):3877-86. doi: 10.4049/jimmunol.1501359. Epub 2016 Mar 25. PubMed
Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity. Krapp C, Hotter D, Gawanbacht A, McLaren PJ, Kluge SF, Stürzel CM, Mack K, Reith E, Engelhart S, Ciuffi A, Hornung V, Sauter D, Telenti A, Kirchhoff F.
Cell Host Microbe. 2016 Apr 13;19(4):504-14. doi: 10.1016/j.chom.2016.02.019. Epub 2016 Mar 17. PubMed
Correction: ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.
Lässig C, Matheisl S, Sparrer KM, de Oliveira Mann CC, Moldt M, Patel JR, Goldeck M, Hartmann G, García-Sastre A, Hornung V, Conzelmann KK, Beckmann R, Hopfner KP.
Elife. 2016 Mar 2;5. pii: e14954. doi: 10.7554/eLife.14954. No abstract available. PubMed
Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses.
Holm CK, Rahbek SH, Gad HH, Bak RO, Jakobsen MR, Jiang Z, Hansen AL, Jensen SK, Sun C, Thomsen MK, Laustsen A, Nielsen CG, Severinsen K, Xiong Y, Burdette DL, Hornung V, Lebbink RJ, Duch M, Fitzgerald KA, Bahrami S, Mikkelsen JG, Hartmann R, et al.
Nat Commun. 2016 Feb 19;7:10680. doi: 10.1038/ncomms10680. PubMed
Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use.
Sun J, Li N, Oh KS, Dutta B, Vayttaden SJ, Lin B, Ebert TS, De Nardo D, Davis J, Bagirzadeh R, Lounsbury NW, Pasare C, Latz E, Hornung V, Fraser ID.
Sci Signal. 2016 Jan 5;9(409):ra3. doi: 10.1126/scisignal.aab2191. PubMed
Phosphorylation of murine SAMHD1 regulates its antiretroviral activity.
Wittmann S, Behrendt R, Eissmann K, Volkmann B, Thomas D, Ebert T, Cribier A, Benkirane M, Hornung V, Bouzas NF, Gramberg T.
Retrovirology. 2015 Dec 15;12:103. doi: 10.1186/s12977-015-0229-6. PubMed
ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA. Lässig C, Matheisl S, Sparrer KM, de Oliveira Mann CC, Moldt M, Patel JR, Goldeck M, Hartmann G, García-Sastre A, Hornung V, Conzelmann KK, Beckmann R, Hopfner KP.
Elife. 2015 Nov 26;4. pii: e10859. doi: 10.7554/eLife.10859. Erratum in: Elife. 2016;5. pii: e14954. doi: 10.7554/eLife.14954. PubMed
A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation.
Schmid-Burgk JL, Chauhan D, Schmidt T, Ebert TS, Reinhardt J, Endl E, Hornung V.
J Biol Chem. 2016 Jan 1;291(1):103-9. doi: 10.1074/jbc.C115.700492. Epub 2015 Nov 9. PubMed
Human TLR8 senses UR/URR motifs in bacterial and mitochondrial RNA.
Krüger A, Oldenburg M, Chebrolu C, Beisser D, Kolter J, Sigmund AM, Steinmann J, Schäfer S, Hochrein H, Rahmann S, Wagner H, Henneke P, Hornung V, Buer J, Kirschning CJ.
EMBO Rep. 2015 Dec;16(12):1656-63. doi: 10.15252/embr.201540861. Epub 2015 Nov 6. PubMed
MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment.
Riesenberg S, Groetchen A, Siddaway R, Bald T, Reinhardt J, Smorra D, Kohlmeyer J, Renn M, Phung B, Aymans P, Schmidt T, Hornung V, Davidson I, Goding CR, Jönsson G, Landsberg J, Tüting T, Hölzel M.
Nat Commun. 2015 Nov 4;6:8755. doi: 10.1038/ncomms9755. PubMed
BrowserGenome.org: web-based RNA-seq data analysis and visualization.
Schmid-Burgk JL, Hornung V.
Nat Methods. 2015 Nov;12(11):1001. doi: 10.1038/nmeth.3615. PubMed
Synthesis of an arrayed sgRNA library targeting the human genome.
Schmidt T, Schmid-Burgk JL, Hornung V.
Sci Rep. 2015 Oct 8;5:14987. doi: 10.1038/srep14987. PubMed
Designer Nuclease-Mediated Generation of Knockout THP1 Cells.
Schmidt T, Schmid-Burgk JL, Ebert TS, Gaidt MM, Hornung V.
Methods Mol Biol. 2016;1338:261-72. doi: 10.1007/978-1-4939-2932-0_19. PubMed
2015
Suppression of intratumoral CCL22 by type i interferon inhibits migration of regulatory T cells and blocks cancer progression.
Anz D, Rapp M, Eiber S, Koelzer VH, Thaler R, Haubner S, Knott M, Nagel S, Golic M, Wiedemann GM, Bauernfeind F, Wurzenberger C, Hornung V, Scholz C, Mayr D, Rothenfusser S, Endres S, Bourquin C.
Cancer Res. 2015 Nov 1;75(21):4483-93. doi: 10.1158/0008-5472.CAN-14-3499. Epub 2015 Oct 2. PubMed
Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA.
Herzner AM, Hagmann CA, Goldeck M, Wolter S, Kübler K, Wittmann S, Gramberg T, Andreeva L, Hopfner KP, Mertens C, Zillinger T, Jin T, Xiao TS, Bartok E, Coch C, Ackermann D, Hornung V, Ludwig J, Barchet W, Hartmann G, Schlee M.
Nat Immunol. 2015 Oct;16(10):1025-33. doi: 10.1038/ni.3267. Epub 2015 Sep 7. PubMed
STING Signaling the enERGIC Way.
Hiller B, Hornung V.
Cell Host Microbe. 2015 Aug 12;18(2):137-9. doi: 10.1016/j.chom.2015.07.014. PubMed
Functional IRF3 deficiency in a patient with herpes simplex encephalitis.
Andersen LL, Márk N, Reinert LS, Kofod-Olsen E, Narita R, Jôrgensen SE, Skipper KA, Höning K, Gad HH, Istergaard L, Irntoft TF, Hornung V, Paludan SR, Mikkelsen JG, Fujita T, Christiansen M, Hartmann R, Mogensen TH.
J Exp Med. 2015 Aug 24;212(9):1371-9. doi: 10.1084/jem.20142274. Epub 2015 Jul 27. PubMed
A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA.
Schuberth-Wagner C, Ludwig J, Bruder AK, Herzner AM, Zillinger T, Goldeck M, Schmidt T, Schmid-Burgk JL, Kerber R, Wolter S, Stümpel JP, Roth A, Bartok E, Drosten C, Coch C, Hornung V, Barchet W, Kümmerer BM, Hartmann G, Schlee M.
Immunity. 2015 Jul 21;43(1):41-51. doi: 10.1016/j.immuni.2015.06.015. Epub 2015 Jul 14. PubMed
Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells.
Schmid-Burgk JL, Gaidt MM, Schmidt T, Ebert TS, Bartok E, Hornung V.
Eur J Immunol. 2015 Oct;45(10):2911-7. doi: 10.1002/eji.201545523. Epub 2015 Aug 6. PubMed
Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice.
Sester DP, Sagulenko V, Thygesen SJ, Cridland JA, Loi YS, Cridland SO, Masters SL, Genske U, Hornung V, Andoniou CE, Sweet MJ, Degli-Esposti MA, Schroder K, Stacey KJ.
J Immunol. 2015 Aug 1;195(3):1233-41. doi: 10.4049/jimmunol.1402859. Epub 2015 Jun 26. PubMed
AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis.
Jakobs C, Perner S, Hornung V.
PLoS One. 2015 Jun 26;10(6):e0131702. doi: 10.1371/journal.pone.0131702. eCollection 2015. PubMed
Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1.
Wassermann R, Gulen MF, Sala C, Perin SG, Lou Y, Rybniker J, Schmid-Burgk JL, Schmidt T, Hornung V, Cole ST, Ablasser A.
Cell Host Microbe. 2015 Jun 10;17(6):799-810. doi: 10.1016/j.chom.2015.05.003. Epub 2015 Jun 2. PubMed
Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling.
Ibsen MS, Gad HH, Andersen LL, Hornung V, Julkunen I, Sarkar SN, Hartmann R.
Nucleic Acids Res. 2015 May 26;43(10):5236-48. doi: 10.1093/nar/gkv389. Epub 2015 Apr 29. PubMed
ATP-dependent effector-like functions of RIG-I-like receptors.
Yao H, Dittmann M, Peisley A, Hoffmann HH, Gilmore RH, Schmidt T, Schmid-Burgk JL, Hornung V, Rice CM, Hur S.
Mol Cell. 2015 May 7;58(3):541-8. doi: 10.1016/j.molcel.2015.03.014. Epub 2015 Apr 16. PubMed
Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference.
Barrangou R, Birmingham A, Wiemann S, Beijersbergen RL, Hornung V, Smith Av.
Nucleic Acids Res. 2015 Apr 20;43(7):3407-19. doi: 10.1093/nar/gkv226. Epub 2015 Mar 23. Review. PubMed
Sox2 as a servant of two masters.
Mankan AK, Hornung V.
Nat Immunol. 2015 Apr;16(4):335-6. doi: 10.1038/ni.3121. No abstract available. PubMed
Influenza virus adaptation PB2-627K modulates nucleocapsid inhibition by the pathogen sensor RIG-I.
Weber M, Sediri H, Felgenhauer U, Binzen I, Bänfer S, Jacob R, Brunotte L, García-Sastre A, Schmid-Burgk JL, Schmidt T, Hornung V, Kochs G, Schwemmle M, Klenk HD, Weber F.
Cell Host Microbe. 2015 Mar 11;17(3):309-19. doi: 10.1016/j.chom.2015.01.005. Epub 2015 Feb 19. PubMed
Extracorporeal photopheresis promotes IL-1β production.
Yakut E, Jakobs C, Peric A, Michel G, Baal N, Bein G, Brüne B, Hornung V, Hackstein H.
J Immunol. 2015 Mar 15;194(6):2569-77. doi: 10.4049/jimmunol.1400694. Epub 2015 Feb 13. PubMed
Control of hepatitis C virus replication in mouse liver-derived cells by MAVS-dependent production of type I and type III interferons.
Anggakusuma, Frentzen A, Gürlevik E, Yuan Q, Steinmann E, Ott M, Staeheli P, Schmid-Burgk J, Schmidt T, Hornung V, Kuehnel F, Pietschmann T.
J Virol. 2015 Apr;89(7):3833-45. doi: 10.1128/JVI.03129-14. Epub 2015 Jan 21. PubMed
2014
SnapShot: Nucleic acid immune sensors, part 2.
Hornung V.
Immunity, 2014; 41: 1066-1066 e1061. PubMed
SnapShot: nucleic acid immune sensors, part 1.
Hornung V.
Immunity, 2014; 41: 868, 868 e861. PubMed
Cytosolic RNA:DNA hybrids activate the cGAS-STING axis.
Mankan AK, Schmidt T, Chauhan D, Goldeck M, Höning K, Gaidt M, Kubarenko AV, Andreeva L, Hopfner KP, Hornung V.
EMBO J. 2014 Dec 17;33(24):2937-46. doi: 10.15252/embj.201488726. Epub 2014 Nov 25. PubMed
Ligation-independent cloning (LIC) assembly of TALEN genes.
Schmid-Burgk JL, Schmidt T, Hornung V.
Methods Mol Biol. 2015;1239:161-9. doi: 10.1007/978-1-4939-1862-1_8. PubMed
Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes.
Kim S, Becker J, Bechheim M, Kaiser V, Noursadeghi M, Fricker N, Beier E, Klaschik S, Boor P, Hess T, Hofmann A, Holdenrieder S, Wendland JR, Fröhlich H, Hartmann G, Nöthen MM, Müller-Myhsok B, Pütz B, Hornung V, Schumacher J.
Nat Commun. 2014 Oct 20;5:5236. doi: 10.1038/ncomms6236. PubMed
Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms.
Pelka K, Phulphagar K, Zimmermann J, Stahl R, Schmid-Burgk JL, Schmidt T, Spille JH, Labzin LI, Agrawal S, Kandimalla ER, Casanova JL, Hornung V, Marshak-Rothstein A, Höning S, Latz E.
J Immunol. 2014 Oct 1;193(7):3257-61. doi: 10.4049/jimmunol.1301886. Epub 2014 Sep 3. PubMed
OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell lines.
Schmid-Burgk JL, Schmidt T, Gaidt MM, Pelka K, Latz E, Ebert TS, Hornung V.
Genome Res. 2014 Oct;24(10):1719-23. doi: 10.1101/gr.176701.114. Epub 2014 Sep 3. PubMed
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids.
Hornung V, Hartmann R, Ablasser A, Hopfner KP.
Nat Rev Immunol. 2014 Aug;14(8):521-8. doi: 10.1038/nri3719. Epub 2014 Jul 18. Review. PubMed
Enzymatic synthesis and purification of a defined RIG-I ligand.
Goldeck M, Schlee M, Hartmann G, Hornung V.
Methods Mol Biol. 2014;1169:15-25. doi: 10.1007/978-1-4939-0882-0_2. PubMed
Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor.
Zhu J, Zhang Y, Ghosh A, Cuevas RA, Forero A, Dhar J, Ibsen MS, Schmid-Burgk JL, Schmidt T, Ganapathiraju MK, Fujita T, Hartmann R, Barik S, Hornung V, Coyne CB, Sarkar SN.
Immunity. 2014 Jun 19;40(6):936-48. doi: 10.1016/j.immuni.2014.05.007. Epub 2014 Jun 12. PubMed
TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner.
Ablasser A, Hemmerling I, Schmid-Burgk JL, Behrendt R, Roers A, Hornung V.
J Immunol. 2014 Jun 15;192(12):5993-7. doi: 10.4049/jimmunol.1400737. Epub 2014 May 9. PubMed
Self-priming determines high type I IFN production by plasmacytoid dendritic cells.
Kim S, Kaiser V, Beier E, Bechheim M, Guenthner-Biller M, Ablasser A, Berger M, Endres S, Hartmann G, Hornung V.
Eur J Immunol. 2014 Mar;44(3):807-18. doi: 10.1002/eji.201343806. Epub 2014 Jan 16. PubMed
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.
Ablasser A, Schmid-Burgk JL, Hemmerling I, Horvath GL, Schmidt T, Latz E, Hornung V.
Nature. 2013 Nov 28;503(7477):530-4. doi: 10.1038/nature12640. Epub 2013 Sep 29. PubMed
Postoperative ileus involves interleukin-1 receptor signaling in enteric glia.
Stoffels B, Hupa KJ, Snoek SA, van Bree S, Stein K, Schwandt T, Vilz TO, Lysson M, Veer CV, Kummer MP, Hornung V, Kalff JC, de Jonge WJ, Wehner S.
Gastroenterology. 2014 Jan;146(1):176-87.e1. doi: 10.1053/j.gastro.2013.09.030. Epub 2013 Sep 22. PubMed
2013
Immunoblotting for active caspase-1.
Jakobs C, Bartok E, Kubarenko A, Bauernfeind F, Hornung V.
Methods Mol Biol. 2013;1040:103-15. doi: 10.1007/978-1-62703-523-1_9. PubMed
Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation.
Yin Q, Sester DP, Tian Y, Hsiao YS, Lu A, Cridland JA, Sagulenko V, Thygesen SJ, Choubey D, Hornung V, Walz T, Stacey KJ, Wu H.
Cell Rep. 2013 Jul 25;4(2):327-39. doi: 10.1016/j.celrep.2013.06.024. Epub 2013 Jul 11. PubMed
Structural mechanism of cytosolic DNA sensing by cGAS.
Civril F, Deimling T, de Oliveira Mann CC, Ablasser A, Moldt M, Witte G, Hornung V, Hopfner KP.
Nature. 2013 Jun 20;498(7454):332-7. doi: 10.1038/nature12305. Epub 2013 May 30. PubMed
cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.
Ablasser A, Goldeck M, Cavlar T, Deimling T, Witte G, Röhl I, Hopfner KP, Ludwig J, Hornung V.
Nature. 2013 Jun 20;498(7454):380-4. doi: 10.1038/nature12306. Epub 2013 May 30. PubMed
Of inflammasomes and pathogens--sensing of microbes by the inflammasome.
Bauernfeind F, Hornung V.
EMBO Mol Med. 2013 Jun;5(6):814-26. doi: 10.1002/emmm.201201771. Epub 2013 May 13. Review. PubMed
RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells. Hagmann CA, Herzner AM, Abdullah Z, Zillinger T, Jakobs C, Schuberth C, Coch C, Higgins PG, Wisplinghoff H, Barchet W, Hornung V, Hartmann G, Schlee M.
PLoS One. 2013 Apr 30;8(4):e62872. doi: 10.1371/journal.pone.0062872. Print 2013. PubMed
Species-specific detection of the antiviral small-molecule compound CMA by STING.
Cavlar T, Deimling T, Ablasser A, Hopfner KP, Hornung V.
EMBO J. 2013 May 15;32(10):1440-50. doi: 10.1038/emboj.2013.86. Epub 2013 Apr 19. PubMed
Nucleic acid driven sterile inflammation.
Ablasser A, Hertrich C, Waßermann R, Hornung V.
Clin Immunol. 2013 Jun;147(3):207-15. doi: 10.1016/j.clim.2013.01.003. Epub 2013 Jan 19. Review. PubMed
DNA sensing unchained.
Ablasser A, Hornung V.
Cell Res. 2013 May;23(5):585-7. doi: 10.1038/cr.2013.28. Epub 2013 Feb 19. PubMed
iGLuc: a luciferase-based inflammasome and protease activity reporter.
Bartok E, Bauernfeind F, Khaminets MG, Jakobs C, Monks B, Fitzgerald KA, Latz E, Hornung V.
Nat Methods. 2013 Feb;10(2):147-54. doi: 10.1038/nmeth.2327. Epub 2013 Jan 6. PubMed
A ligation-independent cloning technique for high-throughput assembly of transcription activator-like effector genes.
Schmid-Burgk JL, Schmidt T, Kaiser V, Höning K, Hornung V.
Nat Biotechnol. 2013 Jan;31(1):76-81. PubMed
2012
Retroviral danger from within: TLR7 is in control.
Mankan AK, Hornung V.
Immunity. 2012 Nov 16;37(5):763-6. doi: 10.1016/j.immuni.2012.10.009. PubMed
NLRP3 inflammasome activity is negatively controlled by miR-223.
Bauernfeind F, Rieger A, Schildberg FA, Knolle PA, Schmid-Burgk JL, Hornung V.
J Immunol. 2012 Oct 15;189(8):4175-81. doi: 10.4049/jimmunol.1201516. Epub 2012 Sep 14. PubMed
Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.
Jin T, Perry A, Jiang J, Smith P, Curry JA, Unterholzner L, Jiang Z, Horvath G, Rathinam VA, Johnstone RW, Hornung V, Latz E, Bowie AG, Fitzgerald KA, Xiao TS.
Immunity. 2012 Apr 20;36(4):561-71. doi: 10.1016/j.immuni.2012.02.014. Epub 2012 Apr 5. PubMed
Induction of type I IFNs by intracellular DNA-sensing pathways.
Cavlar T, Ablasser A, Hornung V.
Immunol Cell Biol. 2012 May;90(5):474-82. doi: 10.1038/icb.2012.11. Epub 2012 Mar 27. Review. PubMed
The NLRP3/ASC/Caspase-1 axis regulates IL-1β processing in neutrophils.
Mankan AK, Dau T, Jenne D, Hornung V.
Eur J Immunol. 2012 Mar;42(3):710-5. doi: 10.1002/eji.201141921. Epub 2012 Jan 19. PubMed
2011
Critical role of nucleotide-binding oligomerization domain-like receptor 3 in vascular repair.
Schlaweck S, Zimmer S, Struck R, Bartok E, Werner N, Bauernfeind F, Latz E, Nickenig G, Hornung V, Ghanem A.
Biochem Biophys Res Commun. 2011 Aug 5;411(3):627-31. doi: 10.1016/j.bbrc.2011.07.006. Epub 2011 Jul 13. PubMed
Where, in antiviral defense, does IFIT1 fit?
Ablasser A, Hornung V.
Nat Immunol. 2011 Jun 20;12(7):588-90. doi: 10.1038/ni.2061. No abstract available. PubMed
Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome.
Bauernfeind F, Bartok E, Rieger A, Franchi L, Núñez G, Hornung V.
J Immunol. 2011 Jul 15;187(2):613-7. doi: 10.4049/jimmunol.1100613. Epub 2011 Jun 15. PubMed
Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions.
Dombrowski Y, Peric M, Koglin S, Kammerbauer C, Göss C, Anz D, Simanski M, Gläser R, Harder J, Hornung V, Gallo RL, Ruzicka T, Besch R, Schauber J.
Sci Transl Med. 2011 May 11;3(82):82ra38. doi: 10.1126/scitranslmed.3002001. PubMed
2010
An unexpected role for RNA in the recognition of DNA by the innate immune system. Bauernfeind F, Ablasser A, Kim S, Bartok E, Hornung V.
RNA Biol. 2010 Mar-Apr;7(2):151-7. Epub 2010 Mar 28. Review. PubMed
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.
Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nunez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E.
Nature. 2010 Apr 29;464(7293):1357-61. doi: 10.1038/nature08938. Erratum in: Nature. 2010 Jul 29;466(7306):652. PubMed
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.
Rathinam VA, Jiang Z, Waggoner SN, Sharma S, Cole LE, Waggoner L, Vanaja SK, Monks BG, Ganesan S, Latz E, Hornung V, Vogel SN, Szomolanyi-Tsuda E, Fitzgerald KA.
Nat Immunol. 2010 May;11(5):395-402. doi: 10.1038/ni.1864. Epub 2010 Mar 28. PubMed
Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome.
Kim S, Bauernfeind F, Ablasser A, Hartmann G, Fitzgerald KA, Latz E, Hornung V.
Eur J Immunol. 2010 Jun;40(6):1545-51. doi: 10.1002/eji.201040425. PubMed
Critical functions of priming and lysosomal damage for NLRP3 activation.
Hornung V, Latz E.
Eur J Immunol. 2010 Mar;40(3):620-3. doi: 10.1002/eji.200940185. Review. PubMed
Intracellular DNA recognition.
Hornung V, Latz E.
Nat Rev Immunol. 2010 Feb;10(2):123-30. doi: 10.1038/nri2690. Review. PubMed
Immunostimulatory RNA blocks suppression by regulatory T cells.
Anz D, Koelzer VH, Moder S, Thaler R, Schwerd T, Lahl K, Sparwasser T, Besch R, Poeck H, Hornung V, Hartmann G, Rothenfusser S, Bourquin C, Endres S.
J Immunol. 2010 Jan 15;184(2):939-46. doi: 10.4049/jimmunol.0901245. Epub 2009 Dec 4. PubMed
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production.
Poeck H, Bscheider M, Gross O, Finger K, Roth S, Rebsamen M, Hannesschläger N, Schlee M, Rothenfusser S, Barchet W, Kato H, Akira S, Inoue S, Endres S, Peschel C, Hartmann G, Hornung V, Ruland J.
Nat Immunol. 2010 Jan;11(1):63-9. doi: 10.1038/ni.1824. Epub 2009 Nov 15. Erratum in: Nat Immunol. 2014 Jan;15(1):109. PubMed
2009
Immunostimulatory RNA oligonucleotides induce an effective antitumoral NK cell response through the TLR7.
Bourquin C, Schmidt L, Lanz AL, Storch B, Wurzenberger C, Anz D, Sandholzer N, Mocikat R, Berger M, Poeck H, Hartmann G, Hornung V, Endres S.
J Immunol. 2009 Nov 15;183(10):6078-86. doi: 10.4049/jimmunol.0901594. PubMed
TLR2 joins the interferon gang.
Bauernfeind F, Hornung V.
Nat Immunol. 2009 Nov;10(11):1139-41. doi: 10.1038/ni1109-1139. PubMed
Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells.
Besch R, Poeck H, Hohenauer T, Senft D, Häcker G, Berking C, Hornung V, Endres S, Ruzicka T, Rothenfusser S, Hartmann G.
J Clin Invest. 2009 Aug;119(8):2399-411. doi: 10.1172/JCI37155. Epub 2009 Jul 20. PubMed
RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate.
Ablasser A, Bauernfeind F, Hartmann G, Latz E, Fitzgerald KA, Hornung V.
Nat Immunol. 2009 Oct;10(10):1065-72. doi: 10.1038/ni.1779. Epub 2009 Jul 16. PubMed
Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.
Schlee M, Roth A, Hornung V, Hagmann CA, Wimmenauer V, Barchet W, Coch C, Janke M, Mihailovic A, Wardle G, Juranek S, Kato H, Kawai T, Poeck H, Fitzgerald KA, Takeuchi O, Akira S, Tuschl T, Latz E, Ludwig J, Hartmann G.
Immunity. 2009 Jul 17;31(1):25-34. doi: 10.1016/j.immuni.2009.05.008. Epub 2009 Jul 2. PubMed
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, Speert D, Fernandes-Alnemri T, Wu J, Monks BG, Fitzgerald KA, Hornung V, Latz E.
J Immunol. 2009 Jul 15;183(2):787-91. doi: 10.4049/jimmunol.0901363. Epub 2009 Jul 1. PubMed
Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes.
Ablasser A, Poeck H, Anz D, Berger M, Schlee M, Kim S, Bourquin C, Goutagny N, Jiang Z, Fitzgerald KA, Rothenfusser S, Endres S, Hartmann G, Hornung V.
J Immunol. 2009 Jun 1;182(11):6824-33. doi: 10.4049/jimmunol.0803001. PubMed
TLR8-driven IL-12-dependent reciprocal and synergistic activation of NK cells and monocytes by immunostimulatory RNA.
Berger M, Ablasser A, Kim S, Bekeredjian-Ding I, Giese T, Endres S, Hornung V, Hartmann G.
J Immunother. 2009 Apr;32(3):262-71. doi: 10.1097/CJI.0b013e318198bd2a. PubMed
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.
Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey DR, Latz E, Fitzgerald KA.
Nature. 2009 Mar 26;458(7237):514-8. doi: 10.1038/nature07725. Epub 2009 Jan 21. PubMed
Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif.
Lichtnekert J, Vielhauer V, Zecher D, Kulkarni OP, Clauss S, Segerer S, Hornung V, Mayadas TN, Beutler B, Akira S, Anders HJ.
Am J Physiol Renal Physiol. 2009 Apr;296(4):F867-74. doi: 10.1152/ajprenal.90213.2008. Epub 2009 Jan 21. PubMed
2008
Viral 5'-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses.
Allam R, Pawar RD, Kulkarni OP, Hornung V, Hartmann G, Segerer S, Akira S, Endres S, Anders HJ.
Eur J Immunol. 2008 Dec;38(12):3487-98. doi: 10.1002/eji.200838604. PubMed
5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma.
Poeck H, Besch R, Maihoefer C, Renn M, Tormo D, Morskaya SS, Kirschnek S, Hornung V, Gaffal E, Landsberg J, Hellmuth J, Schmidt A, Anz D, Bscheider M, Schwerd T, Berking C, Bourquin C, Kalinke U, Kremmer E, Kato H, Akira S, Meyers R, Häcker G, et al.
Nat Med. 2008 Nov;14(11):1256-63. doi: 10.1038/nm.1887. Epub 2008 Nov 2. PubMed
Superior immunogenicity of inactivated whole virus H5N1 influenza vaccine is primarily controlled by Toll-like receptor signalling.
Geeraedts F, Goutagny N, Hornung V, Severa M, de Haan A, Pool J, Wilschut J, Fitzgerald KA, Huckriede A.
PLoS Pathog. 2008 Aug 29;4(8):e1000138. doi: 10.1371/journal.ppat.1000138. PubMed
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.
Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E.
Nat Immunol. 2008 Aug;9(8):847-56. doi: 10.1038/ni.1631. Epub 2008 Jul 11. PubMed
The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Hornung V, Reinheckel T, Fitzgerald KA, Latz E, Moore KJ, Golenbock DT.
Nat Immunol. 2008 Aug;9(8):857-65. doi: 10.1038/ni.1636. Epub 2008 Jul 11. PubMed
RNA recognition via TLR7 and TLR8.
Hornung V, Barchet W, Schlee M, Hartmann G.
Handb Exp Pharmacol. 2008;(183):71-86. Review. PubMed
2007
A mammalian microRNA expression atlas based on small RNA library sequencing.
Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Müller RU, Schermer B, Bissels U, Hornung V et al.
Cell. 2007 Jun 29;129(7):1401-14. PubMed
Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response.
Bourquin C, Schmidt L, Hornung V, Wurzenberger C, Anz D, Sandholzer N, Schreiber S, Voelkl A, Hartmann G, Endres S.
Blood. 2007 Apr 1;109(7):2953-60. PubMed
2006
5'-Triphosphate RNA is the ligand for RIG-I.
Hornung V, Ellegast J, Kim S, Brzozka K, Jung A, Kato H, Poeck H, Akira S, Conzelmann KK, Schlee M, Endres S, Hartmann G.
Science. 2006 Nov 10;314(5801):994-7. Epub 2006 Oct 12. PubMed
siRNA and isRNA: two edges of one sword.
Schlee M, Hornung V, Hartmann G.
Mol Ther. 2006 Oct;14(4):463-70. Epub 2006 Jul 31. Review. PubMed
T cell-independent, TLR-induced IL-12p70 production in primary human monocytes.
Bekeredjian-Ding I, Roth SI, Gilles S, Giese T, Ablasser A, Hornung V, Endres S, Hartmann G.
J Immunol. 2006 Jun 15;176(12):7438-46. PubMed
2005
CpG ODN enhance antigen-specific NKT cell activation via plasmacytoid dendritic cells.
Marschner A, Rothenfusser S, Hornung V, Prell D, Krug A, Kerkmann M, Wellisch D, Poeck H, Greinacher A, Giese T, Endres S, Hartmann G.
Eur J Immunol. 2005 Aug;35(8):2347-57. PubMed
Inhibition of toll-like receptor 7- and 9-mediated alpha/beta interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virus.
Schlender J, Hornung V, Finke S, Günthner-Biller M, Marozin S, Brzozka K, Moghim S, Endres S, Hartmann G, Conzelmann KK.
J Virol. 2005 May;79(9):5507-15. PubMed
Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN.
Bekeredjian-Ding IB, Wagner M, Hornung V, Giese T, Schnurr M, Endres S, Hartmann G.
J Immunol. 2005 Apr 1;174(7):4043-50. Erratum in: J Immunol. 2005 May 1;174(9):5884. Berkeredjian-Ding, Isabelle Beatrice [corrected to Bekeredjian-Ding, Isabelle Beatrice]. PubMed
Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7.
Hornung V, Guenthner-Biller M, Bourquin C, Ablasser A, Schlee M, Uematsu S, Noronha A, Manoharan M, Akira S, de Fougerolles A, Endres S, Hartmann G.
Nat Med. 2005 Mar;11(3):263-70. Epub 2005 Feb 20. PubMed
Spontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-alpha induction by CpG-A in plasmacytoid dendritic cells.
Kerkmann M, Costa LT, Richter C, Rothenfusser S, Battiany J, Hornung V, Johnson J, Englert S, Ketterer T, Heckl W, Thalhammer S, Endres S, Hartmann G.
J Biol Chem. 2005 Mar 4;280(9):8086-93. Epub 2004 Dec 8. PubMed
2004
Replication-dependent potent IFN-alpha induction in human plasmacytoid dendritic cells by a single-stranded RNA virus.
Hornung V, Schlender J, Guenthner-Biller M, Rothenfusser S, Endres S, Conzelmann KK, Hartmann G.
J Immunol. 2004 Nov 15;173(10):5935-43. PubMed
Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help.
Poeck H, Wagner M, Battiany J, Rothenfusser S, Wellisch D, Hornung V, Jahrsdorfer B, Giese T, Endres S, Hartmann G.
Blood. 2004 Apr 15;103(8):3058-64. Epub 2003 Dec 30. PubMed
CpG-A and CpG-B oligonucleotides differentially enhance human peptide-specific primary and memory CD8+ T-cell responses in vitro.
Rothenfusser S, Hornung V, Ayyoub M, Britsch S, Towarowski A, Krug A, Sarris A, Lubenow N, Speiser D, Endres S, Hartmann G.
Blood. 2004 Mar 15;103(6):2162-9. Epub 2003 Nov 20. PubMed
2003
Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells.
Kerkmann M, Rothenfusser S, Hornung V, Towarowski A, Wagner M, Sarris A, Giese T, Endres S and Hartmann G.
J Immunol. 2003; 170: 4465-4474. PubMed
2002
Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides.
Hornung V, Rothenfusser S, Britsch S, Krug A, Jahrsdorfer B, Giese T, Endres S and Hartmann G.
J Immunol, 2002; 168: 4531-4537. PubMed
2001
Distinct CpG oligonucleotide sequences activate human gamma delta T cells via interferon-alpha/-beta.
Rothenfusser S, Hornung V, Krug A, Towarowski A, Krieg A M, Endres S and Hartmann G.
Eur J Immunol, 2001; 31: 3525-3534. PubMed
Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12.
Krug A, Towarowski A, Britsch S, Rothenfusser S, Hornung V, Bals R, Giese T, Engelmann H, Endres S, Krieg A M and Hartmann G.
Eur J Immunol, 2001; 31: 3026-3037. PubMed
Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells.
Krug A, Rothenfusser S, Hornung V, Jahrsdorfer B, Blackwell S, Ballas Z K, Endres S, Krieg A M and Hartmann G.
Eur J Immunol, 2001; 31: 2154-2163. PubMed