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Hornung Lab - Publications


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2018




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2017

ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect.
Zinecker H, Ouaret D, Ebner D, Gaidt MM, Taylor S, Aulicino A, Jagielowicz M, Hornung V, Simmons A.
Oncotarget. 2017 Nov 1;8(63):106764-106777. doi: 10.18632/oncotarget.22264. eCollection 2017 Dec 5. PubMed

Frequently used bioinformatics tools overestimate the damaging effect of allelic variants.
Andersen LL, Terczyńska-Dyla E, Mørk N, Scavenius C, Enghild JJ, Höning K, Hornung V, Christiansen M, Mogensen TH, Hartmann R.
Genes Immun. 2017 Dec 4. doi: 10.1038/s41435-017-0002-z. [Epub ahead of print]. PubMed

The NLRP3 inflammasome renders cell death pro-inflammatory.
Gaidt MM, Hornung V.
J Mol Biol. 2017 Dec 1. pii: S0022-2836(17)30563-6. doi: 10.1016/j.jmb.2017.11.013. [Epub ahead of print] Review. PubMed

Modeling Primary Human Monocytes with the Trans-Differentiation Cell Line BLaER1.
Gaidt MM, Rapino F, Graf T, Hornung V.
Methods Mol Biol. 2018;1714:57-66. doi: 10.1007/978-1-4939-7519-8_4. PubMed

Prolonged IKKβ Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells.
Heuser C, Gotot J, Piotrowski EC, Philipp MS, Courrèges CJF, Otte MS, Guo L, Schmid-Burgk JL, Hornung V, Heine A, Knolle PA, Garbi N, Serfling E, Evaristo C, Thaiss F, Kurts C.
Cell Rep. 2017 Oct 17;21(3):578-586. doi: 10.1016/j.celrep.2017.09.082. PubMed

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.
Gaidt MM, Ebert TS, Chauhan D, Ramshorn K, Pinci F, Zuber S, O'Duill F, Schmid-Burgk JL, Hoss F, Buhmann R, Wittmann G, Latz E, Subklewe M, Hornung V.
Cell. 2017 Nov 16;171(5):1110-1124.e18. doi: 10.1016/j.cell.2017.09.039. Epub 2017 Oct 12. PubMed

The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression.
Ghosh S, Wallerath C, Covarrubias S, Hornung V, Carpenter S, Fitzgerald KA.
J Immunol. 2017 Nov 1;199(9):3249-3260. doi: 10.4049/jimmunol.1700823. Epub 2017 Sep 20. PubMed

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.
Andreeva L, Hiller B, Kostrewa D, Lässig C, de Oliveira Mann CC, Jan Drexler D, Maiser A, Gaidt M, Leonhardt H, Hornung V, Hopfner KP.
Nature. 2017 Sep 21;549(7672):394-398. doi: 10.1038/nature23890. Epub 2017 Sep 13. PubMed

Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations.
Kim-Hellmuth S, Bechheim M, Pütz B, Mohammadi P, Nédélec Y, Giangreco N, Becker J, Kaiser V, Fricker N, Beier E, Boor P, Castel SE, Nöthen MM, Barreiro LB, Pickrell JK, Müller-Myhsok B, Lappalainen T, Schumacher J, Hornung V.
Nat Commun. 2017 Aug 16;8(1):266. doi: 10.1038/s41467-017-00366-1. PubMed

Corrigendum: SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.
Schneider C, Oellerich T, Baldauf HM, Schwarz SM, Thomas D, Flick R, Bohnenberger H, Kaderali L, Stegmann L, Cremer A, Martin M, Lohmeyer J, Michaelis M, Hornung V, Schliemann C, Berdel WE, Hartmann W, Wardelmann E, Comoglio F, Hansmann ML, Yakunin AF, Geisslinger G, et al.
Nat Med
. 2017 Jun 6;23(6):788. doi: 10.1038/nm0617-788a. No abstract available. PubMed

RIG-I Resists Hypoxia-Induced Immunosuppression and Dedifferentiation.
Engel C, Brügmann G, Lambing S, Mühlenbeck LH, Marx S, Hagen C, Horví¡th D, Goldeck M, Ludwig J, Herzner AM, Drijfhout JW, Wenzel D, Coch C, Tüting T, Schlee M, Hornung V, Hartmann G, Van den Boorn JG.
Cancer Immunol Res. 2017 Jun;5(6):455-467. doi: 10.1158/2326-6066.CIR-16-0129-T. Epub 2017 May 3. PubMed

Cyclic Dinucleotides in the Scope of the Mammalian Immune System.
Mankan AK, Müller M, Witte G, Hornung V.
Handb Exp Pharmacol
. 2017;238:269-289. doi: 10.1007/164_2016_5002. PubMed

Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina.
Karlstetter M, Kopatz J, Aslanidis A, Shahraz A, Caramoy A, Linnartz-Gerlach B, Lin Y, Lückoff A, Fauser S, Düker K, Claude J, Wang Y, Ackermann J, Schmidt T, Hornung V, Skerka C, Langmann T, Neumann H.
EMBO Mol Med
. 2017 Feb;9(2):154-166. doi: 10.15252/emmm.201606627. PubMed

SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.
Schneider C, Oellerich T, Baldauf HM, Schwarz SM, Thomas D, Flick R, Bohnenberger H, Kaderali L, Stegmann L, Cremer A, Martin M, Lohmeyer J, Michaelis M, Hornung V, Schliemann C, Berdel WE, Hartmann W, Wardelmann E, Comoglio F, Hansmann ML, Yakunin AF, Geisslinger G, et al.
Nat Med
. 2017 Feb;23(2):250-255. doi: 10.1038/nm.4255. Epub 2016 Dec 19. PubMed

Warfarin and vitamin K compete for binding to Phe55 in human VKOR.
Czogalla KJ, Biswas A, Höning K, Hornung V, Liphardt K, Watzka M, Oldenburg J.
Nat Struct Mol Biol
. 2017 Jan;24(1):77-85. doi: 10.1038/nsmb.3338. Epub 2016 Dec 12. PubMed

Alternative inflammasome activation enables IL-1β release from living cells. Gaidt MM, Hornung V.
Curr Opin Immunol
. 2017 Feb;44:7-13. doi: 10.1016/j.coi.2016.10.007. Epub 2016 Nov 11. Review. PubMed

The Second-Generation Exportin-1 Inhibitor KPT-8602 Demonstrates Potent Activity against Acute Lymphoblastic Leukemia.
Vercruysse T, De Bie J, Neggers JE, Jacquemyn M, Vanstreels E, Schmid-Burgk JL, Hornung V, Baloglu E, Landesman Y, Senapedis W, Shacham S, Dagklis A, Cools J, Daelemans D.
Clin Cancer Res
. 2017 May 15;23(10):2528-2541. doi: 10.1158/1078-0432.CCR-16-1580. Epub 2016 Oct 25. PubMed

Pore formation by GSDMD is the effector mechanism of pyroptosis.
Gaidt MM, Hornung V.
EMBO J
. 2016 Oct 17;35(20):2167-2169. Epub 2016 Aug 29. No abstract available. PubMed

STING Contributes to Abnormal Bone Formation Induced by Deficiency of DNase II in Mice.
Baum R, Sharma S, Organ JM, Jakobs C, Hornung V, Burr DB, Marshak-Rothstein A, Fitzgerald KA, Gravallese EM.
Arthritis Rheumatol
. 2017 Feb;69(2):460-471. doi: 10.1002/art.39863. PubMed

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2016

cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites.
Xu S, Ducroux A, Ponnurangam A, Vieyres G, Franz S, Müsken M, Zillinger T, Malassa A, Ewald E, Hornung V, Barchet W, Häussler S, Pietschmann T, Goffinet C.
Cell Host Microbe
. 2016 Oct 12;20(4):443-457. doi: 10.1016/j.chom.2016.09.003. PubMed

Aging-Associated TNF Production Primes Inflammasome Activation and NLRP3-Related Metabolic Disturbances.
Bauernfeind F, Niepmann S, Knolle PA, Hornung V.
J Immunol
. 2016 Oct 1;197(7):2900-8. doi: 10.4049/jimmunol.1501336. Epub 2016 Aug 26. PubMed

CRISPaint allows modular base-specific gene tagging using a ligase-4-dependent mechanism.
Schmid-Burgk JL, Höning K, Ebert TS, Hornung V.
Nat Commun
. 2016 Jul 28;7:12338. doi: 10.1038/ncomms12338. PubMed

Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production.
Andrade WA, Firon A, Schmidt T, Hornung V, Fitzgerald KA, Kurt-Jones EA, Trieu-Cuot P, Golenbock DT, Kaminski PA.
Cell Host Microbe
. 2016 Jul 13;20(1):49-59. doi: 10.1016/j.chom.2016.06.003. PubMed

Inflammasome-Dependent Induction of Adaptive NK Cell Memory.
van den Boorn JG, Jakobs C, Hagen C, Renn M, Luiten RM, Melief CJ, Tüting T, Garbi N, Hartmann G, Hornung V.
Immunity
. 2016 Jun 21;44(6):1406-21. doi: 10.1016/j.immuni.2016.05.008. Epub 2016 Jun 7. PubMed

Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4.
Andrade WA, Agarwal S, Mo S, Shaffer SA, Dillard JP, Schmidt T, Hornung V, Fitzgerald KA, Kurt-Jones EA, Golenbock DT.
Cell Rep
. 2016 Jun 14;15(11):2438-48. doi: 10.1016/j.celrep.2016.05.030. Epub 2016 Jun 2. PubMed

An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice.
Ludwig-Portugall I, Bartok E, Dhana E, Evers BD, Primiano MJ, Hall JP, Franklin BS, Knolle PA, Hornung V, Hartmann G, Boor P, Latz E, Kurts C.
Kidney Int
. 2016 Sep;90(3):525-39. doi: 10.1016/j.kint.2016.03.035. Epub 2016 Jun 2. PubMed

Measuring IL-1β Processing by Bioluminescence Sensors II: The iGLuc System.
Bartok E, Kampes M, Hornung V.
Methods Mol Biol
. 2016;1417:97-113. doi: 10.1007/978-1-4939-3566-6_6. PubMed

Cre-dependent DNA recombination activates a STING-dependent innate immune response.
Pépin G, Ferrand J, Höning K, Jayasekara WS, Cain JE, Behlke MA, Gough DJ, G Williams BR, Hornung V, Gantier MP.
Nucleic Acids Res
. 2016 Jun 20;44(11):5356-64. doi: 10.1093/nar/gkw405. Epub 2016 May 10. PubMed

Human plasmacytoid dentritic cells elicit a Type I Interferon response by sensing DNA via the cGAS-STING signaling pathway.
Bode C, Fox M, Tewary P, Steinhagen A, Ellerkmann RK, Klinman D, Baumgarten G, Hornung V, Steinhagen F.
Eur J Immunol
. 2016 Jul;46(7):1615-21. doi: 10.1002/eji.201546113. Epub 2016 May 27. PubMed

NSs Virulence Factor of Rift Valley Fever Virus Engages the F-Box Proteins FBXW11 and β-TRCP1 To Degrade the Antiviral Protein Kinase PKR. Kainulainen M, Lau S, Samuel CE, Hornung V, Weber F.
J Virol
. 2016 Jun 10;90(13):6140-7. doi: 10.1128/JVI.00016-16. Print 2016 Jul 1. PubMed

Recognition of Endogenous Nucleic Acids by the Innate Immune System.
Roers A, Hiller B, Hornung V.
Immunity. 2016 Apr 19;44(4):739-54. doi: 10.1016/j.immuni.2016.04.002. Review. PubMed

cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells. Paijo J, Döring M, Spanier J, Grabski E, Nooruzzaman M, Schmidt T, Witte G, Messerle M, Hornung V, Kaever V, Kalinke U.
PLoS Pathog. 2016 Apr 8;12(4):e1005546. doi: 10.1371/journal.ppat.1005546. eCollection 2016 Apr. PubMed

Human Monocytes Engage an Alternative Inflammasome Pathway.
Gaidt MM, Ebert TS, Chauhan D, Schmidt T, Schmid-Burgk JL, Rapino F, Robertson AA, Cooper MA, Graf T, Hornung V.
Immunity
. 2016 Apr 19;44(4):833-46. doi: 10.1016/j.immuni.2016.01.012. Epub 2016 Mar 29. PubMed

MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction.
Cuevas RA, Ghosh A, Wallerath C, Hornung V, Coyne CB, Sarkar SN.
J Immunol
. 2016 May 1;196(9):3877-86. doi: 10.4049/jimmunol.1501359. Epub 2016 Mar 25. PubMed

Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity. Krapp C, Hotter D, Gawanbacht A, McLaren PJ, Kluge SF, Stürzel CM, Mack K, Reith E, Engelhart S, Ciuffi A, Hornung V, Sauter D, Telenti A, Kirchhoff F.
Cell Host Microbe
. 2016 Apr 13;19(4):504-14. doi: 10.1016/j.chom.2016.02.019. Epub 2016 Mar 17. PubMed

Correction: ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.
Lässig C, Matheisl S, Sparrer KM, de Oliveira Mann CC, Moldt M, Patel JR, Goldeck M, Hartmann G, Garcí­a-Sastre A, Hornung V, Conzelmann KK, Beckmann R, Hopfner KP.
Elife
. 2016 Mar 2;5. pii: e14954. doi: 10.7554/eLife.14954. No abstract available. PubMed

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses.
Holm CK, Rahbek SH, Gad HH, Bak RO, Jakobsen MR, Jiang Z, Hansen AL, Jensen SK, Sun C, Thomsen MK, Laustsen A, Nielsen CG, Severinsen K, Xiong Y, Burdette DL, Hornung V, Lebbink RJ, Duch M, Fitzgerald KA, Bahrami S, Mikkelsen JG, Hartmann R, et al.
Nat Commun
. 2016 Feb 19;7:10680. doi: 10.1038/ncomms10680. PubMed

Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use.
Sun J, Li N, Oh KS, Dutta B, Vayttaden SJ, Lin B, Ebert TS, De Nardo D, Davis J, Bagirzadeh R, Lounsbury NW, Pasare C, Latz E, Hornung V, Fraser ID.
Sci Signal
. 2016 Jan 5;9(409):ra3. doi: 10.1126/scisignal.aab2191. PubMed

Phosphorylation of murine SAMHD1 regulates its antiretroviral activity.
Wittmann S, Behrendt R, Eissmann K, Volkmann B, Thomas D, Ebert T, Cribier A, Benkirane M, Hornung V, Bouzas NF, Gramberg T.
Retrovirology. 2015 Dec 15;12:103. doi: 10.1186/s12977-015-0229-6. PubMed

ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA. Lässig C, Matheisl S, Sparrer KM, de Oliveira Mann CC, Moldt M, Patel JR, Goldeck M, Hartmann G, Garcí­a-Sastre A, Hornung V, Conzelmann KK, Beckmann R, Hopfner KP.
Elife
. 2015 Nov 26;4. pii: e10859. doi: 10.7554/eLife.10859. Erratum in: Elife. 2016;5. pii: e14954. doi: 10.7554/eLife.14954. PubMed

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation.
Schmid-Burgk JL, Chauhan D, Schmidt T, Ebert TS, Reinhardt J, Endl E, Hornung V.
J Biol Chem
. 2016 Jan 1;291(1):103-9. doi: 10.1074/jbc.C115.700492. Epub 2015 Nov 9. PubMed

Human TLR8 senses UR/URR motifs in bacterial and mitochondrial RNA.
Krüger A, Oldenburg M, Chebrolu C, Beisser D, Kolter J, Sigmund AM, Steinmann J, Schäfer S, Hochrein H, Rahmann S, Wagner H, Henneke P, Hornung V, Buer J, Kirschning CJ.
EMBO Rep
. 2015 Dec;16(12):1656-63. doi: 10.15252/embr.201540861. Epub 2015 Nov 6. PubMed

MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment.
Riesenberg S, Groetchen A, Siddaway R, Bald T, Reinhardt J, Smorra D, Kohlmeyer J, Renn M, Phung B, Aymans P, Schmidt T, Hornung V, Davidson I, Goding CR, Jönsson G, Landsberg J, Tüting T, Hölzel M.
Nat Commun
. 2015 Nov 4;6:8755. doi: 10.1038/ncomms9755. PubMed

BrowserGenome.org: web-based RNA-seq data analysis and visualization.
Schmid-Burgk JL, Hornung V.
Nat Methods
. 2015 Nov;12(11):1001. doi: 10.1038/nmeth.3615.  PubMed

Synthesis of an arrayed sgRNA library targeting the human genome.
Schmidt T, Schmid-Burgk JL, Hornung V.
Sci Rep
. 2015 Oct 8;5:14987. doi: 10.1038/srep14987. PubMed

Designer Nuclease-Mediated Generation of Knockout THP1 Cells.
Schmidt T, Schmid-Burgk JL, Ebert TS, Gaidt MM, Hornung V.
Methods Mol Biol
. 2016;1338:261-72. doi: 10.1007/978-1-4939-2932-0_19. PubMed

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2015

Suppression of intratumoral CCL22 by type i interferon inhibits migration of regulatory T cells and blocks cancer progression.
Anz D, Rapp M, Eiber S, Koelzer VH, Thaler R, Haubner S, Knott M, Nagel S, Golic M, Wiedemann GM, Bauernfeind F, Wurzenberger C, Hornung V, Scholz C, Mayr D, Rothenfusser S, Endres S, Bourquin C.
Cancer Res
. 2015 Nov 1;75(21):4483-93. doi: 10.1158/0008-5472.CAN-14-3499. Epub 2015 Oct 2. PubMed

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA.
Herzner AM, Hagmann CA, Goldeck M, Wolter S, Kübler K, Wittmann S, Gramberg T, Andreeva L, Hopfner KP, Mertens C, Zillinger T, Jin T, Xiao TS, Bartok E, Coch C, Ackermann D, Hornung V, Ludwig J, Barchet W, Hartmann G, Schlee M.
Nat Immunol
. 2015 Oct;16(10):1025-33. doi: 10.1038/ni.3267. Epub 2015 Sep 7. PubMed

STING Signaling the enERGIC Way.
Hiller B, Hornung V.
Cell Host Microbe
. 2015 Aug 12;18(2):137-9. doi: 10.1016/j.chom.2015.07.014. PubMed

Functional IRF3 deficiency in a patient with herpes simplex encephalitis.
Andersen LL, Márk N, Reinert LS, Kofod-Olsen E, Narita R, Jôrgensen SE, Skipper KA, Höning K, Gad HH, Istergaard L, Irntoft TF, Hornung V, Paludan SR, Mikkelsen JG, Fujita T, Christiansen M, Hartmann R, Mogensen TH.
J Exp Med
. 2015 Aug 24;212(9):1371-9. doi: 10.1084/jem.20142274. Epub 2015 Jul 27. PubMed

A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA.
Schuberth-Wagner C, Ludwig J, Bruder AK, Herzner AM, Zillinger T, Goldeck M, Schmidt T, Schmid-Burgk JL, Kerber R, Wolter S, Stümpel JP, Roth A, Bartok E, Drosten C, Coch C, Hornung V, Barchet W, Kümmerer BM, Hartmann G, Schlee M.
Immunity
. 2015 Jul 21;43(1):41-51. doi: 10.1016/j.immuni.2015.06.015. Epub 2015 Jul 14. PubMed

Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells.
Schmid-Burgk JL, Gaidt MM, Schmidt T, Ebert TS, Bartok E, Hornung V.
Eur J Immunol
. 2015 Oct;45(10):2911-7. doi: 10.1002/eji.201545523. Epub 2015 Aug 6. PubMed

Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice.
Sester DP, Sagulenko V, Thygesen SJ, Cridland JA, Loi YS, Cridland SO, Masters SL, Genske U, Hornung V, Andoniou CE, Sweet MJ, Degli-Esposti MA, Schroder K, Stacey KJ.
J Immunol
. 2015 Aug 1;195(3):1233-41. doi: 10.4049/jimmunol.1402859. Epub 2015 Jun 26. PubMed

AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis.
Jakobs C, Perner S, Hornung V.
PLoS One
. 2015 Jun 26;10(6):e0131702. doi: 10.1371/journal.pone.0131702. eCollection 2015. PubMed

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1.
Wassermann R, Gulen MF, Sala C, Perin SG, Lou Y, Rybniker J, Schmid-Burgk JL, Schmidt T, Hornung V, Cole ST, Ablasser A.
Cell Host Microbe
. 2015 Jun 10;17(6):799-810. doi: 10.1016/j.chom.2015.05.003. Epub 2015 Jun 2. PubMed

Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling.
Ibsen MS, Gad HH, Andersen LL, Hornung V, Julkunen I, Sarkar SN, Hartmann R.
Nucleic Acids Res. 2015 May 26;43(10):5236-48. doi: 10.1093/nar/gkv389. Epub 2015 Apr 29. PubMed

ATP-dependent effector-like functions of RIG-I-like receptors.
Yao H, Dittmann M, Peisley A, Hoffmann HH, Gilmore RH, Schmidt T, Schmid-Burgk JL, Hornung V, Rice CM, Hur S.
Mol Cell
. 2015 May 7;58(3):541-8. doi: 10.1016/j.molcel.2015.03.014. Epub 2015 Apr 16. PubMed

Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference.
Barrangou R, Birmingham A, Wiemann S, Beijersbergen RL, Hornung V, Smith Av.
Nucleic Acids Res
. 2015 Apr 20;43(7):3407-19. doi: 10.1093/nar/gkv226. Epub 2015 Mar 23. Review. PubMed

Sox2 as a servant of two masters.
Mankan AK, Hornung V.
Nat Immunol
. 2015 Apr;16(4):335-6. doi: 10.1038/ni.3121. No abstract available. PubMed

Influenza virus adaptation PB2-627K modulates nucleocapsid inhibition by the pathogen sensor RIG-I.
Weber M, Sediri H, Felgenhauer U, Binzen I, Bänfer S, Jacob R, Brunotte L, Garcí­a-Sastre A, Schmid-Burgk JL, Schmidt T, Hornung V, Kochs G, Schwemmle M, Klenk HD, Weber F.
Cell Host Microbe
. 2015 Mar 11;17(3):309-19. doi: 10.1016/j.chom.2015.01.005. Epub 2015 Feb 19. PubMed

Extracorporeal photopheresis promotes IL-1β production.
Yakut E, Jakobs C, Peric A, Michel G, Baal N, Bein G, Brüne B, Hornung V, Hackstein H.
J Immunol
. 2015 Mar 15;194(6):2569-77. doi: 10.4049/jimmunol.1400694. Epub 2015 Feb 13. PubMed

Control of hepatitis C virus replication in mouse liver-derived cells by MAVS-dependent production of type I and type III interferons.
Anggakusuma, Frentzen A, Gürlevik E, Yuan Q, Steinmann E, Ott M, Staeheli P, Schmid-Burgk J, Schmidt T, Hornung V, Kuehnel F, Pietschmann T.
J Virol
. 2015 Apr;89(7):3833-45. doi: 10.1128/JVI.03129-14. Epub 2015 Jan 21. PubMed

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2014

SnapShot: Nucleic acid immune sensors, part 2.
Hornung V.
Immunity
, 2014; 41: 1066-1066 e1061. PubMed

SnapShot: nucleic acid immune sensors, part 1.
Hornung V.
 
Immunity
, 2014; 41: 868, 868 e861. PubMed

Cytosolic RNA:DNA hybrids activate the cGAS-STING axis.
Mankan AK, Schmidt T, Chauhan D, Goldeck M, Höning K, Gaidt M, Kubarenko AV, Andreeva L, Hopfner KP, Hornung V.
EMBO J
. 2014 Dec 17;33(24):2937-46. doi: 10.15252/embj.201488726. Epub 2014 Nov 25. PubMed

Ligation-independent cloning (LIC) assembly of TALEN genes.
Schmid-Burgk JL, Schmidt T, Hornung V.
Methods Mol Biol
. 2015;1239:161-9. doi: 10.1007/978-1-4939-1862-1_8. PubMed

Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes.
Kim S, Becker J, Bechheim M, Kaiser V, Noursadeghi M, Fricker N, Beier E, Klaschik S, Boor P, Hess T, Hofmann A, Holdenrieder S, Wendland JR, Fröhlich H, Hartmann G, Nöthen MM, Müller-Myhsok B, Pütz B, Hornung V, Schumacher J.
Nat Commun
. 2014 Oct 20;5:5236. doi: 10.1038/ncomms6236. PubMed

Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms.
Pelka K, Phulphagar K, Zimmermann J, Stahl R, Schmid-Burgk JL, Schmidt T, Spille JH, Labzin LI, Agrawal S, Kandimalla ER, Casanova JL, Hornung V, Marshak-Rothstein A, Höning S, Latz E.
J Immunol
. 2014 Oct 1;193(7):3257-61. doi: 10.4049/jimmunol.1301886. Epub 2014 Sep 3. PubMed

OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell lines.
Schmid-Burgk JL, Schmidt T, Gaidt MM, Pelka K, Latz E, Ebert TS, Hornung V.
Genome Res
. 2014 Oct;24(10):1719-23. doi: 10.1101/gr.176701.114. Epub 2014 Sep 3. PubMed

OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids.
Hornung V
, Hartmann R, Ablasser A, Hopfner KP.
Nat Rev Immunol
. 2014 Aug;14(8):521-8. doi: 10.1038/nri3719. Epub 2014 Jul 18. Review. PubMed

Enzymatic synthesis and purification of a defined RIG-I ligand.
Goldeck M, Schlee M, Hartmann G, Hornung V.
Methods Mol Biol
. 2014;1169:15-25. doi: 10.1007/978-1-4939-0882-0_2. PubMed

Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor.
Zhu J, Zhang Y, Ghosh A, Cuevas RA, Forero A, Dhar J, Ibsen MS, Schmid-Burgk JL, Schmidt T, Ganapathiraju MK, Fujita T, Hartmann R, Barik S, Hornung V, Coyne CB, Sarkar SN.
Immunity
. 2014 Jun 19;40(6):936-48. doi: 10.1016/j.immuni.2014.05.007. Epub 2014 Jun 12. PubMed

TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner.
Ablasser A, Hemmerling I, Schmid-Burgk JL, Behrendt R, Roers A, Hornung V.
J Immunol
. 2014 Jun 15;192(12):5993-7. doi: 10.4049/jimmunol.1400737. Epub 2014 May 9. PubMed

Self-priming determines high type I IFN production by plasmacytoid dendritic cells.
Kim S, Kaiser V, Beier E, Bechheim M, Guenthner-Biller M, Ablasser A, Berger M, Endres S, Hartmann G, Hornung V.
Eur J Immunol
. 2014 Mar;44(3):807-18. doi: 10.1002/eji.201343806. Epub 2014 Jan 16. PubMed

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.
Ablasser A, Schmid-Burgk JL, Hemmerling I, Horvath GL, Schmidt T, Latz E, Hornung V.
Nature
. 2013 Nov 28;503(7477):530-4. doi: 10.1038/nature12640. Epub 2013 Sep 29. PubMed

Postoperative ileus involves interleukin-1 receptor signaling in enteric glia.
Stoffels B, Hupa KJ, Snoek SA, van Bree S, Stein K, Schwandt T, Vilz TO, Lysson M, Veer CV, Kummer MP, Hornung V, Kalff JC, de Jonge WJ, Wehner S.
Gastroenterology
. 2014 Jan;146(1):176-87.e1. doi: 10.1053/j.gastro.2013.09.030. Epub 2013 Sep 22. PubMed

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2013

Immunoblotting for active caspase-1.
Jakobs C, Bartok E, Kubarenko A, Bauernfeind F, Hornung V.
Methods Mol Biol
. 2013;1040:103-15. doi: 10.1007/978-1-62703-523-1_9. PubMed

Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation.
Yin Q, Sester DP, Tian Y, Hsiao YS, Lu A, Cridland JA, Sagulenko V, Thygesen SJ, Choubey D, Hornung V, Walz T, Stacey KJ, Wu H.
Cell Rep
. 2013 Jul 25;4(2):327-39. doi: 10.1016/j.celrep.2013.06.024. Epub 2013 Jul 11. PubMed

Structural mechanism of cytosolic DNA sensing by cGAS.
Civril F, Deimling T, de Oliveira Mann CC, Ablasser A, Moldt M, Witte G, Hornung V, Hopfner KP.
Nature
. 2013 Jun 20;498(7454):332-7. doi: 10.1038/nature12305. Epub 2013 May 30. PubMed

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.
Ablasser A, Goldeck M, Cavlar T, Deimling T, Witte G, Röhl I, Hopfner KP, Ludwig J, Hornung V.
Nature
. 2013 Jun 20;498(7454):380-4. doi: 10.1038/nature12306. Epub 2013 May 30. PubMed

Of inflammasomes and pathogens--sensing of microbes by the inflammasome.
Bauernfeind F, Hornung V.
EMBO Mol Med
. 2013 Jun;5(6):814-26. doi: 10.1002/emmm.201201771. Epub 2013 May 13. Review. PubMed

RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells. Hagmann CA, Herzner AM, Abdullah Z, Zillinger T, Jakobs C, Schuberth C, Coch C, Higgins PG, Wisplinghoff H, Barchet W, Hornung V, Hartmann G, Schlee M.
PLoS One
. 2013 Apr 30;8(4):e62872. doi: 10.1371/journal.pone.0062872. Print 2013. PubMed

Species-specific detection of the antiviral small-molecule compound CMA by STING.
Cavlar T, Deimling T, Ablasser A, Hopfner KP, Hornung V.
EMBO J
. 2013 May 15;32(10):1440-50. doi: 10.1038/emboj.2013.86. Epub 2013 Apr 19. PubMed

Nucleic acid driven sterile inflammation.
Ablasser A, Hertrich C, Waßermann R, Hornung V.
Clin Immunol
. 2013 Jun;147(3):207-15. doi: 10.1016/j.clim.2013.01.003. Epub 2013 Jan 19. Review. PubMed

DNA sensing unchained.
Ablasser A, Hornung V.
Cell Res
. 2013 May;23(5):585-7. doi: 10.1038/cr.2013.28. Epub 2013 Feb 19. PubMed

iGLuc: a luciferase-based inflammasome and protease activity reporter.
Bartok E, Bauernfeind F, Khaminets MG, Jakobs C, Monks B, Fitzgerald KA, Latz E, Hornung V.
Nat Methods
. 2013 Feb;10(2):147-54. doi: 10.1038/nmeth.2327. Epub 2013 Jan 6. PubMed

A ligation-independent cloning technique for high-throughput assembly of transcription activator-like effector genes.
Schmid-Burgk JL, Schmidt T, Kaiser V, Höning K, Hornung V.
Nat Biotechnol
. 2013 Jan;31(1):76-81. PubMed

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2012

Retroviral danger from within: TLR7 is in control.
Mankan AK, Hornung V.
Immunity. 2012 Nov 16;37(5):763-6. doi: 10.1016/j.immuni.2012.10.009. PubMed 


NLRP3 inflammasome activity is negatively controlled by miR-223.
Bauernfeind F, Rieger A, Schildberg FA, Knolle PA, Schmid-Burgk JL, Hornung V.
J Immunol. 2012 Oct 15;189(8):4175-81. doi: 10.4049/jimmunol.1201516. Epub 2012 Sep 14. PubMed 

Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.
Jin T, Perry A, Jiang J, Smith P, Curry JA, Unterholzner L, Jiang Z, Horvath G, Rathinam VA, Johnstone RW, Hornung V, Latz E, Bowie AG, Fitzgerald KA, Xiao TS.
Immunity. 2012 Apr 20;36(4):561-71. doi: 10.1016/j.immuni.2012.02.014. Epub 2012 Apr 5. PubMed 

Induction of type I IFNs by intracellular DNA-sensing pathways.
Cavlar T, Ablasser A, Hornung V.
Immunol Cell Biol. 2012 May;90(5):474-82. doi: 10.1038/icb.2012.11. Epub 2012 Mar 27. Review. PubMed

The NLRP3/ASC/Caspase-1 axis regulates IL-1β processing in neutrophils.
Mankan AK, Dau T, Jenne D, Hornung V.
Eur J Immunol. 2012 Mar;42(3):710-5. doi: 10.1002/eji.201141921. Epub 2012 Jan 19. PubMed

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2011

Critical role of nucleotide-binding oligomerization domain-like receptor 3 in vascular repair.
Schlaweck S, Zimmer S, Struck R, Bartok E, Werner N, Bauernfeind F, Latz E, Nickenig G, Hornung V, Ghanem A.
Biochem Biophys Res Commun
. 2011 Aug 5;411(3):627-31. doi: 10.1016/j.bbrc.2011.07.006. Epub 2011 Jul 13. PubMed

Where, in antiviral defense, does IFIT1 fit?
Ablasser A, Hornung V.
Nat Immunol. 2011 Jun 20;12(7):588-90. doi: 10.1038/ni.2061. No abstract available. PubMed

Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome.
Bauernfeind F, Bartok E, Rieger A, Franchi L, Núñez G, Hornung V.
J Immunol
. 2011 Jul 15;187(2):613-7. doi: 10.4049/jimmunol.1100613. Epub 2011 Jun 15. PubMed

Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions.
Dombrowski Y, Peric M, Koglin S, Kammerbauer C, Göss C, Anz D, Simanski M, Gläser R, Harder J, Hornung V, Gallo RL, Ruzicka T, Besch R, Schauber J.
Sci Transl Med
. 2011 May 11;3(82):82ra38. doi: 10.1126/scitranslmed.3002001. PubMed

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2010

An unexpected role for RNA in the recognition of DNA by the innate immune system. Bauernfeind F, Ablasser A, Kim S, Bartok E, Hornung V.
RNA Biol. 2010 Mar-Apr;7(2):151-7. Epub 2010 Mar 28. Review. PubMed

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.
Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nunez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E.
Nature. 2010 Apr 29;464(7293):1357-61. doi: 10.1038/nature08938. Erratum in: Nature. 2010 Jul 29;466(7306):652. PubMed

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.
Rathinam VA, Jiang Z, Waggoner SN, Sharma S, Cole LE, Waggoner L, Vanaja SK, Monks BG, Ganesan S, Latz E, Hornung V, Vogel SN, Szomolanyi-Tsuda E, Fitzgerald KA.
Nat Immunol. 2010 May;11(5):395-402. doi: 10.1038/ni.1864. Epub 2010 Mar 28. PubMed

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome.
Kim S, Bauernfeind F, Ablasser A, Hartmann G, Fitzgerald KA, Latz E, Hornung V.
Eur J Immunol. 2010 Jun;40(6):1545-51. doi: 10.1002/eji.201040425. PubMed

Critical functions of priming and lysosomal damage for NLRP3 activation.
Hornung V, Latz E.
Eur J Immunol. 2010 Mar;40(3):620-3. doi: 10.1002/eji.200940185. Review. PubMed

Intracellular DNA recognition.
Hornung V, Latz E.
Nat Rev Immunol. 2010 Feb;10(2):123-30. doi: 10.1038/nri2690. Review. PubMed 

Immunostimulatory RNA blocks suppression by regulatory T cells.
Anz D, Koelzer VH, Moder S, Thaler R, Schwerd T, Lahl K, Sparwasser T, Besch R, Poeck H, Hornung V, Hartmann G, Rothenfusser S, Bourquin C, Endres S.
J Immunol. 2010 Jan 15;184(2):939-46. doi: 10.4049/jimmunol.0901245. Epub 2009 Dec 4. PubMed

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production.
Poeck H, Bscheider M, Gross O, Finger K, Roth S, Rebsamen M, Hannesschläger N, Schlee M, Rothenfusser S, Barchet W, Kato H, Akira S, Inoue S, Endres S, Peschel C, Hartmann G, Hornung V, Ruland J.
Nat Immunol. 2010 Jan;11(1):63-9. doi: 10.1038/ni.1824. Epub 2009 Nov 15. Erratum in: Nat Immunol. 2014 Jan;15(1):109. PubMed

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2009

Immunostimulatory RNA oligonucleotides induce an effective antitumoral NK cell response through the TLR7.
Bourquin C, Schmidt L, Lanz AL, Storch B, Wurzenberger C, Anz D, Sandholzer N, Mocikat R, Berger M, Poeck H, Hartmann G, Hornung V, Endres S.
J Immunol. 2009 Nov 15;183(10):6078-86. doi: 10.4049/jimmunol.0901594. PubMed

TLR2 joins the interferon gang.
Bauernfeind F, Hornung V.
Nat Immunol. 2009 Nov;10(11):1139-41. doi: 10.1038/ni1109-1139. PubMed

Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells.
Besch R, Poeck H, Hohenauer T, Senft D, Häcker G, Berking C, Hornung V, Endres S, Ruzicka T, Rothenfusser S, Hartmann G.
J Clin Invest. 2009 Aug;119(8):2399-411. doi: 10.1172/JCI37155. Epub 2009 Jul 20. PubMed

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate.
Ablasser A, Bauernfeind F, Hartmann G, Latz E, Fitzgerald KA, Hornung V.
Nat Immunol. 2009 Oct;10(10):1065-72. doi: 10.1038/ni.1779. Epub 2009 Jul 16. PubMed

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.
Schlee M, Roth A, Hornung V, Hagmann CA, Wimmenauer V, Barchet W, Coch C, Janke M, Mihailovic A, Wardle G, Juranek S, Kato H, Kawai T, Poeck H, Fitzgerald KA, Takeuchi O, Akira S, Tuschl T, Latz E, Ludwig J, Hartmann G.
Immunity. 2009 Jul 17;31(1):25-34. doi: 10.1016/j.immuni.2009.05.008. Epub 2009 Jul 2. PubMed 

Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, Speert D, Fernandes-Alnemri T, Wu J, Monks BG, Fitzgerald KA, Hornung V, Latz E.
J Immunol. 2009 Jul 15;183(2):787-91. doi: 10.4049/jimmunol.0901363. Epub 2009 Jul 1. PubMed

Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes.
Ablasser A, Poeck H, Anz D, Berger M, Schlee M, Kim S, Bourquin C, Goutagny N, Jiang Z, Fitzgerald KA, Rothenfusser S, Endres S, Hartmann G, Hornung V.
J Immunol. 2009 Jun 1;182(11):6824-33. doi: 10.4049/jimmunol.0803001. PubMed 

TLR8-driven IL-12-dependent reciprocal and synergistic activation of NK cells and monocytes by immunostimulatory RNA.
Berger M, Ablasser A, Kim S, Bekeredjian-Ding I, Giese T, Endres S, Hornung V, Hartmann G.
J Immunother. 2009 Apr;32(3):262-71. doi: 10.1097/CJI.0b013e318198bd2a. PubMed 

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.
Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey DR, Latz E, Fitzgerald KA.
Nature. 2009 Mar 26;458(7237):514-8. doi: 10.1038/nature07725. Epub 2009 Jan 21. PubMed

Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif.
Lichtnekert J, Vielhauer V, Zecher D, Kulkarni OP, Clauss S, Segerer S, Hornung V, Mayadas TN, Beutler B, Akira S, Anders HJ.
Am J Physiol Renal Physiol. 2009 Apr;296(4):F867-74. doi: 10.1152/ajprenal.90213.2008. Epub 2009 Jan 21. PubMed

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2008

Viral 5'-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses.
Allam R, Pawar RD, Kulkarni OP, Hornung V, Hartmann G, Segerer S, Akira S, Endres S, Anders HJ.
Eur J Immunol. 2008 Dec;38(12):3487-98. doi: 10.1002/eji.200838604. PubMed 

5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma.
Poeck H, Besch R, Maihoefer C, Renn M, Tormo D, Morskaya SS, Kirschnek S, Hornung V, Gaffal E, Landsberg J, Hellmuth J, Schmidt A, Anz D, Bscheider M, Schwerd T, Berking C, Bourquin C, Kalinke U, Kremmer E, Kato H, Akira S, Meyers R, Häcker G, et al.
Nat Med. 2008 Nov;14(11):1256-63. doi: 10.1038/nm.1887. Epub 2008 Nov 2. PubMed

Superior immunogenicity of inactivated whole virus H5N1 influenza vaccine is primarily controlled by Toll-like receptor signalling.
Geeraedts F, Goutagny N, Hornung V, Severa M, de Haan A, Pool J, Wilschut J, Fitzgerald KA, Huckriede A.
PLoS Pathog. 2008 Aug 29;4(8):e1000138. doi: 10.1371/journal.ppat.1000138. PubMed

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.
Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E.
Nat Immunol. 2008 Aug;9(8):847-56. doi: 10.1038/ni.1631. Epub 2008 Jul 11. PubMed 

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Hornung V, Reinheckel T, Fitzgerald KA, Latz E, Moore KJ, Golenbock DT.
Nat Immunol. 2008 Aug;9(8):857-65. doi: 10.1038/ni.1636. Epub 2008 Jul 11. PubMed

RNA recognition via TLR7 and TLR8.
Hornung V, Barchet W, Schlee M, Hartmann G.
Handb Exp Pharmacol. 2008;(183):71-86. Review. PubMed

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2007

A mammalian microRNA expression atlas based on small RNA library sequencing.
Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Müller RU, Schermer B, Bissels U, Hornung V et al.
Cell. 2007 Jun 29;129(7):1401-14. PubMed 

Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response.
Bourquin C, Schmidt L, Hornung V, Wurzenberger C, Anz D, Sandholzer N, Schreiber S, Voelkl A, Hartmann G, Endres S.
Blood. 2007 Apr 1;109(7):2953-60. PubMed

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2006

5'-Triphosphate RNA is the ligand for RIG-I.
Hornung V, Ellegast J, Kim S, Brzozka K, Jung A, Kato H, Poeck H, Akira S, Conzelmann KK, Schlee M, Endres S, Hartmann G.
Science. 2006 Nov 10;314(5801):994-7. Epub 2006 Oct 12. PubMed 

siRNA and isRNA: two edges of one sword.
Schlee M, Hornung V, Hartmann G.
Mol Ther. 2006 Oct;14(4):463-70. Epub 2006 Jul 31. Review. PubMed 

T cell-independent, TLR-induced IL-12p70 production in primary human monocytes.
Bekeredjian-Ding I, Roth SI, Gilles S, Giese T, Ablasser A, Hornung V, Endres S, Hartmann G.
J Immunol. 2006 Jun 15;176(12):7438-46. PubMed

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2005

CpG ODN enhance antigen-specific NKT cell activation via plasmacytoid dendritic cells.
Marschner A, Rothenfusser S, Hornung V, Prell D, Krug A, Kerkmann M, Wellisch D, Poeck H, Greinacher A, Giese T, Endres S, Hartmann G.
Eur J Immunol. 2005 Aug;35(8):2347-57. PubMed 

Inhibition of toll-like receptor 7- and 9-mediated alpha/beta interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virus.
Schlender J, Hornung V, Finke S, Günthner-Biller M, Marozin S, Brzozka K, Moghim S, Endres S, Hartmann G, Conzelmann KK.
J Virol. 2005 May;79(9):5507-15. PubMed

Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN.
Bekeredjian-Ding IB, Wagner M, Hornung V, Giese T, Schnurr M, Endres S, Hartmann G.
J Immunol. 2005 Apr 1;174(7):4043-50. Erratum in: J Immunol. 2005 May 1;174(9):5884. Berkeredjian-Ding, Isabelle Beatrice [corrected to Bekeredjian-Ding, Isabelle Beatrice]. PubMed 

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7.
Hornung V, Guenthner-Biller M, Bourquin C, Ablasser A, Schlee M, Uematsu S, Noronha A, Manoharan M, Akira S, de Fougerolles A, Endres S, Hartmann G.
Nat Med. 2005 Mar;11(3):263-70. Epub 2005 Feb 20. PubMed 

Spontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-alpha induction by CpG-A in plasmacytoid dendritic cells.
Kerkmann M, Costa LT, Richter C, Rothenfusser S, Battiany J, Hornung V, Johnson J, Englert S, Ketterer T, Heckl W, Thalhammer S, Endres S, Hartmann G.
J Biol Chem. 2005 Mar 4;280(9):8086-93. Epub 2004 Dec 8. PubMed

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2004

Replication-dependent potent IFN-alpha induction in human plasmacytoid dendritic cells by a single-stranded RNA virus.
Hornung V
, Schlender J, Guenthner-Biller M, Rothenfusser S, Endres S, Conzelmann KK, Hartmann G.
J Immunol. 2004 Nov 15;173(10):5935-43. PubMed

Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help.
Poeck H, Wagner M, Battiany J, Rothenfusser S, Wellisch D, Hornung V, Jahrsdorfer B, Giese T, Endres S, Hartmann G.
Blood
. 2004 Apr 15;103(8):3058-64. Epub 2003 Dec 30. PubMed 

CpG-A and CpG-B oligonucleotides differentially enhance human peptide-specific primary and memory CD8+ T-cell responses in vitro.
Rothenfusser S, Hornung V, Ayyoub M, Britsch S, Towarowski A, Krug A, Sarris A, Lubenow N, Speiser D, Endres S, Hartmann G.
Blood. 2004 Mar 15;103(6):2162-9. Epub 2003 Nov 20. PubMed 

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2003

Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells.
Kerkmann M, Rothenfusser S, Hornung V, Towarowski A, Wagner M, Sarris A, Giese T, Endres S and Hartmann G. 
J Immunol. 2003; 170: 4465-4474. PubMed

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2002

Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides.
Hornung V, Rothenfusser S, Britsch S, Krug A, Jahrsdorfer B, Giese T, Endres S and Hartmann G.
J Immunol, 2002; 168: 4531-4537. PubMed

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2001

Distinct CpG oligonucleotide sequences activate human gamma delta T cells via interferon-alpha/-beta.
Rothenfusser S, Hornung V, Krug A, Towarowski A, Krieg A M, Endres S and Hartmann G. 
Eur J Immunol, 2001; 31: 3525-3534. PubMed

Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12.
Krug A, Towarowski A, Britsch S, Rothenfusser S, Hornung V, Bals R, Giese T, Engelmann H, Endres S, Krieg A M and Hartmann G.
Eur J Immunol, 2001; 31: 3026-3037. PubMed

Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells.
Krug A, Rothenfusser S, Hornung V, Jahrsdorfer B, Blackwell S, Ballas Z K, Endres S, Krieg A M and Hartmann G.
Eur J Immunol, 2001; 31: 2154-2163. PubMed