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Keppler Lab - Publications

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2018




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2017

Corrigendum: SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.
Schneider C, Oellerich T, Baldauf HM, Schwarz SM, Thomas D, Flick R, Bohnenberger H, Kaderali L, Stegmann L, Cremer A, Martin M, Lohmeyer J, Michaelis M, Hornung V, Schliemann C, Berdel WE, Keppler OT, Hartmann W, Wardelmann E, Comoglio F, Hansmann ML, Yakunin AF, Geisslinger G, et al.
Nat Med
. 2017 Jun 6;23(6):788. doi: 10.1038/nm0617-788a. No abstract available. PubMed

Retrospective analysis of clinical and virological parameters of influenza cases at four university hospitals in Germany, 2015.
Heyd R, Eis-Hübinger AM, Berger A, Bierbaum S, Pietzonka S, Wenzel JJ, Huzly D, Keppler OT, Panning M.
Infection
. 2017 Jun;45(3):349-354. doi: 10.1007/s15010-017-1008-1. Epub 2017 Mar 18. PubMed

Elevated prevalence of multidrug-resistant gram-negative organisms in HIV positive men.
Reinheimer C, Keppler OT, Stephan C, Wichelhaus TA, Friedrichs I, Kempf VA.
BMC Infect Dis
. 2017 Mar 13;17(1):206. doi: 10.1186/s12879-017-2286-z. PubMed

HCV RNA Testing of Plasma Samples from Cornea Donors: Suitability of Plasma Samples Stored at 4 °C for up to 8 Days. Berger A, Salla S, Keppler OT, Rabenau HF.
Transfus Med Hemother
. 2017 Jan;44(1):39-44. doi: 10.1159/000449207. Epub 2016 Nov 4. PubMed

Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.
Baldauf HM, Stegmann L, Schwarz SM, Ambiel I, Trotard M, Martin M, Burggraf M, Lenzi GM, Lejk H, Pan X, Fregoso OI, Lim ES, Abraham L, Nguyen LA, Rutsch F, König R, Kim B, Emerman M, Fackler OT, Keppler OT.
Proc Natl Acad Sci U S A
. 2017 Mar 7;114(10):2729-2734. doi: 10.1073https://www.ncbi.nlm.nih.gov/pnas.1613635114. Epub 2017 Feb 22. PubMed

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2016

SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.
Schneider C, Oellerich T, Baldauf HM, Schwarz SM, Thomas D, Flick R, Bohnenberger H, Kaderali L, Stegmann L, Cremer A, Martin M, Lohmeyer J, Michaelis M, Hornung V, Schliemann C, Berdel WE, Hartmann W, Keppler OT, Wardelmann E, Comoglio F, Hansmann ML, Yakunin AF, Geisslinger G, et al. Nat Med. 2017 Feb;23(2):250-255. doi: 10.1038/nm.4255. Epub 2016 Dec 19. PubMed

Complex Interplay between HIV-1 Capsid and MX2-Independent Alpha Interferon-Induced Antiviral Factors.
Bulli L, Apolonia L, Kutzner J, Pollpeter D, Goujon C, Herold N, Schwarz SM, Giernat Y, Keppler OT, Malim MH, Schaller T.
J Virol
. 2016 Jul 27;90(16):7469-80. doi: 10.1128/JVI.00458-16. Print 2016 Aug 15. PubMed

HIV-1 Vpu Antagonizes CD317/Tetherin by Adaptor Protein-1-Mediated Exclusion from Virus Assembly Sites.
Pujol FM, Laketa V, Schmidt F, Mukenhirn M, Müller B, Boulant S, Grimm D, Keppler OT, Fackler OT.
J Virol
. 2016 Jul 11;90(15):6709-23. doi: 10.1128/JVI.00504-16. Print 2016 Aug 1. PubMed

Evolutionary study of leporid CD4 reveals a hotspot of genetic variability within the D2 domain.
de Sousa-Pereira P, Abrantes J, Baldauf HM, Keppler OT, Esteves PJ.
Immunogenetics
. 2016 Jul;68(6-7):477-82. doi: 10.1007/s00251-016-0909-y. Epub 2016 Mar 15. PubMed

Prevalence of K65R in patients treated with tenofovir disoproxil fumarate: recommendations based on the Frankfurt HIV Cohort Study Resistance Database (FHCS-RD).
Reinheimer C, Wesner A, Keppler OT, Doerr HW, Herrmann E, Stürmer M, Stephan C.
Med Microbiol Immunol
. 2016 Aug;205(4):315-20. doi: 10.1007/s00430-015-0448-4. Epub 2016 Jan 8. PubMed

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2015

No SEVI-mediated enhancement of rectal HIV-1 transmission of HIV-1 in two humanized mouse cohorts.
Van Dis ES, Moore TC, Lavender KJ, Messer RJ, Keppler OT, Verheyen J, Dittmer U, Hasenkrug KJ.
Virology
. 2016 Jan 15;488:88-95. doi: 10.1016/j.virol.2015.11.005. Epub 2015 Nov 21. PubMed

Mouse Siglec-1 Mediates trans-Infection of Surface-bound Murine Leukemia Virus in a Sialic Acid N-Acyl Side Chain-dependent Manner.
Erikson E, Wratil PR, Frank M, Ambiel I, Pahnke K, Pino M, Azadi P, Izquierdo-Useros N, Martinez-Picado J, Meier C, Schnaar RL, Crocker PR, Reutter W, Keppler OT.
J Biol Chem
. 2015 Nov 6;290(45):27345-59. doi: 10.1074/jbc.M115.681338. Epub 2015 Sep 14. PubMed

Vpx mediated degradation of SAMHD1 has only a very limited effect on lentiviral transduction rate in ex vivo cultured HSPCs.
Li D, Schlaepfer E, Audigé A, Rochat MA, Ivic S, Knowlton CN, Kim B, Keppler OT, Speck RF.
Stem Cell Res
. 2015 Sep;15(2):271-80. doi: 10.1016/j.scr.2015.06.012. Epub 2015 Jul 3. PubMed

Complement-Opsonized HIV-1 Overcomes Restriction in Dendritic Cells.
Posch W, Steger M, Knackmuss U, Blatzer M, Baldauf HM, Doppler W, White TE, Hörtnagl P, Diaz-Griffero F, Lass-Flörl C, Hackl H, Moris A, Keppler OT, Wilflingseder D.
PLoS Pathog
. 2015 Jun 29;11(6):e1005005. doi: 10.1371/journal.ppat.1005005. eCollection 2015 Jun. PubMed

Management of Microbiological Samples in a Confirmed Case of Ebola Virus Disease: Constraints and Limitations.
Hogardt M, Wolf T, Kann G, Brodt HR, Brandt C, Keppler OT, Wicker S, Zacharowski K, Gottschalk R, Becker S, Kempf VA.
J Clin Microbiol. 2015 Nov;53(11):3396-400. doi: 10.1128/JCM.01142-15. Epub 2015 Jun 24. PubMed

HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells.
Pino M, Erkizia I, Benet S, Erikson E, Fernández-Figueras MT, Guerrero D, Dalmau J, Ouchi D, Rausell A, Ciuffi A, Keppler OT, Telenti A, Kräusslich HG, Martinez-Picado J, Izquierdo-Useros N.
Retrovirology
. 2015 May 7;12:37. doi: 10.1186/s12977-015-0160-x. PubMed

Quantitation of endogenous nucleoside triphosphates and nucleosides in human cells by liquid chromatography tandem mass spectrometry.
Thomas D, Herold N, Keppler OT, Geisslinger G, Ferreirós N.
Anal Bioanal Chem
. 2015 May;407(13):3693-704. doi: 10.1007/s00216-015-8588-3. Epub 2015 Mar 8. PubMed

SAMHD1's protein expression profile in humans.
Schmidt S, Schenkova K, Adam T, Erikson E, Lehmann-Koch J, Sertel S, Verhasselt B, Fackler OT, Lasitschka F, Keppler OT.
J Leukoc Biol
. 2015 Jul;98(1):5-14. doi: 10.1189/jlb.4HI0714-338RR. Epub 2015 Feb 2. PubMed

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2014

Severe Ebola virus disease with vascular leakage and multiorgan failure: treatment of a patient in intensive care.
Wolf T, Kann G, Becker S, Stephan C, Brodt HR, de Leuw P, Grünewald T, Vogl T, Kempf VA, Keppler OT, Zacharowski K.
Lancet
. 2015 Apr 11;385(9976):1428-35. doi: 10.1016/S0140-6736(14)62384-9. Epub 2014 Dec 19. PubMed

HIV-1 Nef and Vpu are functionally redundant broad-spectrum modulators of cell surface receptors, including tetraspanins.
Haller C, Müller B, Fritz JV, Lamas-Murua M, Stolp B, Pujol FM, Keppler OT, Fackler OT.
J Virol. 2014 Dec;88(24):14241-57. doi: 10.1128/JVI.02333-14. Epub 2014 Oct 1. PubMed

Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells.
Pauls E, Ruiz A, Badia R, Permanyer M, Gubern A, Riveira-Muñoz E, Torres-Torronteras J, Alvarez M, Mothe B, Brander C, Crespo M, Menéndez-Arias L, Clotet B, Keppler OT, Martá­ R, Posas F, Ballana E, Esté JA.
J Immunol. 2014 Aug 15;193(4):1988-97. doi: 10.4049/jimmunol.1400873. Epub 2014 Jul 11. PubMed

Impact of raltegravir on HIV-1 RNA and DNA forms following initiation of antiretroviral therapy in treatment-naive patients.
Stephan C, Baldauf HM, Barry J, Giordano FA, Bartholomae CC, Haberl A, Bickel M, Schmidt M, Laufs S, Kaderali L, Keppler OT.
J Antimicrob Chemother.
2014 Oct;69(10):2809-18. doi: 10.1093/jac/dku213. Epub 2014 Jun 23. PubMed

Differential loss of humoral immunity against measles, mumps, rubella and varicella-zoster virus in children treated for cancer.
Bochennek K, Allwinn R, Langer R, Becker M, Keppler OT, Klingebiel T, Lehrnbecher T.
Vaccine
. 2014 Jun 5;32(27):3357-61. doi: 10.1016/j.vaccine.2014.04.042. Epub 2014 Apr 29. PubMed

p21 regulates the HIV-1 restriction factor SAMHD1.
Pauls E, Ruiz A, Riveira-Muñoz E, Permanyer M, Badia R, Clotet B, Keppler OT, Ballana E, Este JA.
Proc Natl Acad Sci U S A
. 2014 Apr 8;111(14):E1322-4. doi: 10.1073https://www.ncbi.nlm.nih.gov/pnas.1322059111. Epub 2014 Mar 7. No abstract available. PubMed

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2013

MxB/Mx2: the latest piece in HIV's interferon puzzle.
Fackler OT, Keppler OT.
EMBO Rep
. 2013 Dec;14(12):1028-9. doi: 10.1038/embor.2013.172. Epub 2013 Nov 1. No abstract available. PubMed

Restrictions to HIV-1 replication in resting CD4+ T lymphocytes.
Pan X, Baldauf HM, Keppler OT, Fackler OT.
Cell Res
. 2013 Jul;23(7):876-85. doi: 10.1038/cr.2013.74. Epub 2013 Jun 4. Review. PubMed

Low vitamin D serum concentration is associated with high levels of hepatitis B virus replication in chronically infected patients.
Farnik H, Bojunga J, Berger A, Allwinn R, Waidmann O, Kronenberger B, Keppler OT, Zeuzem S, Sarrazin C, Lange CM.
Hepatology
. 2013 Oct;58(4):1270-6. doi: 10.1002/hep.26488. Epub 2013 Aug 7. PubMed

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2012

Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides.
Izquierdo-Useros N, Lorizate M, Puertas MC, Rodriguez-Plata MT, Zangger N, Erikson E, Pino M, Erkizia I, Glass B, Clotet B, Keppler OT, Telenti A, Kräusslich HG, Martinez-Picado J.
PLoS Biol
. 2012;10(12):e1001448. doi: 10.1371/journal.pbio.1001448. Epub 2012 Dec 18. PubMed

SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.
Baldauf HM, Pan X, Erikson E, Schmidt S, Daddacha W, Burggraf M, Schenkova K, Ambiel I, Wabnitz G, Gramberg T, Panitz S, Flory E, Landau NR, Sertel S, Rutsch F, Lasitschka F, Kim B, König R, Fackler OT, Keppler OT.
Nat Med
. 2012 Nov;18(11):1682-7. doi: 10.1038/nm.2964. PubMed

Conformation-specific display of 4E10 and 2F5 epitopes on self-assembling protein nanoparticles as a potential HIV vaccine.
Wahome N, Pfeiffer T, Ambiel I, Yang Y, Keppler OT, Bosch V, Burkhard P.
Chem Biol Drug Des
. 2012 Sep;80(3):349-57. doi: 10.1111/j.1747-0285.2012.01423.x. Epub 2012 Jul 3. PubMed

A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes.
Haid S, Novodomská A, Gentzsch J, Grethe C, Geuenich S, Bankwitz D, Chhatwal P, Jannack B, Hennebelle T, Bailleul F, Keppler OT, Poenisch M, Bartenschlager R, Hernandez C, Lemasson M, Rosenberg AR, Wong-Staal F, Davioud-Charvet E, Pietschmann T.
Gastroenterology
. 2012 Jul;143(1):213-22.e5. doi: 10.1053/j.gastro.2012.03.036. Epub 2012 Mar 27. PubMed

HIV-1 Vpu's lipid raft association is dispensable for counteraction of the particle release restriction imposed by CD317/Tetherin.
Fritz JV, Tibroni N, Keppler OT, Fackler OT.
Virology. 2012 Mar 1;424(1):33-44. doi: 10.1016/j.virol.2011.12.008. Epub 2012 Jan 4. PubMed

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2011

The cellular antiviral restriction factor tetherin does not inhibit poxviral replication.
Sliva K, Resch T, Kraus B, Goffinet C, Keppler OT, Schnierle BS.
J Virol
. 2012 Feb;86(3):1893-6. doi: 10.1128/JVI.05198-11. Epub 2011 Nov 16. PubMed

In vivo expression profile of the antiviral restriction factor and tumor-targeting antigen CD317/BST-2/HM1.24/tetherin in humans.
Erikson E, Adam T, Schmidt S, Lehmann-Koch J, Over B, Goffinet C, Harter C, Bekeredjian-Ding I, Sertel S, Lasitschka F, Keppler OT.
Proc Natl Acad Sci U S A
. 2011 Aug 16;108(33):13688-93. doi: 10.1073https://www.ncbi.nlm.nih.gov/pnas.1101684108. Epub 2011 Aug 1. PubMed

Architecture and regulation of the HIV-1 assembly and holding compartment in macrophages.
Welsch S, Groot F, Kräusslich HG, Keppler OT, Sattentau QJ.
J Virol
. 2011 Aug;85(15):7922-7. doi: 10.1128/JVI.00834-11. Epub 2011 May 25. PubMed

HIV-1 Vpu blocks recycling and biosynthetic transport of the intrinsic immunity factor CD317/tetherin to overcome the virion release restriction.
Schmidt S, Fritz JV, Bitzegeio J, Fackler OT, Keppler OT.
MBio
. 2011 May 24;2(3):e00036-11. doi: 10.1128/mBio.00036-11. Print 2011. PubMed

β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release. Tervo HM, Homann S, Ambiel I, Fritz JV, Fackler OT, Keppler OT.
Retrovirology
. 2011 Feb 10;8:9. doi: 10.1186/1742-4690-8-9. PubMed

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2010

High natural permissivity of primary rabbit cells for HIV-1, with a virion infectivity defect in macrophages as the final replication barrier.
Tervo HM, Keppler OT.
J Virol
. 2010 Dec;84(23):12300-14. doi: 10.1128/JVI.01607-10. Epub 2010 Sep 22. PubMed

Endogenous CD317/Tetherin limits replication of HIV-1 and murine leukemia virus in rodent cells and is resistant to antagonists from primate viruses.
Goffinet C, Schmidt S, Kern C, Oberbremer L, Keppler OT.
J Virol
. 2010 Nov;84(21):11374-84. doi: 10.1128/JVI.01067-10. Epub 2010 Aug 11. PubMed

Poor performance of bioinformatics programs for genotypic prediction of coreceptor usage of HIV-1 group O isolates.
Rupp D, Geuenich S, Keppler OT.
J Acquir Immune Defic Syndr
. 2010 Mar;53(3):412-3. doi: 10.1097/QAI.0b013e3181c9f53f. No abstract available. PubMed

Antagonism of CD317 restriction of human immunodeficiency virus type 1 (HIV-1) particle release and depletion of CD317 are separable activities of HIV-1 Vpu.
Goffinet C, Homann S, Ambiel I, Tibroni N, Rupp D, Keppler OT, Fackler OT.
J Virol
. 2010 Apr;84(8):4089-94. doi: 10.1128/JVI.01549-09. Epub 2010 Feb 10. PubMed

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2009

Biological signature characteristics of primary isolates from human immunodeficiency virus type 1 group O in ex vivo human tonsil histocultures.
Geuenich S, Kaderali L, Allespach I, Sertel S, Keppler OT.
J Virol
. 2009 Oct;83(20):10494-503. doi: 10.1128/JVI.00928-09. Epub 2009 Aug 12. PubMed

HIV-1 Gag processing intermediates trans-dominantly interfere with HIV-1 infectivity.
Müller B, Anders M, Akiyama H, Welsch S, Glass B, Nikovics K, Clavel F, Tervo HM, Keppler OT, Kräusslich HG.
J Biol Chem
. 2009 Oct 23;284(43):29692-703. doi: 10.1074/jbc.M109.027144. Epub 2009 Aug 7. PubMed

Pharmacovirological impact of an integrase inhibitor on human immunodeficiency virus type 1 cDNA species in vivo.
Goffinet C, Allespach I, Oberbremer L, Golden PL, Foster SA, Johns BA, Weatherhead JG, Novick SJ, Chiswell KE, Garvey EP, Keppler OT.
J Virol
. 2009 Aug;83(15):7706-17. doi: 10.1128/JVI.00683-09. Epub 2009 May 20. PubMed

HIV pseudovirion vaccine exposing Env "fusion intermediates"-response to immunisation in human CD4/CCR5-transgenic rats.
Bosch V, Pfeiffer T, Devitt G, Allespach I, Ebensen T, Emerson V, Guzman CA, Keppler OT.
Vaccine
. 2009 Apr 6;27(16):2202-12. doi: 10.1016/j.vaccine.2009.02.014. Epub 2009 Feb 13. PubMed

HIV-1 antagonism of CD317 is species specific and involves Vpu-mediated proteasomal degradation of the restriction factor.
Goffinet C, Allespach I, Homann S, Tervo HM, Habermann A, Rupp D, Oberbremer L, Kern C, Tibroni N, Welsch S, Krijnse-Locker J, Banting G, Kräusslich HG, Fackler OT, Keppler OT.
Cell Host Microbe
. 2009 Mar 19;5(3):285-97. doi: 10.1016/j.chom.2009.01.009. PubMed

Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivo.
Homann S, Tibroni N, Baumann I, Sertel S, Keppler OT, Fackler OT.
Retrovirology
. 2009 Jan 15;6:6. doi: 10.1186/1742-4690-6-6. PubMed

Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo.
Michel N, Goffinet C, Ganter K, Allespach I, Kewalramani VN, Saifuddin M, Littman DR, Greene WC, Goldsmith MA, Keppler OT.
Retrovirology. 2009 Jan 13;6:2. doi: 10.1186/1742-4690-6-2. PubMed

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2008

Mouse T-cells restrict replication of human immunodeficiency virus at the level of integration.
Tervo HM, Goffinet C, Keppler OT.
Retrovirology. 2008 Jul 8;5:58. doi: 10.1186/1742-4690-5-58. PubMed

High-level transfection of primary rabbit T lymphocytes.
Tervo HM, Allespach I, Keppler OT.
J Immunol Methods
. 2008 Jul 20;336(1):85-9. doi: 10.1016/j.jim.2008.03.006. Epub 2008 Apr 7. PubMed 

Aqueous extracts from peppermint, sage and lemon balm leaves display potent anti-HIV-1 activity by increasing the virion density.
Geuenich S, Goffinet C, Venzke S, Nolkemper S, Baumann I, Plinkert P, Reichling J, Keppler OT.
Retrovirology
. 2008 Mar 20;5:27. doi: 10.1186/1742-4690-5-27. PubMed 

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2007

Semen-derived amyloid fibrils drastically enhance HIV infection.
Münch J, Rücker E, Ständker L, Adermann K, Goffinet C, Schindler M, Wildum S, Chinnadurai R, Rajan D, Specht A, Giménez-Gallego G, Sánchez PC, Fowler DM, Koulov A, Kelly JW, Mothes W, Grivel JC, Margolis L, Keppler OT, Forssmann WG, Kirchhoff F.
Cell
. 2007 Dec 14;131(6):1059-71. PubMed

Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression.
Goffinet C, Michel N, Allespach I, Tervo HM, Hermann V, Kräusslich HG, Greene WC, Keppler OT.
Retrovirology
. 2007 Jul 26;4:53. PubMed

HIV-1 buds predominantly at the plasma membrane of primary human macrophages.
Welsch S, Keppler OT, Habermann A, Allespach I, Krijnse-Locker J, Kräusslich HG.
PLoS Pathog
. 2007 Mar;3(3):e36. PubMed

Analysis of the exposure of induced HIV glycoprotein epitopes in a potential HIV pseudovirion vaccine.
Devitt G, Emerson V, Pisch T, Keppler OT, Bosch V.
Vaccine
. 2007 Mar 8;25(12):2161-7. Epub 2006 Dec 27. PubMed

HIV-susceptible transgenic rats allow rapid preclinical testing of antiviral compounds targeting virus entry or reverse transcription.
Goffinet C, Allespach I, Keppler OT.
Proc Natl Acad Sci U S A
. 2007 Jan 16;104(3):1015-20. Epub 2007 Jan 5. PubMed

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2006

Expression of Nef downregulates CXCR4, the major coreceptor of human immunodeficiency virus, from the surfaces of target cells and thereby enhances resistance to superinfection.
Venzke S, Michel N, Allespach I, Fackler OT, Keppler OT.
J Virol
. 2006 Nov;80(22):11141-52. Epub 2006 Aug 23. PubMed

Role of macrophages in HIV infection and persistence.
Venzke S, Keppler OT.
Expert Rev Clin Immunol
. 2006 Jul;2(4):613-26. doi: 10.1586/1744666X.2.4.613. PubMed

The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling.
Michel N, Ganter K, Venzke S, Bitzegeio J, Fackler OT, Keppler OT.
Mol Biol Cell
. 2006 Aug;17(8):3578-90. Epub 2006 Jun 14. PubMed

The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity.
Haller C, Rauch S, Michel N, Hannemann S, Lehmann MJ, Keppler OT, Fackler OT. J Biol Chem. 2006 Jul 14;281(28):19618-30. Epub 2006 May 10. PubMed

Sensory neuropathy in human immunodeficiency virus/acquired immunodeficiency syndrome patients: protease inhibitor-mediated neurotoxicity.
Pettersen JA, Jones G, Worthington C, Krentz HB, Keppler OT, Hoke A, Gill MJ, Power C.
Ann Neurol
. 2006 May;59(5):816-24. PubMed

Efficient nonviral gene delivery into primary lymphocytes from rats and mice.
Goffinet C, Keppler OT.
FASEB J
. 2006 Mar;20(3):500-2. Epub 2006 Jan 9. PubMed

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2005

Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1.
Keppler OT, Tibroni N, Venzke S, Rauch S, Fackler OT.
J Leukoc Biol
. 2006 Mar;79(3):616-27. Epub 2005 Dec 19. PubMed

The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4.
Michel N, Allespach I, Venzke S, Fackler OT, Keppler OT.
Curr Biol
. 2005 Apr 26;15(8):714-23. PubMed

Tissue-resident macrophages are productively infected ex vivo by primary X4 isolates of human immunodeficiency virus type 1.
Jayakumar P, Berger I, Autschbach F, Weinstein M, Funke B, Verdin E, Goldsmith MA, Keppler OT.
J Virol
. 2005 Apr;79(8):5220-6. PubMed

Peripheral nerve-derived HIV-1 is predominantly CCR5-dependent and causes neuronal degeneration and neuroinflammation.
Jones G, Zhu Y, Silva C, Tsutsui S, Pardo CA, Keppler OT, McArthur JC, Power C.
Virology
. 2005 Apr 10;334(2):178-93. PubMed

Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor Nef.
Keppler OT, Allespach I, Schüller L, Fenard D, Greene WC, Fackler OT.
J Virol
. 2005 Feb;79(3):1655-65. PubMed

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2004

Construction and characterization of an HIV-1 group O infectious molecular clone and analysis of vpr- and nef-negative derivatives.
Tebit DM, Zekeng L, Kaptué L, Gürtler L, Fackler OT, Keppler OT, Herchenröder O, Kräusslich HG.
Virology
. 2004 Sep 1;326(2):329-39. PubMed

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2003

In vivo evolution of human immunodeficiency virus type 1 toward increased pathogenicity through CXCR4-mediated killing of uninfected CD4 T cells.
Jekle A, Keppler OT, De Clercq E, Schols D, Weinstein M, Goldsmith MA.
J Virol
. 2003 May;77(10):5846-54. PubMed

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2002

Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1.
Keppler OT, Welte FJ, Ngo TA, Chin PS, Patton KS, Tsou CL, Abbey NW, Sharkey ME, Grant RM, You Y, Scarborough JD, Ellmeier W, Littman DR, Stevenson M, Charo IF, Herndier BG, Speck RF, Goldsmith MA.
J Exp Med
. 2002 Mar 18;195(6):719-36. PubMed

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2001

Versatile biosynthetic engineering of sialic acid in living cells using synthetic sialic acid analogues.
Oetke C, Brossmer R, Mantey LR, Hinderlich S, Isecke R, Reutter W, Keppler OT, Pawlita M.
J Biol Chem. 2002 Feb 22;277(8):6688-95. Epub 2001 Dec 20. PubMed

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2000 and before

Susceptibility of rat-derived cells to replication by human immunodeficiency virus type 1.
Keppler OT, Yonemoto W, Welte FJ, Patton KS, Iacovides D, Atchison RE, Ngo T, Hirschberg DL, Speck RF, Goldsmith MA.
J Virol. 2001 Sep;75(17):8063-73. PubMed 

Efficient biochemical engineering of cellular sialic acids using an unphysiological sialic acid precursor in cells lacking UDP-N-acetylglucosamine 2-epimerase.
Mantey LR, Keppler OT, Pawlita M, Reutter W, Hinderlich S.
FEBS Lett. 2001 Aug 10;503(1):80-4. PubMed 

Evidence for efficient uptake and incorporation of sialic acid by eukaryotic cells.
Oetke C, Hinderlich S, Brossmer R, Reutter W, Pawlita M, Keppler OT.
Eur J Biochem. 2001 Aug;268(16):4553-61. PubMed 

Biosynthesis of N-acetylneuraminic acid in cells lacking UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase.
Hinderlich S, Berger M, Keppler OT, Pawlita M, Reutter W.
Biol Chem. 2001 Feb;382(2):291-7. PubMed 

Biochemical engineering of the N-acyl side chain of sialic acid: biological implications. Keppler OT, Horstkorte R, Pawlita M, Schmidt C, Reutter W. Glycobiology. 2001 Feb;11(2):11R-18R. Review. PubMed 

Differential sialylation of cell surface glycoconjugates in a human B lymphoma cell line regulates susceptibility for CD95 (APO-1/Fas)-mediated apoptosis and for infection by a lymphotropic virus.
Keppler OT, Peter ME, Hinderlich S, Moldenhauer G, Stehling P, Schmitz I, Schwartz-Albiez R, Reutter W, Pawlita M.
Glycobiology. 1999 Jun;9(6):557-69. PubMed 

UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation.
Keppler OT, Hinderlich S, Langner J, Schwartz-Albiez R, Reutter W, Pawlita M.
Science. 1999 May 21;284(5418):1372-6. PubMed 

Elongation of the N-acyl side chain of sialic acids in MDCK II cells inhibits influenza A virus infection.
Keppler OT, Herrmann M, von der Lieth CW, Stehling P, Reutter W, Pawlita M.
Biochem Biophys Res Commun. 1998 Dec 18;253(2):437-42. PubMed 

Biosynthetic modulation of sialic acid-dependent virus-receptor interactions of two primate polyoma viruses.
Keppler OT, Stehling P, Herrmann M, Kayser H, Grunow D, Reutter W, Pawlita M.
J Biol Chem. 1995 Jan 20;270(3):1308-14. PubMed 

Regulation of susceptibility and cell surface receptor for the B-lymphotropic papovavirus by N glycosylation.
Keppler OT, Herrmann M, Oppenländer M, Meschede W, Pawlita M.
J Virol. 1994 Nov;68(11):6933-9. PubMed 

The cell surface receptor is a major determinant restricting the host range of the B-lymphotropic papovavirus.
Haun G, Keppler OT, Bock CT, Herrmann M, Zentgraf H, Pawlita M.
J Virol
. 1993 Dec;67(12):7482-92. PubMed 

Human Golgi beta-galactoside alpha-2,6-sialyltransferase generates a group of sialylated B lymphocyte differentiation antigens.
Keppler OT, Moldenhauer G, Oppenländer M, Schwartz-Albiez R, Berger EG, Funderud S, Pawlita M.
Eur J Immunol
. 1992 Nov;22(11):2777-81. PubMed