Keppler Lab - Research
From understanding fundamental principles of virus-host interaction to the development of HIV-susceptible small animal models
Areas of investigation
HIV/AIDS has become one of the most devastating pandemics in recorded history. AIDS is the fourth-biggest global killer and the leading cause of death in Africa. HIV/AIDS persists as a major cause of morbidity in Western societies, since currently available pharmacotherapies can only partly control, but not cure this immunodestructive viral infection. Furthermore, these drugs frequently cause severe side effects and HIV drug resistance development is rapidly emerging. Globally, the lack of effective treatment regimens causes immense human suffering and high cost for society.
My laboratory seeks to better understand the pathological interplay of HIV with the host’s immune system and its target cells with the goal of providing new approaches for prophylaxis and therapy.