Conzelman Lab - Publications
2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2000 and before
2022
Excessive local host-graft connectivity in aging and amyloid-loaded brain.
Thomas J, Martinez-Reza MF, Thorwirth M, Zarb Y, Conzelmann KK, Hauck SM, Grade S, Götz M.
Sci Adv. 2022 Jun 10;8(23):eabg9287. doi: 10.1126/sciadv.abg9287. PubMed
Brain injury environment critically influences the connectivity of transplanted neurons.
Grade S, Thomas J, Zarb Y, Thorwirth M, Conzelmann KK, Hauck SM, Götz M.
Sci Adv. 2022 Jun 10;8(23):eabg9445. doi: 10.1126/sciadv.abg9445. PubMed
Selective plasticity of callosal neurons in the adult contralesional cortex following murine traumatic brain injury.
Empl L, Chovsepian A, Chahin M, Kan WYV, Fourneau J, Van Steenbergen V, Weidinger S, Marcantoni M, Ghanem A, Bradley P, Conzelmann KK, Cai R, Ghasemigharagoz A, Ertürk A, Wagner I, Kreutzfeldt M, Merkler D, Liebscher S, Bareyre FM.
Nat Commun. 2022 May 12;13(1):2659. doi: 10.1038/s41467-022-29992-0. PubMed
General anesthesia globally synchronizes activity selectively in layer 5 cortical pyramidal neurons.
Bharioke A, Munz M, Brignall A, Kosche G, Eizinger MF, Ledergerber N, Hillier D, Gross-Scherf B, Conzelmann KK, Macé E, Roska B.
Neuron. 2022 Jun 15;110(12):2024-2040.e10. doi: 10.1016/j.neuron.2022.03.032. PubMed
Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4+ T cells allows complex functional analyses.
Albanese M, Ruhle A, Mittermaier J, Mejías-Pérez E, Gapp M, Linder A, Schmacke NA, Hofmann K, Hennrich AA, Levy DN, Humpe A, Conzelmann KK, Hornung V, Fackler OT, Keppler OT.
Nat Methods. 2022 Jan;19(1):81-89. PubMed
2021
Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy.
Lentini C, d'Orange M, Marichal N, Trottmann MM, Vignoles R, Foucault L, Verrier C, Massera C, Raineteau O, Conzelmann KK, Rival-Gervier S, Depaulis A, Berninger B, Heinrich C.
Cell Stem Cell. 2021 Sep 24:S1934-5909(21)00378-7. doi: 10.1016/j.stem.2021.09.002. PubMed
Glycoproteins of Predicted Amphibian and Reptile Lyssaviruses Can Mediate Infection of Mammalian and Reptile Cells.
Oberhuber M, Schopf A, Hennrich AA, Santos-Mandujano R, Huhn AG, Seitz S, Riedel C, Conzelmann KK.
Viruses. 2021 Aug 30;13(9):1726. doi: 10.3390/v13091726. PubMed
Optimization of whole-brain rabies virus tracing technology for small cell populations.
Roelofs TJM, Menting-Henry S, Gol LM, Speel AM, Wielenga VH, Garner KM, Luijendijk MCM, Hennrich AA, Conzelmann KK, Adan RAH.
Sci Rep. 2021 May 17;11(1):10400. doi: 10.1038/s41598-021-89862-5. PubMed
Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities.
Hayn M, Hirschenberger M, Koepke L, Nchioua R, Straub JH, Klute S, Hunszinger V, Zech F, Prelli Bozzo C, Aftab W, Christensen MH, Conzelmann C, Müller JA, Srinivasachar Badarinarayan S, Stürzel CM, Forne I, Stenger S, Conzelmann KK, Münch J, Schmidt FI, Sauter D, Imhof A, Kirchhoff F, Sparrer KMJ.
Cell Rep. 2021 May 18;35(7):109126. doi: 10.1016/j.celrep.2021.109126. PubMed
Safe and effective two-in-one replicon-and-VLP minispike vaccine for COVID-19: Protection of mice after a single immunization.
Hennrich AA, Sawatsky B, Santos-Mandujano R, Banda DH, Oberhuber M, Schopf A, Pfaffinger V, Wittwer K, Riedel C, Pfaller CK, Conzelmann KK.
PLoS Pathog. 2021 Apr 21;17(4):e1009064. doi: 10.1371/journal.ppat.1009064. PubMed
2020
The Insula Cortex Contacts Distinct Output Streams of the Central Amygdala.
Ponserre M, Peters C, Fermani F, Conzelmann KK, Klein R.
J Neurosci. 2020 Nov 11;40(46):8870-8882. doi: 10.1523/JNEUROSCI.0567-20.2020. PubMed
A whole-brain connectivity map of mouse insular cortex.
Gehrlach DA, Weiand C, Gaitanos TN, Cho E, Klein AS, Hennrich AA, Conzelmann KK, Gogolla N.
Elife. 2020 Sep 17;9:e55585. doi: 10.7554/eLife.55585. PubMed
Components and Architecture of the Rhabdovirus Ribonucleoprotein Complex.
Riedel C, Hennrich AA, Conzelmann KK.
Viruses. 2020 Aug 29;12(9):959. doi: 10.3390/v12090959. PubMed
Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons.
Tang Y, Benusiglio D, Lefevre A, Hilfiger L, Althammer F, Bludau A, Hagiwara D, Baudon A, Darbon P, Schimmer J, Kirchner MK, Roy RK, Wang S, Eliava M, Wagner S, Oberhuber M, Conzelmann KK, Schwarz M, Stern JE, Leng G, Neumann ID, Charlet A, Grinevich V.
Nat Neurosci. 2020 Sep;23(9):1125-1137. doi: 10.1038/s41593-020-0674-y. Epub 2020 Jul 27. PubMed
Formation of somatosensory detour circuits mediates functional recovery following dorsal column injury.
Granier C, Schwarting J, Fourli E, Laage-Gaupp F, Hennrich AA, Schmalz A, Jacobi A, Wesolowski M, Conzelmann KK, Bareyre FM.
Sci Rep. 2020 Jul 2;10(1):10953. doi: 10.1038/s41598-020-67866-x. PubMed
Mitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling.
Gӧbel J, Engelhardt E, Pelzer P, Sakthivelu V, Jahn HM, Jevtic M, Folz-Donahue K, Kukat C, Schauss A, Frese CK, Giavalisco P, Ghanem A, Conzelmann KK, Motori E, Bergami M.
Cell Metab. 2020 Apr 7;31(4):791-808.e8. doi: 10.1016/j.cmet.2020.03.005. PubMed
2019
Xenotransplanted Human Cortical Neurons Reveal Species-Specific Development and Functional Integration into Mouse Visual Circuits.
Linaro D, Vermaercke B, Iwata R, Ramaswamy A, Libé-Philippot B, Boubakar L, Davis BA, Wierda K, Davie K, Poovathingal S, Penttila PA, Bilheu A, De Bruyne L, Gall D, Conzelmann KK, Bonin V, Vanderhaeghen P.
Neuron. 2019 Dec 4;104(5):972-986.e6. doi: 10.1016/j.neuron.2019.10.002. PubMed
Mapping Brain-Wide Afferent Inputs of Parvalbumin-Expressing GABAergic Neurons in Barrel Cortex Reveals Local and Long-Range Circuit Motifs.
Hafner G, Witte M, Guy J, Subhashini N, Fenno LE, Ramakrishnan C, Kim YS, Deisseroth K, Callaway EM, Oberhuber M, Conzelmann KK, Staiger JF.
Cell Rep. 2019 Sep 24;28(13):3450-3461.e8. doi: 10.1016/j.celrep.2019.08.064. PubMed
Aversive state processing in the posterior insular cortex.
Gehrlach DA, Dolensek N, Klein AS, Roy Chowdhury R, Matthys A, Junghänel M, Gaitanos TN, Podgornik A, Black TD, Reddy Vaka N, Conzelmann KK, Gogolla N.
Nat Neurosci. 2019 Sep;22(9):1424-1437. doi: 10.1038/s41593-019-0469-1. PubMed
Cryo EM structure of the rabies virus ribonucleoprotein complex.
Riedel C, Vasishtan D, Pražák V, Ghanem A, Conzelmann KK, Rümenapf T.
Sci Rep. 2019 Jul 3;9(1):9639. doi: 10.1038/s41598-019-46126-7. PubMed
Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins.
Braun E, Hotter D, Koepke L, Zech F, Groß R, Sparrer KMJ, Müller JA, Pfaller CK, Heusinger E, Wombacher R, Sutter K, Dittmer U, Winkler M, Simmons G, Jakobsen MR, Conzelmann KK, Pöhlmann S, Münch J, Fackler OT, Kirchhoff F, Sauter D.
Cell Rep. 2019 May 14;27(7):2092-2104.e10. doi: 10.1016/j.celrep.2019.04.063. PubMed
2018
Learning-Related Plasticity in Dendrite-Targeting Layer 1 Interneurons.
Abs E, Poorthuis RB, Apelblat D, Muhammad K, Pardi MB, Enke L, Kushinsky D, Pu DL, Eizinger MF, Conzelmann KK, Spiegel I, Letzkus JJ.
Neuron. 2018 Nov 7;100(3):684-699.e6. doi: 10.1016/j.neuron.2018.09.001. PubMed
Anatomical projections of the dorsomedial hypothalamus to the periaqueductal grey and their role in thermoregulation: a cautionary note.
de Git KCG, van Tuijl DC, Luijendijk MCM, Wolterink-Donselaar IG, Ghanem A, Conzelmann KK, Adan RAH.
Physiol Rep. 2018 Jul;6(14):e13807. doi: 10.14814/phy2.13807. PubMed
Virus stamping for targeted single-cell infection in vitro and in vivo.
Schubert R, Trenholm S, Balint K, Kosche G, Cowan CS, Mohr MA, Munz M, Martinez-Martin D, Fläschner G, Newton R, Krol J, Scherf BG, Yonehara K, Wertz A, Ponti A, Ghanem A, Hillier D, Conzelmann KK, Müller DJ, Roska B.
Nat Biotechnol. 2018 Jan;36(1):81-88. doi: 10.1038/nbt.4034. PubMed
2017
TNFα drives mitochondrial stress in POMC neurons in obesity.
Yi CX, Walter M, Gao Y, Pitra S, Legutko B, Kälin S, Layritz C, Garcìa-Càceres C, Bielohuby M, Bidlingmaier M, Woods SC, Ghanem A, Conzelmann KK, Stern JE, Jastroch M, Tsch√∂p MH.
Nat Commun. 2017 May 10;8:15143. doi: 10.1038/ncomms15143. PubMed
Neuronal LRP4 regulates synapse formation in the developing CNS.
Karakatsani A, Marichal N, Urban S, Kalamakis G, Ghanem A, Schick A, Zhang Y, Conzelmann KK, Rüegg MA, Berninger B, Ruiz de Almodovar C, Gascón S, Kröger S.
Development. 2017 Dec 15;144(24):4604-4615. doi: 10.1242/dev.150110. Epub 2017 Oct 23. PubMed
Identification of Two Classes of Somatosensory Neurons That Display Resistance to Retrograde Infection by Rabies Virus.
Albisetti GW, Ghanem A, Foster E, Conzelmann KK, Zeilhofer HU, Wildner H.
J Neurosci. 2017 Oct 25;37(43):10358-10371. doi: 10.1523/JNEUROSCI.1277-17.2017. Epub 2017 Sep 26. PubMed
Central amygdala circuits modulate food consumption through a positive-valence mechanism.
Douglass AM, Kucukdereli H, Ponserre M, Markovic M, Gründemann J, Strobel C, Alcala Morales PL, Conzelmann KK, Lüthi A, Klein R.
Nat Neurosci. 2017 Oct;20(10):1384-1394. doi: 10.1038/nn.4623. Epub 2017 Aug 21. PubMed
Erratum: Transplanted embryonic neurons integrate into adult neocortical circuits.
Falkner S, Grade S, Dimou L, Conzelmann KK, Bonhoeffer T, Götz M, Hübener M.
Nature. 2017 Jan 5;541(7635):122. doi: 10.1038/nature20808. Epub 2016 Dec 7. PubMed
2016
Erratum: Transplanted embryonic neurons integrate into adult neocortical circuits.
Falkner S, Grade S, Dimou L, Conzelmann KK, Bonhoeffer T, Götz M, Hübener M.
Nature. 2017 Jan 5;541(7635):122. doi: 10.1038/nature20808. Epub 2016 Dec 7. No abstract available. PubMed
Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model.
Romanelli E, Merkler D, Mezydlo A, Weil MT, Weber MS, Nikitá I, Potz S, Meinl E, Matznick FE, Kreutzfeldt M, Ghanem A, Conzelmann KK, Metz I, Bröck W, Routh M, Simons M, Bishop D, Misgeld T, Kerschensteiner M.
Nat Commun. 2016 Nov 16;7:13275. doi: 10.1038/ncomms13275. PubMed
Transplanted embryonic neurons integrate into adult neocortical circuits.
Falkner S, Grade S, Dimou L, Conzelmann KK, Bonhoeffer T, Götz M, Hübener M.
Nature. 2016 Nov 10;539(7628):248-253. doi: 10.1038/nature20113. Epub 2016 Oct 26. Erratum in: Nature. 2017 Jan 5;541(7635):122. PubMed
Quantification of Lyssavirus-Neutralizing Antibodies Using Vesicular Stomatitis Virus Pseudotype Particles.
Moeschler S, Locher S, Conzelmann KK, Krämer B, Zimmer G.
Viruses. 2016 Sep 16;8(9). pii: E254. doi: 10.3390/v8090254. PubMed
Correction: ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.
Lässig C, Matheisl S, Sparrer KM, de Oliveira Mann CC, Moldt M, Patel JR, Goldeck M, Hartmann G, Garcìa-Sastre A, Hornung V, Conzelmann KK, Beckmann R, Hopfner KP.
Elife. 2016 Mar 2;5. pii: e14954. doi: 10.7554/eLife.14954. No abstract available. PubMed
Melanocortin 3 Receptor Signaling in Midbrain Dopamine Neurons Increases the Motivation for Food Reward.
Pandit R, Omrani A, Luijendijk MC, de Vrind VA, Van Rozen AJ, Ophuis RJ, Garner K, Kallo I, Ghanem A, Liposits Z, Conzelmann KK, Vanderschuren LJ, la Fleur SE, Adan RA.
Neuropsychopharmacology. 2016 Aug;41(9):2241-51. doi: 10.1038/npp.2016.19. Epub 2016 Feb 8. PubMed
2015
Abortively Infected Astrocytes Appear To Represent the Main Source of Interferon Beta in the Virus-Infected Brain.
Pfefferkorn C, Kallfass C, Lienenklaus S, Spanier J, Kalinke U, Rieder M, Conzelmann KK, Michiels T, Staeheli P.
J Virol. 2015 Dec 9;90(4):2031-8. doi: 10.1128/JVI.02979-15. PubMed
Recombinant Fluorescent Rabies Virus Vectors for Tracing Neurons and Synaptic Connections.
Hagendorf N, Conzelmann KK.
Cold Spring Harb Protoc. 2015 Dec 2;2015(12):pdb.top089391. doi: 10.1101/pdb.top089391. PubMed
Pseudotyping of G-Gene-Deficient Rabies Virus.
Hagendorf N, Conzelmann KK.
Cold Spring Harb Protoc. 2015 Dec 2;2015(12):pdb.prot089417. doi: 10.1101/pdb.prot089417. PubMed
Recovery of Replication-Competent and G-Gene-Deleted Rabies Viruses from cDNA.
Hagendorf N, Conzelmann KK.
Cold Spring Harb Protoc. 2015 Dec 2;2015(12):pdb.prot089409. doi: 10.1101/pdb.prot089409. PubMed
ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.
Lässig C, Matheisl S, Sparrer KM, de Oliveira Mann CC, Moldt M, Patel JR, Goldeck M, Hartmann G, Garc√≠a-Sastre A, Hornung V, Conzelmann KK, Beckmann R, Hopfner KP.
Elife. 2015 Nov 26;4. pii: e10859. doi: 10.7554/eLife.10859. Erratum in: Elife. 2016;5. pii: e14954. doi: 10.7554/eLife.14954. PubMed
PRESYNAPTIC NETWORKS. Single-cell-initiated monosynaptic tracing reveals layer-specific cortical network modules.
Wertz A, Trenholm S, Yonehara K, Hillier D, Raics Z, Leinweber M, Szalay G, Ghanem A, Keller G, Ròzsa B, Conzelmann KK, Roska B.
Science. 2015 Jul 3;349(6243):70-4. doi: 10.1126/science.aab1687. PubMed
G gene-deficient single-round rabies viruses for neuronal circuit analysis.
Ghanem A, Conzelmann KK.
Virus Res. 2016 May 2;216:41-54. doi: 10.1016/j.virusres.2015.05.023. Epub 2015 Jun 8. Review. PubMed
Targeted ablation, silencing, and activation establish glycinergic dorsal horn neurons as key components of a spinal gate for pain and itch.
Foster E, Wildner H, Tudeau L, Haueter S, Ralvenius WT, Jegen M, Johannssen H, Hösli L, Haenraets K, Ghanem A, Conzelmann KK, Bösl M, Zeilhofer HU.
Neuron. 2015 Mar 18;85(6):1289-304. doi: 10.1016/j.neuron.2015.02.028. PubMed
A critical period for experience-dependent remodeling of adult-born neuron connectivity. Bergami M, Masserdotti G, Temprana SG, Motori E, Eriksson TM, Göbel J, Yang SM, Conzelmann KK, Schinder AF, Götz M, Berninger B.
Neuron. 2015 Feb 18;85(4):710-7. doi: 10.1016/j.neuron.2015.01.001. Epub 2015 Feb 5. PubMed
2014
Cell-penetrating and neurotargeting dendritic siRNA nanostructures.
Brunner K, Harder J, Halbach T, Willibald J, Spada F, Gnerlich F, Sparrer K, Beil A, Möckl L, Bräuchle C, Conzelmann KK, Carell T.
Angew Chem Int Ed Engl. 2015 Feb 2;54(6):1946-9. doi: 10.1002/anie.201409803. Epub 2014 Dec 17. PubMed
Pre-existing astrocytes form functional perisynaptic processes on neurons generated in the adult hippocampus.
Krzisch M, Temprana SG, Mongiat LA, Armida J, Schmutz V, Virtanen MA, Kocher-Braissant J, Kraftsik R, Vutskits L, Conzelmann KK, Bergami M, Gage FH, Schinder AF, Toni N.
Brain Struct Funct. 2015 Jul;220(4):2027-42. doi: 10.1007/s00429-014-0768-y. Epub 2014 Apr 19. PubMed
Complete Genome Sequence of a Wild-Type Measles Virus Isolated during the Spring 2013 Epidemic in Germany.
Sparrer KM, Krebs S, Jäger G, Santibanez S, Mankertz A, Blum H, Conzelmann KK.
Genome Announc. 2014 Apr 17;2(2). pii: e00157-14. doi: 10.1128/genomeA.00157-14. PubMed
In vivo ligands of MDA5 and RIG-I in measles virus-infected cells.
Runge S, Sparrer KM, Lässig C, Hembach K, Baum A, García-Sastre A, Söding J, Conzelmann KK, Hopfner KP.
PLoS Pathog. 2014 Apr 17;10(4):e1004081. doi: 10.1371/journal.ppat.1004081. eCollection 2014 Apr. PubMed
A modified screening system for loss-of-function and dominant negative alleles of essential MCMV genes. Pogoda M, Bosse JB, Conzelmann KK, Koszinowski UH, Ruzsics Z.
PLoS One. 2014 Apr 14;9(4):e94918. doi: 10.1371/journal.pone.0094918. eCollection 2014. PubMed
An anterograde rabies virus vector for high-resolution large-scale reconstruction of 3D neuron morphology. Haberl MG, Viana da Silva S, Guest JM, Ginger M, Ghanem A, Mulle C, Oberlaender M, Conzelmann KK, Frick A.
Brain Struct Funct. 2015;220(3):1369-79. doi: 10.1007/s00429-014-0730-z. Epub 2014 Apr 11. PubMed
2013
Inflammation-induced alteration of astrocyte mitochondrial dynamics requires autophagy for mitochondrial network maintenance.
Motori E, Puyal J, Toni N, Ghanem A, Angeloni C, Malaguti M, Cantelli-Forti G, Berninger B, Conzelmann KK, Götz M, Winklhofer KF, Hrelia S, Bergami M.
Cell Metab. 2013 Dec 3;18(6):844-59. doi: 10.1016/j.cmet.2013.11.005. PubMed
The first stage of cardinal direction selectivity is localized to the dendrites of retinal ganglion cells.
Yonehara K, Farrow K, Ghanem A, Hillier D, Balint K, Teixeira M, Jüttner J, Noda M, Neve RL, Conzelmann KK, Roska B.
Neuron. 2013 Sep 18;79(6):1078-85. doi: 10.1016/j.neuron.2013.08.005. Epub 2013 Aug 22. PubMed
Retrograde monosynaptic tracing reveals the temporal evolution of inputs onto new neurons in the adult dentate gyrus and olfactory bulb.
Deshpande A, Bergami M, Ghanem A, Conzelmann KK, Lepier A, Götz M, Berninger B.
Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):E1152-61. doi: 10.1073/pnas.1218991110. Epub 2013 Mar 4. PubMed
Revealing the secrets of neuronal circuits with recombinant rabies virus technology.
Ginger M, Haberl M, Conzelmann KK, Schwarz MK, Frick A.
Front Neural Circuits. 2013 Jan 24;7:2. doi: 10.3389/fncir.2013.00002. eCollection 2013. Review. PubMed
Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling.
Motz C, Schuhmann KM, Kirchhofer A, Moldt M, Witte G, Conzelmann KK, Hopfner KP.
Science. 2013 Feb 8;339(6120):690-3. doi: 10.1126/science.1230949. Epub 2013 Jan 17. PubMed
The microtubule motor protein KIF13A is involved in intracellular trafficking of the Lassa virus matrix protein Z.'
Fehling SK, Noda T, Maisner A, Lamp B, Conzelmann KK, Kawaoka Y, Klenk HD, Garten W, Strecker T.
Cell Microbiol. 2013 Feb;15(2):315-34. doi: 10.1111/cmi.12095. Epub 2013 Jan 10. PubMed
2012
Charting monosynaptic connectivity maps by two-color light-sheet fluorescence microscopy.
Niedworok CJ, Schwarz I, Ledderose J, Giese G, Conzelmann KK, Schwarz MK.
Cell Rep. 2012 Nov 29;2(5):1375-86. doi: 10.1016/j.celrep.2012.10.008. Epub 2012 Nov 8. Erratum in: Cell Rep. 2012 Dec 27;2(6):1774-5. PubMed
Membrane and inclusion body targeting of lyssavirus matrix proteins.
Pollin R, Granzow H, Köllner B, Conzelmann KK, Finke S.
Cell Microbiol. 2013 Feb;15(2):200-12. doi: 10.1111/cmi.12037. Epub 2012 Oct 26. PubMed
Click-modified anandamide siRNA enables delivery and gene silencing in neuronal and immune cells.
Willibald J, Harder J, Sparrer K, Conzelmann KK, Carell T.
J Am Chem Soc. 2012 Aug 1;134(30):12330-3. doi: 10.1021/ja303251f. Epub 2012 Jul 23. PubMed
Chimeric rabies viruses for trans-species comparison of lyssavirus glycoprotein ectodomain functions in virus replication and pathogenesis.
Genz B, Nolden T, Negatsch A, Teifke JP, Conzelmann KK, Finke S.
Berl Munch Tierarztl Wochenschr. 2012 May-Jun;125(5-6):219-27. PubMed
Interferon in lyssavirus infection.
Rieder M, Finke S, Conzelmann KK.
Berl Munch Tierarztl Wochenschr. 2012 May-Jun;125(5-6):209-18. PubMed
Respiratory syncytial virus potentiates ABCA3 mutation-induced loss of lung epithelial cell differentiation.
Kaltenborn E, Kern S, Frixel S, Fragnet L, Conzelmann KK, Zarbock R, Griese M.
Hum Mol Genet. 2012 Jun 15;21(12):2793-806. doi: 10.1093/hmg/dds107. Epub 2012 Mar 20. PubMed
A radial glia-specific role of RhoA in double cortex formation.
Cappello S, Böhringer CR, Bergami M, Conzelmann KK, Ghanem A, Tomassy GS, Arlotta P, Mainardi M, Allegra M, Caleo M, van Hengel J, Brakebusch C, Götz M.
Neuron. 2012 Mar 8;73(5):911-24. doi: 10.1016/j.neuron.2011.12.030. PubMed
Measles virus C protein interferes with Beta interferon transcription in the nucleus.
Sparrer KM, Pfaller CK, Conzelmann KK.
J Virol. 2012 Jan;86(2):796-805. doi: 10.1128/JVI.05899-11. Epub 2011 Nov 9. PubMed
2011
Immunogenicity studies in carnivores using a rabies virus construct with a site-directed deletion in the phosphoprotein.
Vos A, Conzelmann KK, Finke S, Müller T, Teifke J, Fooks AR, Neubert A.
Adv Prev Med. 2011;2011:898171. doi: 10.4061/2011/898171. Epub 2011 Sep 21. PubMed
Interferon in rabies virus infection.
Rieder M, Conzelmann KK.
Adv Virus Res. 2011;79:91-114. doi: 10.1016/B978-0-12-387040-7.00006-8. Review. PubMed
Significantly improved rescue of rabies virus from cDNA plasmids.
Ghanem A, Kern A, Conzelmann KK.
Eur J Cell Biol. 2012 Jan;91(1):10-6. doi: 10.1016/j.ejcb.2011.01.008. Epub 2011 Mar 12. PubMed
The importance of being short: the role of rabies virus phosphoprotein isoforms assessed by differential IRES translation initiation.
Marschalek A, Drechsel L, Conzelmann KK.
Eur J Cell Biol. 2012 Jan;91(1):17-23. doi: 10.1016/j.ejcb.2011.01.009. Epub 2011 Mar 12. PubMed
The measles virus V protein binds to p65 (RelA) to suppress NF-kappaB activity.
Schuhmann KM, Pfaller CK, Conzelmann KK.
J Virol. 2011 Apr;85(7):3162-71. doi: 10.1128/JVI.02342-10. Epub 2011 Jan 26. PubMed
Genetic dissection of interferon-antagonistic functions of rabies virus phosphoprotein: inhibition of interferon regulatory factor 3 activation is important for pathogenicity.
Rieder M, Brzòzka K, Pfaller CK, Cox JH, Stitz L, Conzelmann KK.
J Virol. 2011 Jan;85(2):842-52. doi: 10.1128/JVI.01427-10. Epub 2010 Nov 17. Erratum in: J Virol. 2012 Apr;86(8):4720. PubMed
2009
Rhabdovirus evasion of the interferon system.
Rieder M, Conzelmann KK.
J Interferon Cytokine Res. 2009 Sep;29(9):499-509. doi: 10.1089/jir.2009.0068. Review. PubMed
2008
Attenuation of rabies virus replication and virulence by picornavirus internal ribosome entry site elements.
Marschalek A, Finke S, Schwemmle M, Mayer D, Heimrich B, Stitz L, Conzelmann KK.
J Virol. 2009 Feb;83(4):1911-9. doi: 10.1128/JVI.02055-08. Epub 2008 Dec 10. PubMed
Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction. Pfaller CK, Conzelmann KK.
J Virol. 2008 Dec;82(24):12365-73. doi: 10.1128/JVI.01321-08. Epub 2008 Oct 15. PubMed
The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I.
Cui S, Eisenächer K, Kirchhofer A, Brzòzka K, Lammens A, Lammens K, Fujita T, Conzelmann KK, Krug A, Hopfner KP.
Mol Cell. 2008 Feb 1;29(2):169-79. doi: 10.1016/j.molcel.2007.10.032. PubMed
Double-labeled rabies virus: live tracking of enveloped virus transport.
Klingen Y, Conzelmann KK, Finke S.
J Virol. 2008 Jan;82(1):237-45. Epub 2007 Oct 10. PubMed
2007
Comparative analysis of the full genome sequence of European bat lyssavirus type 1 and type 2 with other lyssaviruses and evidence for a conserved transcription termination and polyadenylation motif in the G-L 3' non-translated region.
Marston DA, McElhinney LM, Johnson N, Müller T, Conzelmann KK, Tordo N, Fooks AR.
J Gen Virol. 2007 Apr;88(Pt 4):1302-14. PubMed
Monosynaptic restriction of transsynaptic tracing from single, genetically targeted neurons.
Wickersham IR, Lyon DC, Barnard RJ, Mori T, Finke S, Conzelmann KK, Young JA, Callaway EM.
Neuron. 2007 Mar 1;53(5):639-47. PubMed
2006
Retrograde neuronal tracing with a deletion-mutant rabies virus.
Wickersham IR, Finke S, Conzelmann KK, Callaway EM.
Nat Methods. 2007 Jan;4(1):47-9. Epub 2006 Dec 10. PubMed
Title Description Details Resource URL 5'-Triphosphate RNA is the ligand for RIG-I.
Hornung V, Ellegast J, Kim S, Brzòzka K, Jung A, Kato H, Poeck H, Akira S, Conzelmann KK, Schlee M, Endres S, Hartmann G.
Science. 2006 Nov 10;314(5801):994-7. Epub 2006 Oct 12. PubMed
Inhibition of interferon signaling by rabies virus phosphoprotein P: activation-dependent binding of STAT1 and STAT2.
Brzòzka K, Finke S, Conzelmann KK.
J Virol. 2006 Mar;80(6):2675-83. PubMed
2005
Recombinant rhabdoviruses: vectors for vaccine development and gene therapy.
Finke S, Conzelmann KK.
Curr Top Microbiol Immunol. 2005;292:165-200. Review. PubMed
Viruses know it all: new insights into IFN networks.
Hengel H, Koszinowski UH, Conzelmann KK.
Trends Immunol. 2005 Jul;26(7):396-401. Review. PubMed
Identification of the rabies virus alpha/beta interferon antagonist: phosphoprotein P interferes with phosphorylation of interferon regulatory factor 3.
Brzòzka K, Finke S, Conzelmann KK.
J Virol. 2005 Jun;79(12):7673-81. PubMed
Replication strategies of rabies virus.
Finke S, Conzelmann KK.
Virus Res. 2005 Aug;111(2):120-31. Review. PubMed
Inhibition of toll-like receptor 7- and 9-mediated alpha/beta interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virus.
Schlender J, Hornung V, Finke S, Günthner-Biller M, Marozin S, Brzòzka K, Moghim S, Endres S, Hartmann G, Conzelmann KK.
J Virol. 2005 May;79(9):5507-15. PubMed
Transcriptional activation of alpha/beta interferon genes: interference by nonsegmented negative-strand RNA viruses.
Conzelmann KK.
J Virol. 2005 May;79(9):5241-8. Review. No abstract available. PubMed
2004
Replication-dependent potent IFN-alpha induction in human plasmacytoid dendritic cells by a single-stranded RNA virus.
Hornung V, Schlender J, Guenthner-Biller M, Rothenfusser S, Endres S, Conzelmann KK, Hartmann G.
J Immunol. 2004 Nov 15;173(10):5935-43. PubMed
Tracking fluorescence-labeled rabies virus: enhanced green fluorescent protein-tagged phosphoprotein P supports virus gene expression and formation of infectious particles.
Finke S, Brzózka K, Conzelmann KK.
J Virol. 2004 Nov;78(22):12333-43. PubMed
Reverse genetics of mononegavirales.
Conzelmann KK.
Curr Top Microbiol Immunol. 2004;283:1-41. Review. PubMed
2003
Dissociation of rabies virus matrix protein functions in regulation of viral RNA synthesis and virus assembly.
Finke S, Conzelmann KK.
J Virol. 2003 Nov;77(22):12074-82. PubMed
Virokinin, a bioactive peptide of the tachykinin family, is released from the fusion protein of bovine respiratory syncytial virus.
Zimmer G, Rohn M, McGregor GP, Schemann M, Conzelmann KK, Herrler G.
J Biol Chem. 2003 Nov 21;278(47):46854-61. Epub 2003 Sep 2. PubMed
Nonstructural proteins NS1 and NS2 of bovine respiratory syncytial virus block activation of interferon regulatory factor 3.
Bossert B, Marozin S, Conzelmann KK.
J Virol. 2003 Aug;77(16):8661-8. PubMed
Role of alpha/beta interferons in the attenuation and immunogenicity of recombinant bovine respiratory syncytial viruses lacking NS proteins.
Valarcher JF, Furze J, Wyld S, Cook R, Conzelmann KK, Taylor G.
J Virol. 2003 Aug;77(15):8426-39. PubMed
Rabies virus matrix protein regulates the balance of virus transcription and replication.
Finke S, Mueller-Waldeck R, Conzelmann KK.
J Gen Virol. 2003 Jun;84(Pt 6):1613-21. PubMed
Respiratory syncytial virus (RSV) fusion protein subunit F2, not attachment protein G, determines the specificity of RSV infection.
Schlender J, Zimmer G, Herrler G, Conzelmann KK.
J Virol. 2003 Apr;77(8):4609-16. PubMed
2002
Cleavage at the furin consensus sequence RAR/KR(109) and presence of the intervening peptide of the respiratory syncytial virus fusion protein are dispensable for virus replication in cell culture.
Zimmer G, Conzelmann KK, Herrler G.
J Virol. 2002 Sep;76(18):9218-24. PubMed
Respiratory syncytial virus (RSV) nonstructural (NS) proteins as host range determinants: a chimeric bovine RSV with NS genes from human RSV is attenuated in interferon-competent bovine cells.
Bossert B, Conzelmann KK.
J Virol. 2002 May;76(9):4287-93. PubMed
Respiratory syncytial virus fusion protein mediates inhibition of mitogen-induced T-cell proliferation by contact.
Schlender J, Walliser G, Fricke J, Conzelmann KK.
J Virol. 2002 Feb;76(3):1163-70. PubMed
2000 and before
Bovine respiratory syncytial virus nonstructural proteins NS1 and NS2 cooperatively antagonize alpha/beta interferon-induced antiviral response.
Schlender J, Bossert B, Buchholz U, Conzelmann KK.
J Virol. 2000 Sep;74(18):8234-42. PubMed
Spread and pathogenic characteristics of a G-deficient rabies virus recombinant: an in vitro and in vivo study.
Etessami R, Conzelmann KK, Fadai-Ghotbi B, Natelson B, Tsiang H, Ceccaldi PE.
J Gen Virol. 2000 Sep;81(Pt 9):2147-53. PubMed
Differential transcription attenuation of rabies virus genes by intergenic regions: generation of recombinant viruses overexpressing the polymerase gene.
Finke S, Cox JH, Conzelmann KK.
J Virol. 2000 Aug;74(16):7261-9. PubMed
Neuronal expression of foreign genes with recombinant rabies virus variants.
Etessami R, Conzelmann KK, Marion R, Tsiang H, Ceccaldi PE.
Rev Neurol (Paris). 2000 Mar;156(3):236-41. French. PubMed
Monoclonal antibodies to the GP5 of porcine reproductive and respiratory syndrome virus are more effective in virus neutralization than monoclonal antibodies to the GP4.
Weiland E, Wieczorek-Krohmer M, Kohl D, Conzelmann KK, Weiland F.
Vet Microbiol. 1999 Apr 19;66(3):171-86. PubMed
Virus promoters determine interference by defective RNAs: selective amplification of mini-RNA vectors and rescue from cDNA by a 3' copy-back ambisense rabies virus.
Finke S, Conzelmann KK.
J Virol. 1999 May;73(5):3818-25. PubMed
Nonsegmented negative-strand RNA viruses: genetics and manipulation of viral genomes.
Conzelmann KK.
Annu Rev Genet. 1998;32:123-62. Review. PubMed
Generation of bovine respiratory syncytial virus (BRSV) from cDNA: BRSV NS2 is not essential for virus replication in tissue culture, and the human RSV leader region acts as a functional BRSV genome promoter.
Buchholz UJ, Finke S, Conzelmann KK.
J Virol. 1999 Jan;73(1):251-9. PubMed
Matrix protein of rabies virus is responsible for the assembly and budding of bullet-shaped particles and interacts with the transmembrane spike glycoprotein G.
Mebatsion T, Weiland F, Conzelmann KK.
J Virol. 1999 Jan;73(1):242-50. PubMed
Infection characteristics of rabies virus variants with deletion or insertion in the pseudogene sequence.
Ceccaldi PE, Fayet J, Conzelmann KK, Tsiang H.
J Neurovirol. 1998 Feb;4(1):115-9. PubMed
Mapping the interacting domains between the rabies virus polymerase and phosphoprotein.
Chenik M, Schnell M, Conzelmann KK, Blondel D.
J Virol. 1998 Mar;72(3):1925-30. PubMed
Ambisense gene expression from recombinant rabies virus: random packaging of positive- and negative-strand ribonucleoprotein complexes into rabies virions.
Finke S, Conzelmann KK.
J Virol. 1997 Oct;71(10):7281-8. PubMed
A CXCR4/CD4 pseudotype rhabdovirus that selectively infects HIV-1 envelope protein-expressing cells.
Mebatsion T, Finke S, Weiland F, Conzelmann KK.
Cell. 1997 Sep 5;90(5):841-7. PubMed
Specific infection of CD4+ target cells by recombinant rabies virus pseudotypes carrying the HIV-1 envelope spike protein.
Mebatsion T, Conzelmann KK.
Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11366-70. PubMed
Genetic engineering of animal RNA viruses.
Conzelmann KK, Meyers G.
Trends Microbiol. 1996 Oct;4(10):386-93. Review. PubMed
Highly stable expression of a foreign gene from rabies virus vectors.
Mebatsion T, Schnell MJ, Cox JH, Finke S, Conzelmann KK.
Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7310-4. PubMed
Budding of rabies virus particles in the absence of the spike glycoprotein.
Mebatsion T, Konig M, Conzelmann KK.
Cell. 1996 Mar 22;84(6):941-51. PubMed
Genetic manipulation of non-segmented negative-strand RNA viruses.
Conzelmann KK.
J Gen Virol. 1996 Mar;77 ( Pt 3):381-9. Review. No abstract available. PubMed
Polymerase activity of in vitro mutated rabies virus L protein.
Schnell MJ, Conzelmann KK.
Virology. 1995 Dec 20;214(2):522-30. PubMed
Mokola virus glycoprotein and chimeric proteins can replace rabies virus glycoprotein in the rescue of infectious defective rabies virus particles.
Mebatsion T, Schnell MJ, Conzelmann KK.
J Virol. 1995 Mar;69(3):1444-51. PubMed
Infectious rabies viruses from cloned cDNA.
Schnell MJ, Mebatsion T, Conzelmann KK.
EMBO J. 1994 Sep 15;13(18):4195-203. PubMed
Rescue of synthetic genomic RNA analogs of rabies virus by plasmid-encoded proteins.
Conzelmann KK, Schnell M.
J Virol. 1994 Feb;68(2):713-9. PubMed
Molecular analysis of rabies-related viruses from Ethiopia.
Mebatsion T, Cox JH, Conzelmann KK.
Onderstepoort J Vet Res. 1993 Dec;60(4):289-94. PubMed
Molecular characterization of porcine reproductive and respiratory syndrome virus, a member of the arterivirus group.
Conzelmann KK, Visser N, Van Woensel P, Thiel HJ.
Virology. 1993 Mar;193(1):329-39. PubMed
Molecular characterization of positive-strand RNA viruses: pestiviruses and the porcine reproductive and respiratory syndrome virus (PRRSV).
Thiel HJ, Meyers G, Stark R, Tautz N, Rümenapf T, Unger G, Conzelmann KK.
Arch Virol Suppl. 1993;7:41-52. Review. PubMed
An L (polymerase)-deficient rabies virus defective interfering particle RNA is replicated and transcribed by heterologous helper virus L proteins.
Conzelmann KK, Cox JH, Thiel HJ.
Virology. 1991 Oct;184(2):655-63. PubMed
Molecular cloning and complete nucleotide sequence of the attenuated rabies virus SAD B19.
Conzelmann KK, Cox JH, Schneider LG, Thiel HJ.
Virology. 1990 Apr;175(2):485-99. PubMed
Regulatory structures of gene expression, DNA-replication and DNA-rearrangement in macronuclear genes of Stylonychia lemnae, a hypotrichous ciliate.
Helftenbein E, Conzelmann KK, Becker KF, Fritzenschaf H.
Eur J Protistol. 1989 Oct 27;25(2):158-67. doi: 10.1016/S0932-4739(89)80026-4. Epub 2012 Jan 30. PubMed
Nucleotide sequence and expression of two beta-tubulin genes in Stylonychia lemnae.
Conzelmann KK, Helftenbein E.
J Mol Biol. 1987 Dec 20;198(4):643-53. PubMed